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Journal : pharmacoscript

DEVELOPMENT AND EVALUATION OF PEPEROMIA PELLUCIDA L. PEEL-OFF GEL MASK AS ANTI-ACNE AGENT Indra, Indra; Yadi Aditya, Prawira; Fajar, Setiawan
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.1981

Abstract

This study investigates the development of a peel-off gel mask formulated with Peperomia pellucida L. extract as a natural treatment for acne. Peperomia pellucida L., traditionally valued for its medicinal properties, was characterized microscopically and macroscopically to confirm the plant’s identity and quality. Ethanol extraction yielded 16.54% bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, known for their antibacterial and anti-inflammatory activities. The research utilized a concentration-dependent approach, formulating three gel variants with 5% (F1), 10% (F2), and 15% (F3) extract concentrations. Antibacterial testing against Propionibacterium acnes showed that F3 exhibited the largest inhibition zone (10.72 mm), significantly outperforming the positive control (4.6 mm). Stability testing revealed that the formulations maintained consistent color, odor, and pH but faced challenges in viscosity and homogeneity at extreme temperatures. Hedonic testing indicated that participants favored F2 (10% extract) for its balanced aroma, color, and ease of application, although F1 and F3 were preferred for texture. Despite stability challenges, the formulations, mainly F3, demonstrated promising antibacterial efficacy. In conclusion, the peel-off gel mask containing Peperomia pellucida L. extract (F3) shows significant potential as a natural alternative to synthetic acne treatments. Further refinement is needed to enhance stability and user experience while maintaining its high antibacterial activity. study explores the development of a peel-off gel mask formulated with Peperomia pellucida L. extract for acne treatment. Peperomia pellucida L., traditionally known for its medicinal properties, was characterized microscopically and macroscopically, confirming the plant’s identity and quality. The ethanol extraction process yielded 16.54% of bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, known for their antibacterial and anti-inflammatory properties. Phytochemical screening confirmed these compounds’ presence, and antibacterial testing against Propionibacterium acnes revealed concentration-dependent inhibition, with the highest inhibition zone observed in the 15% extract formulation (F3). The gel formulations were evaluated for physical properties, stability, and user acceptance. Stability testing demonstrated consistency in colour, odour, and pH but revealed challenges in inhomogeneity and viscosity at extreme temperatures. Despite these issues, the formulations maintained antibacterial efficacy, mainly F3. Hedonic testing showed that participants favored F2 (10% extract) for its balanced aroma, color, and ease of application, although F1 and F3 were preferred for texture. In conclusion, the peel-off gel mask containing Peperomia pellucida L. shows significant potential as a natural, effective treatment for acne. However, further refinement is needed to optimize stability and user-friendliness while maintaining high antibacterial efficacy. These findings suggest that the extract could be a valuable addition to topical acne treatments, offering a natural alternative to synthetic products
Co-Authors Achmad Hidayatullah Aden Fani Rahmasari Adi Putra, Deni Agustin Rinawati Albar, Zainuddin Amriti Amalia Adnan Amalia Adnan Amelia Shabrina Cahyarani Aminatuzzuhriyyah Amirullah, Afif Andas Nidaa'an Khofiyya Andina Budi Ari Kusumawati Anggraeni Nur Khasanah Ariatama, Ilham Putra Aris Wahyuningsih Arum Mulyaningsih Arya Setya Nugroho Badruli Martati, Badruli Bagus Nurul Iman Bunga Nur Fadillah Caska - Dimontiq Salsabilla Putri Andy Dina Nur Amala Fadhilah Dwi Amalia Fajar Albana Febri Dwi Yanti Fitri Hamidah Fitriani Fitriani Gani Supriyanto Habibullah Habibullah Hambali Hambali hasna quin afdhila Hida Septina Syaikha Hilda Yuliatina Holy Ichda Wahyuni Imron, Ilmawati Fahmi Indra Indra Indra, Indra Insani Wahyu Mubarok, Insani Wahyu In’amatul Azimah Iwan Sugihartono Koga, Yohanes Kunti Dian Ayu Afiani Lala Anggraini Lilik Binti Mirnawati M. Safri Sholahudin Maratushsholihah Maratushsholihah Marlinda Apriyani Meirza Nanda Faradita Meydi Villareal , Daniel Moch. Gusnul Arifin Moh Hafinuddin Monica Dewi Amalia Muhammad Al Haddar Muhammad Alfian, Muhammad Muhammad Fazli Taib Bin Saearani Muhammad Lukman Hakim, Muhammad Lukman Mukayat Al Amin Naila, Ishmatun Nanang Khoirul Umam Nanda Putri Meilina Nanik Erlia Santi Nanik Suciati Nauratul Mufidah nia rahmawati Ninis Ayu Suryani Nuraeni Dwi Dharmawati Nurfina Yudasari Panjalu, Gandhung Fajar Paramitha, Aghfanny Prajna Putri Safitri Raniah Dityan Ufairah Rif’ah Wulandari Rochmatillah Ariffiyani Saktian Dwi Hartantri Shofa Qolbiyun Nurul Latifah Shofiatul Halawah Siti Rahmawati Siti Rochimah Slamet Slamet Sukamto, Sukamto Sutarni, Sutarni Syarifuddin Syarifuddin Tsabita Salsabila Umar Haiq Umi Laili Yuhana Uswatun Hasanah Yadi Aditya, Prawira Yulia Khurriyati yusti hari winayu