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All Journal Jurnal Kedokteran Muhammadiyah Journal Of Vocational Health Studies Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Buletin Farmatera Jurnal Surya Masyarakat MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan South East Asia Nursing Research Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Medica Arteriana (Med-Art) PENGABDIAN SOSIAL Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran Prosiding Seminar Kesehatan Masyarakat Prosiding Seminar Nasional Unimus
Rochman Basuki
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pengaruh Dexmedetomidine Intravena terhadap Kadar Superoxide Dismutase 1 (Sod-1) Hepar Kelinci pada Hepatic Ischemic Reperfusion Injury Model Kuncoro, Dodhi; Noviasari, Nina Anggraeni; Istiqomah, Istiqomah; Muslimah, Muslimah; Basuki, Rochman
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i2.56921

Abstract

Ischemic Reperfusion Injury is a state where there is cellular damage as a result of organ hypoxia are accompanied by improved delivery oksigen.Cedera after ischemia reperfusion marked with an oxidant production, complement activation, leukocyte endothelial cell adhesion, platelet aggregation of leukocytes, increased microvascular permeability and a decrease in the endothelium relaxation dependent.Enzym ie superoxide scavenging superoxide dismutase (SOD), plays a role in protecting the organ from organ damage due to ischemia-reperfusion injury.Hepar is the organ most in producing superoxide dismutase (SOD-1)as a result of injury after ischemic reperfusion. To determine the effect of intravenous dexmedetomidine on levels of superoxide dismutase 1 (SOD-1) rabbit liver in hepatic ischemic reperfusion injury. Methods, An experimental study Randomize Post Test Only Control Group Design uses 10 New Zealand rabbits. 5 rabbits given the form of dexmedetomidine treatment of 0.5 mcg / kg / h and performed occlusion of the portal vein hepatica (K1). 5 rabbits untreated (KK) also performed hepatic portal vein occlusion and examination superoxide dismutase 1 (SOD-1) as a control. Shapiro Wilk normality test and parametric tests using independent t-test. Results, The mean levels of SOD-1 group konrol 0.54 ± 0.24 and a P value of 0.76 (normal) and average levels of SOD-1 in the treatment group 1.22 ± 0.43 and a P value of 0.129 (normal).Uji parametric test with Independent t-test available p = 0,017.Because value of p <0.05, we conclude there is a significant difference. Conclusion, Dexmedetomidine significantly increase the value of superoxide dismutase 1 (SOD-1) in rabbits given new zealand treatment of occlusion of the hepatic portal vein.
Co-Authors - Darmono SS A. Farhan Fian Mubarok A.A. Ketut Agung Cahyawan W Afiah, Dieska Laudza Aga Tri Kurnia Ali Imron Amalia Isnaini Bela Bagus Setiawan Dadan Fakhrurijal Dahlia Dwi Prasetyaningrum Desi Ariyana Rahayu Devy Isella Lilyani Dewi, Novita Sari Dyah Mustika N Eko Budhiarti Faiz, Muhammad Fath Farabi, Aristo Fuad, Wijayanti Gunadi - Hsieh, Chia-Jung istiqomah istiqomah Kasno - Kuncoro, Dodhi Lilia Dewiyanti M. Naharuddin Jenie Mardiyan Hayati Meivitaningrum, Rahmawati Nur Merry Tiyas Anggraini Mohammad Fatkhul Mubin, Mohammad Fatkhul Muhammad Riza Setiawan Muhammad Sudiat Muslimah Muslimah Muslimah Nina Anggraeni Noor Yazid Noviasari, Nina Anggraeni Novitri, Ersa Agriana Nurul Ariani Rahmayanti Oimori Prayogo, Indra Kunto Putri Novi Kurniasari Reina Dhamanik Reza Arnedi Syahrul Hakim Rihadini - Rizqi Animah Rizqulloh, Dzaky Azmi Rohmat Suprapto Satriya Pranata Setyoko - Sulfika, Sheryl Ula Esfandiany Tri Kartika S Wijayanti Fuad Yanuarita Tursinawati Yazid Ahmad Hanif Yunita Elfia Zimamul Fikri