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All Journal e-GIGI Jurnal e-Biomedik PHARMACON JURNAL BIOMEDIK The Studies of Social Sciences Heca Journal of Applied Sciences Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology
Widdhi Bodhi
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Social Sciences

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Pengaruh Jus Buah Apel Merah (Pyrus malus L.) Terhadap Kadar Kolesterol HDL (High Density Lipoprotein) Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Nelwan, Gabriel N; Wullur, Adeanne C; Bodhi, Widdhi
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.511

Abstract

The aims of this research were to study the effect of red apple juice (Pyrus malus L.)on Blood HDL cholesterol (High Density Lipoprotein) of white male mice strain wistar(Rattus norvegicus).This research using experimental method,and Pre and Post testRandomized Controlled Group Design. The subjects in these research were 25 mices, whichpossess 180-200g weight. Mices were divided into 5 groups, namely negative control(aquadest), positive control (Simvastatin) and Pyrus malus juice treatments concentration 2ml per day treatment (P1), 4 ml/day treatment (P2) and 8 ml/day treatment (P3). Every groupconsists of five mices.Treatment starts by feds mices with high content of lipids diet for tendays.At day eleven, all mices were analyzedits HDL cholesterol (pre-test).Thenall miceswere feds with high content of lipids diet and its treatment.After ten days of treatment, posttestwere conducted.Data were analyzed using spss ver.19. The differences betweentreatmentswere analyzed usingone way ANOVA. The results shows that 8 ml/day Pyrusmalus juice significantly increase HDL cholesterol of white male wistar(p<0,05). Pyrusmalus juice(P3)possess activity as simvastatin.Keywords: Pyrus malus L., Rattus norvegicus L., HDL cholesterol
UJI EFEK HEPATOPROTEKTOR EKSTRAK ETANOL DAUN BENALU LANGSAT (Dendrophthoe petandra (L.) Miq.) terhadap KADAR MALONDIALDEHID (MDA) pada HATI TIKUS PUTIH JANTAN GALUR WISTAR yang DIINDUKSI KARBON TETRAKLORIDA (CCl4) Tristanti, Irma; Fatimawali, Fatimawali; Bodhi, Widdhi
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2383

Abstract

ABSTRACTLeaves of Langsat parasite (Dendrophthoe petandra (L.) Miq.) contains flavonoids. Theobjective of this research was to examine hepatoprotector effect of leave extract from langsatparasite on white male rats induced with CCl4. Treatment was conducted for 8 days to 13 rats,which group I (P1) were administered with EDBL 35mg/KgBB,group II (P2) wereadministered with EDBL 70mg/KgBB,group III (K+) were administered withCurcuma81mg/KgBB orally. Group IV (K-) and V (KP) were administered with aquadestad libitum.At 8th day, all groups except (KP) were induced with CCl4 1mL/KgBB intraperitoneally.Eighteen hours after inducing time, all rats in every group were sacrafied to take its liver.Rats liver were analyzed using TBARS (Thiobarbituric Acid Reactive Subtance) method tocalculate MDA (Malondialdehid) level that were the end product of lipid peroxidation in ratsliver.MDA content of P1 were 2,715μM, P2 were 2,080μM, K+ were 1,708μM, and K- were3,413μM. Data analysis using SPSS ver.20 by One-Way ANOVA and Duncan Multiple RangeTest.Keywords : leave of Langsat parasite, hepatoprotector effect,CCl4, MDA
PENGUJIAN EFEK DIURETIK SARI WORTEL (Daucus carota L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Sinaga, Mery A R; Bodhi, Widdhi; Yamlean, Paulina V Y
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.484

Abstract

Carrot (Daucus carota L.) is a plant which used as traditional medicine and one of its benefits isas diuretic. The research was aimed to find out diuretic effect of Carrot juice and relationship ofthe increases of Carrot juice (Daucus carota L.) concentration on white male mice strain Wistar(Rattus norvegicus). Fifteen mices were divided into five group of treatment, namely negativecontrol group (CMC 1% suspension), positive control group (furosemid suspension), 15%suspension of carrot juice group, 30% suspension of carrot juice group and 60% suspension ofCarrot juice group.The test of diuretic effect were conducted by calculate volume of excretedurine during 24 hours treatment. Data were analyzed using spss ver.19. The differences betweentreatments were analyzed using one way ANOVA.The result shows that suspension of Carrotjuice treatment increase urine volume. The increases of juice concentration shows better effect.Based on result, it can be concluded that Carrot juice possess diuretic effect (p<0,05), and thereare correlation between concentrations of Carrot juice to the increasing of urinevolume.Keywords : Carrot juice, diuretic effect, Rattus norvegicus
Molecular Docking Senyawa Gingerol dan Zingiberol pada Tanaman Jahe sebagai Penanganan COVID-19 Ratu, Belinda D. P. M.; Bodhi, Widdhi; Budiarso, Fona; Kepel, Billy J.; Fatimawali, .; Manampiring, Aaltje
eBiomedik Vol 9, No 1 (2021): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.9.1.2021.32361

Abstract

Abstract: COVID-19 is a new disease. Many people feel the impact of this disease. There is no definite cure for COVID-19, so many people use traditional medicine to ward off COVID-19, including ginger. This study aims to determine whether there is an interaction between compounds in ginger (gingerol and zingiberol) and the COVID-19’s main protease (6LU7). This study uses a molecular docking method using 4 main applications, namely Autodock Tools, Autodock Vina, Biovia Discovery Studio 2020, and Open Babel GUI. The samples used were gingerol and zingiberol compounds in ginger plants downloaded from Pubchem. The data used in this study used Mendeley, Clinical Key, and PubMed database. The study showed that almost all of the amino acid residues in the gingerol compound acted on the 6LU7 active site, whereas the zingiberol did not. The results of the binding affinity of ginger compounds, both gingerol and zingiberol, do not exceed the binding affinity of remdesivir, a drug that is widely researched as a COVID-19 handling drug. In conclusion, gingerol and zingiberol compounds in ginger can’t be considered as COVID-19’s treatment.Keywords: molecular docking, gingerol, zingiberol Abstrak: COVID-19 merupakan sebuah penyakit yang baru. Banyak masyarakat yang merasakan dampak dari penyakit ini. Belum ada pengobatan pasti untuk menyembuhkan COVID-19, sehingga banyak masyarakat yang menggunakan pengobatan tradisional untuk menangkal COVID-19, termasuk jahe. Penelitian ini bertujuan untuk mengetahui apakah ada interaksi antara senyawa pada jahe (gingerol dan zingiberol) dengan main protease COVID-19 (6LU7). Penelitian ini menggunakan metode molecular docking dengan menggunakan 4 aplikasi utama, yaitu Autodock Tools, Autodock Vina, Biovia Discovery Studio 2020, dan Open Babel GUI. Sampel yang digunakan yaitu senyawa gingerol dan zingiberol pada tanaman jahe yang diunduh di Pubchem. Data yang digunakan dalam penelitian ini menggunakan database Mendeley, Clinical Key, dan PubMed. Penelitian menunjukkan bahwa hampir semua residu asam amino pada senyawa gingerol bekerja pada sisi aktif 6LU7, sedangkan tidak demikian pada zingiberol. Hasil binding affinity senyawa jahe, baik gingerol maupun zingiberol tidak  melebihi binding affinity remdesivir, obat yang banyak diteliti sebagai obat penanganan COVID-19. Sebagai simpulan, senyawa gingerol dan zingiberol pada tanaman jahe tidak dapat dipertimbangkan sebagai penanganan COVID-19Kata Kunci: molecular docking, gingerol, zingiberol
Molecular Docking terhadap Senyawa Isoeleutherin dan Isoeleutherol sebagai Penghambat Pertumbuhan SARS-CoV-2 Prasetio, Nathanael F.; Kepel, Billy J.; Bodhi, Widdhi; Fatimawali, .; Manampiring, Aaltje; Budiarso, Fona
e-Biomedik Vol 9, No 1 (2021): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v9i1.31809

Abstract

Abstract: Dayak onions are herbal plants used by Indonesians as an anti-inflammatory, anticancer, antimicrobial, antidiabetic, antihypertensive and antiviral. By consuming herbal plants, it can increase immunity which is the main key in preventing the virus, especially COVID-19. This study was aimed to determine the effect of dayak active compound anchoring on the growth of the corona virus. This study used molecular docking method. The results of visualization of molecular docking when compared to the binding affinity of remdesivir obtained a binding affinity of -7.3, while the binding affinity of isoeleutherin and isoeleutherol was -6.9, so the result was lower than remdesivir. isoeleutherin and isoeleutherol compounds have a lower binding affinity value than remdesivir, so isoeleutherin and isoeleutherol compounds have lower yields as inhibitors of COVID-19.Keywords: dayak onions, SARS-CoV-2, molecular docking  Abstrak: Bawang Dayak merupakan tanaman herbal yang digunakan masyarakat Indonesia sebagai antiinflamasi, antikanker, antimikroba, antidiabetes, antihipertensi dan antivirus. Dengan mengkonsumsi tanaman herbal dapat meningkatkan kekebalan tubuh yang menjadi kunci utama dalam mencegah virus terlebih COVID-19. Penelitian ini bertujuan untuk mengetahui pengaruh penambatan senyawa aktif bawang dayak terhadap pertumbuhan dari corona virus. Jenis penelitian ini menggunakan metode penelitian penambatan molekul (molecular docking). Hasil visualisasi molecular docking jika dibandingkan binding affinity dari remdesivir didapatkan binding affinity yaitu -7,3 sedangkan binding affinity dari isoeleutherin dan isoeleutherol adalah -6,9, maka diperoleh hasil yang lebih rendah dari remdesivir. senyawa isoeleutherine dan isoeleutherol memiliki nilai binding affinity yang lebih rendah dari remdesivir, maka senyawa isoeleutherin dan isoeleutherol memiliki hasil yang lebih rendah sebagai penghambat COVID-19.Kata Kunci: bawang dayak, SARS-CoV-2, molecular docking
Molekuler Docking tehadap Senyawa Eugenol dan Myricetin pada Tanaman Cengkeh (Syzygium aromaticum) sebagai Penghambat Pertumbuhan SARS-CoV-2 Gerungan, Yizreel Y.; Kepel, Billy J.; Fatimawali, .; Manampiring, Aaltje; Budiarso, Fona D.; Bodhi, Widdhi
e-Biomedik Vol 9, No 1 (2021): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v9i1.31748

Abstract

Abstract: Cloves contain many chemical compounds that can be used for health. COVID-19 is a disease that is shaking the world today. Many people feel the impact of this disease. Until now, there is no definite cure and vaccine for the handling of COVID-19.  Objective to determine the interaction between compounds in cloves (eugenol and myricetin) and the main protease COVID-19 (6LU7). This study use a molecular docking, method using 4 main applications: autodock tools, autodock vina, biovia discovery studio and open babel. This study showed that almost all amino acid residues in the eugenol and myricetin compounds worked on the 6LU7 active site. The binding affinity of eugenol compounds in clove plants does not exceed the binding affinity of remdesivir, a drug studied as a drug for handling COVID-19, while the binding affinity of myricetin compounds in cloves plant exceeds the binding affinity of remdesivir. In conclusion, myricetin compounds have better results for use as a growth inhibitor for COVID-19 than eugenol.Key words: Cloves, COVID-19, molecular docking.  Abstrak: Cengkeh memiliki banyak kandungan senyawa kimia yang dapat dimanfaatkan bagi kesehatan. COVID-19 merupakan penyakit yang mengguncang dunia saat ini. Banyak masyarakat yang merasakan dampak dari penyakit ini. Hingga saat ini belum ada obat dan vaksin yang pasti untuk penanganan COVID-19. Penelitian ini bertujuan untuk mengetahui interaksi antara senyawa pada cengkeh (eugenol dan myricetin) dengan main protease COVID-19 (6LU7). Jenis penelitian ini menggunakan metode molekuler docking dengan menggunakan 4 aplikasi utama: autodock tools, autodock vina, biovia discovery studio dan open babel. Hasil penelitian ini menunjukkan bahwa hampir semua residu asam amino pada senyawa eugenol dan myricetin bekerja pada sisi aktif 6LU7. Hasil binding affinity senyawa eugenol pada tumbuhan cengkeh tidak melebihi binding affinity dari remdesivir, obat yang diteliti sebagai obat penanganan COVID-19, sedangkan hasil binding affinity senyawa myricetin pada tumbuhan cengkeh melebihi binding affinity dari remdesivir. Simpulan penelitian ini ialah senyawa myricetin memiliki hasil yang lebih baik untuk digunakan sebagai penghambat pertumbuhan COVID-19 dari pada eugenol.Kata kunci: Cengkeh, COVID-19, molekuler docking.
UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL DAUN KUMIS KUCING (Orthosiphon aristatus (Blume) Miq.) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus) Mokalu, Frinsia Rutly; Bodhi, Widdhi; Lebang, Julianri S.
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32765

Abstract

ABSTRACT Kumis Kucing Leaves (Orthosiphon aristatus (Blume) Miq.) contains flavonoid compounds that has antioxidants activity that inhibits the action of the enzyme xanthine oxidase with reduced uric acid as result. This research is done to find out the effects antihyperuricemia ethanol extract of Kumis Kucing leaves on male white rat (Rattus norvegicus). 15 rats were used in this research and there were 5 treatment groups that is negative control (NACMC 1%), positive control (Allopurinol) 1,8 mg, and Kumis Kucing leaves extract group with dosage of 4,5 mg, 9 mg, 18 mg. The result of this research showed a decrease on uric acid value after ethanol extract of Kumis Kucing leave were given. The next result of this research used ANOVA test and LSD test, that showed the ethanol extract of Kumis Kucing leave had Antihyperuricemia activity on male white rat.Keywords:  Orthosiphon aristatus (Blume.) Miq., Antihyperuricemia, Rattus norvegicus.   ABSTRAK Daun kumis kucing (Orthosiphon aristatus (Blume) Miq.) mengandung senyawa flavonoid yang mempunyai aktivitas antioksidan yang dapat menghambat kerja enzim xantin oksidase sehingga pembentukan asam urat berkurang. Penelitian ini dilakukan untuk mengetahui efek antihiperurisemia ekstrak etanol daun kumis kucing, terhadap tikus putih jantan (Rattus norvegicus). Penelitian ini menggunakan 15 ekor tikus dan terdapat 5 kelompok perlakuan yaitu kontrol negatif (NaCMC 1%), kontrol positif (Allopurinol) 1,8 mg, dan kelompok ekstrak daun kumis kucing dengan dosis 4,5 mg, 9 mg, 18 mg. Hasil penelitian menunjukkan nilai asam urat mengalami penurunan setelah diberikan ekstrak etanol daun kumis kucing. Hasil penelitian selanjutnya dianalisis menggunakan uji ANOVA dan uji LSD, menunjukkan bahwa ekstrak etanol daun kumis kucing memiliki aktivitas antihiperurisemia terhadap tikus putih jantan. Kata kunci: Orthosiphon aristatus (Blume.) Miq., Antihiperurisemia, Rattus norvegicus
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN JARAK PAGAR (Jatropha curcas L.) SEBAGAI ANTIHIPERGLIKEMIA TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) Pingkan, Aprilia; Yamlean, Paulina V.Y; Bodhi, Widdhi
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31359

Abstract

ABSTRACTHyperglicemia is condition where blood sugar levels surge or excessive, which will eventually become a disease called Diabetes Mellitus (DM). One of the plants that can be used for antidiabetic activity or to repair pancreatic β cells is jarak pagar. The study conducted using 15 rats induced with 3 mL of 60% glucosa. Animals then divided into 5 groups, Metformin(10.557 mg), Na-CMC, 125 mg/kg BW, 250 mg/kg BW and 375 mg/kg BW of ethanol extract of jarak pagar leaves. The results showed the percentage value of decrease in blood sugar D1 (19.46%), D2 (15.91%), D3 (53.17%) and the positive group (Metformin) (10.24%). Conclusion: the extract group dose 375 mg/kgBW can reduce blood sugar levels better that the group given extracts dose D1 and D2.  Keywords: Jarak Pagar Leaves (Jatropha curcas L.), Ethanol Extract, Antihyperglycemia, Diabetes.  ABSTRAKHiperglikemia adalah keadaan dimana kadar gula darah melebihi nilai normal dan merupakan salah satu indikasi pada penyakit Diabetes Melitus. Salah satu tumbuhan yang dapat dimanfaatkan untuk aktifitas antidiabetes atau memperbaiki sel β pankreas adalah jarak  pagar. Penelitian dilakukan untuk mengetahui efektivitas ekstrak etanol daun jarak pagar dalam menurunkan kadar gula darah tikus putih jantan. Penelitian menggunakan hewan uji sebanyak 15 ekor untuk diinduksikan dengan glukosa 60% sebanyak 3 mL/ekor. Hewan uji kemudian dibagi menjadi 5 kelompok, kelompok positif, kelompok negatif, dosis 125 mg/kgBB, dosis 250 mg/kgBB, dan dosis 375 mg/kgBB. Hasil penelitian menunjukkan nilai persentase penurunan gula darah D1 (19.46%), D2 (15.91%), D3 (53.17%) dan kelompok positif (Metformin) (10.24%). Kesimpulan: kelompok ekstrak dosis 375 mg/kgBB dapat menurunkan kadar gula darah lebih baik dibandingkan kelompok yang diberikan ekstrak dosis D1 dan D2. Kata kunci :    Daun Jarak Pagar (Jatropha Curcas L.) , Ekstrak Etanol, Antihiperglikemia, Diabetes.          
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN PEGAGAN (Centella asiatica (L.) Urban) SEBAGAI ANTIDIABETES TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Tulung, Grace Laury; Bodhi, Widdhi; Siampa, Jainer Pasca
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32767

Abstract

ABSTRACT Gotu Kola Leaf (Centella asiatica (L.) Urban) are known to contain flavonoid compound, and flavonoid are known to decrease blood glucose level by stimulating pancreas beta cells to produce insulin. The aim of this research is to find out wether the ethanol extract of gotu kola leaf (Centella asiatica (L.) Urban) has the antidiabetic effectiveness or not. This research used Completely Randomized Design method. There were 15 rats used in this research that were split into 5 groups that is negative control (Aquadest), positive control (Metformin), and ethanol extract of gotu kola leaf with the dosage of 5.4 mg;10.8 mg;21.6 mg. The acquired data were analyzed with ANOVA test and LSD test. The analysis result showed that ethanol extract of gotu kola leaf had antidiabetic effectiveness against male white rat. Keywords:  Centella asiatica (L.) Urban, antidiabetic, Rattus norvegicus  ABSTRAK  Daun Pegagan (Centella asiatica (L.) Urban) diketahui mengandung zat flavonoid, dimana flavonoid telah diketahui mempunyai kemampuan menurunkan kadar glukosa darah dengan merangsang sel beta pankreas untuk memproduksi insulin. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol daun pegagan memiliki efekivitas antidiabetes. Penelitian ini menggunakan metode Rancangan Acak Lengkap. Tikus yang digunakan sebanyak 15 ekor dan dibagi dalam 5 kelompok yaitu kontrol negatif (aquadest), kontrol positif (metformin), dan ekstrak etanol daun pegagan dengan dosis 5,4 mg; 10,8 mg; 21,6 mg. Data yang ada dianalisis dengan menggunakan uji ANOVA dan uji LSD. Hasil analisis menujukkan bahwa ekstrak etanol daun pegagan memiliki efektivitas antidiabetes terhadap tikus putih jantan (Rattus norvegicus). Kata kunci: Centella asiatica (L.) Urban, antidiabetes, Rattus norvegicus
UJI AKTIVITAS ANTELMINTIK EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) TERHADAP CACING GELANG (Ascaris lumbricoides) SECARA IN VITRO Sumual, Priskila Feicy; Bodhi, Widdhi; Lebang, Julianri Sari
PHARMACON Vol 10, No 2 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.34038

Abstract

ABSTRACTGreen betel leaves are one of the native plants in Indonesia which are widespread in Manado, North Sulawesi. In green betel leaves plants, there are tannin compounds that can inhibit enzymes and interfere with the digestive metabolic processes of worms which can cause the death of worms. This study aims to determine the effect of green betel leaves ethanol extract on Ascaris lumbricoides worms. This research is a laboratory experiment with The post-test only with controlled group design. The tests used the betel leaves ethanol extract with concentrations of 5%, 10%, and 15% respectively. Worms was observed for 12 hours with intervals of 3 hours. The number of worm deaths was recorded every 3 hours and further, it was analysed with using the Kruskal Wallis test and it was continued with using the Mann Whitney test. Result showed that extract at concentration of 5% the number of worm deaths was 4 worms, a concentration of 10% was 7 worms, and at a concentration of 15% 9 worms. The statistical results showed that there was no significant difference between the number of worm deaths in the treatment group and negative control at p <0.05. The concentrations of 10 and 15 showed no significant difference with the positive control. It can be concluded that concentrations of 10% and 15% have the same anthelmintic activity but the best concentration is at a concentration of 10%. Keywords: Anthelmintic, Piper betle L., Ascaris lumbricoides   ABSTRAKDaun sirih hijau merupakan salah satu tanaman asli di Indonesia yang tersebar luas di kota Manado, Sulawesi Utara. Pada tumbuhan daun sirih hijau terdapat senyawa tanin yang mampu menghambat kerja enzim dan mengganggu proses metabolisme pencernaan pada cacing yang dapat menyebabkan kematian cacing. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun sirih hijau terhadap cacing Ascaris lumbricoides. Penelitian ini ialah eksperimental laboratorium dengan rancangan penelitian The post-test only with controlled group design. Pengujian dilakukan menggunakan ekstrak etanol daun sirih dengan konsentrasi 5%, 10%, dan 15%. Aktivitas cacing diamati selama 12 jam dengan interval waktu 3 jam. Jumlah cacing yang mati dicatat setiap 3 jam dan selanjutnya dianalisis menggunakan uji Kruskal Wallis dan dilanjutkan dengan uji Mann Whitney. Hasil pengujian menunjukkan pada konsentrasi 5% jumlah kematian cacing sebanyak 4 ekor, konsentrasi 10% sebanyak 7 ekor dan pada konsentrasi 15% sebanyak 9 ekor. Hasil statistik menunjukkan tidak ada perbedaan signifikan antara jumlah kematian cacing pada kelompok perlakuan dengan kontrol negatif pada p<0.05. Konsentrasi 10 dan 15 menunjukkan tidak ada perbedaan signifikan dengan kontrol positif. Dapat disimpulkan bahwa pada konsentrasi 10% dan 15% memiliki aktivitas antelmintik yang sama namun konsentrasi yang paling baik terdapat pada konsentrasi 10%. Kata kunci: Antelmintik, Piper betle L., Ascaris lumbricoides
Co-Authors Aaltje E. Manampiring Aaltje Manampiring Adeanne C Wullur Adithya Yudistira Assa, Stevano M. Billy J. Kepel Billy Kepel Billy Senduk, Billy Brily Lombogia, Brily Budiarso, Fona Hermina Dwiana Budiarso, Fone D.H. Cheryl Kawatu Clara Pongantung Clementia Luigy Moot Datu, Olvie Syenni Debra Tiwow Deviwanti Batara, Deviwanti Edi, Hosea J. Edi, Hosea Jaya Eggy P. J. Ngantung, Eggy P. J. Ekawati Tallei, Trina Elly Suoth Fatimawali , Fatimawali Fatimawali . Felomina Jempormase, Felomina Fitria Angela Umar Fona Budiarso Gabriel N Nelwan Gabriela V.Ch Walewangko Gemi Nastiti Gerungan, Yizreel Y. Hasan, Puput Herawati Hasan, Puput Herawati Said Hosea Jaya Edy I Made Putra Suwertayasa Irma Tristanti Jayanto, Imam Jeane Mongi Julianri Sari Lebang, Julianri Sari Jusuf, Deva Dewanti Karen Tizia Mogi Kaunang, Christian Excelino Kaunang, Matthias D. Kepel, Billy Johnson Lady zha-zha Luntungan Lahamendu, Beatriks Lebang, Julianri S. Lengkong, Cheisy Anastasya Gratia Malino, Angeline Priscillia Manampiring, Aaltje Ellen Manopo, Chintia M. Marina Mamarimbing Mery A R Sinaga Mokalu, Frinsia Rutly Muharli Qadri Kanon Nainggolan, Ivana C. Ni Putu Ratna Sari Ningsi Hadji Ali Nofri P. Kurama Novel Kojong Olii, Ariesthya D. C. Olii, Ariesthya Dwi Cahyani Pangow, Sofia Paulina yamlean Pingkan, Aprilia Polii, Reiner C. Prasetio, Nathanael F. Putri Virgie Pandey Ratu, Belinda D. P. M. Rompas, Imanuela Zefanya Rompis, Tessalonicha J. Rumangu, Chrisa P. Siampa, Jainer Pasca Siringo-Ringo, Aurian Fricilia Sumakul, Gilbert Samuel Sumual, Priskila Feicy Sutanto, Stella Tamahiwu, Natasya Ester Rebeca Tulung, Grace Laury Turama, Dwilanda E. Turangan, Pricilia Dona Valentino Rakasiwi, Valentino Weny Wiyono Widjaya, Selin Yoas P. Simangunsong, Yoas P.