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Widdhi Bodhi
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Social Sciences

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UJI AKTIVITAS ANTIHIPERURISEMIA KOMBINASI EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum (Wight.) Walp) dan TUMBUHAN SURUHAN (Peperomia pellucida (L.) Kunth) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus) Manopo, Chintia M.; Bodhi, Widdhi; Suoth, Elly J.
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31368

Abstract

ABSTRACTBay leaves (Syzygium polyanthum (Wight.) Walp) and herbs (Peperomia pellucida (L.) Kunth) are known to contain flavonoids, where flavonoids have been known to have the ability to inhibit the ksantin oxidase, which causes uric acid levels in the blood to drop. This study used a completely randomized design method. This study aims to determine whether the combined ethanol extract of bay leaves (Syzygium polyanthum (Wight.) Walp) and suruhan (Peperomia pellucida (L.) Kunth) has antihyperuricemic activity. There were 15 rats used and divided into 5 groups, namely negative control (CMC 1%), positive control (Allopurinol), and ethanol extracts of bay leaves and herbs with a dose of 50 m, 100 mg, 200 mg. Existing data were analyzed using the ANOVA test and LSD test. The analysis showed that the combined ethanol extract of bay leaves (Syzygium polyanthum (Wight.) Walp) and suruhan (Peperomia pellucida (L.) Kunth) had antihyperuricemic activity against male white rats. Keywords: Syzygium polyanthum (Wight.) Walp) and Peperomia pellucida (L.) Kunth, Antihyperuricemia, Rattus Norvegicus.ABSTRAKDaun salam (Syzygium polyanthum (Wight.) Walp) dan tumbuhan suruhan (Peperomia pellucida (L.) Kunth) diketahui mengandung zat flavonoid, dimana flavonoid telah diketahui mempunyai kemampuan dalam menghambat ksantin oksidase, yang menyebabkan kadar asam urat di dalam darah turun. Penelitian ini menggunakan metode Rancangan Acak Lengkap. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol kombinasi dari daun salam (Syzygium polyanthum (Wight.) Walp ) dan tumbuhan suruhan (Peperomia pellucida (L.) Kunth) memiliki aktivitas antihiperurisemia. Tikus yang digunakan sebanyak 15 ekor dan dibagi dalam 5 kelompok yaitu kontrol negatif (CMC 1%), kontrol positif (Allopurinol), dan ekstrak etanol daun salam dan tumbuhan suruhan dengan dosis 50 mg, 100 mg, 200 mg. Data yang ada dianalisis dengan menggunakan uji ANOVA dan uji LSD. Hasil analisis menunjukkan bahwa ekstrak etanol kombinasi daun salam (Syzygium polyanthum (Wight.) Walp) dan tumbuhan suruhan (Peperomia pellucida (L.) Kunth ) memiliki aktivitas antihiperurisemia terhadap tikus putih jantan.Kata kunci: Syzygium polyanthum (Wight.) Walp) dan  Peperomia pellucida (L.) Kunth, Antihiperurisemia, Rattus Norvegicus
UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Sari, Ni Putu Ratna; Bodhi, Widdhi; Lebang, Julianri S.
PHARMACON Vol 10, No 3 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.35601

Abstract

ABSTRACTPapaya leaves (Carica papaya L.) contain flavonoids and tannins which have anti-inflammatory actuvuty. This study aims to determined antiinflamatory activity of papaya leaves extract using caragenan induce paw edema. The test was carried out on 5 groups of animals, namely, the negative control group was given 1% CMC suspension, the positive control group was given sodium diclofenac 0,9mg / 200gBB and the test group was given a papaya leaf ethanol extract suspension at a dose of 9mg / 200gBB, 13,5mg / 200gBB, and 18mg /200gBB. The results showed that all extract doses were able to inhibit edema, respectively 92.13%, 100%, 89% in volume measurements and 96,66%, 100%, 93,49% in diameter measurements and significantly different from negative control (ρ ≤0.05). It can be concluded that the extract dose of 13,5 mg / 200gBW provided the best inhibition of edema and was not significantly different from the positive control (ρ≥0.05). Keywords: Carica papaya L., Anti-inflammatory, Inflammatory Volume, Inflammation Diameter.   ABSTRAKDaun pepaya (Carica papaya L.) mengandung senyawa flavonoid dan tanin yang berkhasiat sebagai antiinflamasi. Penelitian ini bertujuan untuk menguji aktivitas ekstrak etanol daun pepaya sebagai antiinflamasi. Aktivitas antiinflamasi dilakukan dengan metode induksi edema pada telapak kaki tikus menggunakan karagenan 1%. Pengujian dilakukan pada 5 kelompok hewan yaitu kelompok kontrol negatif diberi suspensi CMC 1%, kelompok kontrol positif diberi natrium diklofenak 0,9mg/200gBB dan kelompok uji diberikan suspensi ekstrak etanol daun pepaya dengan dosis 9mg/200gBB, 13,5mg/200gBB dan 18mg/200gBB. Hasil penelitian menunjukan semua dosis ekstrak mampu menghambat edema berturut-turut sebesar 92,13%, 100%, 89% pada pengukuran volume dan 96,66%, 100%, 93,49% pada pengukuran diameter dan berbeda signifikan dengan kontrol negatif (ρ≤0,05). Dapat disimpulkan bahwa ekstrak dosis 13,5mg/200gBB memberikan penghambatan edema paling baik serta tidak berbeda secara signifikan dengan kontrol positi (ρ≥0,05). Kata kunci: Carica papaya L., Antiiflamasi, Volume Radang, Diameter Radang.
UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN GEDI (Abelmoschus manihot L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Jusuf, Deva Dewanti; Bodhi, Widdhi; Lebang, Julianri S.
PHARMACON Vol 10, No 3 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.35602

Abstract

ABSTRACTGedi (Abelmoschus manihot L.) is a plant used as traditional medicine by the people of North Sulawesi. Gedi leaves contain flavonoid which has analgesic effects. This study aims to determine the analgesic effect of the ethanol extract of Gedi leaves (Abelmoschus manihot L.) in Wistar male white rats (Rattus norvegicus). Analgesic testing was conducted on Wistar male white rats using the heat pain method by observing the response of the rats such as jumping and licking their legs when the heat stimulation was given. This study using 15 Wistar male white rats which is divided into 5 treatment groups, the negative control group (CMC), the positive control group (mefenamic acid dose 9mg). The results showed that the group doses of 100 mg / KgBB, 200 mg / KgBB and 300 mg / KgBB showed a better response to induction than the negative control group. Statistical tests using One Way ANOVA and LSD showed that the gedi leaves extract given to male white rats at a dose of 100 mg / KgBB, 200 mg / KgBB and 300 mg / KgBB has an analgesic effect. Keywords: Analgesics, Gedi Leaves (Abelmoschus manihot L.), Heat Pain Induction   ABSTRAKGedi (Abelmoschus manihot L.), merupakan tanaman yang  digunakan sebagai obat tradisional oleh masyarakat Sulawesi Utara. Daun tanaman ini diketahui memiliki kandungan flavonoid yang memiliki efek analgesik. Penelitian ini bertujuan untuk mengetahui adanya efek analgesik ekstrak etanol daun gedi (Abelmoschus manihot L.) pada tikus putih jantan galur wistar (Rattus norvegicus). Pengujian analgesik dilakukan pada tikus putih jantan galur wistar dengan metode nyeri panas dilakukan dengan melihat respon tikus berupa melompat dan menjilat kaki saat diberi rangsangan panas. Sebanyak 15 ekor tikus dibagi 5 kelompok perlakuan, yaitu kelompok kontrol negatif (CMC), kelompok kontrol positif (dosis asam mefenamat 9mg), dan kelompok ekstrak etanol daun gedi dosis 100 mg/KgBB, 200 mg/KgBB, 300 mg/KgBB. Respon tikus diamati sebelum pemberian bahan uji dan setelah pemberian bahan uji pada menit ke 30, 60, 90, 120. Hasil penelitian menunjukkan kelompok dosis 100 mg/KgBB, 200 mg/KgBB, 300 mg/KgBB menunjukkan aktivitas/respon terhadap induksi lebih baik dibandingkan kelompok kontrol negatif. Uji statistik menggunakan One Way ANOVA dan LSD menunjukan bahwa ekstrak daun gedi yang diberikan pada tikus putih jantan dengan dosis 100 mg/KgBB, 200 mg/KgBB, 300 mg/KgBB memiliki efek analgesik.Kata kunci: Analgesik, Daun Gedi (Abelmoschus manihot L.), Induksi Nyeri Panas.
UJI EFEKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus manihot L.Medik) TERHADAP TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR YANG DIINDUKSI ALOKSAN Rompas, Imanuela Zefanya; Bodhi, Widdhi; Lebang, Julianri S.
PHARMACON Vol 10, No 3 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.35595

Abstract

ABSTRACTGedi (Abelmoschus manihot L. Medik) has been know as food that can consume by people in North Sulawesi. The purpose of this study is determine the antihyperglycemic effect of the ethanol extract of red gedi leaves on white rats (Rattus norvegicus) wistar strain induced by alloxan. Animals was devided into 5 groups, namely negative control and metformin as positive control and ethanol extract of red gedi leaves with doses of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kg of body weight, each group was given alloxan i.p. Blood glucose was measurements on day 0 (three days after induction), day 7 and day 14. The results showed group that treat with red gedi leaves extract could reduce blood glucose levels. The dose of 150 mg/kgBW had a decreased percentage of blood glucose on day 7 and day 14 of 15.48% and 74.84%, respectively. Doses of 300 mg/kgBW had a decreased percentage of blood glucose on day 7 and day 14 of 33.64% and 70.5%, respectively. The dose of 600 mg/kgBW had a decreased percentage of blood glucose on day 7 and day 14 of 27.11% and 71.93%, respectively. Statistical analysis shows that the dosage of 300 mg/kg body weight has a significant difference with the dosage of 150 mg/kgBW and 600 mg/kgBW. It can be concluded that the dose of 300 mg/kgBW has the best antihyperglycemic activity. Keywords: Antihyperglycemic, Red gedi leaves, Alloxan, White ratsABSTRAKGedi (Abelmoschus manihot L. Medik) telah lama dikenal masyarakat Sulawesi Utara sebagai tanaman pangan. Tujuan dari penelitian ini untuk mengetahui efek antihiperglikemik ekstrak etanol daun gedi merah pada tikus putih (Rattus norvegicus) galur wistar yang diinduksi aloksan. Penelitian ini menggunakan 5 kelompok perlakuan yaitu kontrol negatif dan metformin sebagai kontrol positif dan ekstrak etanol daun gedi merah dengan dosis 150 mg/kgBB, 300 mg/kgBB, dan 600 mg/kgBB, setiap kelompok diberikan alloksan. Pengukuran glukosa darah dilakukan pada hari ke-0 (tiga hari sesudah diinduksi), hari ke-7 dan hari ke-14. Hasil penelitian menunjukan bahwa pemberian ekstrak daun gedi merah dapat menurunkan kadar glukosa darah. Dosis 150 mg/kgBB memiliki presentase penurunan glukosa darah pada hari ke-7 dan hari ke-14 masing-masing sebesar 15,48 % dan 74,84 %. Dosis 300 mg/kgBB memiliki presentase penurunan glukosa darah pada hari ke-7 dan hari ke-14 masing-masing sebesar 33,64 % dan 70,5 %. Dosis 600 mg/kgBB memiliki presentase penurunan glukosa darah pada hari ke-7 dan hari ke-14 masing-masing sebesar 27,11 % dan 71,93 %. Analisis statistik menunjukan dosis 300 mg/kgBB memiliki perbedaan signifikan dengan dosis 150 mg/kgBB dan 600 mg/kgBB. Dapat disimpulkan bahwa dosis 300 mg/kgBB memiliki aktivitas antihiperglikemik yang paling baik. Kata Kunci: Antihiperglikemik, Daun Gedi Merah, Alloksan, Tikus Putih
EVALUASI KELENGKAPAN ADMINISTRATIF RESEP DARI DOKTER SPESIALIS ANAK PADA TIGA APOTEK DI KOTA MANADO Mamarimbing, Marina; Fatimawali,, Fatimawali; Bodhi, Widdhi
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.485

Abstract

Prescription can reduce the administrative / prevent dangerous medication errors, withadverse effects on patients by the drugs used during the management of health care. This studyis aimed to evaluate the administrative prescriptions by examining the possibility of medicationerrors by a Pediatricians at three pharmacies in the city of Manado. This is a descriptive studyconducted a retrospective review of patient prescriptions. The method of sampling took randomreceipts using the Slovin formula. 12,225 receipts was vised in the three pharmacy and found338 sheets sample of prescription from period of January to December 2011 then processed andevaluated administrative completeness. Administrative completeness prescription written by apediatrician at the Manado City Permit Practice (11.37%), Address patients (53.7%), Gender(0%), weight loss (27.5%), Age (78 , 3%), date prescription (98.4%) and to mark the R /, DoctorName, Address Doctor, Initials Doctor, Patient Name, Drug Name, Dosage, Number of Drugs,How to use a clear (100%). From these data we can conclude the potential occurrence ofmedication errors and can not find any recipes that meet the screening criteria for theprescription paperwork based on the Decree of the Minister of Healthno.:1027/MENKES/SK/1X/2004.Keywords: Administrative Complete Receipts, Receipts Pediatrician, Medication Error
UJI EFEK ANTIPIRETIK INFUSA DAUN SESEWANUA (Clerodendron squamatum Vahl.) TERHADAP KELINCI JANTAN YANG DIINDUKSI VAKSIN DTP HB Moot, Clementia Luigy; Bodhi, Widdhi; Mongi, Jeane
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2379

Abstract

ABSTRACTSesewanua leaves (Clerodendron squamatum Vahl.) empirically used for an alternavite fevertreatment. The aims of this study was to investigate infuse of Sesewanua leaves hadantipyretic effectts for rabbits induced by vaccine DTP HB. This assay uses 15 rabbitsgrouped into 5 groups, the negative control (destilled water), the treatment (infuse ofSesewanua leaves 20%, 40% and 80%) and a positive (parasetamol). Rabbits induced pyrexiawith vaccine DTP HB doses 0,25ml/KgBB by intramuscular route. Rabbit’s rectaltemperature was measured every 1 hour until 4 hours after the oral administration. Thedecrease of rabbit’s rectal temperatur were analyzed by one way ANOVA and LSD test (α =0,05%). The result showed that infuse of Sesewanua in concentrates 20%, 40% and 80% hadantipyretics effect for rabbits induced by vaccine DTP HB.Keywords : Antipyretics effect test, Clerodendron squamatum Vahl., Vaccine DTP HB,rabbits
In Vitro Test of Antioxidant Activity of Leilem Leaf Ethanol Extract (Clerodendrum minahassae) Using DPPH and FRAP Methods Malino, Angeline Priscillia; Kepel, Billy Johnson; Budiarso, Fona Dwiana Hermina; Fatimawali, Fatimawali; Manampiring, Aaltje Ellen; Bodhi, Widdhi
Heca Journal of Applied Sciences Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v2i1.135

Abstract

The risk of degenerative diseases is increasing due to unhealthy lifestyles. Many people consume junk food, smoke, and do not protect themselves from sun exposure and pollution, exposing their bodies to free radicals. Free radicals can cause oxidative stress, necessitating the need for antioxidants to neutralize them. The leilem plant (Clerodendrum minahassae) is an endemic plant from North Sulawesi that is often used in traditional dishes and medicine. Moreover, leilem leaves are believed to be a source of natural antioxidants. This study aimed to determine the efficacy of leilem leaf ethanol extract as a source of antioxidants. The antioxidant potential was evaluated using phytochemical screening and antioxidant assays such as 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) methods, with ascorbic acid as a comparison. The level of antioxidant activity was measured by determining the IC50 value, which corresponds to the concentration of extract required to inhibit 50% of free radicals. The results of phytochemical screening showed that the ethanol extract of leilem (Clerodendrum minahassae) leaves contains active compounds such as phenols, flavonoids, saponins, tannins, steroids/triterpenoids, and alkaloids, indicating a high potential for antioxidant activity. The IC50 value for the DPPH method was 78.799 ppm, and the IC50 value for the FRAP method was 92.127 ppm. These results demonstrate that the ethanol extract of leilem leaves has strong antioxidant activity in both the DPPH and FRAP methods.
Penyuluhan Pembuatan Permen Jahe-Nanas Sebagai Suplemen Antioksidan pada Kelompok Ibu-Ibu Majelis Taklim Al-Hidayah Kelurahan Malendeng Fatimawali, Fatimawali; Kepel, Billy; Bodhi, Widdhi; Manampiring, Aaltje; Budiarso, Fona; Yamlean, Paulina; Ekawati Tallei, Trina
The Studies of Social Sciences Vol. 6 No. 2 (2024): The Studies of Social Sciences
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35801/tsss.v6i2.56832

Abstract

dimanfaatkan dan diolah secara tradisional sebagai pencegahan maupun pengobatan suatu penyakit. Sampai saat ini keberadaan obat tradisional jamu terus berkembang karena sebagian besar masyarakat mengkonsumsi jamu yang memberikan manfaat kesehatan baik untuk pencegahan dan pengobatan terhadap suatu penyakit maupun meningkatkan stamina tubuh. Tujuan penyuluhan ini adalah untuk memberikan pengetahuan mengenai manfaat tanaman obat tradisional jahe yang dapat dicampur dengan nanas untuk diolah menjadi permen yang bermanfaat sebagai suplemen antioksidan. Kegiatan pengabdian pada masyarakat ini dilakukan penyuluhan pada Ibu-ibu Majelis Taklim Al-Hidayah Kelurahan Malendeng Kecamatan Paal 2 Kota Manado, Provinsi Sulawesi Utara. Pelaksanan dimulai dengan penyuluhan pentingnya pemeriksaan kesehatan secara rutin dan dilanjutkan dengan pemeriksaan tekanan darah, kolesterol, asam urat dan gula darah kepada ibu-ibu Majelis Taklim Al-Hidayah. Setelah penyuluhan kesehatan, dilanjutkan dengan penyuluhan pembuatan permen jahe-nanas sebagai minuman suplemen antioksidan yang aman dan dapat dibuat secara sederhana dan dapat dikonsumsi setiap hari. Berdasarkan hasil pemeriksaan kesehatan, ada beberapa ibu yang mempunyai tekanan darah, kadar asam urat, kolesterol dan gula darah yang berada diatas kondisi normal. Ibu-ibu Majelis Taklim juga mengetahui manfaat tanaman obat tradisional jahe dan nanas serta dapat mengetahui cara pembuatan permen jahe sebagai suplemen antioksidan yang dapat meningkatkan stamina tubuh. Disarankan kepada ibu-ibu untuk secara rutin mengunjungi puskesmas setempat untuk menjalani pemeriksaan dan pengobatan demi menjaga kondisi kesehatan tetap normal.
From Nature to Laboratory: The Impact of Leilem Leaves’ Ethanol Extract on Pancreatic Lipase Enzyme Activity Siringo-Ringo, Aurian Fricilia; Fatimawali, Fatimawali; Bodhi, Widdhi; Manampiring, Aaltje E.; Kepel, Billy J.; Budiarso, Fone D.H.
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.23

Abstract

For many years, there have been theories on the possibility of preventing or delaying type 2 Diabetes Mellitus by altering some of its risk factors. Drugs that combat obesity have recently been researched concerning the prevention of type 2 Diabetes Mellitus. Inhibition of the digestive enzyme pancreatic lipase is a potential therapeutic strategy in treating and managing chronic diseases such as diabetes and obesity. Plants containing bioactive compounds are identified as potential sources of pancreatic lipase enzyme inhibitors. The use of natural compounds in inhibiting pancreatic lipase enzyme activity is considered to have more potential due to low toxicity and side effects. This study aims to determine the potential and activity effect of ethanol extract of leilem leaves on inhibiting pancreatic lipase enzyme. This study is a laboratory experimental study, the method of measuring lipase inhibition potential was performed using porcine lipase and PNPB with several modifications and using Orlistat as a positive control. Readings were taken using an ELISA reader at a wavelength of 405 nm. The data were then processed to obtain the IC50 value and relative potency. The results of in vitro studies have shown the potential of leilem leaf extract to inhibit pancreatic lipase enzyme activity. Qualitatively, the results showed that leilem leaf extract contains secondary metabolite compounds such as Alkaloids, Flavonoids, Tannins, Saponins, Steroids, and Terpenoids. Quantitatively, the results showed that the ethanol extract of leilem leaves had an absorbance value at the lowest concentration of 1.346 ± 0.53 and 0.709 ± 0.29 for the highest concentration. The IC50 result obtained was 137.89 μg/mL while the IC50 value of the positive control Orlistat was 77.022 μg/mL. Ethanol extract of leilem leaves (Clerodendrum minahassae Teijsm. & Binn) has a potential value of 0.558.
EFFECTS OF ETHANOL EXTRACT OF LEILEM LEAVES (Clerodendrum minahassae) ON BLOOD GLUCOSE LEVELS OF MALE WHITE RATS Lengkong, Cheisy Anastasya Gratia; Bodhi, Widdhi; Datu, Olvie Syenni; Fatimawali
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49750

Abstract

Diabetes mellitus is a global chronic disease with more than 500 million patientes. Leilem leaf is an endemic plant of North Sulawesi from the genus Clerodendrum which is believed potentially antidiabetic. The purpose of this study was to determine the effect of ethanol extract of leilem leaf on blood glucose levels and body weight of male white rats. The extraction of leilem leaves using maceration method with 96% ethanol solvent. This study used the pretest posttest control group design method with 5 groups, namely group I positive control of metformin, group II negative control of 0.5% Na-CMC, group III, IV, and V were extract doses of 100, 200, and 400 mg/kgBW. All groups were induced with 120 mg/kg BW of alloxan. The results showed that leilem leaf extract had a significant effect (Asymp. Sig. (2-tailed) 0.001) on rats blood glucose levels with the best percentage in group V extract dose of 400 mg/kgBW and had no significant effect on body weight.
Co-Authors Aaltje E. Manampiring Aaltje Manampiring Adeanne C Wullur Adithya Yudistira Assa, Stevano M. Billy J. Kepel Billy Kepel Billy Senduk, Billy Brily Lombogia, Brily Budiarso, Fona Hermina Dwiana Budiarso, Fone D.H. Cheryl Kawatu Clara Pongantung Clementia Luigy Moot Datu, Olvie Syenni Debra Tiwow Deviwanti Batara, Deviwanti Edi, Hosea J. Edi, Hosea Jaya Eggy P. J. Ngantung, Eggy P. J. Ekawati Tallei, Trina Elly Suoth Fatimawali , Fatimawali Fatimawali . Felomina Jempormase, Felomina Fitria Angela Umar Fona Budiarso Gabriel N Nelwan Gabriela V.Ch Walewangko Gemi Nastiti Gerungan, Yizreel Y. Hasan, Puput Herawati Hasan, Puput Herawati Said Hosea Jaya Edy I Made Putra Suwertayasa Irma Tristanti Jayanto, Imam Jeane Mongi Julianri Sari Lebang, Julianri Sari Jusuf, Deva Dewanti Karen Tizia Mogi Kaunang, Christian Excelino Kaunang, Matthias D. Kepel, Billy Johnson Lady zha-zha Luntungan Lahamendu, Beatriks Lebang, Julianri S. Lengkong, Cheisy Anastasya Gratia Ley, Gabriella Therezia Ley Malino, Angeline Priscillia Manampiring, Aaltje Ellen Manopo, Chintia M. Marina Mamarimbing Mery A R Sinaga Mokalu, Frinsia Rutly Muharli Qadri Kanon Nainggolan, Ivana C. Ni Putu Ratna Sari Ningsi Hadji Ali Nofri P. Kurama Novel Kojong Olii, Ariesthya D. C. Olii, Ariesthya Dwi Cahyani Pangow, Sofia Paulina yamlean Pingkan, Aprilia Polii, Reiner C. Prasetio, Nathanael F. Putri Virgie Pandey Ratu, Belinda D. P. M. Rompas, Imanuela Zefanya Rompis, Tessalonicha J. Rumangu, Chrisa P. Siampa, Jainer Pasca Siringo-Ringo, Aurian Fricilia Sumakul, Gilbert Samuel Sumual, Priskila Feicy Sutanto, Stella Tamahiwu, Natasya Ester Rebeca Tulung, Grace Laury Turama, Dwilanda E. Turangan, Pricilia Dona Valentino Rakasiwi, Valentino Weny Wiyono Widjaya, Selin Yoas P. Simangunsong, Yoas P.