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All Journal Medical Journal of Indonesia Universa Medicina Majalah Kedokteran Andalas Journal of General Procedural Dermatology and Venereology Indonesia Ebers Papyrus
Kusmarinah Bramono
Department Of Dermatology And Venereology, Faculty Of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The effects of vitamin D on chronic wounds Priyanto, Mufqi Handaru; Miranda, Eliza; Yusharyahya, Shannaz Nadia; Legiawati, Lili; Novianto, Endi; Bramono, Kusmarinah; Krisanti, Roro Inge Ade
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Wounds that fail to proceed through the normal healing process are referred to as chronic wounds, also known as ulcers. Chronic wounds have immeasurable biological, psychological, social, and economic effects, bringing tremendous challenges for patients, doctors, healthcare providers, and healthcare systems. Discussion: This condition is associated with a variety of comorbidities and complex etiologies. The global incidence of chronic wounds is expected to increase with longer life expectancy. Thus, a holistic approach is necessary, such as proper wound management, proper control of comorbidities, and provision of adequate nutrition, including vitamin D supplementation. Vitamin D is an essential pro-hormone for cell differentiation, proliferation, and growth. It affects the skin’s immune response, and is therefore thought to promote wound healing and tissue repair. Many studies have been published on the association between low vitamin D levels and chronic wounds. However, whether or not vitamin D supplementation directly contributes to wound healing still needs to be elucidated. Conclusion: Despite the many reports on vitamin D as an adjuvant treatment for chronic wounds, further large-scale clinical studies are needed to cement the role of vitamin D as an effective standard therapy for chronic wound healing.
Cotton swabs for the measurement of NF-ĸB, IFN-γ, and FOXP3+Treg from lesions of anogenital wart patients Hutabarat, Hernayati; Bramono, Kusmarinah; Indriatmi, Wresti; Wibowo, Heri; Budianti, Windy Keumala; Suyatna, Fransiscus Dhyanagiri; Prihartono, Joedo; Mawardi, Prasetya
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247496

Abstract

BACKGROUND Local tissue immunity plays a significant role in anogenital warts’ (AGW) pathomechanism and persistence. Assessing biomarkers from lesions instead of serum is recommended to evaluate therapeutic response. Since biopsy is invasive, it is necessary to find less invasive and more comfortable methods. This study aimed to assess the reliability of cotton swabs and tape stripping for evaluating AGW’s lesions biomarkers. METHODS We compared cotton swab versus tape stripping method to quantify nuclear factor-κappaB (NF-ĸB), interferon-gamma (IFN-γ), and FOXP3+regulatory T cell (FOXP3+Treg) from 3 patients with AGW in the preliminary study. The method was selected based on contamination possibility, side effects, and a simpler approach. The main study examined 48 patients with AGW for reliability and reproducibility using the best sampling method from preliminary result and Spearman’s Rho analysis, while considering the HIV status and CD4+ counts. RESULTS Both cotton swabs and tape stripping obtained adequate protein content for biomarkers examination. However, the tape stripping method was causing serum contamination and painful for patients due to the stripping. The total lesion volume in cotton swab method was positively correlated with all patients’ NF-ĸB (p = 0.001). IFN-γ had a negative correlation in all reactive HIV patients (p = 0.012). FOXP3+Treg and CD4+ counts were negatively correlated with total volume in reactive HIV patients (p = 0.046 and 0.017, respectively). CONCLUSIONS The cotton swab method was reliable in examining NF-ĸB, IFN-γ, and FOXP3+Treg due to its convenience and lack of serum contamination from AGW lesions, potentially improving patient comfort and practical benefits.
Co-Authors Aria Kekalih Ariyati Yosi Artini Wijayanti Islami Astriningrum, Rinadewi Darmawan, Irene Dewi Friska Eliza Miranda Eliza Miranda Endi Novianto Etik Mardliyati Etik Mardliyati Githa Rahmayunita Hans Joachim Freisleben Hans Joachim Freisleben Hartanto, David Dwiadiputra Henry Wan-Peng Lim Heri Wibowo Herqutanto - Herwinda Brahmanti Hoemardani, Aida SD Hutabarat, Hernayati Islami, Artini Wijayanti Joedo Prihartono Kartika, Emiliana Krisanti, Roro Inge Ade Lili Legiawati Lim, Henry W Linda Yuliati Lusiana Lusiana Lusiana Lusiana M. Yulianto Listiawan Mawardi, Prasetya Miranda, Eliza Mughni, Fadhli Aulia Oktavia, Nikken Rima Prayogo, Rizky Lendi Priyanto, Mufqi Handaru Rizky Lendl Prayogo Sali Rahadi Asih Sammy Yahya Sampurna, Adhimukti T. Sandra Widaty Sandra Widaty Sandra Widaty Sari, Siti Maulidya Satya Wydya Yenny Shannaz Nadia Yusharyahya Siskawati, Yulia Sitohang, Irma Bernadette S. Sitohang, Irma Bernadette Simbolon Sri L. Menaldi Sujudi, Yufanti Sutarjo, Agassi Suseno Suyatna, Fransiscus Dhyanagiri Wijayadi, Linda Julianti Windy Keumala Budianti Wresti Indriatmi B. Makes Yahya, Sammy Yosi, Ariyati Zainal Hakim