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Blood mercury levels and PCR-based GSTP1 and GSTT1 gene profiles in artisanal gold miners: A cross-sectional study Wimpy, Wimpy; Silviani, Yusianti; Hidayati, Nur; Aribowo, Daffina Ramadhani Putri; Septiani, Erni Dwi; Masykuri, Mohammad
Journal of Environment and Sustainability Education Vol. 4 No. 1 (2026)
Publisher : Education and Development Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62672/joease.v4i1.159

Abstract

Mercury (Hg) exposure from artisanal and small-scale gold mining (ASGM) remains a major public health concern, particularly in communities where mercury amalgamation is still widely practiced. Chronic mercury exposure is known to induce oxidative stress and may interfere with detoxification pathways involving glutathione S-transferase enzymes, including GSTP1 and GSTT1. This study aimed to assess blood mercury levels and PCR-based GSTP1 and GSTT1 gene profiles among artisanal gold miners in Central Java. A cross-sectional descriptive study was conducted using whole blood samples from 10 adult males, consisting of 5 artisanal gold miners and 5 non-miner controls. Blood mercury concentrations were measured spectrophotometrically, while GSTP1 and GSTT1 gene profiles were evaluated using polymerase chain reaction (PCR). Blood mercury levels in miners ranged from 20.244 to 67.987 µg/L, exceeding the recommended reference value of <20 µg/L, whereas control subjects showed levels below the threshold. PCR analysis demonstrated expected GSTP1 and GSTT1 bands in all control samples. In contrast, miner samples showed variations in PCR band patterns, including larger than expected amplicons for GSTP1 and absence of GSTT1 amplification in two samples, which may indicate altered gene profiles associated with mercury exposure. In conclusion, artisanal gold miners exhibited elevated blood mercury levels alongside variations in GSTP1 and GSTT1 PCR profiles. Although the small sample size limits definitive genetic interpretation, these findings suggest that combined biomonitoring of mercury burden and detoxification-related gene profiles may provide useful preliminary indicators for assessing susceptibility to mercury exposure in ASGM settings.
Co-Authors Adisty, Candrika Andriyani - Puspitaningrum Andriyani Puspitaningrum Anjarani, Ajeng Viona Putri Anjaswari, Vivi Capawati Anjela Bella Dora Natalia Ardy Prian Nirwana Ardy Prian Nirwana, Ardy Prian Aribowo, Daffina Ramadhani Putri Astriana, Sevy Astuti Setiyani Bambang Hadi Sugito Binuko Amarseto Darjati Dedi Kurniawan Demes Nurmayanti Didik Wahyudi Didik Wahyudi Dwi Iswanto, Endro Endarini, Lully Hani Evi Yunita N Hadi Suryono Halwatiah, Halwatiah Handayani, Susanti Herlinda Darmastuti Indah Lestari, Indah Indito, Adelio Szaky Putra Indriati, Elli Ira Puspita Sari Isfentiani, Dina Juliana Christyaningsih Kartika Pertiwi Khambali, Khambali Khasanah, Barhoroh Nurul Kiaonarni OW Kusumaningrum, Septiana Lembunai Tat Alberta, Lembunai Tat Lenzu, Henrek Miko Leonardo Bagus Utomo Maulandi, Andi Mohammad Masykuri Mulatningtyas, Zevanya Mutianingsih, Nur Mutiarawati, Diah Titik N. S. Widodo Niassinta, Julita Novita Sari, Dyah Ayu Nur Hatijah Nur Hidayati Nurhidayat Nurhidayat Octaviana Ikka Sandra Susanti Pembayun, Raflesia Rasmiati Putri Pengge, Nuning Marina Pramuditha, Zevanya Mulatningtyas PuriMahaliya, Karisma Puspitadewi, Teresia Retna Puspitasari, Afita Indah Putri, Alifa Purwahari Putu Salsabila Rida Okta Rahayu, Ayu Puji Rahayuningsih, Christ Kartika Rahmawati, Afrilia Retno Sasongkowati Sari, Aprilia Saroh, Dewi Septiani, Erni Dwi Septiani, Risma Dyah Septiyan, Erni Dwi Siagian, Hotmaida Siti Alfiah Suciati Sudarisman Sugiyarto Sugiyarto Suliati Sumasto, Hery Sungkar, Rizky Fadzillah Susanti Handayani Syafa, Alya Nur Tantias, Farmasiriana Deli Tri Harningsih, Tri Wahono Putri, Yordha Maharani Wandan Wisdyafanny, Marcelina Wimpy, W Yanti, Rahma Yulianti, Adhiesti Nur Yulianti, Widya Ratri Intan Yuniarta, Abdullah Burhan Zahra, Angelique Fadhilah Zuhria Nurullita