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Journal : Alotrop Jurnal Pendidikan dan Ilmu Kimia

PENENTUAN POTENSI EKSTRAK KULIT BATANG TUMBUHAN SIKKAM (Bischofia javanica Blume) SEBAGAI ANTIOKSIDAN DENGAN METODE DPPH DAN SITOTOKSIK DENGAN METODE BSLT Dapot Parulian Manurung; Agus Sundaryono; Hermansyah Amir
ALOTROP Vol 4, No 1 (2020)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v4i1.13715

Abstract

This study aims to determine the level of antioxidant activity of Sikkam bark extract (Bischofia javanica Blume) and its potential as an anticancer agent. This research was conducted in November 2018 - April 2019 in the Laboratory of Chemical Education Guidance and Counseling and Basic Science Laboratory, University of Bengkulu. The sample in this study was obtained from Gunung Mariah village in Simalungun district, North Sumatra. The method used in this study was extraction using maceration, liquid-liquid fractionation, phytochemical test, DPPH (Diphenylpicrylhiydrazyl) test and BSLT test (Brine Shrimp Lethality Test). Extraction maceration using ethanol 96%, fractionation using a solvent n-hexane and ethyl acetate, phytochemical tests using Mayer's reagent, Lieberman-Burchard, FeCl3 1% and H2SO4 2N, antioxidant test using DPPH (1,1-diphenyl-2-picrylhydrazyl) and cytotoxic tests using shrimp Artemia salina Leach larvae. The results of the study on maceration of 800 grams of Sikkam bark obtained a crude extract of 53.6 grams (6.7%). Fractionation from 10 grams of crude extract obtained 7.24 gram ethanol fraction (72.4%), ethyl acetate fraction 2.14 gram (21.4%) and n-Hexane fraction 0.39 gram (3.9%). Phytochemical test results obtained the content of alkaloids, flavonoids, tannins, saponins and terpenoids with the highest yield on tannin compounds. The antioxidant activity test results obtained IC50 values in crude extracts of 20.94 ppm, ethanol fraction 36.29 ppm, ethyl acetate fraction 83.28 ppm and n-Hexane fraction 39.13 ppm which showed that crude extract, ethanol fraction, n-Hexane fraction were categorized as very strong antioxidants and Ethyl acetate fraction is categorized as a strong antioxidant. The cytotoxic test results using crude extract obtained an LC50 value of 54,827 ppm which showed that Sikkam bark extract was toxic so that it was potential as an anticancer agent.
PENGARUH MODEL PEMBELAJARAN FLIPPED CLASSROOM TERHADAP HASIL BELAJAR KIMIA SISWA PADA MATERI LARUTAN PENYANGGA DI SMAN 5 KOTA BENGKULU Rantika Khumairah; Agus Sundaryono; Dewi Handayani
ALOTROP Vol 4, No 2 (2020)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v4i2.13832

Abstract

The purposes of this study is to know student learning outcomes of chemistry using flipped classroom learning model and know influence of flipped classroom learning model to on buffer solution. The study was conducted in February-March of 2019 in SMAN 5 Bengkulu City This study is pre-experimental design with one-grup pretes-posttest design. Population of this study is all of XI MIPA’s student which a total of 216 students with sample of this study is XI MIPA 5’s student which a total of 36 students. Technique of sampling in this study is used with purposive sampling technique. Instrument of this study used test of learning outcomes with 20 items pretest and posttest. Analysis of the data used are mean values, normality test, homogeneity test, and t-test to the student learning outcomes. Based on normality test and homogeneity test obtained that pretest and posttest have normal distribution and distributed to homogeneous. Average value of pretest and posttest are 60,1 and 80,0. The result of hypotheses using t-test showed that value of significance is 0.000 < 0.05, so flipped classroom model influenced of significance to student learning outcomes. The result of this study showed that flipped classroom learning model can positive influence to learning outcomes and increased student learning outcomes on buffer solution in XI MIPA 5 SMA N 5 Bengkulu city on academic year of 2018/2019.
UJI AKTIVITAS ANTIPLASMODIUM FRAKSI N-HEKSANA DAUN Peronema canescens TERHADAP Mus musculus Fenny Andriani; Agus Sundaryono; Nurhamidah Nurhamidah
ALOTROP Vol 1, No 1 (2017)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v1i1.2712

Abstract

Peronema canescens (Sungkai) has been used in Bengkulu as raw herbal remedy to reduce the fever, some people are using as a malaria drug. P.  canescens leaves contain alkaloids, flavonoids, tannins and terpenoids – steroids .This study aims to analyze the effect of P.  canescens leaves  n-hexane fraction.  against paracetemias in Mus musculus infected with Plasmodium berghei, then to prove whether the . P.  canescens leaves n-hexane fraction  has potential as alternative medicine for malaria .   To make P. canescens extract , leaves was macerated using EtOH (96%), then filtrate was evaporated using a rotary evaporator, then fractionated with n-hexane. The 25 healthy  M.musculus  weighing 20-40g each, infected with P.berghei, grouped into 5 ie group 1 (K-) was treated orally with aquades, group 2 (K +) was treated orally with 0.42 mg of Chloroquine, Group 3 (P1) Group 4 (P2), group 5 (P3) was treated orally with a P.  canescens leaves n-hexane fraction  each at a dose of 0.028 ,  0.056 and 0.084 g / kgBW. After 3 days of digestion for each treatment, the amount of erythrocytes was calculated under a microscope. : The giving of the with dose 0,028 g / kgBW able to inhibit paracetemia 33,49%,  0,056 g / kgBW able to  57.91% and  0,084 g / kgBW able to  61.69%   The conclusion is the P. canescens leaves n-hexane fraction  at a dose of 0.028 , 0.056 , and 0.084 g / kgBW orally wil be decreased the amount of paracetemia in M.musculus, and the higher the dose given the higher percent of the inhibition.
PEMBUATAN NANOPARTIKEL-PERAK EKSTRAK DAUN UBI JALAR ORANGE (Ipomoea batatas L.) DENGAN METODE BIOREDUKSI DAN UJI AKTIVITAS TERHADAP JUMLAH TROMBOSIT Mus musculus Ririn Trinanda; Agus Sundaryono; Dewi Handayani
ALOTROP Vol 3, No 1 (2019)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v3i1.9042

Abstract

This study aims to make silver nanoparticles (NPP) of orange Sweet potato extract (Ipomoea batatas L.) using bioreduction method and test the effect of giving silver nanoparticles - leaf extract of Ipomoea batatas L. orange (Ipomoea batatas L.) to the number of thrombocyte from male of  Mus musculus induced by aspirin. The precursor used is 1 mM AgNO3 solution and as bioreductor is an antioxidant compound in orange sweet potato extract (Ipomoea batatas L.). The ratio of AgNO3 1 mM solution volume and orange sweet potato leaf extract is 9: 1 with 2 hours time. The characteristic test again obtained NPP is done using FTIR and Particle Size Analyzer (PSA) using Dynamyc Light Scattering method (DLS). The results showed that from the PSA analysis is known the average size of NPP – I. Batatas, L leaf extract  is an average of 86.0 nm with a polydispersity value (PDI) of 0.17 < 1 that indicates that the  NPP-leaf extract particle size distribution It is less homogeneous and are less stable.The results show that the administration of silver nanoparticles - orange sweet potato extract (Ipomoea batatas L.) can increase the platelet count of male mice significantly Dose of 0.014 g / Kgbb of 259,600 / mm3. 
PENGEMBANGAN E-MODUL KIMIA BERBASIS KEMAMPUAN BERPIKIR KREATIF DENGAN MENGGUNAKAN KVISOFT FLIPBOOK MAKER Cici Romayanti; Agus Sundaryono; Dewi Handayani
ALOTROP Vol 4, No 1 (2020)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v4i1.13709

Abstract

The aim of this research is to determining level of feasibility and response of students from the development of e-modules in chemistry course based on creative thinking ability using the Kvisoft Flipbook Maker on material electrolyte and non-electrolyte solution in SMA Negeri 9 Kota Bengkulu. The type of research used is R & D (Research & Development), which uses the ADDIE development model (analysis, design, development, implementation, evaluation) with the limitation of stage until implementation. The results of this research show that the chemistry-based E-Module based on creative very feasible and feasible to use with the validation results from media experts was 97.7%, material expert validation was 90.2%, readability the small group trials conducted by 9 students in class X MIPA 2 was 97.04% and student responses in the large group trial conducted by 25 students in class X MIPA 1 was 86.4% (very feasible category). This shows that e-modules in chemistry course based on the ability to think creatively by using the kvisoft flipbook maker are very suitable to be used in the learning process
SINTESIS DAN KARAKTERISASI NANOPARTIKEL KEBIUL (Caesalpinia bonduc L ) TERSALUT LIPID PADAT TRIMIRISTIN Chyntia Margareta; Agus Sundaryono; Nurhamidah Nurhamidah
ALOTROP Vol 5, No 2 (2021)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v5i2.17137

Abstract

SINTESIS METIL ESTER DARI LIMBAH KELAPA SAWIT DENGAN SONOCHEMISTRY DAN CRACKING MENJADI BIOFUEL DENGAN KATALIS CrMo/HZ Jertadi Putri Dhani; Agus Sundaryono; Dewi Handayani
ALOTROP Vol 3, No 2 (2019)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v3i2.10498

Abstract

This study aims to calculate the percentage methyl ester converted to biofuel through catalytic cracking reaction,analyzes component and determine characteristics using catalyst CrMo/HZ. This research begins with impregnation sample preparation which includes heating oil,degumming,bleaching and determination free fatty acid (FFA). Methyl ester obtained from liquid waste conversion crude palm oil through an esterification and transesterification reaction with H2SO4 and NaOH catalyst with sonochemistry methode is a method that utilizes ultrasonic waves origanating from a device is ultrasonic cleaner for one hour at temperature 60oC. The methyl ester obtained was cracked with a CrMo/HZ catalyst which was carried out for 2 hours at temperatur 380oC. To find out the components of compounds formed in methyl ester, an analysis was performed using GCMS then characteristics of biofuel are determined from the result of catalytic cracking obtained through acid number testing,density,viscosity,pour point and fog point. The result obtained from the conversion of methyl ester to biofuel with Crmo/HZ Catalyst Is 60,17% And For Testing The Physical Characteristics Of Biofuel Namely The Acid Number 1,87 Mg KOH/G, density 0,804 g/cm3, viscosity 1,162 Cst, pour point 0oC and fog point 1,4oC. The result of cracking produce a consituent component of biofuel namely gasoline 33,67%, kerosene 16,26%, gas oil 10,24% beside that, there are still methyl ester as much as21,89%.
AKTIVITAS FRAKSI ETANOL DARI EKSTRAK DAUN Peronema canescens TERHADAP TINGKAT PERTUMBUHAN Plasmodium berghei Dhea Prasiwi; Agus Sundaryono; Dewi Handayani
ALOTROP Vol 2, No 1 (2018)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v2i1.4601

Abstract

 [THE ACTIVITY OF THE Peronema canescens LEAVES ETHANOL EXTRACTS FRACTION AGAINST Plasmodium berghei GROWTH RATE ] The purpose of this research was to identify the secondary metabolites of compounds contained in the fraction of ethanol from leaves of Peronema canescens (Sungkai) as well as to measure the level of activity of ethanol fraction antiplasmodium leaf P.canescens against the male mice (Mus musculus) infected with Plasmodium berghei which is parasitic hemaprotozoa that can cause malaria in rodents such as rats and mice as well as molecular similarity with the parasite Plasmodium. falciparum that causes malaria in humans. The methods used in this study i.e. in maceration extraction methods to attract secondary metabolite compounds from the leaves of P.canescens followed by oil bath method to get a fraction of ethanol with the purpose of separating polar compounds from a mixture of secondary metabolite compounds contained in the sample leaf P.canescens. Assay activity against antiplasmodium males mice infected with P. berghei is done by dividing into the 5 mice group treatment i.e. Group K (-) that are quads, group K (+) given kloroquin anti malarial drug, and P1, P2, P3, which each group was given a dose of ethanol fraction from leaves of P. canescens with each dose of 0.028 (P1); 0.056 (P2), and 0.0084 g/kgBB (P3).The results of research conducted showed that administering ethanol fraction from leaves of P. canescens antimalarial activity can increase with very real on the best dose of kg BB 0084 g i.e. with the percentage inhibition of 54.06%.
PROFIL FITOKIMIA DAN PENGARUH EKSTRAK TANGKAI DAUN TALAS KEMUMU (Colocasia gigantea Hook.f ) TERHADAP JUMLAH LEUKOSIT Mus musculus Rofiqa Asri; Dewi Handayani; Agus Sundaryono
ALOTROP Vol 3, No 1 (2019)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v3i1.9038

Abstract

This research aims to identify secondary metabolite compounds in Talas kemumu leaf stalk (Colocasia gigantea Hook.f) and to determine the effect of extract on the number of male Mus musculus leukocytes that have been induced aspirin. Aspirin is used to increase the number of M.musculus leucocytes.The method used in this research is the method of extraction by maceration to attract secondary metabolites of active compounds  C.gigantea leaf stalk and the measurement of blood leukocyte counts are calculated using a hemocytometer (improved neubauer). Test of the effect of the leaf stalk of C.giganteaextract on the number leukocytes of M.musculus  was performed by dividing into 5 groups with 5 replications according to the Federer formula, namely K (-) were given distilled water, K (+) were given aspirin, P1, P2 and P3 are each given a dose of extract of  C.gigantea leaf stalk of 0,028 g/KgBB, 0,056 g/KgBB and 0,084 g/KgBB. The results showed that the identification of phytochemical profile in C.gigantea leaf stalk contains secondary metabolite compounds such as alkaloids, flavonoids, terpenoids, tannins and saponins. The results shows that giving of C.gigantea leaf stalk extract can reduce the number of leukocytes M.musculus which have induced aspirin. The giving of C.gigantea leaf stalk extract can decrease the number of aspirin-induced M.musculus leukocytes. This is evident from the results of One Way Anova analysis and the Smallest Real Difference Test (BNT) because in each treatment group has a significant influence. The effective dose that has the greatest activity in decreasing the number of M.musculus leukocytes found in the P1 treatment of 0,028 g /KgBB can decrease the blood leukocyte count by 6,830 / mm3.
UJI BIOFUEL HASIL PERENGKAHAN METIL ESTER DARI LIMBAH CAIR PABRIK MINYAK KELAPA SAWIT DENGAN KATALIS MoNi/HZ Dian Kartika Sari; Agus Sundaryono; Dewi Handayani
ALOTROP Vol 1, No 2 (2017)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v1i2.3534

Abstract

[CONVERSION OF LIQUID WASTE OIL PALM OIL FACTORY BECOME BIOFUEL WITH MONi / HZ CATALYST] This study aims to produce biofuel from liquid waste oil PMKS with worditik cracking using catalystMoNi / HZ. This study involves the preparation of a catalyst performed by means of a separate impregnation, this impregnation lasting for 12 hours. The next stage of sample preparation includes heating, filtering, degumming, bleaching and ALB determination, followed by the production of methyl esters through esterification and transesterification processes. Then the obtained methyl ester was cracked using a catalyst for 2 hours at 380 °C and followed by distillation of the product for 2 hours at 380 °C, followed by distillation step at 380 °C to obtain methyl ester. The physical characteristics of biofuel resulting from the catalytic cracking reaction of the methyl ester using the MoNi / HZ catalyst of the PMKS wastewater include the acid number 1.92 mg KOH / g, density 0.803 g/cm3, kinematic viscosity 1,113 cSt, a pour poin of 0oC and fog poin at 1,43 oC. Biofuel resulting from catalytic cracking using this MoNi / HZ catalyst of very high biofuel acid numbers can be used in areas that have a cold climate. the biofuel viscosity of the experimental results has not matched the viscosity of gasoline or kerosene, so it can not be used as fuel equivalent to gasoline and kerosene with the composition of 100% biofuel density from biofuel is still slightly above gasoline and kerosene
Co-Authors ACENG RUYANI Ade Indriani Putri Alfia Novera Indah Esa Kasih Arina Fatharani Arsela Eko Listiono Bedah Rupaedah Bedah Rupaedah, Bedah Bhakti Karyadi BHAKTI KARYADI Bhakti Karyadi Bonodikun Bonodikun Candrawati, Emilia Candrawati, Emilia Chyntia Margareta Cici Romayanti Dapot Parulian Manurung Devi Silsia Devi Silsia Dewi Handayani Dhea Prasiwi Dian Kartika Sari Eko Swistoro Elvinawati Elvinawati Emi Hartati Emilia Candrawati Emilia Candrawati Endang Widi Winarni Endang Widi Winarni Ernis, Gustria Euis Nursa’adah Fahrurrozi, Fahrurrozi Fenny Andriani Fitri Yuwita Fuji Ramadenti Hadi Apriyoanda Hadi Apriyonda Henny Johan Herison, Catur Hermansyah Amir I Nyoman Candra I Nyoman Chandra Ilham Agus Saputra Jertadi Putri Dhani Kirent Arikhsa Putri Krisandini, Triana Lina Widawati M Lutfi Firdaus M. Farid M. Lutfi Firdaus M. Lutfi Firdaus Maya Wahyunarti Mayshah Purnamasari Megasari Megasari Meizul Zuki Mellyta Uliyadari Mina Sihite Hutasoit Muchammad Farid Mukhsin Mukhsin Muzanip Alperi Nur Wakidatul Khasanah Nurhamidah Nurhamidah Nurhamidah Nurhamidah Nurhamidah Nurhamidah Nurleli Nurleli Nurlia Latifah Nursaa'adah, Euis Nursaadah, Euis Pandu Imam Sudibyo Adib Pandu Imam Sudibyo Adib Pramesthi Regita Putri Putri Suci Asriani Rantika Khumairah Rasie Janika Reni Jumika Ridwan Yahya Rika Partika Sari Rina Elvia Rina Elvia Rina Elvia, Rina Rina Endriani Ririn Trinanda Rofiqa Asri Sari Puspita Ningsih Shiba Meike Indira Shinta Lestari Sipriyadi Sri Astuti Sumpono Sumpono Sumpono Sumpono Sumpono, Sumpono Suryadi Suryadi Theo Kuntara Tuti Maryana Tyas Sri Muryati Ulfah Anis Umaya Umi kalsum Wuri Marsigit Yenni Okfrianti Yohannes Adimar Marbun Yulia Suparti Zulman Efendi