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Journal : Bioeksperimen

Ethanolic Extract of Tamarindus indica Leaves Lowers Total Cholesterol, Triglycerides, and HDL but Without Affecting LDL in Hyperlipidemic Rats Susiloningsih, Tri; Christijanti, Wulan; Marianti, Aditya; WH, Nugrahaningsih
Bioeksperimen: Jurnal Penelitian Biologi September 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v11i2.12103

Abstract

Hyperlipidaemia is a condition of increased lipid levels, especially cholesterol, triglycerides, LDL and an abnormal decrease in HDL in the blood. Tamarind leaves contain flavonoid and quercetin compounds that have the ability as antihyperlipidemia agents. The purpose of this study was to examine the effect of tamarind leaf ethanol extract on the lipid profile of hyperlipidaemia rats. Samples of 16 male Wistar rats were divided into 4 groups; Control group and the tamarind leaf ethanol extract treatment group was divided into 3, namely P1 350 mg/kgBB, P2 500 mg/kgBB, and P3 650 mg/kgBB. All rats were given lard 3 mL/head/day for 2 weeks. In weeks 3 and 4, rats were given extract of Tamarindus indica leaves and 2 hours interval was given lard. The data obtained were statistically analysed using one-way ANOVA and the Least Significant Difference (LSD) test at the 95% confidence level. In this study, HDL levels decreased along with reductions in total cholesterol and triglycerides, but had no effect in reducing LDL levels. Reduced cholesterol synthesis limits substrate availability for HDL formation, resulting in proportional decreases in HDL-C. The conclusion of this study is that tamarind leaf ethanol extract has an effect in reducing lipid profile levels.
Potential of butterfly pea (Clitoria ternatea) nanoherbal on spermatozoa quality in hyperglycemic rats Putri, Komala Amelia; Christijanti, Wulan; Marianti, Aditya
Bioeksperimen: Jurnal Penelitian Biologi March 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v12i1.15239

Abstract

Hyperglycemia is a condition characterized by elevated blood glucose levels that induce free radical formation, leading to reduced spermatozoa quality. Butterfly pea (Clitoria ternatea) contains antioxidant compounds and is formulated as a nanoherbal to enhance bioavailability. This study aimed to evaluate the potential of butterfly pea nanoherbal in improving spermatozoa quality in hyperglycemic rats. This experimental study employed a post-test only control group design using 25 male Wistar rats divided into a healthy control group and hyperglycemic groups induced by alloxan (125 mg/kg BW). The hyperglycemic groups consisted of a metformin control (400 mg/kg BW) and butterfly pea nanoherbal treatment groups at doses of 12.5, 25, and 50 mg/kg BW administered for 28 days. Data were analyzed using One-Way ANOVA followed by the Least Significant Difference (LSD) post hoc test. The results showed that spermatozoa concentration in the healthy control group differed significantly from the positive control, P1, and P2 groups (p<0.05), but not from the P3 group. Spermatozoa motility and viability also showed significant differences among groups (p<0.05). It can be concluded that butterfly pea flower nanoherbal significantly improves spermatozoa quality in hyperglycemic rats.
Co-Authors - Suprihatin, - Aditya Marianti Alfiatun N, Alfiatun Amanatul Munawaroh, Amanatul Andreas Priyono Budi Prasetyo Anggoro, Naufal Sebastian Anisa Dewi Sri Puspitasari Ari Yuniastuti Arya Iswara Arya Iswara Aulia, Maliqa Ayu Etna Ningtyas, Ayu Etna Azkiyah, Nimas Catur Badingatus Sholihah Bagus Hammam Falah Cahya Buana Cahya Buana Damar Galih Dewi Mustikaningtyas Dimarti, Safira Chaerani Dimarti, Safira Chairani Edward Louis Krey Eling Purwantoyo Ely Rudyatmi, Ely Endah Peniati Falistina, Amna Fifti Istiklaili, Fifti Fitri Arum Sasi, Fitri Arum Fonda, Sarah Shabrina Galih, Damar Hammam, Bagus Ibnul Mubarok Indriyani Indriyani Jabar, Muhammad Abdul Kartika Widyaningrum Kikie Septiyana, Kikie Kusuma, Putri Patria Kusuma, Zeni Herawati Laraswati, Vivi Anggraeni Lina Herlina Lisdiana Lisdiana M.A. Sunny Maridah Nurjanah, Maridah Martien Herna Susanti Maulana, Silvia Faori Mighfar Khamida, Mighfar Mirtaati Na’ima Mohamed, Mohd Salim Bin Mu’afy, Faizal Daffa Na’ima, Mirtaati Nana Kariada Trimartuti Ning Setiati Nisa', Lailatun Nisa' Nissa, Ma’isyatun Noor Aini Habibah Nugrahaningsih WH Nugrahaningsih WH, Nugrahaningsih Nugrahaningsih, WH Nur Rahayu Utami Nur Rahayu Utami Nuryanti, Novi Pauline, Maretha Putri Pramesti Dewi Priyanto, Yudi Purnamaningrum, Sisilia Prita Dewi Putri, Komala Amelia R Susanti R. Susanti R. Susanti R. Susanti Rakainsa, Senda Kartika Ramadhanti, Shifa Ramasamy, Sujatha Rismanika Anggraeni, Rismanika Rizki Raharyu Noviami, Rizki Raharyu Rizki Raharyu, Rizki Sasabila Mumtaz Sekar Dwi Ardianti Senda Kartika Rakainsa Septiningtyas, Sinta Dwi Sholihah, Badingatus Sigit Saptono Siti Harnina Bintari Siti Qomariah, Siti Sriyadi , Sriyadi Sriyadi Sriyadi, Sriyadi Stephani Diah Pamelasari, Stephani Diah Sumad Sumad Sumad Sumad, Sumad Supriyanto - Suryonegoro, Bayu Murti Susiloningsih, Tri Talitha Widiatningrum Tsaniyah, Nurotun Najmatus Udin Ahmad Syahri, Udin Ahmad Wardani, Agata Iswiana Diah Widiyaningrum, Kartika Widyaningrum, Kartika Wijaya, Ifan Badra Wiwi Isnaeni Woro Sumarni Yudi Priyanto Zaenafree, Intan