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All Journal Abdimas Jurnal Penelitian Pendidikan Rekayasa: Jurnal Penerapan Teknologi dan Pembelajaran Sainteknol : Jurnal Sains dan Teknologi Journal of Biology Education Universa Medicina Unnes Science Education Journal Biosaintifika: Journal of Biology & Biology Education Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Pembelajaran dan Biologi Nukleus Jurnal ABDINUS : Jurnal Pengabdian Nusantara Abdimasku : Jurnal Pengabdian Masyarakat ABDIMAS Jurnal Pengabdian Kepada Masyarakat Life Science Prosiding Seminar Nasional Biologi Unnes Science Education Journal Bioeksperimen Jurnal Ilmu Kesehatan Masyarakat (The Public Health Science Journal) Indonesian Journal of Mathematics and Natural Sciences Life Science
Wulan Christijanti
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

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Pengaruh Nanopartikel Ekstrak Asam Jawa terhadap Perubahan Morfologi dan Histologi Testis Tikus Hiperglikemia Christijanti, Wulan; R. Susanti; Marianti, Aditya; Widiyaningrum, Kartika
Indonesian Journal of Mathematics and Natural Sciences Vol. 48 No. 2 (2025): Vol. 48 No. 2 (2025): Volume 48 Nomor 2 October 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jm.v48i2.37045

Abstract

Hiperglikemia dapat menimbulkan kerusakan jaringan serta menimbulkan berbagai komplikasi, seperti neuropati, nefropati, retinopati, dan gangguan pada sistem reproduksi. Asam jawa mampu menurunkan kadar gula darah sekaligus mengurangi radikal bebas menunjukkan potensi efek pencegahan kerusakan testis. Ukuran partikel yang sangat kecil mampu meningkatkan distribusi, penyerapan  dan interaksi lebih efektif dengan target biologis. Tujuan penelitian adalah mengkaji pengaruh nanopartikel ekstrak asam jawa pada testis secara morfologi dan histologis tikus pada kondisi hiperglikemia. Tikus diinduksi aloksan monohidrat 150 mg/kg berat badan intraperitoneal. Kriteria hiperglikmeia dengan kadar glukosa > 120 mg/dl setelah 3 hari induksi. Tikus dibagi menjadi Kontrol hiperglikemia (K), vitamin C 150 mg/kg (PC) ,  glibenklamid 5 mg/kg (PG) dan nanopartikel asam jawa 30 mg (PB 1) serta 60 mg/kg (PB 2) per oral selama 4 minggu. Variabel yang diamati berupa berat, panjang, diameter dan derajat spermatogenesis testis. Data dianalisis dengan Anova dan uji lanjut Beda Nyata Terkecil. Hasil penelitian menunjukkan perlakuan mempengaruhi variabel dan  memberikan perbedaan signifikan pada berat dan derajat sepermatogenesis p<0,05, namun tidak signifikan untuk panjang dan diameter testis. Simpulan penelitian adalah nanopartikel asam jawa berpengaruh terhadap berat dan derajat spermatogenesis tikus hiperglikemia.
Ethanolic Extract of Tamarindus indica Leaves Lowers Total Cholesterol, Triglycerides, and HDL but Without Affecting LDL in Hyperlipidemic Rats Susiloningsih, Tri; Christijanti, Wulan; Marianti, Aditya; WH, Nugrahaningsih
Bioeksperimen: Jurnal Penelitian Biologi September 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v11i2.12103

Abstract

Hyperlipidaemia is a condition of increased lipid levels, especially cholesterol, triglycerides, LDL and an abnormal decrease in HDL in the blood. Tamarind leaves contain flavonoid and quercetin compounds that have the ability as antihyperlipidemia agents. The purpose of this study was to examine the effect of tamarind leaf ethanol extract on the lipid profile of hyperlipidaemia rats. Samples of 16 male Wistar rats were divided into 4 groups; Control group and the tamarind leaf ethanol extract treatment group was divided into 3, namely P1 350 mg/kgBB, P2 500 mg/kgBB, and P3 650 mg/kgBB. All rats were given lard 3 mL/head/day for 2 weeks. In weeks 3 and 4, rats were given extract of Tamarindus indica leaves and 2 hours interval was given lard. The data obtained were statistically analysed using one-way ANOVA and the Least Significant Difference (LSD) test at the 95% confidence level. In this study, HDL levels decreased along with reductions in total cholesterol and triglycerides, but had no effect in reducing LDL levels. Reduced cholesterol synthesis limits substrate availability for HDL formation, resulting in proportional decreases in HDL-C. The conclusion of this study is that tamarind leaf ethanol extract has an effect in reducing lipid profile levels.
Potential of butterfly pea (Clitoria ternatea) nanoherbal on spermatozoa quality in hyperglycemic rats Putri, Komala Amelia; Christijanti, Wulan; Marianti, Aditya
Bioeksperimen: Jurnal Penelitian Biologi March 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v12i1.15239

Abstract

Hyperglycemia is a condition characterized by elevated blood glucose levels that induce free radical formation, leading to reduced spermatozoa quality. Butterfly pea (Clitoria ternatea) contains antioxidant compounds and is formulated as a nanoherbal to enhance bioavailability. This study aimed to evaluate the potential of butterfly pea nanoherbal in improving spermatozoa quality in hyperglycemic rats. This experimental study employed a post-test only control group design using 25 male Wistar rats divided into a healthy control group and hyperglycemic groups induced by alloxan (125 mg/kg BW). The hyperglycemic groups consisted of a metformin control (400 mg/kg BW) and butterfly pea nanoherbal treatment groups at doses of 12.5, 25, and 50 mg/kg BW administered for 28 days. Data were analyzed using One-Way ANOVA followed by the Least Significant Difference (LSD) post hoc test. The results showed that spermatozoa concentration in the healthy control group differed significantly from the positive control, P1, and P2 groups (p<0.05), but not from the P3 group. Spermatozoa motility and viability also showed significant differences among groups (p<0.05). It can be concluded that butterfly pea flower nanoherbal significantly improves spermatozoa quality in hyperglycemic rats.
Effectiveness of Clitoria ternatea L. Nanoherbal on Blood Glucose and Malondialdehyde Levels of Hyperglycemic Rats Cahya Buana; Wulan Christijanti; Ari Yuniastuti
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 12, No 1: Jurnal Pembelajaran Dan Biologi Nukleus March 2026
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v12i1.8874

Abstract

Background: Hyperglycemia induces excessive production of reactive oxygen species (ROS), leading to oxidative stress and lipid peroxidation characterized by increased malondialdehyde (MDA) levels. This study evaluated the effectiveness of butterfly pea flower nanoherbal formulated as alginate-based nanoparticles using the ionic gelation method in reducing blood glucose and MDA levels in hyperglycemic rats. Methodology: 25 male Wistar rats (Rattus norvegicus) were divided into five groups: normal control (NC), metformin control (MC), and three nanoherbal treatment groups (NT1, NT2, and NT3) receiving doses of 12.5, 25, and 50 mg/kg body weight (BW), respectively. Hyperglycemia was induced by a single intraperitoneal injection of alloxan monohydrate (125 mg/kg BW). Blood glucose was measured on days 1, 14, and 28, while MDA levels were analyzed on day 28 using the TBARS method. The analysis of blood glucose levels was conducted using a Repeated Measures Two-Way ANOVA followed by a Bonferroni post hoc test, while MDA data were evaluated through a One-Way ANOVA with Duncan’s multiple range test (p < 0.05). Findings: A significant, dose-dependent reduction in blood glucose levels was observed following nanoherbal treatment. The NT3 group (50 mg/kg BW) showed the greatest reduction, with mean glucose decreasing from 471.4 ± 142.00 mg/dL on day 1 to 146.4 ± 68.58 mg/dL on day 28. MDA levels also differed significantly, with NT3 showing 2.84 ± 0.19 nmol/mL, indicating lower oxidative stress. Contributions: These findings indicate that alginate-based butterfly pea nanoherbal can reduce blood glucose and MDA levels in hyperglycemic rats, suggesting its potential role in improving glycemic control and reducing oxidative stress under hyperglycemic conditions
Penerapan Biosekuriti Lingkungan Kandang dalam Upaya Pencegahan Penyakit Menular Wulan Christijanti; Komala Amelia Putri; Cahya Buana; Amna Falistina; Sriyadi Sriyadi; Safira Chaerani Dimarti; Ibnul Mubarok; Lina Herlina; R. Susanti; Maretha Putri Pauline
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 9 No 3 (2025): Volume 9 Nomor 3 Tahun 2025
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v9i3.26763

Abstract

Mangunsari Village is one of the goat farming centers in Gunungpati District, Semarang. They raise goats from generation to generation and based on experience, so care patterns are often not uniform from one to another. In addition to feed, animal hygiene and health are very important to implement in enforcing biosecurity in the pen and its surrounding environment. The goal of this activity is to improve goat health and the safety of the pen environment through biosecurity. The community service is divided into two: providing materials and training followed by practice. Twenty participants, members of the Mekar Sari 2 livestock farmer group, were accompanied by a team of nine lecturers, technicians, and students. The activity began with filling out a questionnaire, theory, and ended with practice. Data obtained showed that 53.8% were aged > 50 years and 23.1% were < 40 years. In addition, 84.6% of participants had been members of the livestock farmer group for a long time (≥ 10 years). There was a 0.2% increase in knowledge regarding infectious diseases, a 2% increase in leaf and grass feed, a 61.6% increase in forage that must be wilted, and a 7.7% increase in pen cleanliness. Participants also understood that forage is best not provided wet (40.5%). The results concluded that this activity improved knowledge about biosecurity components and the participants' skills in physical examination of goats and pen cleanliness.
Co-Authors - Suprihatin, - Aditya Marianti Alfiatun N, Alfiatun Amanatul Munawaroh, Amanatul Amna Falistina Andreas Priyono Budi Prasetyo Anggoro, Naufal Sebastian Anisa Dewi Sri Puspitasari Ari Yuniastuti Arya Iswara Arya Iswara Aulia, Maliqa Ayu Etna Ningtyas, Ayu Etna Azkiyah, Nimas Catur Badingatus Sholihah Bagus Hammam Falah Cahya Buana Damar Galih Dewi Mustikaningtyas Dimarti, Safira Chairani Edward Louis Krey Eling Purwantoyo Ely Rudyatmi, Ely Endah Peniati Fifti Istiklaili, Fifti Fitri Arum Sasi, Fitri Arum Fonda, Sarah Shabrina Hammam, Bagus Ibnul Mubarok Jabar, Muhammad Abdul Kartika Widyaningrum Kikie Septiyana, Kikie Komala Amelia Putri Kusuma, Putri Patria Kusuma, Zeni Herawati Lina Herlina Lina Herlina Lisdiana Lisdiana M.A. Sunny Maretha Putri Pauline Maridah Nurjanah, Maridah Martien Herna Susanti Maulana, Silvia Faori Mighfar Khamida, Mighfar Mirtaati Na’ima Mu’afy, Faizal Daffa Na’ima, Mirtaati Nana Kariada Trimartuti Ning Setiati Nisa', Lailatun Nisa' Nissa, Ma’isyatun Noor Aini Habibah Nugrahaningsih WH Nugrahaningsih WH, Nugrahaningsih Nur Rahayu Utami Nur Rahayu Utami Nuryanti, Novi Pramesti Dewi Priyanto, Yudi Purnamaningrum, Sisilia Prita Dewi Putri, Komala Amelia R Susanti R. Susanti R. Susanti R. Susanti Ramadhanti, Shifa Rismanika Anggraeni, Rismanika Rizki Raharyu Noviami, Rizki Raharyu Rizki Raharyu, Rizki Safira Chaerani Dimarti Sasabila Mumtaz Sekar Dwi Ardianti Senda Kartika Rakainsa Sholihah, Badingatus Sigit Saptono Siti Harnina Bintari Siti Qomariah, Siti Sriyadi , Sriyadi Sriyadi Sriyadi Sriyadi Sriyadi, Sriyadi Stephani Diah Pamelasari, Stephani Diah Sumad Sumad Sumad Sumad, Sumad Supriyanto - Suryonegoro, Bayu Murti Susiloningsih, Tri Talitha Widiatningrum Tsaniyah, Nurotun Najmatus Udin Ahmad Syahri, Udin Ahmad Wardani, Agata Iswiana Diah Widiyaningrum, Kartika Widyaningrum, Kartika Wijaya, Ifan Badra Wiwi Isnaeni Woro Sumarni Yudi Priyanto Zaenafree, Intan