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Amelogenin and alkaline phosphatase expression in ameloblast after saltwater fish consumption in pregnant mice (Mus musculus) Christiono, Sandy; Pradopo, Seno; Sudiana, I Ketut; Hutami, Islamy Rahma; Mayangsari, Regilia Shinta; Rochmah, Yayun Siti; Ibrahim, Zurairah
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p166-171

Background: The intricate process of tooth formation during embryonic development ensures sufficient nutrition for the growth of healthy dental tissues. Amelogenin and alkaline phosphatase (ALP) are serine proteinases secreted by the ameloblast during the transition and maturation phases of the amelogenesis process. Consumption of saltwater fish is predicted to increase the expression of amelogenin and ALP in ameloblast cells during tooth formation. Only now have the function of each gene, tooth-forming cells, and the proteins they produce in the biomolecular amelogenesis of tooth enamel, which began during prenatal development, been clarified. Purpose: This study aims to determine how saltwater fish powder affects the ability of mother mice to increase the expression of amelogenin and ALP in cell ameloblast. Methods: Using a completely randomized design, this study was experimental and aimed to examine the effects of sardine (Sardinella fimbriata), splendid ponyfish (Leiognathus splendens), and tuna (Euthynnus affinis) powder. As samples, twenty-four female mice (Mus musculus) were used. Two groups of mice were created: group 1 (2.14 mg/0.5 ml) and the control group. The expression of amelogenin and ALP was determined using immunohistochemistry (IHC) and t-test (p0.05). Results: Expression of ameloblast was significantly different between the treatment and control groups (p0.05). Conclusion: The consumption of saltwater fish reduces the amelogenin and ALP expressions of mouse fetal ameloblast cells during tooth development in vivo.

ORAL AND DENTAL MANAGEMENT IN CHILDREN WITH TETRALOGY OF FALLOT : A LITERATURE REVIEW Anggarani, Welly; Christiono, Sandy; Agusmawanti, Prima
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Congenital heart disease is a condition of heart anomaly and or disfunction of heart since birth. The most common congenital heart disease is Tetralogy Of Fallot (TOF). The disorder has four features, a ventricular septal defect, aortic overriding, stenosis pulmonary, and hypertrophy right ventricular.Method: This review aimed to talk about oral manifestations and discuss options of several oral and dental management in children with TOF.Result: Oral and dental treatment of pediatric patient with cardiovascular disease is important to be carried out with the risk of bacterial endocarditis.Conclusion: Oral and dental management in a child with congenital heart disease is very important. Main point of dental management are dental health education, preventive dental treatment and control periodic after dental treatment.

PENGARUH SUSU IBU HAMIL TERHADAP EKSPRESI KALLIKREIN-RELATED PEPTIDASE-4 (KLK-4) PADA SEL AMELOBLAS DALAM TUMBUH KEMBANG GIGI Samia, Salma; Christiono, Sandy; Sari, Rina Kartika
Odonto : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Tooth development during the embryonic period is a complex process that needs enough nutrition for the formation of healthy dental tissue. Kallikrein-related peptidase-4 (KLK-4) is a serine proteinase secreted by ameloblast during transition and maturation stages in the amelogenesis process which functions to degrade protein matrices so enamel could reach the final hardness. Pregnancy milk contains various nutrients that can increase KLK-4 expression of ameloblast cells in the tooth development. This study aims to determine the impact of pregnancy milk against the KLK-4 expression of ameloblast cell in the tooth development process.Method: 12 pregnant female mice (Mus Musculus L.) divided into control group (given sterile aquadest) and treatment group (given pregnancy milk + sterile aquadest) for 18 days then the tooth germ was taken. Samples were stained to see the KLK-4 expression. Data were analyzed using an Independent sample t-test.Result: Our study showed that the average amounts of KLK-4 expression in the treatment group are higher than the control group. Based on the Independent sample t-test statistic methods, there is a significant difference with the value of p=0,017.Conclusion: The pregnancy milk could influence the Kallikrein-related peptidase-4 (KLK-4) expression of ameloblast cell in the mice fetusâ€™s tooth development.

PENGARUH SUSU IBU HAMIL TERHADAP EKSPRESI KALLIKREIN-RELATED PEPTIDASE-4 (KLK-4) PADA SEL AMELOBLAS DALAM TUMBUH KEMBANG GIGI Samia, Salma; Christiono, Sandy; Sari, Rina Kartika
Odonto : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.2.98-103

Background: Tooth development during the embryonic period is a complex process that needs enough nutrition for the formation of healthy dental tissue. Kallikrein-related peptidase-4 (KLK-4) is a serine proteinase secreted by ameloblast during transition and maturation stages in the amelogenesis process which functions to degrade protein matrices so enamel could reach the final hardness. Pregnancy milk contains various nutrients that can increase KLK-4 expression of ameloblast cells in the tooth development. This study aims to determine the impact of pregnancy milk against the KLK-4 expression of ameloblast cell in the tooth development process.Method: 12 pregnant female mice (Mus Musculus L.) divided into control group (given sterile aquadest) and treatment group (given pregnancy milk + sterile aquadest) for 18 days then the tooth germ was taken. Samples were stained to see the KLK-4 expression. Data were analyzed using an Independent sample t-test.Result: Our study showed that the average amounts of KLK-4 expression in the treatment group are higher than the control group. Based on the Independent sample t-test statistic methods, there is a significant difference with the value of p=0,017.Conclusion: The pregnancy milk could influence the Kallikrein-related peptidase-4 (KLK-4) expression of ameloblast cell in the mice fetusâ€™s tooth development.

PROPOLIS EXTRACT AS ANTI-CORROSIVE AGENT INHIBITS METAL IONIC RELEASE FROM ORTHODONTIC BRACKETS Grahita Aditya; Erdianto Setya Wardhana; Islamy Rahma Hutami; Sandy Christiono; Rosa Pratiwi
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18868

Background: A combination of nickel (Ni), chromium (Cr), and iron (Fe) can be found in the stainless steel orthodontic bracket. Ion release takes place as a result of the chemical interaction between metals and the oral environment, which leads to the potential of hypersensitivity during fixed orthodontic treatment. Propolis contains phytochemicals that have the ability to reduce corrosion, making it a potential treatment option. Purpose: to determine the release of Ni, Cr, and Fe in metal brackets in an 8.2% propolis solutionMethod: Four sets of six brackets were made from 24 brackets. Artificial saliva, sodium fluoride, sterilized distilled water (aquabidest), and 8.2% propolis were applied to these brackets. After incubating at 37°C for seven days, ICP EOS measured the metal ions Ni, Cr, and Fe. The analysis revealed significant differences (p<0.05) in ionic release of Ni, Cr, and Fe among groups exposed to sterilized distilled water (aquabidest) and an 8.2% propolis solution. Additionally, the Mann-Whitney test showed substantial Ni ion release differences (p<0.05) between 8.2% propolis solution and sterilized distilled water. The 8.2% propolis solution and sodium fluoride solution released Cr ions differently. Fe ion levels differed between propolis solution 8.2%, sodium fluoride solution, sterilized distilled water, and fake saliva. Conclusion: Propolis affects metal bracket ionic release of Ni, Cr, and Fe. Keywords : Cr and Fe, ions of Ni, propolis solution, Stainless steel bracket

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