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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Teknotan: Jurnal Industri Teknologi Pertanian Jurnal Penelitian Hasil Hutan Jurnal Bioteknologi & Biosains Indonesia (JBBI) INDONESIAN JOURNAL OF ESSENTIAL OIL Jurnal Perikanan Universitas Gadjah Mada Chemistry Indonesian Journal of Chemical Research Eksakta : Berkala Ilmiah Bidang MIPA Fullerene Journal of Chemistry Jurnal Penelitian Hasil Hutan Science Nature Jurnal Pengabdian Masyarakat (ABDIRA) JURNAL TEKNIK INDUSTRI BAKIRA: Jurnal Pengabdian Kepada Masyarakat Innovation for Community Service Journal Jurnal Penelitian Hasil Hutan
Kapelle, Imanuel B. D.
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Pattimura, Ambon, Indonesia
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PENGARUH METODE PROSES SINTESIS ANALOG KURKUMIN ASIMETRIS TERHADAP EFEK HEPATOPROTEKTIF MENCIT (Mus musculus L.) Imanuel Berly Delvis Kapelle; Wasmen Manalu
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 7 No. 2 (2020): December 2020
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1337.743 KB) | DOI: 10.29122/jbbi.v7i2.4206

Abstract

Effect of Synthesis Process Method of Asymmetric Curcumin Analog on the Hepatoprotective Effect of Mice (Mus musculus L.) Asymmetric curcumin analogs (ACA) can be synthesized from cullilawan oil. ACA products can be synthesized using conventional methods and microwaves. Synthesis methods can affect physical properties and pharmacological effects. The purpose of this study was to determine the effect of the process method on the hepatoprotective ability of ACA and to determine the effective dose. ACA products were tested in vivo in mice (Mus musculus L.) with CCl4-induced liver damage. The parameters observed were biochemical liver enzymes (AST and ALT) and histological analysis. The results showed that animals treated with ACA-k products had better weight gain, lower AST and ALT levels, and fewer histological signs of liver damage at higher ACA doses than those observed in animals that were untreated or treated with ACA-m products. Thus, asymmetric curcumin analog products that were processed by conventional method were more hepatoprotective. Keywords: ACA, culilawan oil, hepatoprotection, in vivo, product diversification ABSTRAK Analog kurkumin asimetris (AKAS) dapat disintesis dari minyak kulit lawang. Produk AKAS dapat disintesis menggunakan metode konvensional dan microwave. Metode sintesis dapat mempengaruhi sifat fisik dan efek farmakologis. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh metode proses pada kemampuan hepatoprotektif AKAS dan untuk menentukan dosis efektif. Produk AKAS diuji in vivo pada mencit (Mus musculus L.) dengan kerusakan hati yang diinduksi CCl­4. Parameter yang diamati adalah biokimia enzim hati (AST dan ALT) dan analisis histologis. Hasil penelitian menunjukkan bahwa hewan yang diobati dengan produk AKAS-k memiliki kenaikan berat badan yang lebih baik, tingkat AST dan ALT yang lebih rendah, dan lebih sedikit tanda histologis kerusakan hati pada dosis AKAS yang lebih tinggi daripada yang terlihat pada hewan yang tidak diperlakukan atau diobati dengan produk AKAS-m. Dengan demikian, produk analog kurkumin asimetris yang diproses dengan metode konvensional lebih hepatoprotektif.
DIVERSIFIKASI PRODUK FARMASI DARI MINYAK LAWANG DENGAN PENDEKATAN SINTESIS KIMIA Imanuel Berly Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
INDONESIAN JOURNAL OF ESSENTIAL OIL Vol 1, No 1 (2016)
Publisher : Institut Atsiri Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.071 KB) | DOI: 10.21776/ub.ijeo.2016.001.01.03

Abstract

Indonesia merupakan negara yang terkenal dengan jenis–jenis tumbuhan penghasil minyak atsiri namun penggunaannya tidak banyak digunakan untuk diolah menjadi produk jadi seperti obat–obatan. Salah satu minyak atsiri yang sangat potensial dan diproduksi di wilayah Indonesia Timur khususnya Maluku dan Papua adalah minyak lawang. Tujuan yang ingin dicapai adalah membuat produk farmasi analog kurkumin dari minyak lawang dengan jalur sintesis kimia. Terdapat beberapa tahapan proses yang dilakukan, mulai dari proses isolasi safrol dari minyak lawang, proses isomerisasi safrol, proses oksidasi isosafrol dan tahapan proses reaksi kondensasi. Safrol diisolasi dari minyak lawang menggunakan metode kimia (NaOH) dan menghasilkan safrol 17,21%. Proses isomerisasi safrol menghasilkan isosafrol menggunakan sistem bebas pelarut dengan katalis alkali KOH pada suhu 120oC selama 6 jam diperoleh rendemen 77,56%. Piperonal diperoleh dari reaksi oksidasi isosafrol menggunakan oksidator KMnO4 sebanyak 65,63%. Produk analog kurkumin simetris (1,5-bis-benzo[1,3]dioxol-5-yl-penta-1,4-dien-3-one) yang diperoleh dari reaksi kondensasi antara piperonal dengan aseton. Rendemen produk menggunakan metode gelombang mikro pada daya 140 watt selama 2 menit adalah 53,3% (t.l=180 oC) dan metode konvensional selama 3 jam adalah 78,43% (t.l=191 oC). Produk analog kurkumin tidak simetris (5-benzo[1,3]dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) disintesis menggunakan dua tahapan reaksi kondensasi. Tahapan kondensasi yang pertama antara piperonal dengan asetaldehid menggunakan katalis basa dan metanol selama 3 jam diperoleh produk intermediate (3-benzo[1,3]dioxol-5-yl-propenal) 70,28%. Reaksi kondensasi tahap kedua antara produk intermediate dengan asetofenon menggunakan metode gelombang mikro pada daya 140 watt selama 2 menit diperoleh rendemen 82,82% (t.l = 104 oC) dan metode konvensional selama 3 jam diperoleh 99,55% (t.l = 111 oC).
REKAYASA PROSES SINTESIS PIPERONAL DARI KULIT LAWANG (Cinnamomum culilawan Blume) SEBAGAI PREKURSOR OBAT KANKER Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
Jurnal Penelitian Hasil Hutan Vol 34, No 3 (2016): Jurnal Penelitian Hasil Hutan
Publisher : Pusat Penelitian dan Pengembangan Hasil Hutan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2902.466 KB) | DOI: 10.20886/jphh.2016.34.3.217-229

Abstract

Piperonal as a precursor of cancer drug (Curcumin analogues) can be synthesized from extract of lawang’s bark (Cinnamomum culilawan Blume) with multiple stages, among others: isolation of  essential oils, isolation safrole, safrole isomerization, and synthesis of piperonal. Essential oils were isolated from the bark of lawang (the water content of 46.2%) using a water distillation system with 1/3 volume of high boiler for five hours. Isolation of safrole from lawang bark oils was performed using NaOH solution and purified using reduced pressure distillation system at a temperature of 90-123°C / 1 mmHg. The safrole isomerization was undergone using alkali catalyst (KOH) without solvent at a temperature of 120°C for 8 hours. Oxidation of isosafrol was performed using KMnO4 in acidic conditions using a KTF tween 80 at a temperature below 30°C, and purified using silica gel. Results of isolation yield 0.94% with 14 components were determined through GC-MS, including 67.35% eugenol, safrole 13.96%, 12.61% methyl eugenol, 4-terpineol sineol 1.79% and 1.55%. The isolated safrole yield of 17.21% with purity testing and identification using FTIR, 1H- NMR and GCMS confirmed the product was safrole. The isomerization obtained yield of 77.56% with GC analysis indicated compounds of  cis-isosafrole and trans-isosafrole. The results of  oxidation obtained yield of  65.63% with a purity of 100% by GCMS and the 1H-NMR indicated the product is piperonal.
REKAYASA PROSES SINTESIS PIPERONAL DARI KULIT LAWANG (Cinnamomum culilawan Blume) SEBAGAI PREKURSOR OBAT KANKER Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
Jurnal Penelitian Hasil Hutan Vol 34, No 3 (2016): Jurnal Penelitian Hasil Hutan
Publisher : Pusat Penelitian dan Pengembangan Hasil Hutan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2016.34.3.217-229

Abstract

Piperonal as a precursor of cancer drug (Curcumin analogues) can be synthesized from extract of lawang’s bark (Cinnamomum culilawan Blume) with multiple stages, among others: isolation of  essential oils, isolation safrole, safrole isomerization, and synthesis of piperonal. Essential oils were isolated from the bark of lawang (the water content of 46.2%) using a water distillation system with 1/3 volume of high boiler for five hours. Isolation of safrole from lawang bark oils was performed using NaOH solution and purified using reduced pressure distillation system at a temperature of 90-123°C / 1 mmHg. The safrole isomerization was undergone using alkali catalyst (KOH) without solvent at a temperature of 120°C for 8 hours. Oxidation of isosafrol was performed using KMnO4 in acidic conditions using a KTF tween 80 at a temperature below 30°C, and purified using silica gel. Results of isolation yield 0.94% with 14 components were determined through GC-MS, including 67.35% eugenol, safrole 13.96%, 12.61% methyl eugenol, 4-terpineol sineol 1.79% and 1.55%. The isolated safrole yield of 17.21% with purity testing and identification using FTIR, 1H- NMR and GCMS confirmed the product was safrole. The isomerization obtained yield of 77.56% with GC analysis indicated compounds of  cis-isosafrole and trans-isosafrole. The results of  oxidation obtained yield of  65.63% with a purity of 100% by GCMS and the 1H-NMR indicated the product is piperonal.
The Influence of Calcination Temperatures in TiO2 Impregnated Ouw’s Natural Clay on Its Degradation Activity of Methylene Blue Dye Moylani Teddy; Catherina M. Bijang; Muh. Nurdin; Berly Kapelle
SCIENCE NATURE Vol 1 No 1 (2018): SCIENCE NATURE
Publisher : Faculty of Mathematics and Natural Sciences, University of Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/SNvol1iss1pp008-014year2018

Abstract

The influence of calcination temperatures in TiO2 impregnated Ouw’s natural clay on its degradation activity of methylene blue dye has been done. Calcination process was conducted at various temperatures of 200, 300, and 400 oC. The characterization of TiO2 impregnated clay’s structure was examined by IR analysis. The result showed that Ouw’s natural clay has characterized vibrations of montmorillonite and thermal effect didn’t affect the structure of TiO2 impregnated clay. The highest result of methylene blue’s degradation occurred in the addition of TiO2 impregnated clay calcinated at 200 oC (98.69%). This result was found that calcination temperatures of impregnation process were significantly affect the degradation activity of TiO2­ impregnated clays.
Phytochemical and Antioxidant Test of Binahong (Anredera cordifolia (Tenore) Steenis) Leaves Ethanol Extract Fensia Analda Souhoka; Imanuel Berly Delvis Kapelle; Elisabeth Sihasale
Jurnal Kimia Fullerene Vol 6 No 1 (2021): Fullerene Journal of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v6i1.248

Abstract

Binahong Anredera cordifolia (Tenore) Steenis leaves contain chemical compounds that can be used as antioxidants. This study aims to examine the phytochemical and antioxidant activity of the ethanol extract of binahong leaves. Binahong leaves were extracted using the maceration method with an ethanol solvent. The phytochemical test showed that the ethanol extract of binahong leaves contained phenolic compounds, flavonoids, alkaloids, and tannins to have potential antioxidants. The antioxidant activity test was carried out using the DPPH method and absorbance measurement with a UV-Vis spectrophotometer at a wavelength of 517 nm. The results showed that the ethanol extract of binahong leaves had strong antioxidant activity, as evidenced by the IC50 value of 87.423 µg/mL.
Evaluation of Curcumin Analog Supplementation in Diet for Hematological Response and Growth Performance of Red tilapia (Oreochromis niloticus) Meillisa Carlen Mainassy; Wasmen Manalu; Andriyanto; Agus Oman Sudrajat; Imanuel Berly Delvis Kapelle; Bambang Gunadi
Acta VETERINARIA Indonesiana Vol. 10 No. 2 (2022): Juli 2022
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.10.2.182-192

Abstract

Nilai hematologi dapat digunakan untuk mengevaluasi respon fisiologi pada ikan. Suplementasi bahan herbal ke dalam pakan merupakan salah satu cara meningkatkan produksi akuakultur melalui peningkatan kekebalan dan fungsi fisiologis yang berhubungan dengan kesehatan ikan. Penelitian ini bertujuan untuk mengevaluasi pengaruh pemberian pakan dengan suplementasi analog kurkumin terhadap nilai hematologi ikan nila merah (Oreochromis niloticus). Rancangan yang digunakan adalah rancangan acak lengkap dengan tujuh perlakuan dan tiga kali ulangan. Sampel yang digunakan berupa induk nila betina dengan bobot badan 294,11±51,40 g. Pemeliharaan dilakukan selama 6 minggu pada jaring masing-masing berukuran 2x1x1m, dengan kepadatan 5 ekor/jaring. Pengambilan sampel darah sebanyak tiga kali, yaitu pada minggu ke-2,minggu ke-4, dan minggu ke-6. Hasil penelitian menunjukkan bahwa pemberian analog kurkumin memengaruhi respons hematologi dan kinerja pertumbuhan ikan nila merah. Berdasarkan penelitian yang telah dilakukan, suplementasi analog kurkumin 2,4 mg/100 g pakan adalah dosis yang terbaik untuk peningkatan kesehatan dan pertumbuhan ikan nila.
INOVASI PRODUK SABUN HERBAL TRANSPARAN MENGGUNAKAN METODE MICROWAVE DARI LIMBAH PALA Kapelle I.B.D; M. Syamsul Maarif; Yandra Arkeman
JURNAL TEKNIK INDUSTRI Vol. 4 No. 1 (2014): Volume 4 No 1 Maret 2014
Publisher : Jurusan Teknik Industri, Fakultas Teknologi Indusri Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.462 KB) | DOI: 10.25105/jti.v4i1.1562

Abstract

Nutmeg oil production generates waste in the form of residue distillation are containingcompound trimeristin. Innovation in the waste utilization by producing transparent herbal soapsusing the microwave method for the transesterification process. The production process usesmicrowave method requires a short time, costs and energy are small and good quality is a strength indeveloping product . This product has a market opportunity because it can compete with otherproducts, the advantages that are the effects of aromatherapy herbal ingredients.
Analisis Minyak Atsiri dari Bunga dan Gagang Cengkeh (Syzygium aromaticum L.) Asal Pulau Saparua Maluku Imanuel Berly Delvis Kapelle; Hanoch Julianus Sohilait; Meike L. Haluruk
Teknotan: Jurnal Industri Teknologi Pertanian Vol 17, No 2 (2023): TEKNOTAN, Agustus 2023
Publisher : Fakultas Teknologi Industri Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jtvol17n2.7

Abstract

Maluku merupakan salah satu Provinsi yang memiliki sebaran tanaman penghasil minyak atsiri di semua wilayahnya. Satu jenis tanaman minyak atsiri (cengkeh) yang terdapat di Pulau Saparua yaitu Syzygium  aromaticum  L. Kualitas minyak cengkeh di daerah tersebut untuk minyak dari bunga cengkeh dan gagang cengkeh perlu untuk di analisis karena terdapat perbedaan komposisi kimia pada setiap wilayah. Tujuan dari penelitian ini adalah menganalisis minyak atsiri dari bunga dan gagang cengkeh asal pulau Saparua Maluku. Penelitian menggunakan metode destilasi uap air untuk mengisolasi minyak atsiri, parameter yang dilihat yaitu rendemen minyak dan komposisi kimia minyak menggunakan GCMS. Hasil isolasi minyak menunjukkan bahwa persentase rendemen minyak atsiri tertinggi pada bunga cengkeh yaitu Desa Booi (13,41%), sedangkan persentase rendemen minyak atsiri tertinggi pada gagang cengkeh yaitu Desa Paperu sebesar (3,27%).  Analisis komponen  minyak  cengkeh  menggunakan GC-MS menunjukkan bahwa terdapat tiga komponen utama yaitu pada minyak bunga cengkeh mengandung eugenol (46,69%–64,91%), eugenil asetat (21,66%–34,67%), dan trans- kariofilen (11,11%–19,06%), sedangkan pada minyak gagang cengkeh terkandung eugenol (74,59%–91,34%), trans-kariofilen (3,64%–13,13%), dan eugenil asetat (2,93%–6,65%).
PELATIHAN PEMBUATAN VIRGIN COCONUT OIL (VCO) DENGAN METODE BASAH KEPADA IBU-IBU PKK NEGERI KILANG SEBAGAI UPAYA PENINGKATAN NILAI EKONOMIS BUAH KELAPA Serly J. Sekewael; Netty Siahaya; Hellna Tehubijuluw; Imanuel Berly Delvis Kapelle; Fensia Analda Souhoka; Linda Lattuputty
BAKIRA: Jurnal Pengabdian Kepada Masyarakat Vol 3 No 1 (2022): BAKIRA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bakira.2022.3.1.45-52

Abstract

The training for making Virgin Coconut Oil (VCO) with the wet method has been carried out for the PKK women of Negeri Kilang, South Leitimur District, Ambon City. VCO with the wet method using liquid coconut milk as raw material. The oil from this liquid coconut milk is extracted by precipitation. After that, the oil that has been separated from water and other solids is transferred to be filtered to make it clear. The steps of this training activity are carried out in three stages, namely preparation, implementation, and evaluation. In the preparatory stage, the team conducted a preliminary survey to determine the field conditions, and the place to be used; and to prepare a plan for the activities to be carried out. Next, the team prepares materials and equipment that will be used in making VCO. At the implementation stage, the team conducted counseling for PKK women by delivering material on how to make VCO and the benefits of VCO in the health sector. Then proceed with the manufacture of VCO with the wet method. In this activity, all participants were trained on how to make VCO, starting from the procedure for making coconut milk from coconuts to forming VCO. The third stage, namely the evaluation stage, is carried out to measure the level of success of the activities that have been carried out. The output produced from this activity is a creative product of coconut plants, namely VCO which has been made by women of PKK Negeri Kilang to be used daily.
Co-Authors Agus Oman Sudrajat Andri Yanto Andriyanto Andriyanto Andriyanto Arpipi, Henderika S. S. Baharudin, Indah Bambang Gunadi Bambang Gunadi Bambang Gunadi Bijang, Chaterina Manukpadang Birahy, Deford Cristy Catherina M. Bijang Dessy Rosye Rooy Dewi Sri Djumali Mangunwidjaja Djumali Mangunwidjaja Djumali Mangunwidjaja DOMINGGUS MALLE Elisabeth Sihasale Fauzan Saleh Fensia Analda Souhoka Gainau, Paskanova Christi Gaspersz, Nelson Hanoch J Sohilait Hanoch Julianus Sohilait Hasanela, Nurani Hattu, Nikmans Hellna Tehubijuluw Hellna Tehubijuluw I Wayan Sutapa Insun Sangadji Ivonne Telussa Laratmase, Marsela S. Lilipaly, Reggi Austin Linda Lattuputty Lopulalan, Flourence M. Syamsul Maarif Maahury, Mirella Fonda Mauhurry, Mirella Fonda Meika Syahbana Rusli Meike L. Haluruk Meillisa Carlen Mainassy Moylani Teddy Muh. Nurdin Neite, Prisca Nelcy Netty Siahaya Nini Munirah Renur Pattiasina, Bethsy Jane Pattiasina, Priska Marisa Pentury, Evangeline Priska Marisa Pattiasina Priska Marissa Pattiasina R, Irwan Rahayu Rahayu Rahayu Rahayu Rante, Natalia C.D. Rosmawaty Rosmawaty Harahap Sabirin Matsjeh Salmawati, Mimi Sekewael, Serly Jolanda Semuel S. Pada Serly J. Sekewael Serly J. Sekewael Shielda Natalia Joris Shielda Natalia Joris Siahaya, Antho Netty Sohilait, H. Sohilait, Mario Rowan Stephanie P. Sohilait Tun Tedja Irawadi Tun Tedja Irawadi Waas, Alsye Walla, Ainun Maharani Wasmen Manalu Yandra Arkeman Yusthinus T. Male Zainal Alim Mas'ud Zainal Alim Mas'ud Zainal Alim Mas'ud