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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Teknotan: Jurnal Industri Teknologi Pertanian Jurnal Penelitian Hasil Hutan Jurnal Bioteknologi & Biosains Indonesia (JBBI) INDONESIAN JOURNAL OF ESSENTIAL OIL Jurnal Perikanan Universitas Gadjah Mada Chemistry Indonesian Journal of Chemical Research Eksakta : Berkala Ilmiah Bidang MIPA Fullerene Journal of Chemistry Jurnal Penelitian Hasil Hutan Science Nature Jurnal Pengabdian Masyarakat (ABDIRA) JURNAL TEKNIK INDUSTRI BAKIRA: Jurnal Pengabdian Kepada Masyarakat Innovation for Community Service Journal Jurnal Penelitian Hasil Hutan
Kapelle, Imanuel B. D.
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Pattimura, Ambon, Indonesia
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Compound Profile of Methanol Extract of Katang-Katang Leaves (Ipomoea pes-caprae) and Evaluation of Its Antibacterial and Antioxidant Activities Dessy Rosye Rooy; Kapelle, Imanuel Berly Delvis; Rosmawaty
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/633

Abstract

 Increasing antibiotic resistance has prompted the search for safer and more sustainable natural alternatives. Ipomoea pes-caprae, a coastal plant traditionally used for the treatment of wounds and inflammation, is known to be rich in secondary metabolites such as flavonoids, terpenoids, alkaloids, and phenolic acids that have potential antioxidant and antibacterial properties. This study aimed to map the metabolite profile of the methanolic extract of I. pes-caprae leaves using LC-HRMS, to analyze its relationship with antioxidant activity measured by the DPPH method, and to evaluate its antibacterial activity against Staphylococcus aureus and Escherichia coli. LC-HRMS analysis identified 406 compounds with Palmitic Acid as the dominant component (24.503%), including primary and secondary metabolite groups such as flavonoids (quercetin, rutin, kaempferol), phenolic acids (caffeic, ferulic, chlorogenic acid), terpenoids (caryophyllene oxide, lupeol), alkaloids, and phytohormones. The methanol extract showed moderate antioxidant activity (IC₅₀ = 136.71 ppm) and antibacterial activity against E. coli (inhibition zone 9.5 mm), which is thought to originate from the synergy of various secondary metabolites through free radical scavenging mechanisms and bacterial membrane damage. These findings strengthen the scientific basis for I. pes-caprae as a natural source of antioxidant and antibacterial agents for the development of natural pharmaceutical products.
Co-Authors Agus Oman Sudrajat Andri Yanto Andriyanto Andriyanto Andriyanto Arpipi, Henderika S. S. Baharudin, Indah Bambang Gunadi Bambang Gunadi Bambang Gunadi Bijang, Chaterina Manukpadang Birahy, Deford Cristy Catherina M. Bijang Dessy Rosye Rooy Dewi Sri Djumali Mangunwidjaja Djumali Mangunwidjaja Djumali Mangunwidjaja DOMINGGUS MALLE Elisabeth Sihasale Fauzan Saleh Fensia Analda Souhoka Gainau, Paskanova Christi Gaspersz, Nelson Hanoch J Sohilait Hanoch Julianus Sohilait Hasanela, Nurani Hattu, Nikmans Hellna Tehubijuluw Hellna Tehubijuluw I Wayan Sutapa Insun Sangadji Ivonne Telussa Laratmase, Marsela S. Lilipaly, Reggi Austin Linda Lattuputty Lopulalan, Flourence M. Syamsul Maarif Maahury, Mirella Fonda Mauhurry, Mirella Fonda Meika Syahbana Rusli Meike L. Haluruk Meillisa Carlen Mainassy Moylani Teddy Muh. Nurdin Neite, Prisca Nelcy Netty Siahaya Nini Munirah Renur Pattiasina, Bethsy Jane Pattiasina, Priska Marisa Pentury, Evangeline Priska Marisa Pattiasina Priska Marissa Pattiasina R, Irwan Rahayu Rahayu Rahayu Rahayu Rante, Natalia C.D. Rosmawaty Rosmawaty Harahap Sabirin Matsjeh Salmawati, Mimi Sekewael, Serly Jolanda Semuel S. Pada Serly J. Sekewael Serly J. Sekewael Shielda Natalia Joris Shielda Natalia Joris Siahaya, Antho Netty Sohilait, H. Sohilait, Mario Rowan Stephanie P. Sohilait Tun Tedja Irawadi Tun Tedja Irawadi Waas, Alsye Walla, Ainun Maharani Wasmen Manalu Yandra Arkeman Yusthinus T. Male Zainal Alim Mas'ud Zainal Alim Mas'ud Zainal Alim Mas'ud