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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Jurnal Veteriner Teknotan: Jurnal Industri Teknologi Pertanian Jurnal Penelitian Hasil Hutan Jurnal Bioteknologi & Biosains Indonesia (JBBI) INDONESIAN JOURNAL OF ESSENTIAL OIL Jurnal Perikanan Universitas Gadjah Mada Chemistry Indonesian Journal of Chemical Research Eksakta : Berkala Ilmiah Bidang MIPA Fullerene Journal of Chemistry Jurnal Penelitian Hasil Hutan Science Nature Jurnal Pengabdian Masyarakat (ABDIRA) JURNAL TEKNIK INDUSTRI BAKIRA: Jurnal Pengabdian Kepada Masyarakat Innovation for Community Service Journal Jurnal Penelitian Hasil Hutan
Kapelle, Imanuel B. D.
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Pattimura, Ambon, Indonesia
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REKAYASA PROSES SINTESIS PIPERONAL DARI KULIT LAWANG (Cinnamomum culilawan Blume) SEBAGAI PREKURSOR OBAT KANKER Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
Jurnal Penelitian Hasil Hutan Vol. 34 No. 3 (2016): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2016.34.3.217-229

Abstract

Piperonal as a precursor of cancer drug (Curcumin analogues) can be synthesized from extract of lawang’s bark (Cinnamomum culilawan Blume) with multiple stages, among others: isolation of essential oils, isolation safrole, safrole isomerization, and synthesis of piperonal. Essential oils were isolated from the bark of lawang (the water content of 46.2%) using a water distillation system with 1/3 volume of high boiler for five hours. Isolation of safrole from lawang bark oils was performed using NaOH solution and purified using reduced pressure distillation system at a temperature of 90-123°C / 1 mmHg. The safrole isomerization was undergone using alkali catalyst (KOH) without solvent at a temperature of 120°C for 8 hours. Oxidation of isosafrol was performed using KMnO in acidic conditions using a KTF 4 tween 80 at a temperature below 30°C, and purified using silica gel. Results of isolation yield 0.94% with 14 components were determined through GC-MS, including 67.35% eugenol, safrole 13.96%, 12.61% methyl eugenol, 4-terpineol sineol 1.79% and 1.55%. The isolated safrole yield of 17.21% with purity testing and identification using FTIR, HNMR and GCMS confirmed the product was safrole. The isomerization obtained yield of 77.56% with GC analysis indicated compounds of cis-isosafrole and trans-isosafrole. The results of oxidation obtained yield of 65.63% with a purity of 100% by GCMS and the H-NMR indicated the product is piperonal.
Co-Authors Agus Oman Sudrajat Andri Yanto Andriyanto Andriyanto Andriyanto Arpipi, Henderika S. S. Baharudin, Indah Bambang Gunadi Bambang Gunadi Bambang Gunadi Bijang, Chaterina Manukpadang Birahy, Deford Cristy Catherina M. Bijang Dewi Sri Djumali Mangunwidjaja Djumali Mangunwidjaja Djumali Mangunwidjaja DOMINGGUS MALLE Elisabeth Sihasale Fauzan Saleh Fensia Analda Souhoka Gainau, Paskanova Christi Gaspersz, Nelson Hanoch J Sohilait Hanoch Julianus Sohilait Hasanela, Nurani Hattu, Nikmans Hellna Tehubijuluw Hellna Tehubijuluw I Wayan Sutapa Insun Sangadji Ivonne Telussa Laratmase, Marsela S. Lilipaly, Reggi Austin Linda Lattuputty Lopulalan, Flourence M. Syamsul Maarif Maahury, Mirella Fonda Mauhurry, Mirella Fonda Meika Syahbana Rusli Meike L. Haluruk Meillisa Carlen Mainassy Moylani Teddy Muh. Nurdin Neite, Prisca Nelcy Netty Siahaya Nini Munirah Renur Pattiasina, Bethsy Jane Pattiasina, Priska Marisa Pentury, Evangeline Priska Marisa Pattiasina Priska Marissa Pattiasina Rahayu Rahayu Rahayu Rahayu Rante, Natalia C.D. Rosmawaty Harahap Runtu, Irwan Sabirin Matsjeh Salmawati, Mimi Sekewael, Serly Jolanda Semuel S. Pada Serly J. Sekewael Serly J. Sekewael Shielda Natalia Joris Shielda Natalia Joris Siahaya, Antho Netty Sohilait, H. Sohilait, Mario Rowan Stephanie P. Sohilait Tun Tedja Irawadi Tun Tedja Irawadi Waas, Alsye Walla, Ainun Maharani Wasmen Manalu Yandra Arkeman Yusthinus T. Male Zainal Alim Mas'ud Zainal Alim Mas'ud Zainal Alim Mas'ud