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All Journal Pharmascience Jurnal Fitofarmaka Indonesia Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Jurnal Pengabdian UNDIKMA Jurnal Kesehatan Tambusai Tropical Health and Medical Research Journal Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy
Buih, Putri Helena Junjung
Universitas Lambung Mangkurat
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ISOLASI SENYAWA KIMIA FRAKSI n-HEKSANA DAUN BILARAN TAPAH (Argyreia nervosa (Burm. F.) ASAL KALIMANTAN SELATAN Sutomo Sutomo; Putri Helena Junjung Buih; Arnida Arnida
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.527

Abstract

ABSTRACTOne of the plants that is used empirically by people in South Kalimantan as a traditional medicine is bilaran tapah (Argyreia nervosa (Burm. F.). This plants that has purposed antiinflamation, antimicroba, antidiabetic, diuretic, and aphrodisiac. This research aims to isolate and explore the chemical compounds of n-hexana fraction of A. nervosa leaves. Extraction is conducted by using maceration method. Isolation is conducted by using Vacumn Liquid Chromatography and gravity chromatography column. Identification qualitative assay of compound used TLC test, UV-Vis and FTIR spectrophotometry. The extraction of 500 grams A. nervosa leaves rough powder with 96% ethanol extracts produces 16,92% of rendement. The fractionation of 30 grams ethanol extracts with n-hexane produces 23,60% of rendement. N-hexane fraction by using VLC with n-hexane : ethyl acetate eluent 25:1; 20:1; 15:1; 10:1; 9:1; 8:2; 7:3 ; 6:4) v/v and methanol : etyl acetate (1:4) v/v produces fractions A, B, C, D, E, F, G, H, and I. Fraction F was chosen for isolation using PTLC with n-hexane :etyl acetate eluent (8:2) v/v. Fraction C is chosen to be isolated by using gravity chromatography column with n-hexane : ethyl acetate eluent (25:1) v/v. TLC qualitative test with H2SO4 10% and Liebermann-Burchard reagent shows that C-4 isolates contains terpenoid compounds. Analysis of C-4 isolates by using UV-Vis spectrophotometry reach peak at λ 245 nm. Analysis FTIR spectra shows that the functional groups of C-4 isolates are -OH (3309.85 cm-1), -CH aliphatic (2939.52 cm -1 and 2870.08 cm-1), C = C (1635.64 cm- 1) and C-O (1033,85 cm-1).
Upaya Peningkatan Pengetahuan Terhadap Permasalahan Penyakit Hipertensi di Desa Tambak Baru Ilir Kabupaten Banjar Rizki, Muhammad Ikhwan; Triyasmono, Liling; Hadi, Samsul; Normaidah, Normaidah; Ratnapuri, Prima Happy; Izma, Hayatun; Mahdi, Nur; Malahayati, Siti; Buih, Putri Helena Junjung; Agustina, Ni Kadek Ayu
Jurnal Pengabdian Masyarakat Panacea Vol 2, No 4 (2024): Jurnal Pengabdian Masyarakat Panacea
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jpmp.v2i4.13964

Abstract

Penyakit tidak menular (PTM) merupakan suatu penyakit yang tidak bisa menular dari satu orang ke orang lainnya. Salah satu PTM yang cukup banyak diderita oleh masyarakat adalah hipertensi. PTM dapat disebabkan pola hidup maupun pola makan yang tidak berimbang menyebabkan angka kejadian penyakit ini terus meningkat dari waktu ke waktu. Tingkat penyakit hipertensi pada masyarakat Desa Tambak Baru Ilir masih tinggi dan diketahui masyarakat desa ini masih memiliki pengetahuan yang minim termasuk keterampilan pengelolaan manajemen hipertensi. Tujuan pengabdian yang telah dilakukan yaitu meningkatkan pengetahuan masyarakat dengan penyakit hipertensi di Desa Tambak Baru Ilir. Kegiatan pengabdian dilakukan pada bulan agustus 2024. Secara umum kegiatan pengabdian diawali dengan sosialisasi kegiatan pada kepala desa. Selanjutnya tim pengbadian masyarakat membuat media edukasi berupa leaflet tentang hipertensiMasyarakat yang akan diberikan edukasi sebelumnya diminta mengisi pretest, selanjutnya diakhir kegiatan mengerjakan posttest. Hasil kegiatan pengabdian masyarakat menunjukkan pengabdian masyakat diikuti oleh 13 orang yang terdiri atas perempuan, usia 38-70 tahun, dan pekerjaan didominasi ibu rumah tangga. Nilai pretest dari skala 0-10 yang didapatkan rata-rata 7,08 dan nilai posttest rata-rata 9,23. Kesimpulannya yaitu terdapat peningkatan pengetahuan masyarakat tentang hiprtensi secara signifikan sebelum dan sesudah edukasi pada kegiatan pengabdian masyarakat di Desa Tambak Baru Ilir. Kata Kunci: Edukasi, Hipetensi, Masyarakat, Pengetahuan, Banjar Non-communicable diseases (NCDs) cannot be transmitted from one person to another. One of the NCDs that is quite common in the community is hypertension. NCDs can be caused by an unbalanced lifestyle or diet, causing the incidence of this disease to continue to increase over time. The level of hypertension in the Tambak Baru Ilir village community is still high and it is known that the people of this village still have minimal knowledge, including hypertension management skills. The purpose of the community service that has been carried out is to increase public knowledge about hypertension in Tambak Baru Ilir village. Community service activities were carried out in August 2024. In general, community service activities began with the socialization of activities to the village head. Furthermore, the community service team made educational media through leaflets about hypertension. The community who would be given education were previously asked to fill out a pretest, then at the end of the activity, they did a posttest. The results of community service activities showed that community service was attended by 13 people consisting of women, aged 38-70 years, and jobs dominated by housewives. The pretest score on a scale of 0-10 obtained an average of 7.08 and the average posttest score was 9.23. The conclusion is that there was a significant increase in public knowledge about hypertension before and after education in community service activities in Tambak Baru Ilir village.
Kacip Fatimah (Labisia pumila) as Natural Sunscreen: Analysis of Flavonoid Content and Ultraviolet Protection Ability Rahmatullah, Satrio Wibowo; Rizki, Muhammad Ikhwan; Sari, Anna Khumaira; Sari, Fitri Novita; Fadlilaturrahmah, Fadlilaturrahmah; Junjung Buih, Putri Helena
Tropical Health and Medical Research Vol. 7 No. 1 (2025): Tropical Health and Medical Research
Publisher : Baiman Bauntung Batuah Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35916/thmr.v7i1.132

Abstract

The cause of melanoma cancer is exposure to high-intensity ultraviolet rays from sunlight. Kacip Fatimah (Labisia pumila) utilizes the people of the interior of Kalimantan to protect their skin from sunlight by attaching leaves to the face or skin. Kacip Fatimah (Labisia pumila) contains flavonoid compounds, which are thought to impact these various properties. This study aimed to determine the ultraviolet protection ability and total flavonoid levels of Kacip Fatimah (Labisia pumila) leaves. Kacip Fatimah (Labisia pumila) leaves originating from Central Kalimantan were cleaned, dried in an oven, ground, and then extracted with air solvents, 70% ethanol, and 96% ethanol. Flavonoid identification was carried out with specific reagents, and total flavonoid levels were determined by colorimetric method using quercetin as a comparison. The ultraviolet protection ability of Kacip Fatimah (Labisia pumila) leaf extract was measured using a UV-Vis Spectrophotometer with the Sun Protection Factor parameter. The results showed the presence of flavonoids in the third extract. The total flavonoid content of air extract, ethanol 70%, and ethanol 96% from Kacip Fatimah (Labisia pumila) leaves were obtained respectively at 1.69%, 2.15%, and 2.38%. The most extracted flavonoids were in ethanol 96%solvent. The ultraviolet protection ability at a concentration of 100 - 500 ppm from air extract was in the range of 2.80 - 7.99, in ethanol 70% extract in the range of 5.69 - 38.39, while in ethanol 96% extract in the range of 8.76 - 49.07. The highest ultraviolet protection was in 96% ethanol extract from Kacip Fatimah (Labisia pumila) leaves. The results showed that Kacip Fatimah (Labisia pumila) leaves can provide ultraviolet protection with the content of active compounds of the flavonoid group. The research results can be scientific evidence for utilizing and developing products from Kacip Fatimah (Labisia pumila).
REVIEW ARTIKEL : TEKNOLOGI DALAM PENGELOLAAN GUDANG INDUSTRI FARMASI Isnani, Nazhipah; Malahayati, Siti; Junjung Buih, Putri Helena
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 7 No 1 (2025)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v7i1.203

Abstract

Application of technology in pharmaceutical industry warehouse management, focusing on warehouse management systems such as Warehouse Management System (WMS), Radio-frequency Identification (RFID), and Reorder Point (RO). This study shows that WMS facilitates real-time stock management and storage arrangements, although it requires significant investment. RFID improves product identification efficiency, but is susceptible to frequency interference. Reorder Point systems help in inventory control, but rely on the accuracy of historical data. In addition, artificial intelligence (AI) has the potential to improve operational efficiency, although it requires high-quality data and large investments. The application of these technologies is expected to improve the effectiveness of pharmaceutical warehouse management, ensure product quality and safety, and optimize inventory management. The latest trends such as Agile, Supply Chain 4.0, and Digital Twin are also discussed as methods that are increasingly popular in industry practice. This study is expected to contribute to the development of science and practice in the pharmaceutical field.
Pelatihan Penerapan Teknologi Alat Produksi dan Pengemasan bagi UMKM Labuana Kota Banjarbaru Kalimantan Selatan Normaidah, Normaidah; Mazdadi, Muhammad Itqan; Ratnapuri, Prima Happy; Buih, Putri Helena Junjung
Jurnal Pengabdian UNDIKMA Vol. 6 No. 1 (2025): February
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v6i1.13538

Abstract

This community service aims to improve the skills of UMKM Labuana in applying production equipment technology and product packaging instruments. The methods used include initial surveys, followed by technology application training, and evaluation with observation methods on improving partner skills in the equipment used. The results of this service show that the increasing skills of UMKM Labuana in applying product production and packaging technology include installation, operation, and maintenance of equipment.
PENDEKATAN DOCKING MOLEKULAR EUGENOL SEBAGAI INHIBITOR SEL KANKER PAYUDARA MCF-7 DAN ANTIOKSIDAN ROS 1 Junjung Buih, Putri Helena; Suryatinah, Yuniarti; Serawaidi, Nadya Putri Auliya
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.56373

Abstract

Eugenol atau yang biasa disebut minyak cengkeh merupakan salah satu senyawa aromatik yang terkandung dalam tanaman cengkeh (Syzigium aromaticum). Efektivitas eugenol sebagai senyawa antioksidan telah ditunjukkan di beberapa studi in vitro. Aktivitas antioksidan sangat berpengaruh terhadap potensinya sebagai antikanker. Tujuan utama docking molekular adalah untuk memperkirakan struktur kompleks antara ligan dan reseptor melalui pendekatan komputasi, guna memperoleh pemahaman mengenai afinitas dan orientasi ikatan yang paling stabil di antara keduanya. Penelitian ini bertujuan untuk mengetahui efektivitas eugenol sebagai antioksidan terhadap radikal bebas Reactive Oxygen Species (ROS1) kinase dan mengetahui potensi aktivitas yang dapat ditimbulkan sebagai antikanker dengan mengamati daya hambat terhadap sel kanker payudara Michigan Cancer Foundation (MCF-7) secara in silico dengan metode docking molekular. Tahapan penelitian yang dilakukan meliputi penyiapan database struktur ligan eugenol dan protein radikal bebas ROS1 kinase dan sel kanker payudara MCF-7 menggunakan aplikasi Biovia Discovery Studio, dilanjutkan dengan docking senyawa eugenol pada protein antioksidan ROS dan sel MCF-7 menggunakan aplikasi Autodock Vina dan visualisasi hasil penambatan ligan-protein dengan menggunakan aplikasi Ligplot+ v2.2. Studi docking molekular ini menunjukkan bahwa senyawa eugenol memiliki afinitas (energy ikatan) dan membentuk ikatan hydrogen dengan radikal bebas ROS1 kinase dan sel MCF-7 masing-masing sebesar -5,7 Kkal/mol dan -6,6 Kkal/mol. Sehingga dapat disimpulkan bahwa senyawa eugenol yang memiliki aktivitas sebagai antioksidan dan berpotensi dalam menghambat sel kanker payudara MCF-7 karena menghasilkan energi ikatan (afinitas) yang baik.
Molecular Docking and In Silico Evaluation of Beluntas (Pluchea indica) Phytochemicals as Potential Angiotensin-Converting Enzyme Inhibitors for Hypertension Treatment Rasjava, Achmad Ramadhanna’il; Akbar, Nabila Hadiah; Arfan, Aulia Rhamdani; Wardani, Dyah Ayu Pramoda; Putra, Aditya Maulana Perdana; Muslimawati, Khoirunnisa; Buih, Putri Helena Junjung; Fakih, Taufik Muhammad
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.9706

Abstract

Hypertension remains a major global health concern due to its high prevalence and strong association with cardiovascular diseases and kidney failure. A key component of blood pressure regulation is the Angiotensin-Converting Enzyme (ACE), which catalyzes the conversion of Angiotensin I into the vasoconstrictor Angiotensin II, making it a primary target for antihypertensive drugs. Although synthetic ACE inhibitors such as ramiprilat are effective, their use is often associated with adverse effects, highlighting the need for safer alternatives. This study employs molecular docking and in silico analysis to evaluate the potential of phytochemicals from beluntas (Pluchea indica) as natural ACE inhibitors. A total of 110 phytoconstituents were screened for pharmacokinetic properties using ADMET analysis, leading to the selection of 20 ligands for docking simulations. Among these, 4,5-di-O-caffeoylquinic acid exhibited the highest binding affinity (-9.409 kcal/mol), followed by di-O-caffeoylquinic acid (-8.984 kcal/mol) and quercetin-3-O-β-D-galactopyranoside (-8.372 kcal/mol). These compounds demonstrated stronger binding affinities than the ACE natural substrate, Angiotensin I (-7.133 kcal/mol), and the ACE inhibitor, ramiprilat (-8.717 kcal/mol), suggesting their potential as competitive ACE inhibitors. The binding interactions of these compounds were characterized by hydrogen bonding with key catalytic residues (HIS368, GLU368), electrostatic stabilization, and hydrophobic interactions within the enzyme active site. Notably, caffeoylquinic acid derivatives closely mimicked the binding mode of ramiprilat, whereas quercetin glycosides exhibited a distinct interaction pattern, indicating a possible alternative inhibitory mechanism. These findings provide evidence supporting the potential of P. indica phytochemicals as natural ACE inhibitors and warrant further investigation into their therapeutic applications in hypertension management.
In Vitro Study of Antibacterial Activity of Patindis Leaf Extract (Urophyllum arboreum) and Microneedle Acne Patch against Propionibacterium acnes and Staphylococcus aureus Hayatun Izma; Deni Setiawan; Putri Helena Junjung Buih; Khoirunnisa Muslimawati; Naila Azizah; Mahfuzatul Ajmi
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24008

Abstract

Acne vulgaris is a cutaneous disorder associated with Propionibacterium acnes and Staphylococcus aureus. This study investigated the antibacterial activity of patindis leaf extract (Urophyllum arboreum) and its microneedle acne patch against both bacteria. The extract was prepared from dried simplicia by maceration using 96% ethanol. Phytochemical screening was conducted using test-tube methods. Antibacterial testing included determination of inhibition zone diameter using the well-diffusion method, as well as the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Clindamycin 1% was used as a positive control, while 20% DMSO and microneedle patches without extract served as negative controls. The U. arboreum leaf extract contained flavonoids, alkaloids, saponins, condensed tannins and terpenoids. At concentrations of 1.25%, 2.5%, and 5%, the extract produced inhibition zones of 12.368, 14.693, 18.403 mm against P. acnes and 14.523, 17.408, 18.840 mm against S. aureus, respectively. The MIC and MBC values against both bacteria were 0.625%. The microneedle acne patch formulations produced inhibition zones of 9.196 mm (F1), 10.140 mm (F2), and 10.713 mm (F3) against P. acnes, but showed no activity against S. aureus. These results indicate that the microneedle acne patch containing U. arboreum leaf extract has potential as an alternative topical antibacterial agent.
Co-Authors Agustina, Ni Kadek Ayu Akbar, Nabila Hadiah Anna Khumaira Sari Arfan, Aulia Rhamdani Arnida Arnida Deni Setiawan Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Hayatun Izma Izma, Hayatun Khoirunnisa Muslimawati Khoirunnisa Muslimawati Liling Triyasmono Mahfuzatul Ajmi Malahayati, Siti Muhammad Ikhwan Rizki Muhammad Itqan Mazdadi Nadya Putri Auliya Serawaidi Naila Azizah Nazhipah Isnani Normaidah, Normaidah Nur Mahdi Putra, Aditya Maulana Perdana Rahmatullah, Satrio Wibowo Rasjava, Achmad Ramadhanna’il Ratnapuri, Prima Happy Samsul Hadi Sari, Fitri Novita Sutomo Sutomo Taufik Muhammad Fakih Wardani, Dyah Ayu Pramoda Yuniarti Suryatinah