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All Journal Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan Jurnal Sain Veteriner Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Biotechnology UNEJ e-Proceeding SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Biosaintifika: Journal of Biology & Biology Education Jurnal Pengabdian Masyarakat Kesehatan Amerta Nutrition Journal of Aquaculture and Fish Health Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati Exact Paper In Compilation (EPIC) Jurnal Kedokteran Hewan Journal of Fisheries & Marine
Win Darmanto
Departement Of Biology, Faculty Of Science And Technology, Airlangga University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : amerta nutrition

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Efektivitas Ekstrak Etanol Umbi Decalobanthus mammosus (Lour.) A.R.Simões & Staples Terhadap Makrofag Paru dan Hati Mencit yang Diinduksi Mycobacterium tuberculosis: The Effectiveness of Ethanol Extract Decalobanthus mammosus (Lour.) A.R.Simões & Staples Tubers Against Mycobacterium tuberculosis Induced Lung and Liver Macrophages in Mice Diah Woelansari, Evy; Darmanto, Win; Dewi, Firli Rohmah Primula; Khambali, Khambali
Amerta Nutrition Vol. 10 No. 1SP (2026): AMERTA NUTRITION SUPPLEMENTARY EDITION
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v10i1SP.2026.52-57

Abstract

Background: Tuberculosis (TB) cases in Indonesia rank third in the highest number of cases. Incomplete TB treatment causes drug resistance. Ethanol extract of Decalobanthus mammosus (Lour.) A.R.Simões & Staples, tubers has the potential as an immunomodulator and antibacterial. Objectives: This research purpose to decide potency of ethanol essence of Decalobanthus mammosus (Lour.) A.R.Simões & Staples tubers on lung and liver macrophage cells in mice induced by Mycobacterium tuberculosis. Methods: Laboratory experimental research using posttest only with control group. The research sample using Mus muculus mice was divided into control and experimental groups, with the administration of extract doses of 50 mg/kgBW, 100 mg/kgBW and 150 mg/kgBW, and injection of Mycobacterium tuberculosis. Result: The results showed that Decalobanthus mammosus extract dose of 150 mg/kgBW, macrophages were able to overcome Mycobacterium tuberculosis infection, with the lowest number of necrotic cells in the lungs. activation of liver macrophages increased at a dose of 50 mg/kgBW extract. Conclusions: There are differences in macrophages between the liver and lungs. Ethanol Extract of Decalobanthus mammosus (Lour.) A.R.Simões & Staples Tubers on lung macrophage cells, the frequency of macrophage activity is much higher compared to the liver.
Co-Authors A, Aulanniam A. Shofy Mubarak Agoes Soegianto Agus Abadi Agus Heri Setyo Wahyudi Alifah Hayati Andita Ayu Mandasari Aulanni'am, Aulanni'am Bambang Poernomo Betti Lukiati Betti Lukiati Binti Yunaida Dewi, Firli Rohmah Primula Diah Woelansari, Evy Djoko Agus P. Dwi Winarni Eko Prihiyantoro Eko Prihiyantoro Endah Rochmatika Endang Dewi Masithah farach Harianto Notopuro Herdiansyah, Mochammad Aqilah I Gede Widhiantara I.B. Rai Pidada Intan Permata Putri Intan Permata Putri Is Yuniar Juliana Christyaningsih Khambali, Khambali Kusala, Muhammad Khaliim Jati Kusala Lailatul Lutfiyah, Lailatul Listijani Suhargo, Listijani Mammed Sagi Manikya Pramudya Mochammad Amin Alamsjah Mufasirin Mutiarawati, Diah Titik Nadyatul Ilma Indah Savira Nanik Siti Aminah Natalia Tri Astuti Nunuk Dyah Retno Lastuti Nurmalasari Darsono Nurmalasari Darsono P Kumaladewi Panjaitan, Novaria Sari Dewi Panjaitan Permatasari, Anak Agung Ayu Putri Pieter Kakisina Pujiastuti Wahyuningsih , Sri Puspita Sari, Evi Putri Andreyna Saragi Putu Angga Wiradana Ramadhana Ramadhana Retnosari Apriasti Ria Harmonis Rochmatika, Endah Rr. Juni Triastuti Samekto Wibowo Sapto Andriyono Sari, Ni Kadek Yunita Sari Siti Rahayu Sri Kadarsih Soedjono Sri Puji Astuti Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Sugiharto Suhendra Agung Wibowo Sukardiman Susanto, Awaluddin Susilowati, Rina Priastini Suvia Widyaningrum Teguh Hari Sucipto, Teguh Hari Tri Dewanti W. Victorin Mega Putri Wiartini, Ni Wayan Ayu Wiartini Widhi Dyah Sawitri YULIA IRNIDAYANTI Yuni Kilawati