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Identifikasi Senyawa Metabolit Sekunder pada Ekstrak Etanol Daun Binahong Aliyyah Nafiisah; Risa Purnamasari; Siti Mudalianah
Jurnal sosial dan sains Vol. 4 No. 11 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i11.27922

Latar Belakang: Tanaman Binahong (Anredera Cordifolia) dalam famili Basellaceae merupalan tanaman yang memiliki bahan fitokarma. Tanaman daun binahong memiliki banyak manfaat seperti mengobati kerusakan ginjal, pemulihan luka, melancarkan tekanan darah dan lain sebagainya. Tujuan: Tujuan dari penelitian ini untuk mengidentifikasi senyawa metabolit sekunder pada Ekstrak Etanol 70 % daun binahong yang telah disimpan selama 12 bulan. Metode: Penelitian bersifat deskriptif kualitatif yang dilakukan dengan menggunakan beberapa reagen, disesuaikan dengan golongan fitokimia (alkaloid, fenolik, flavonoid, saponin, tanin, steroid & triterpenoid). Ekstrak Daun Binahong dilakukan proses penyarian dengan metode maserasi. Ekstrak Daun binahong selanjutnya dilakukan uji fitokimia untuk mengetahui kandungan senyawa metabolit sekunder. Hasil: Hasil dari penelitian ini menunjukkan bahwa pada daun binahong yang telah disimpan selama 12 bulan masih terkandungan senyawa metabolit sekunder yaitu flavonoid, tannin, alkaloid dan saponin. Hal ini dapat menjelaskan ekstrak etanol dapat mempertahankan senyawa metabolit sekunder yang terkandung dalam ekstrak sampai 12 bulan penyimpanan Kesimpulan: Metode maserasi dengan pelarut etanol 70% terbukti efektif dalam mempertahankan senyawa metabolit sekunder selama penyimpanan jangka panjang. Hasil ini dapat menjadi dasar untuk pengembangan metode penyimpanan optimal pada ekstrak tanaman obat, mendukung praktik pengobatan tradisional dan formulasi farmasi berbasis bahan alami.

Penerapan Aplikasi Geogebra Terhadap Motivasi dan Pemahaman Konsep Matematika Siswa Materi Bangun Ruang Sisi Datar Purnamasari, Risa; Supardi
Zona Education Indonesia Vol. 3 No. 3 (2025): June 2025
Publisher : Yayasan Mentari Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar

This study aims to analyze the effect of using the GeoGebra application on students’ motivation and conceptual understanding of mathematics in the topic of flat-faced solid shapes. The research employed an experimental method with a pretest-posttest control group design. The sample consisted of two classes divided into an experimental group, which used GeoGebra in learning, and a control group, which applied conventional teaching methods. Data were collected through conceptual understanding tests, motivation questionnaires before and after treatment, and classroom activity observations. The results showed that the experimental group experienced a significant increase in mathematics conceptual understanding with an average n-gain of 0.65 (medium to high category), compared to the control group, which only achieved an n-gain of 0.41 (low to medium category). Additionally, the motivation of students in the experimental group increased significantly, with 78% of students reaching a high motivation category, while the control group had only 42%. Observations revealed that GeoGebra encouraged students to actively discuss, explore, and interact with the learning material. Based on these findings, it can be concluded that the application of GeoGebra is effective in improving both motivation and conceptual understanding in mathematics learning on the topic of flat-faced solid shapes. This study recommends educators to integrate visual technology-based learning tools to enhance the quality of mathematics teaching and learning processes

Formulation and Characterization Tests of SCOBY Kombucha Gel Agustina, Eva; Nafisah, Raihana Frika; Fiddaroini, Achmad Farchan; Tania, Clarista Eka; Purnamasari, Risa; Andiarna, Funsu; Hidayati, Irul
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.143-151

The wound is the damage to body tissues caused by various factors such as accidents, sharp object scratches, etc. Proper care is necessary to accelerate the wound healing process. Topical medications, such as gel preparations, are commonly used for wounds. Kombucha SCOBY is believed to contain bioactive compounds that can accelerate the wound healing process, making it a potential active ingredient in gel preparations. This research aims to determine the characteristics of kombucha SCOBY gel with various concentration variations. SCOBY is obtained from kombucha fermentation using green tea, sugar, and kombucha culture. Preparing kombucha SCOBY gel involves using carbomer 940, methyl paraben, triethanolamine, glycerin, and SCOBY kombucha. The concentration variations of kombucha SCOBY gel include 0%, 2%, 4%, 8%, 10%, and 12%. Each formula undergoes physical characteristic tests including an organoleptic test, hedonic test, homogeneity test, pH test, spreadability test, and adhesiveness test. Data obtained after physical characteristic tests of the gel preparations are analyzed descriptively. Based on the conducted research, it was found that kombucha SCOBY gel preparations with concentration variations of 0%, 2%, 4%, 8%, 10%, and 12% exhibited different characteristics. The higher the gel concentration, the more acidic the gel's aroma, the more liquid the texture, and the more intense the color. SCOBY added to the gel preparation can increase the pH value, adhesiveness, and spreadability of the gel.

Effect of Variation in Concentration of SCOBY Kombucha Gel Citrus Peel Extract (Citrus nobilis) on Wound Incision (Vulnus Scissum) in Mice (Mus musculus) Shofiyya, Ainina Neihayatus; Eva Agustina; Funsu Andiarna; Irul Hidayati; Risa Purnamasari
International Journal of Applied Biology Vol. 9 No. 1 (2025): International Journal of Applied Biology
Publisher : Hasanuddin University

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A laceration wound is damage to the skin tissue characterized by a neat outline of the wound edge, due to slices by sharp instruments or incisions during surgery. This study aims to evaluate the effect of variations in the concentration of SCOBY Kombucha gel preparations of orange peel extract (Citrus nobilis) on wound healing (Vulnus Scissum) in mice (Mus musculus). SCOBY Kombucha gel was made with six concentration variations (0%, 2%, 4%, 8%, 10%, and 12%) and tested for its effectiveness in accelerating wound healing. The research method involved making incision wounds on male mice, followed by applying the gel according to the specified concentrations. The results showed that SCOBY Kombucha gel with a concentration of 12% was most effective in accelerating wound healing, approaching the effectiveness of the positive control (bioplacenton). Analysis showed that the increase in gel concentration was directly proportional to the effectiveness of wound healing, where higher concentration gels showed significantly faster wound closure.

Efek Kombinasi Linear Alkylbenzene Sulfonates (LAS) dan Tembaga (Cu) pada Kapasitas Fitoremediasi Tanaman Daun Tombak (Sagittaria lancifolia) Agustina, Eva; Nabila, Salsa; Purnamasari, Risa; Irawanto, Rony
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 1 (2023): Juni 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i1.6912

Salah satu masalah lingkungan yang serius saat ini adalah pencemaran air yang dapat membahayakan kesehatan manusia dan organisme lainnya. Salah satu penyebab pencemaran air adalah adanya detergen dan logam berat yang terdapat di lingkungan. Karena dampaknya yang merugikan, perlu dicari solusi untuk menangani masalah ini. Salah satu solusinya adalah menggunakan teknik fitoremediasi dengan memanfaatkan tanaman daun tombak (Sagittaria lancifolia) yang terbukti mampu menyerap berbagai polutan dari lingkungan. Oleh karena itu, penelitian ini bertujuan untuk mengevaluasi efektivitas fitoremediasi tanaman daun tombak (Sagittaria lancifolia) dalam menangani kontaminasi detergen LAS (Linear Alkylbenzene Sulfonates) dan logam berat tembaga (Cu) pada air. Penelitian ini menggunakan metode eksperimental dengan Rancangan Acak Lengkap (RAL) dengan empat perlakuan berbeda konsentrasi LAS + Cu, yaitu 0 mg/L, 10 mg/L + 3 mg/L, 30 mg/L + 3 mg/L, dan 50 mg/L + 3 mg/L. Hasil penelitian menunjukkan daya penyisihan LAS tertinggi sebesar 96% pada variasi konsentrasi LAS 10 mg/L + Cu 3 mg/L, dan daya penyisihan Cu tertinggi sebesar 72% pada variasi konsentrasi LAS 50 mg/L + Cu 3 mg/L. lebih lanjut, nilai efektifitas penyerapan logam Cu tertinggi sebesar 59% pada variasi konsentrasi LAS 50 mg/L + Cu 3 mg/L. Hasil penelitian juga menunjukkan semakin tinggi LAS yang diberikan maka semakin tinggi pula penyerapan logam berat Cu oleh tanaman. Berdasarkan hasil tersebut, terbukti bahwa tanaman daun daun tombak (Sagittaria lancifolia) efektif untuk menyerap LAS dan logam berat Cu di lingkungan.

Biosynthesis of Gold Nanoparticles using Fig Leaf (Ficus Carica) Isolate as a Reducing Agent Lusiana, Nova; Ma'arif, Muhammad; Agustina, Eva; Purnamasari, Risa
Journal of Health Science and Prevention Vol. 8 No. 2 (2024): JHSP Vol 8 No 2 – 2024
Publisher : State Islamic University of Sunan Ampel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/jhsp.v8i2.290

Proper and swift treatment is crucial for cancer patients. The fig plant contains antioxidants that show inhibition of cancer cell proliferation. By converting its particle size into nano, the active compounds are expected to more easily reach the target cells. The aim of this study is to determine the effectiveness of gold nanoparticles with a reducing agent from fig leaf isolate (Ficus carica). The research method used is laboratory experimentation to produce gold nanoparticles with fig leaf extract as the reducing agent, and the antioxidant activity was tested by observing the IC50 value. The results of the study showed that gold nanoparticles from fig leaf extract were successfully created, as evidenced by UV-Vis spectrophotometer testing at a wavelength of 528 nm. The antioxidant test demonstrated that gold nanoparticles from fig leaf extract have greater potential as an antioxidant agent compared to fig leaf extract alone.

Identifikasi Senyawa Metabolit Sekunder pada Ekstrak Etanol Daun Binahong Nafiisah, Aliyyah; Purnamasari, Risa; Mudalianah, Siti
Jurnal sosial dan sains Vol. 4 No. 11 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i11.27922

Latar Belakang: Tanaman Binahong (Anredera Cordifolia) dalam famili Basellaceae merupalan tanaman yang memiliki bahan fitokarma. Tanaman daun binahong memiliki banyak manfaat seperti mengobati kerusakan ginjal, pemulihan luka, melancarkan tekanan darah dan lain sebagainya. Tujuan: Tujuan dari penelitian ini untuk mengidentifikasi senyawa metabolit sekunder pada Ekstrak Etanol 70 % daun binahong yang telah disimpan selama 12 bulan. Metode: Penelitian bersifat deskriptif kualitatif yang dilakukan dengan menggunakan beberapa reagen, disesuaikan dengan golongan fitokimia (alkaloid, fenolik, flavonoid, saponin, tanin, steroid & triterpenoid). Ekstrak Daun Binahong dilakukan proses penyarian dengan metode maserasi. Ekstrak Daun binahong selanjutnya dilakukan uji fitokimia untuk mengetahui kandungan senyawa metabolit sekunder. Hasil: Hasil dari penelitian ini menunjukkan bahwa pada daun binahong yang telah disimpan selama 12 bulan masih terkandungan senyawa metabolit sekunder yaitu flavonoid, tannin, alkaloid dan saponin. Hal ini dapat menjelaskan ekstrak etanol dapat mempertahankan senyawa metabolit sekunder yang terkandung dalam ekstrak sampai 12 bulan penyimpanan Kesimpulan: Metode maserasi dengan pelarut etanol 70% terbukti efektif dalam mempertahankan senyawa metabolit sekunder selama penyimpanan jangka panjang. Hasil ini dapat menjadi dasar untuk pengembangan metode penyimpanan optimal pada ekstrak tanaman obat, mendukung praktik pengobatan tradisional dan formulasi farmasi berbasis bahan alami.

Effect of Different Concentration of SCOBY Kombucha as an Anti-acne Against Staphylococcus aureus in The Ear of Mice (Mus musculus) Ferdyanti, Anggun Putri; Agustina, Eva; Faizah, Hanik; Purnamasari, Risa
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1143-1150

SCOBY (Symbiotic Culture of Bacteria and Yeast) results from symbiosis between yeast and bacteria during fermentation. SCOBY kombucha gel combined with orange peel extract has antibacterial compounds that can inhibit the growth of S. aureus bacteria. The method in this study was to make variations in the concentration of SCOBY in the gel and inject S. aureus bacteria into the ears of mice. After 2x24 hours, the diameter of the inflammation caused was observed and SCOBY kombucha gel was applied (0%, 2%, 4%, 8%, 10%, and 12%), positive control (Mediclin 1%), and negative control (without gel application). The results showed that the higher the concentration of SCOBY, the faster the healing activity of the gel against S. aureus. SCOBY kombucha gel has the fastest healing activity in inhibiting acne pathogen S. aureus 12% SCOBY gel. Inflammation in the ears of mice treated with 12% SCOBY gel had healed by the 90th hour, while in other groups of mice it had only healed at the last observation hour, namely the 114th hour.

Effectiveness and Role of Symbiotic Culture of Bacteria and Yeast (SCOBY) Kombucha Gel on Incisional Wound Healing in Mice (Mus musculus) Nafisah, Raihana Frika; Agustina, Eva; Purnamasari, Risa; Andiarna, Funsu; Hidayati, Irul
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 3 (2025): October 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i3.11282

Incision wounds are common occurrences in daily life, and appropriate wound management is essential to promote and accelerate the healing process. Wound care can be performed using topical preparations such as gels containing bioactive compounds. SCOBY kombucha is believed to contain bioactive compounds, such as compounds from green tea (especially polyphenols) and metabolites produced by microbes (organic acids, alcohols, vitamins, etc.) The aim of this research is to determine the effectiveness of SCOBY kombucha gel on the healing of incision wounds in mice (Mus musculus). The method used in this research is a Completely Randomized Design (CRD) with 8 treatment groups, including 2 control groups and 6 test groups. The concentrations of SCOBY kombucha gel used are 0%, 2%, 4%, 8%, 10%, and 12%. The SCOBY kombucha gel is applied twice daily until the wound closes. Observation of the incision wound is carried out by measuring the length of the wound that has not yet closed. Based on the conducted research, it was found that SCOBY kombucha gel is effective in healing incision wounds as evidenced by the reduction in wound size due to the bioactive compounds in SCOBY. The most significant wound healing effect was observed with the 12% SCOBY kombucha gel, as there was a significant difference compared to the negative control group, 0%, 2%, 4%, and 8% SCOBY kombucha gels.

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