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Subchronic toxicity test of black garlic (Allium sativum) ethanol extract in liver histology of female mice (Mus musculus) Huwaidah, Jihan Farhah; Agustina, Eva; Purnamasari, Risa
Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Vol 7, No 1 (2024): June
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/biolokus.v7i1.2922

Black garlic is an innovative product from garlic which contains S-allyl cysteine (SAC), flavonoids, and polyphenols during the aging process. The use of black garlic as a medicine has not been studied regarding its toxicity to the liver, so research is needed regarding the safety of its use through toxicity tests. The purpose of this study was to determine the effect of giving various doses of black garlic ethanol extract on liver histology and to determine the safe dosage of black garlic ethanol extract for consumption. The method used was the treatment of black garlic ethanol extract in the treatment group at doses of 5, 50, 100, 300, 600, 1000, and 2000 mg/kg BW orally in mice to determine the effect on the histology of the mice's liver. The results showed that the greater the treatment dose of black garlic ethanol extract, the greater the percentage of damage to hepatocyte cells in the form of necrosis in the histology of the mice liver. The highest percentage of damaged cells experiencing necrosis was 49% at a dose of 2000 mg/kg BW. The use of doses that are safe for consumption has not been found in this study due to cell damage found > 30% in the category of moderate damage. So further testing is needed using a lower dose or by administering the extract over a shorter period of time to determine the safe dose for consumption.

Identifikasi Senyawa Metabolit Sekunder pada Ekstrak Etanol Daun Binahong Aliyyah Nafiisah; Risa Purnamasari; Siti Mudalianah
Jurnal sosial dan sains Vol. 4 No. 11 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i11.27922

Latar Belakang: Tanaman Binahong (Anredera Cordifolia) dalam famili Basellaceae merupalan tanaman yang memiliki bahan fitokarma. Tanaman daun binahong memiliki banyak manfaat seperti mengobati kerusakan ginjal, pemulihan luka, melancarkan tekanan darah dan lain sebagainya. Tujuan: Tujuan dari penelitian ini untuk mengidentifikasi senyawa metabolit sekunder pada Ekstrak Etanol 70 % daun binahong yang telah disimpan selama 12 bulan. Metode: Penelitian bersifat deskriptif kualitatif yang dilakukan dengan menggunakan beberapa reagen, disesuaikan dengan golongan fitokimia (alkaloid, fenolik, flavonoid, saponin, tanin, steroid & triterpenoid). Ekstrak Daun Binahong dilakukan proses penyarian dengan metode maserasi. Ekstrak Daun binahong selanjutnya dilakukan uji fitokimia untuk mengetahui kandungan senyawa metabolit sekunder. Hasil: Hasil dari penelitian ini menunjukkan bahwa pada daun binahong yang telah disimpan selama 12 bulan masih terkandungan senyawa metabolit sekunder yaitu flavonoid, tannin, alkaloid dan saponin. Hal ini dapat menjelaskan ekstrak etanol dapat mempertahankan senyawa metabolit sekunder yang terkandung dalam ekstrak sampai 12 bulan penyimpanan Kesimpulan: Metode maserasi dengan pelarut etanol 70% terbukti efektif dalam mempertahankan senyawa metabolit sekunder selama penyimpanan jangka panjang. Hasil ini dapat menjadi dasar untuk pengembangan metode penyimpanan optimal pada ekstrak tanaman obat, mendukung praktik pengobatan tradisional dan formulasi farmasi berbasis bahan alami.

Identifikasi Senyawa Metabolit Sekunder pada Ekstrak Etanol Daun Binahong Aliyyah Nafiisah; Risa Purnamasari; Siti Mudalianah
Jurnal sosial dan sains Vol. 4 No. 11 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i11.27922

Latar Belakang: Tanaman Binahong (Anredera Cordifolia) dalam famili Basellaceae merupalan tanaman yang memiliki bahan fitokarma. Tanaman daun binahong memiliki banyak manfaat seperti mengobati kerusakan ginjal, pemulihan luka, melancarkan tekanan darah dan lain sebagainya. Tujuan: Tujuan dari penelitian ini untuk mengidentifikasi senyawa metabolit sekunder pada Ekstrak Etanol 70 % daun binahong yang telah disimpan selama 12 bulan. Metode: Penelitian bersifat deskriptif kualitatif yang dilakukan dengan menggunakan beberapa reagen, disesuaikan dengan golongan fitokimia (alkaloid, fenolik, flavonoid, saponin, tanin, steroid & triterpenoid). Ekstrak Daun Binahong dilakukan proses penyarian dengan metode maserasi. Ekstrak Daun binahong selanjutnya dilakukan uji fitokimia untuk mengetahui kandungan senyawa metabolit sekunder. Hasil: Hasil dari penelitian ini menunjukkan bahwa pada daun binahong yang telah disimpan selama 12 bulan masih terkandungan senyawa metabolit sekunder yaitu flavonoid, tannin, alkaloid dan saponin. Hal ini dapat menjelaskan ekstrak etanol dapat mempertahankan senyawa metabolit sekunder yang terkandung dalam ekstrak sampai 12 bulan penyimpanan Kesimpulan: Metode maserasi dengan pelarut etanol 70% terbukti efektif dalam mempertahankan senyawa metabolit sekunder selama penyimpanan jangka panjang. Hasil ini dapat menjadi dasar untuk pengembangan metode penyimpanan optimal pada ekstrak tanaman obat, mendukung praktik pengobatan tradisional dan formulasi farmasi berbasis bahan alami.

Penerapan Aplikasi Geogebra Terhadap Motivasi dan Pemahaman Konsep Matematika Siswa Materi Bangun Ruang Sisi Datar Purnamasari, Risa; Supardi
Zona Education Indonesia Vol. 3 No. 3 (2025): June 2025
Publisher : Yayasan Mentari Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar

This study aims to analyze the effect of using the GeoGebra application on students’ motivation and conceptual understanding of mathematics in the topic of flat-faced solid shapes. The research employed an experimental method with a pretest-posttest control group design. The sample consisted of two classes divided into an experimental group, which used GeoGebra in learning, and a control group, which applied conventional teaching methods. Data were collected through conceptual understanding tests, motivation questionnaires before and after treatment, and classroom activity observations. The results showed that the experimental group experienced a significant increase in mathematics conceptual understanding with an average n-gain of 0.65 (medium to high category), compared to the control group, which only achieved an n-gain of 0.41 (low to medium category). Additionally, the motivation of students in the experimental group increased significantly, with 78% of students reaching a high motivation category, while the control group had only 42%. Observations revealed that GeoGebra encouraged students to actively discuss, explore, and interact with the learning material. Based on these findings, it can be concluded that the application of GeoGebra is effective in improving both motivation and conceptual understanding in mathematics learning on the topic of flat-faced solid shapes. This study recommends educators to integrate visual technology-based learning tools to enhance the quality of mathematics teaching and learning processes

Formulation and Characterization Tests of SCOBY Kombucha Gel Agustina, Eva; Nafisah, Raihana Frika; Fiddaroini, Achmad Farchan; Tania, Clarista Eka; Purnamasari, Risa; Andiarna, Funsu; Hidayati, Irul
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.143-151

The wound is the damage to body tissues caused by various factors such as accidents, sharp object scratches, etc. Proper care is necessary to accelerate the wound healing process. Topical medications, such as gel preparations, are commonly used for wounds. Kombucha SCOBY is believed to contain bioactive compounds that can accelerate the wound healing process, making it a potential active ingredient in gel preparations. This research aims to determine the characteristics of kombucha SCOBY gel with various concentration variations. SCOBY is obtained from kombucha fermentation using green tea, sugar, and kombucha culture. Preparing kombucha SCOBY gel involves using carbomer 940, methyl paraben, triethanolamine, glycerin, and SCOBY kombucha. The concentration variations of kombucha SCOBY gel include 0%, 2%, 4%, 8%, 10%, and 12%. Each formula undergoes physical characteristic tests including an organoleptic test, hedonic test, homogeneity test, pH test, spreadability test, and adhesiveness test. Data obtained after physical characteristic tests of the gel preparations are analyzed descriptively. Based on the conducted research, it was found that kombucha SCOBY gel preparations with concentration variations of 0%, 2%, 4%, 8%, 10%, and 12% exhibited different characteristics. The higher the gel concentration, the more acidic the gel's aroma, the more liquid the texture, and the more intense the color. SCOBY added to the gel preparation can increase the pH value, adhesiveness, and spreadability of the gel.

Effect of Variation in Concentration of SCOBY Kombucha Gel Citrus Peel Extract (Citrus nobilis) on Wound Incision (Vulnus Scissum) in Mice (Mus musculus) Shofiyya, Ainina Neihayatus; Eva Agustina; Funsu Andiarna; Irul Hidayati; Risa Purnamasari
International Journal of Applied Biology Vol. 9 No. 1 (2025): International Journal of Applied Biology
Publisher : Hasanuddin University

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A laceration wound is damage to the skin tissue characterized by a neat outline of the wound edge, due to slices by sharp instruments or incisions during surgery. This study aims to evaluate the effect of variations in the concentration of SCOBY Kombucha gel preparations of orange peel extract (Citrus nobilis) on wound healing (Vulnus Scissum) in mice (Mus musculus). SCOBY Kombucha gel was made with six concentration variations (0%, 2%, 4%, 8%, 10%, and 12%) and tested for its effectiveness in accelerating wound healing. The research method involved making incision wounds on male mice, followed by applying the gel according to the specified concentrations. The results showed that SCOBY Kombucha gel with a concentration of 12% was most effective in accelerating wound healing, approaching the effectiveness of the positive control (bioplacenton). Analysis showed that the increase in gel concentration was directly proportional to the effectiveness of wound healing, where higher concentration gels showed significantly faster wound closure.

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