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All Journal VALENSI Jurnal Teknik Mesin FIKkeS Jurnal Profesi Kependidikan Jurnal Matematika & Sains The Journal of Pure and Applied Chemistry Research Journal of Mathematical and Fundamental Sciences Jurnal Kimia dan Kemasan Indonesian Journal of Biotechnology Jurnal Keramik dan Gelas Indonesia JURNAL NASIONAL TEKNIK ELEKTRO Science and Technology Indonesia Jurnal Sains Teh dan Kina Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Communications in Science and Technology Molekul: Jurnal Ilmiah Kimia Jurnal Keramik dan Gelas Indonesia Jurnal Kimia dan Kemasan Jurnal Manusia dan Lingkungan Bulletin of Chemical Reaction Engineering & Catalysis Borneo Journal of Pharmacy Scientific Contributions Oil and Gas
Didin Mujahidin
Institut Teknologi Bandung
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Physics Social Sciences

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Sintesis Senyawa Berbasis Gadolinium Menggunakan Gliseril Monooleat Sebagai Ligan Dan Potensinya Sebagai Contrast Agents Teguh Hafiz Ambarwibawa; Didin Mujahidin
Jurnal Kimia dan Kemasan Vol. 41 No. 2 Oktober 2019
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (580.715 KB) | DOI: 10.24817/jkk.v41i2.3850

Abstract

Magnetic Resonance Imaging (MRI) merupakan salah satu teknik diagnosis yang paling banyak digunakan di bidang kedokteran. Agar diperoleh visibilitas yang baik, digunakan contrast agents namun terkadang kontras yang dihasilkan masih rendah, sehingga diperlukan dosis contrast agents lebih tinggi agar diperoleh kontras optimum. Untuk mengatasi keterbatasan tersebut, dilakukan pembuatan contrast agents berbasis Gadolinium (Gd) menggunakan Gliseril Monooleat (GMO) sebagai ligan. Pada penelitian ini dilakukan sintesis GMO, kompleksasi Gd-GMO, pengukuran turbiditas mikroemulsi, serta pengukuran waktu relaksasi T2 GMO dan Gd-GMO menggunakan alat Nuclear Magnetic Resonance (NMR). Hasil sintesis 2,2-dimetil-1,3-dioksolana gliserol menghasilkan rendemen 82,6%, sedangkan dari hasil sintesis GMO diperoleh rendemen 94,2%. Hasil pengukuran waktu relaksasi T2, Gd-GMO menghasilkan waktu relaksasi T2 lebih rendah dibandingkan dengan GMO sebesar 15,4% sampai dengan 32,7%. Data waktu relaksasi T2 tersebut menunjukkan bahwa Gd-GMO berpotensi untuk digunakan sebagai contrast agents.
Time-Kill Assay of 4-Hydroxypanduratin A Isolated from Kaempferia Pandurata Against Foodborne Pathogens Soerya Dewi Marliyana; Didin Mujahidin; Yana M Syah; Yaya Rukayadi
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.658 KB) | DOI: 10.20884/1.jm.2017.12.2.363

Abstract

Time–kill assay was performed for 4-hydroxypanduratin A that was isolated from Kaempferia pandurata rizhome against four important foodborne pathogens, namely Bacillus cereus ATCC 21772, Bacillu subtilis ATCC 6633, Staphylococcus aureus ATCC 29737,  and  Proteus mirabilis ATCC 21100. The methods have been investigated in term of Minimum Inhibitory Concentration (MIC) and killing time curve using methods of Clinical and Laboratory Standards Institute (CLSI) guidelines. The results showed that 4-hydroxypanduratin A rapid acting in killing bacteria as follow: B. cereus : 1×MIC for 4 h, P. mirabilis: 4×MIC for 0.5 h, meanwhile  B. subtilis and S. aureus were 1×MIC for 2 h. In conclusion, 4-hydroxypanduratin A showed strong antimicrobial activity against four important foodborne pathogens.
TRANSFORMATION OF ETHYL-P-METHOXYCINNAMATE TO P –METHOXYCINNAMIC ACID FROM KENCUR (Kaempheria galanga L.) AND THEIR ANTIBACTERIAL ACTIVITY Muhamad Salman Fareza; Rehana Rehana; Nuryanti Nuryanti; Didin Mujahidin
ALCHEMY Jurnal Penelitian Kimia Vol 13, No 2 (2017): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.13.2.8472.176-190

Abstract

This study aimed to evaluate the antibacterial properties of ethyl-p-methoxycinnamate and p-methoxycinnamate acid from Kaempheria galanga L. Ethyl-p-methoxycinnamate was isolated from the n-hexane rhizome extract of Kaempheria galanga L. Separation and purification of this compound was carried out with vacuum liquid chromatography and column chromatography. Hydrolysis of ethyl-p-methoxycinnamic under alkaline conditions obtained p-methoxycinnamic acid with a good yield of 85 %. The structure of the compounds were charactrized with IR, NMR spectrophotometer (1H-NMR and 13C-NMR) and mass spectrophotometer. The antibacterial properties of the compounds were evaluated using microdilution methods against B. cereus ATCC 11778, L. monocytogenes ATCC 7644, E. coli ATCC 25922, S. enterica sv Typhimurium ATCC 14028, and E. aerogenes ATCC 13048. The compounds showed weak antibacterial properties. Only ethyl p-methoxycinnamate showed the strongest antibacterial activity, especially against B. cereus ATCC 11778 bacteria with MIC values of 62.5 mg /mL. The change of the functional groups provided no significant impact on the antibacterial activity.
Encapsulation of Fe3O4 with amina modified silica Robby Roswanda; Didin Mujahidin
Jurnal Keramik dan Gelas Indonesia Vol 26, No 1 (2017): Jurnal Keramik dan Gelas Indonesia
Publisher : Balai Besar Keramik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32537/jkgi.v26i1.3915

Abstract

Superparamagnet iron oxide Fe3O4 particles were encapsulated with amina modified silica via Stober Method. The particles generated were rod-like whose length was c.a. 2 µm and the thickness of silica shell was c.a. 75 nm. Magnetization measurements show that the silica shell does not disrupt the superparamagnetic property of Fe3O4. The amine group on the encapsulated particles was confirmed by attaching FITC (Fluorescein isothiocyanate) dye and checked under fluorescence microscope. The encapsulated particle is useful to be modified further for various applications that need magnetic field control.
Synthesis and Antibacterial Activity of 1,3,5,7-Tetrahydroxy-9,10-Anthraquinone and Anthrone Derivatives Siti Nurbayti; Didin Mujahidin; Yana Maolana Syah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 2, November 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i2.25279

Abstract

In this research, the synthesis of 1,3,5,7-tetrahydroxy-9,10-anthraquinone (1) and two anthrone derivatives, 1,3,5,7-tetrahydroxy-10H-anthracene-9-one (2) and 1-hydroxy-3,5,7,9-tetramethoxyanthracene (3) has been done. Compound 1 was synthesized by a symmetrical condensation reaction of 3,5-dihydroxybenzoic acid in concentrated sulfuric acid. Reduction of the carbonyl group in compound 1 with SnCl2/HCl-HOAc affords compound 2. Compound 3 was prepared by modifying the hydroxy groups of compound 2 by a methylation reaction. The synthesized compounds were identified using nuclear magnetic resonance spectroscopy (NMR) and a high-resolution mass spectrometry (HR-ESI-MS). The antibacterial activity test of the synthesized compounds against four pathogenic bacteria, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Salmonella typhi, was carried out using the microdilution method. Compound 3 showed moderate activity against B. subtilis, E. coli and S. typhi with a MIC value of 37.5 µg/mL. Moderate activity was also shown by compound 2 against S. aureus, while compound 1 showed weak activity with a MIC value of 75 µg/mL against the four test bacteria.
ANALISIS DIAZINON SECARA DIFERENSIAL PULSA VOLTAMETRI DIBANDINGKAN DENGAN KROMATOGRAFI (Diazinon Analysis with Differential Pulse Voltametry Compared to Chromatography) Pirim Setiarso; Buchari Buchari; Indra Noviandri; Didin Mujahidin
Jurnal Manusia dan Lingkungan Vol 18, No 2 (2011): Juli
Publisher : Pusat Studi Lingkungan Hidup Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jml.18815

Abstract

ABSTRAKTelah dilakukan penelitian penentuan diazinon dari sampel tanah pertanian di beberapa kecamatan Kabupaten Nganjuk Jawa Timur menggunakan elektroda kerja tembaga amalgam padat (CuSAE) secara diferensial pulsa voltametri (DPV) dibandingkan dengan metode kromatografi. 100 g sampel tanah pertanian yang dihaluskan dengan ukuran 100 mesh diekstraksi menggunakan aseton. Ekstraksi dilakukan menggunakan ekstraktror soxhlet dengan 10 kali sirkulasi. Hasil ekstraksi sebagian ditambahkan surfaktan SDS untuk dianalisis secara voltametri menggunakan elektroda CuSAE dan sebagian dianalisis menggunakan kromatografi cair kinerja tinggi (HPLC). Analisis voltametri dilakukan pada pH 3 dengan elektrolit pendukung CaCl 2 menggunakan standar adisi, sedangkan analisis dengan HPLC menggunakan grafik standar. Berdasarkan data voltamogram dan kromatogram yang telah diolah dengan program origin 7.0 menghasilkan perolehan kembali rata-rata diazinon (97.40 ± 1.02) % pada voltametri dan (100.98 ± 7.10) % pada HPLC. Analisis diazinon kedua metode dibandingkan dengan uji t (t hitung = 0.4785 < t tabel = 2.31) sehingga tidak ada perbedaan hasil antara metode voltametri dan HPLC.ABSTRACTThe research has been done for determination of diazinon in agricultural soil samples from several districts n Nganjuk, East Java . Solid copper amalgam (CuSAE) used  as a working electrode using differential ulse voltammetry (DPV) compared with chromatographic method. Around 100 g sample of agricultural soil ith a size 100 mesh was extracted using 100 ml acetone. The extraction was done using extractor oxhlet with 10 times the circulation. A part of the extraction  yield  was  added SDS surfactant for analysis by DPV,  and another part analyzed  by using high performance liquid chromatography (HPLC). Voltammetric analysis carried out at pH 3 with CaCl2 as a supporting electrolyte   using standard addition method, while the analysis by HPLC using calibration curve (standard graphic).Based on the data from voltammograms and chromatograms after processing data using Origin 7.0 programme, the  average of  recovery of diazinon found to be 97.40 ± 1.02 % and 100.98 ± 7.10 % using voltammetry  and HPLC methods, respectively. The results from both of methods compared using t test  (t count = 0.4785 < ttable = 2.31). Therefore, there is no difference between the results from voltammety method compared with HPLC method.
Synthesis of quinine N-oxide and an NMR tutorial in its structure determination Aisyah Aisyah; Nila Berghuis Tamaela; Joko Santoso; Yana Maolana Syah; Didin Mujahidin
Jurnal Penelitian Teh dan Kina Vol 17 No 1 (2014)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/pptk.jur.jptk.v17i1.45

Abstract

Cinchona alkaloids are one of abundant natural chiral pool for organocatalysts. The application of an N-oxide group containing molecule in asymmetric reaction is currently wide developed. The structure of quinine consist two amine groups that could be oxidized to the N-oxide groups at N-1’ of quinoline and at N-1 of quinuclidine moieties. The oxidation reaction took place selectively at quinuclidine moiety by controlling the concentration of oxidizing agents. In this study we showed that N-1-oxide quinine could be occurred chemo­selectively by using a low concentration of ozone thana palladium catalyzed oxidation. The structure of products N1-oxide quinine was elucidated by spectroscopy data including 1H-NMR, 13C-NMR, 2D-NMR, infra-red and mass spectrometry. The developed method is a chemoselectively and eco-friendly method for synthesis N1-oxide quinine.
The oxidation reaction of quinine by potassium permanganate (KMnO4) Reny Rosalina; Anita Alni; Didin Mujahidin; Joko Santoso
Jurnal Penelitian Teh dan Kina Vol 18 No 2 (2015)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/pptk.jur.jptk.v18i2.76

Abstract

Quinine was known widely as malarial drug and a bitter taste ini soft drink. Recently, quinine have been also applied in organo-catalysis process, separation and purification of chiral compounds from enantiomeric mixture by diasteromeric salt crystallization and chiral chromatography. Quinine contains various functional groups which easily transforms by oxidations. This research was to study the oxi-dation reaction of quinine by using potassium permanganate (KMnO4) as oxidator. The KMnO4 oxidation carried out under acidic con-ditions. The separation and purification of pro-ducts were done by radial chromatography with chloroform : metanol : tri ethyl amine (9:1:0.1) as eluent. The structure of products were cha-racterized by spectroscopic data including: in-frared spectroscopy, NMR, and mass spectro-metry as quinine-1-N-oxide and quininal.
Synthesis of 1-azabicyclo[3.2.2]nonane from cinchonidine Didin Mujahidin; Hans Martin Rudolf Hoffman
Jurnal Penelitian Teh dan Kina Vol 16 No 2 (2013)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/pptk.jur.jptk.v16i2.89

Abstract

The 1-azabicyclo[3.2.2]nonane is a potent building block which have important bio­logicaly activities including for Alzheimer and ashmatic treatment. The skeleton can be accessed by rearrangement of quinuclidine ring in Cinchona alkaloids. The rearrange­ment established three chiral center at C-2, C-3, and C-6. The rearrangement of qui­nuclidine moiety to azabicyclic[3.2.2]nonana system of mesylated cinchonidine took place by hydrolysis in a mixture of acetone–water (1:1) with 47% yields. The structure determination of the product and its absolute configuration of chiral centers were esta­blished by using spectroscopy data including, 1H NMR, 13C NMR, 1D NOE and HR-MS.
A Straightforward Selective Acylation of Phenols over ZSM-5 towards Making Paracetamol Precursors Robby Roswanda; Alfhons Daniel Sirampun; Rino Rakhmata Mukti; Didin Mujahidin
Bulletin of Chemical Reaction Engineering & Catalysis 2018: BCREC Volume 13 Issue 3 Year 2018 (December 2018)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.13.3.2856.573-587

Abstract

Commercially available ZSM-5 was minimally treated as the catalyst to selectively acylate phenols. The ZSM-5 was simply immersed in ammonium nitrate in order to fill the pores with Brönsted acid to concentrate the catalytic reactions inside the pores. The reactions were carried out in liquid phase at 383 K. Acetic acid and propionic acid were chosen as the acyl substrate. Gas chromatography reveals two products which are phenyl acetate and almost exclusively para-hydroxyacetophenone meaning no ortho product observed. This para selectivity can be attributed to the pores of ZSM-5 where the reaction is assumed to be happening via intermolecular reaction. It is a relatively straightforward method in making para-hydroxyacetophenone which is known as paracetamol precursor. 
Co-Authors Abdul Rajab Achmad Romadin Ade Danova Affrida Affrida Agustono Wibowo Ahmad Fauzi Ahwan Ahwan Aisyah Aisyah Aisyah Aisyah Alfhons Daniel Sirampun Aminudin Sulaeman Andi Pawawoi Andi Suhendi Anita Alni Anita Alni Anita Alni, Anita Ari D. Pasek Aryadi Suwono Asep Aripin Asnizar Asnizar Buchari Buchari Chavasiri, Warinthorn Dadan Damayandri Danova, Ade Eliza Eliza Emilia Evi Marlina Emilio L. Ghisalberti Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Fareza, Muhamad Salman Fera Kurniadewi Hans Martin Rudolf Hoffman Hans Martin Rudolf Hoffman, Hans Martin Rudolf Hermawati, Elvira Hiromitsu Takayama Hiromitsu Takayama Ilham Ardatul Putra Indra Noviandri Iqbal Musthapa Irfansyah Rizal Joko Santoso Kurniadewi, Fera Lia Dewi Juliawati Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Mariko Kitajima Mariko Kitajima Meilisa Dara Puspita Muhtadi Muhtadi Nila Berghuis Tamaela Nila Berghuis Tamaela, Nila Berghuis Nindita Fransiska Rahmawati Norio Aimi Norio Aimi Nuryanti Nuryanti Pirim Setiarso Pirim Setiarso Rehana Rehana Reny Rosalina Reny Rosalina Rino Rakhmata Mukti Robby Roswanda Rusjdi Tamin Rusjdi Tamin Sa'adah, Pipih Lutfi Shinta Ellisya Fauzia Siti Nurbayti Siti Zubaidah Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Soerya Dewi Marliyana Soerya Dewi Marliyana Sulaeman, Aminudin Syamsurizal Syamsurizal Tedi Abdul Ghofar Teguh Hafiz Ambarwibawa Tukiran Tukiran Valentina Adimurti Yana M Syah Yana Maolana Syah Yani F. Alli YAYA RUKAYADI Yohanes B.D. Wangge Yoharmus Syamsu Yudha Taufantri Yuli S. Indartono