Article Per Year (5 Year)
p-Index From 2021 - 2026
2.612
P-Index
This Author published in this journals
All Journal Jurnal Teknologi Dan Industri Pangan Teknotan: Jurnal Industri Teknologi Pertanian Jurnal AGROTEKNOLOGI Berkala Ilmiah Pertanian Agrointek Jurnal Penelitian Pascapanen Pertanian Jurnal Pangan dan Agroindustri Jurnal Keteknikan Pertanian Tropis dan Biosistem Jurnal Teknologi Pertanian Indonesian Journal of Pharmaceutical Science and Technology Journal of Agromedicine and Medical Sciences WARTA Warta IHP (Warta Industri Hasil Pertanian) Jurnal Hasil Penelitian Industri Industria: Jurnal Teknologi dan Manajemen Agroindustri JMM (Jurnal Masyarakat Mandiri) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Food ScienTech Journal BERNAS: Jurnal Pengabdian Kepada Masyarakat Narra J Warta LPM Dental Agromedis
Nurud Diniyah
Jurusan Teknologi Hasil Pertanian, Fakultas Teknologi Pertanian, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, Jember 68121 Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 47 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Narra J

 1 
Exploring the role of polysaccharides in mitigating organ damage caused by pesticide-induced toxicity: A systematic review and meta-analysis of in vivo studies Sakinah, Elly N.; Diniyah, Nurud; Subagio, Achmad; Marchianti, Ancah CN.; Firdaus, Jauhar; Fambudi, Stela S.; Amini, Stefia A.; Putri, Dhiani E.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1553

Abstract

Although polysaccharides have demonstrated potential in alleviating dysbiosis, the overall impact of polysaccharides on minimizing oxidative stress and organ damage in vivo has not been thoroughly investigated. The aim of this study was to investigate the comprehensive effects of polysaccharides in mitigating pesticide toxicity in animal studies, focusing on biomarkers related to oxidative stress, antioxidant activity, kidney injury, lipid profiles, liver function, and the preservation of liver and kidney weights. A systematic search was conducted across nine indexed databases, including PubMed, Cochrane CENTRAL, Taylor & Francis, Scopus, Sage, EBSCO, ProQuest, ScienceDirect, and Google Scholar. Rayyan.ai was used to screen in vivo studies that met the predefined inclusion and exclusion criteria. The quality of the selected in vivo studies was evaluated using SYRCLE’s Risk of Bias tool, specifically designed for animal studies. Thirteen randomized animal studies, comprising 330 mice and rats, were included in the analysis. The findings revealed that polysaccharides significantly increased antioxidant levels, including catalase (CAT) (p<0.00001), superoxide dismutase (SOD) (p<0.00001), glutathione peroxidase (GPx) (p<0.00001), and reduced glutathione (GSH) (p<0.00001). Polysaccharides also significantly reduced oxidative stress markers, such as malondialdehyde (MDA) (p<0.00001) and nitric oxide (NO) (p<0.0001), as well as kidney injury biomarkers, including serum creatinine (p<0.00001) and urea (p<0.00001). Additionally, improvements in lipid profiles were observed, with significant reductions in triglycerides (TG) (p=0.04) and total cholesterol (TC) (p<0.00001). However, there were no significant differences in high-density lipoprotein (HDL) (p=0.28) and low-density lipoprotein (LDL) (p=0.32) levels. Polysaccharides significantly alleviate liver biomarkers, including aspartate transaminase (AST) (p<0.0001), alanine transaminase (ALT) (p<0.005), and alkaline phosphatase (ALP) (p<0.0001). Polysaccharides also contributed to the maintenance of liver weight (p=0.009), although no significant differences were observed in kidney weights (p=0.81). The study highlights that polysaccharides exert significant effects in enhancing antioxidant levels, reducing oxidative stress and organ damage biomarkers, and preserving liver weights.
Co-Authors -, Giyarto -, Maryanto Achmad Subagio Agafatmi, Izzun Agustin Akhiriani, Resti Agustin Akhiriani, Resti Ahmad Nafi Ahmad Nafi Ahmad Nafi&#039; Ainur Rofiah, Alif Alif Ainur Rofiah Alshammari, Fanar Hamad Amelia Puspitasari Amini, Stefia A. Ancah Caesarina Novi Marchianti Ararinda Kusweni, Nelfi Arifah, Naila Zanuba Azkiyah, Lailatul Bambang Piluharto Banun Kusumawardani Budi Yuwono Budi Yuwono Choiriyah, Arika Dani Setiawan Dani Setiawan Deltaningtyas Tri Cahyaningrum Denik Setiawati Dessy eka Kuliahsari Dian Agung Pangaribowo Dwiyanti, Inayatus Nur Dyanshah, Danny Agus Elly Nurus Sakinah, Elly Nurus Fahmi, Dafiq Kurniawan Fambudi, Stela S. Fatimah Wahyu Febriani Tri Hastuti Firdaus, Lutfi Fithri Choirun Nisa Gita Vindy, Pradiska Giyarto Giyarto Gustika Umiyati Hari Purnomo Herdina, Risa Herry Purnomo, Bambang I Dewa Ayu Ratna Dewanti Iguchi, Miyuki Inayatus Nur Dwiyanti Indarto Indarto indarto indarto Iqbaldi, Ryanda Irsyam, Mahrus Iswahyono Iswahyono Jauhar Firdaus Leseni, Ni Ketut Lindrianasari Lutfi Firdaus Madani, Alvis Alicia Marchianti, Ancah CN. Maryanto - Maryanto - Mega Pusva Sintha Muhammad Afifudin Anwar Muhammad Nurul Amin Mukhammad Fauzi Nafi', Ahmad Naning Retnowati Nanto, Mai nFN Maryanto Ngizati, Naila Alfi Ni Ketut Leseni Ni Ketut Leseni Nia Ariani Putri Nia Kristiningrum Ningrum, Nawang Sih Kusuma Nugraha Yuwana Nugraha Yuwana Nur Aini Nur Lutfian Sari, Riri Nurhayati Nurhayati Pradiska Gita Vindy Pradiska Gita Vindy Ganesha Prasetya, Sesarino Prasetyo, Aris Puspitarini, Mas Arum Putri Gita Kurniasari Putri, Dhiani E. R. Abdoel Djamali Retno Purwandari Riri Nur Lutfian Sari Riri Nur Lutfian Sari Riska Rian Fauziah Roedy Budirahardjo Roudotul Jannah Rusdianto, Andrew Setiawan Sakinah, Elly N. Sallama, Solihatus Sang-Han Lee Shahira, Silvia Faradjdilara Sih Yuwanti Simon Bambang Wijanarko Siti Windrati, Wiwik Siti Windrati, Wiwik Sukatiningsih Sukatiningsih Sumono, Agus Tecky Indriana Titik Khoiriyah Tri Susanto Tyastiningsih, Vivin Utiya Listy Biyumna Wardani, Windi Windi Wardani Wiwik Siti Windrati Wiwik Siti Windrati Wiwik Siti Windrati Wiwik Siti Windrati Wiwik Siti Windrati Wiwik Siti Windrati Yoshino, Tomoyuki Yuli Wibowo Yulia Rahmawati, Yulia Yuwana, Nugraha Zakiyatul Fachirah