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All Journal Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Journal of Mathematical and Fundamental Sciences JURNAL PHARMASCIENCE Pharmascience Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Journal of Global Health research Mattawang: Jurnal Pengabdian Masyarakat Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan
Asmiyenti Djaliasrin Djalil
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Pengembangan Eksipien Cetak Langsung dari Crosslinked Pati Buah Pisang Kepok dengan Silicon Dioxide Menggunakan Teknik Coprocessing: Development of Direct Compression Excipient from Crosslinked Kepok Banana Starch with Silicon Dioxide Using Coprocessing Techniques Rahmawati, Tias Eka; Siswanto, Agus; Djalil, Asmiyenti Djaliasrin
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2284

Abstract

This research aims to create and evaluate the crosslink coprocess of Kepok banana starch with silica dioxide as an additional material for making tablets using the direct compression method. Coprocessing is carried out using the coprecipitation method of silica on the surface of starch that has been crosslinked with sodium tripolyphosphate. Coprocesses were evaluated based on solubility characteristics, swelling power, angle of repose, Hausner ratio, compressibility index, FTIR, and SEM microscopy. The starch-silica coprocess showed better flow properties and compressibility compared to other frequently used super disintegrants. FTIR showed that there was no chemical reaction between the two starch and silica materials during the coprecipitation process. Coprocess crosslink kepok banana starch can be used as an excipient for making tablets using the direct compression method because it has better flow properties and a compressibility index. Keywords:          Banana Starch, Coprocess, Crosslink starch, Silicon dioxide   Abstrak Tujuan dari penelitian ini adalah untuk membuat dan melakukan evaluasi coproses crosslink pati buah pisang kepok dengan silika dioxide sebagai eksipien pembuatan tablet dengan metode cetak langsung. Pembuatan coprosess dilakukan dengan metode kopresipitasi silika pada permukaan pati yang sudah di crosslink dengan sodium tripoluphospate. Coprosess dievaluasi berdasarkan karakteristik kelarutan, daya pengembangan, sudut diam, rasio hausner, indeks kompresibilitas, FTIR dan mikroskop SEM. Coprocess pati-silika menunjukkan sifat alir dan kompresibilitas yang lebih baik dibandingkan dengan superdisintegran lain yang sering digunakan. FTIR menunjukkan tidak ada reaksi kimia antara kedua bahan pati dan silika selama proses kopresipitasi. Coprosess crosslink pati buah pisang kepok dapat digunakan sebagai eksipien pembuatan tablet dengan metode kempa langsung karena memiliki sifat alir dan indeks kompresibilitas yang lebih baik. Kata Kunci:         Coprocess, Pati buah pisang, Pati ikat silang, Silicon dioxide
Co-Authors Aditya Hanif Evridianto Agus Siswanto Alwani Hamad Alwani Hamad Andestia Sinaga, Risda Yunita Andestia Sinaga, Risda Yunita Andry Nur Hidayat Anna Nurlativah Arba, Muhammad Arinda Nur Cahyani Arry Yanuar Ayu Mulyani Azzahra, Ratu Bayu Satria Nugroho Putra Daryono Hadi Tjahjono Dhanti, Kurnia Ritma Dwi Hartanti Dwi Hartanti Dwi Hartanti Dwi Hartanti Eka Yuliani Saputri Eli Nurlaeli, Eli Fadhilah Zahra Nadia Fadlilah, Intan Nur Genatrika, Erza Hartanti, Dwi Hasnita Ika Diandana Yulia Asmara Ika Yuni Astuti Ika Yuni Astuti Ivani, Adhika Rifki Kumala, Rosa Muhammad Sulaiman Zubair Mulyani, Ayu Nur Yulianingsih Nurul Fadhilah Deni Saputri Nurul Fadhilah Deni Saputri, Nurul Fadhilah Deni Pradani, Dea Yulinestria Pri Iswati Utami Rahmawati, Tias Eka Retno Sulistiyowati Retno Wahyuningrum Risda Yunita Andestia Sinaga Sanang Nur Safitri Siti Musyarofah Subagio, Resita Suparman Suparman Suparman Susanti Susanti Syah Putri, Tina Tina Syah Putri Wahyu Utaminingrum Widyowati, Ulfi Wiranti Sri Rahayu Yulianingsih, Nur Zainur Rahman Hakim