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All Journal Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Journal of Mathematical and Fundamental Sciences JURNAL PHARMASCIENCE Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Journal of Global Health research BERNAS: Jurnal Pengabdian Kepada Masyarakat Mattawang: Jurnal Pengabdian Masyarakat MAHESA : Malahayati Health Student Journal Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Lontara Journal Of Health Science And Technology Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Journal of Pharmascience
Asmiyenti Djaliasrin Djalil
Universitas Muhammadiyah Purwokerto
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Potensi Biji Orok-orok (Crotalaria juncea L.) sebagai Kandidat Obat Insomnia Asmiyenti Djaliasrin Djalil; Siti Musyarofah; Bayu Satria Nugroho Putra; Erza Genatrika; Ika Yuni Astuti
Journal of Pharmascience Vol. 4 No. 1 (2017): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i1.5749

Abstract

ABSTRAK Insomnia merupakan gangguan yang menyebabkan penderita mengalami ketidakmampuan untuk mencukupi kebutuhan tidur. Pemilihan terapi insomnia di Desa Lembarawa, Brebes, secara empiris biasanya menggunakan biji orok-orok (Crotalaria juncea L.) sebagai sedatif. Penelitian ini bertujuan untuk membuktikan bahwa biji orok-orok memiliki potensi sebagai sedatif dengan dosis yang tepat. Biji orok-orok diekstrak menggunakan pelarut metanol. Ekstrak yang diperoleh selanjutnya difraksinasi dengan pelarut etil asetat dan metanol. Ekstrak dan fraksi yang diperoleh kemudian diujikan terhadap mencit. Mencit dibagi menjadi 12 kelompok, kelompok I kontrol positif (fenobarbital 60 mg/Kg BB) kelompok II kontrol negatif (NaCMC 1%), kelompok III-IV merupakan kelompok perlakuan ekstrak metanol dengan konsentrasi 50 dan 200 mg/Kg BB, kelompok V-VIII merupakan fraksi etil asetat dengan konsentrasi berturut-turut 7,5; 15; 22,5; dan 30 mg/Kg BB, kelompok IX-XII merupakan fraksi metanol dengan konsentrasi berturut-turut 25, 50, 75, dan 100 mg/Kg BB. Parameter yang digunakan adalah daya cengkeram mencit, reflek balik badan mencit, diameter pupil mata, serta daya jatuh menit. Hasil uji menunjukkan bahwa fraksi etil asetat dan metanol memiliki efek sedatif. Efek sedatif paling baik ditunjukkan oleh fraksi metanol 100 mg/Kg BB yang mendukung terapi untuk insomnia. Kata kunci: biji orok-orok, Crotalaria juncea L., sedatif. ABSTRACT Insomnia is a disruption that can not supply the needs of sleeping. In Lembarawa, Brebes, insomnia was treated empirically using Crotalaria Juncea L. (orok-orok). The purpose of this study was to prove that the seeds of Crotalaria juncea L. had potential as a sedative. Orok-orok seeds methanolic extract, ethyl acetate fraction, and methanolic fraction were observed as a sedative. Mice were divided into 12 groups: positive control group (phenobarbital 60 mg/Kg BW), negative control group (Na CMC 1%), methanolic extract of orok-orok seeds with doses of 50 and 100 mg/Kg BW, ethyl acetate fraction with doses of 7.5; 15; 22.5; and 30 mg/Kg BW, methanolic extract with doses of 25; 50; 75; and 100 mg/Kg BW. The sedative activity was investigated in mice including diameter mouse’s pupil, grip strange performances, return mice reflect, and rotarod performances. The results suggest that methanolic extract, ethyl acetate fraction, and methanolic fraction of orok-orok seeds possess potent sedative activity. The highest activity was obtained by using 100 mg/Kg BW of methanolic fraction, which supported its therapeutic use for insomnia. Keywords: Crotalaria juncea L., Orok-orok seeds, a sedative.
Hubungan Kuantitatif Struktur-Aktifitas dan Doking Molekular Senyawa Meso-Tetraphenylporphyrin dan Meso-Tetraphenylchlorin sebagai Fotosensitizer untuk Terapi Fotodinamik Asmiyenti Djaliasrin Djalil; Nurul Fadhilah Deni Saputri; Suparman Suparman; Alwani Hamad
Journal of Pharmascience Vol. 3 No. 1 (2016): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v3i1.5831

Abstract

ABSTRAK Terapi fotodinamik (Photodynamic Therapy/PDT) merupakan metode alternatif pengobatan kanker yang selektif. Terapi ini memerlukan fotosensitizer yang diberi penyinaran dalam lingkungan oksigen sehingga dihasilkan oksigen singlet yang mampu menghancurkan sel kanker dan merusak jaringan. Meso-tetraphenylchlorin (MTPP) dan meso-tetraphenylporphyrin (MTPC) adalah fotosensitizer yang memiliki struktur molekul yang mirip, hanya berbeda kejenuhan pada satu cincin pirolnya. MTPP adalah tetrapirol makrosiklik dengan cincin pirol tidak tereduksi sedangkan struktur MTPC tereduksi pada salah satu cincin pirolnya. Penelitian ini bertujuan untuk memprediksi hubungan antara struktur tetrapirol makrosiklik terhadap aktivitasnya secara in silico. Analisis hubungan kuantitatif-struktur aktifitas (HKSA) menggunakan serangkaian senyawa turunan porfirin dilakukan untuk memperoleh persamaan yang secara statistik memiliki kemampuan korelatif dan prediktif. Perangkat lunak Molecular Operating Environment (MOE) digunakan untuk melakukan analisis HKSA. Doking molekul dilakukan terhadap human serum albumine (HSA) dan  peripheral benzodiazepine receptor (PBR) untuk memperoleh energi doking yang berhubungan dengan energi afinitas antara ligan dan reseptor. Simulasi doking dilakukan dengan menggunakan perangkat lunak AutoDock. Hasil menunjukkan bahwa MTPC memiliki energi doking terhadap HSA dan PBR yang paling baik. Analisis HKSA yang diperoleh  menunjukkan bahwa MTPC lebih potensial sebagai fotosensitizer yang ditunjukkan dengan nilai IC50 yang lebih kecil.  Kata kunci: doking molekular, fotosensitizer, HKSA, MTPC, MTPP, PDT ABSTRACTPhotodynamic Therapy (PDT) is an alternative cancer treatment method that can exert a selective cytotoxic activity toward malignant cells. PDT requires a sensitizing agents and light energy, which, in the presence of oxygen, leads to the generation of singlet molecular oxygen in cell. Singlet oxygen molecules are able to kill or inhibit growth of cancer cells. Meso-tetraphenylchlorin (MTPC), a photosensitizer, is similar to meso-tetraphenylporphyrin (MTPP) but the structure has one reduced pyrrole ring. The present study aimed to develop an in silico prediction model that considers PDT activity. The Quantitative-Structure Activity Relationship (QSAR) analysis using a series of porphyrin derivatives was carried out to build a statistically significant model possessing a good correlative and predictive capability for photosensitizer in PDT. Molecular Operating Environment (MOE) software was used to performed the QSAR analysis. Docking molecule of MTPP and MTPC on human serum albumine (HSA) and peripheral benzodiazepine receptor (PBR) had been done to test the docking energy associated with binding affinity between ligand and receptor. Docking simulation was performed by AutoDock software. The results showed that MTPC had the best docking energy to HSA and PBR. Furthermore, the QSAR analysis showed that MTPC had lower IC50 value compare with  MTPP.  Based on QSAR and molecular docking analysis, MTPC exhibit better photosensitizer as compare with MTPP.Keywords: molecular docking, photosensitizers, QSAR, MTPC, MTPP, PDT.
Correlation Between Lead Levels and Percentage of Basophilic Stippling in the Blood of Silver Men Ratu Azzahra; Kurnia Ritma Dhanti; Asmiyenti Djaliasrin Djalil; Retno Sulistiyowati
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6818

Abstract

The phenomenon of silver men has become increasingly prevalent in recent years. The direct application of metallic paint to the body and the nature of their activities are major factors contributing to potential lead expsure. Elevated blood lead levels can disrupt hematopoiesis, leading to various blood abnormalities, including the presence of basophilic stippling. Basophilic stippling is a distinctive marker indicative of heavy metal toxicity, particularly lead poisoning. This study aims to examine the correlation between blood lead levels and the presence of basophilic stippling in the blood of silver men in Purbalingga Regency and Purwokerto Sub-district. This study employed an observational analytical design with a cross-sectional approach. The research sample consisted of blood specimens from 14 silver men, selected using accidental sampling. Blood samples (3 mL) were collected from the respondents arms into EDTA tubes. Blood lead levels were analyzed using Atomic Absorption Spectrophotometry (AAS), while basophilic stippling was examined through Giemsa-stained blood smears observed under a microscope. The collected data were analyzed using Pearsons correlation test. The Pearson correlation test yielded a p-value of 0.045 (p 0.05) and a correlation coefficient of 0.542, indicating a strong positive correlation. There is a strong correlation between blood lead levels andthe presence of basophilic stippling in silver men. An increase in blood lead levels is accompanied by the occurrence of basophilic stippling, highlighting the potential toxic effects of lead exposure in this population.
PENETAPAN KADAR AMIODARON HIDROKLORIDA DALAM TABLET MENGGUNAKAN METODE RP HPLC-UV Asmiyenti Djaliasrin Djalil; Rosa Kumala; Resita Subagio
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 5 No. 2 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v5i2.2388

Abstract

Metode Kromatografi Cair Kinerja Tinggi Fase Balik – Ultra Violet (KCKT FB – UV) telah dikembangkan untuk menentukan kadar amiodaron hidroklorida dalam tablet. Metode kromatografi cair ini menggunakan kolom Shim-pack CLC-ODS column (C18) untuk pemisahan dengan detektor UV pada panjang gelombang 242 nm. Elusi isokratik dilakukan menggunakan fase gerak campuran methanol : asetonitril : buffer (25 mM KH2PO4 + 3 mM H2SO4 + 3,6 mM trietilamina) (63:12:25, v/v/v) dengan laju alir 0,8 mL/menit. Metode analisis divalidasi dengan parameter meliputi limit deteksi, limit kuantitasi, kisaran konsentrasi analisis, presisi, dan akurasi. Hasil validasi menunjukan linearitas yang baik pada kisaran konsentrasi amiodaron hidroklorida 2-10 μg mL-1. Perolehan kembali yang tinggi dan standar deviasi pengukuran yang rendah menunjukkan bahwa metode ini sesuai untuk analisis rutin amiodaron hidroklorida dalam tablet.
Hubungan Kadar Trigliserida pada Wanita Usia Lebih Dari 45 Tahun dengan Pemberian Susu Tempe Selama 7 Hari Berturut-turut Aisyah Aisyah; Retno Sulistiyowati; Asmiyenti Djaliasrin Djalil; Uli Mas'uliyah Indrawati
MAHESA : Malahayati Health Student Journal Vol 6, No 4 (2026): Volume 6 Nomor 4 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i4.21873

Abstract

ABSTRACT Women Women over the age of 45 often experience pre-menopausal physiological changes, including alterations in lipid metabolism. One consequence is an increased risk of hypertriglyceridemia, which is associated with cardiovascular disease, atherosclerosis, pancreatitis, and metabolic syndrome. Identifying dietary interventions that can help manage lipid levels is essential in promoting long-term health in this population. This study aimed to evaluate the effect of daily tempeh milk consumption for seven consecutive days on triglyceride levels in women aged over 45 years. A total of 25 women aged above 45 years from Ledug Village, Kembaran District, Banyumas Regency, participated in this pre-experimental study. Triglyceride levels were measured before and after the 7-day intervention using photometric analysis at the UMP Clinical Laboratory. Statistical analysis was conducted using the Wilcoxon signed-rank test to assess the significance of changes in triglyceride levels. The findings revealed a statistically significant reduction in triglyceride levels following tempeh milk consumption (p = 0.011). The mean decrease observed was 3.92 mg/dL. Keywords: Triglycerides, Tempeh, Pre-menopause.  ABSTRAK Wanita berusia lebih dari 45 tahun biasanya sudah memasuki masa pre-menopause yang menyebabkan perubahan metabolisme lemak dalam tubuh. Peningkatan kadar trigliserida melebihi normal (hipertrigliseridemia) dapat menyebabkan masalah kesehatan diantaranya peningkatan risiko kardiovaskular, arterosklerosis, pankreatitis dan sindrom metabolik. Tujuan penelitian ini dilakukan untuk mengetahui hubungan kadar trigliserida pada wanita berusia lebih dari 45 (empat puluh lima) tahun dengan pemberian susu tempe selama 7 (tujuh) hari berturut-turut. Sampel pada penelitian ini berupa wanita yang telah memasuki usia lebih dari 45 tahun di Kelurahan Ledug, Kecamatan Kembaran, Kabupaten Banyumas berjumlah 25 orang. Pengukuran kadar trigliserida dilakukan sebelum dan setelah konsumsi susu tempe selama 7 hari bertutut-turut menggunakan metode pemeriksaan fotometer di laboratorium Klinik Pratama Rawat Jalan UMP. Data dianalisis menggunakan uji analisis Wilcoxon dengan hasil nilai P = 0,011. Hasil menunjukan susu tempe berpengaruh secara signifikan dalam penurunan kadar trigliserida yang ditunjukkan dengan nilai P 0,05 dan rata-rata penurunan kadar trigliserida sebanyak 3,92 mg/dL. Kata Kunci: Trigliserida, Tempe, Pre-menopause.
Co-Authors Aditya Hanif Evridianto Agus Siswanto Aisyah Aisyah Alwani Hamad Andestia Sinaga, Risda Yunita Andestia Sinaga, Risda Yunita Andry Nur Hidayat Anna Nurlativah Arba, Muhammad Arinda Nur Cahyani Arry Yanuar Ayu Mulyani Balqis , Alifa Tiara Bayu Satria Nugroho Putra Daryono Hadi Tjahjono Dhanti , Kurnia Ritma Dhanti, Kurnia Ritma Dwi Hartanti Dwi Hartanti Dwi Hartanti Dwi Hartanti Eka Yuliani Saputri Eli Nurlaeli, Eli Fadhilah Zahra Nadia Fadlilah, Intan Nur Genatrika, Erza Hartanti, Dwi Hasnita Ika Diandana Yulia Asmara Ika Yuni Astuti Ika Yuni Astuti Ivani, Adhika Rifki Kumala, Rosa Muhammad Sulaiman Zubair Mulyani, Ayu Nur Yulianingsih Nurul Fadhilah Deni Saputri Nurul Fadhilah Deni Saputri, Nurul Fadhilah Deni Pradani, Dea Yulinestria Pri Iswati Utami Rahmawati, Tias Eka Ratu Azzahra Regawa Bayu Pamungkas Resita Subagio Retno Sulistiyowati Retno Sulistiyowati Retno Wahyuningrum Risda Yunita Andestia Sinaga Rosa Kumala Sanang Nur Safitri Siti Musyarofah Subagio, Resita Suparman Suparman Suparman Susanti, Susanti Syah Putri, Tina Tina Syah Putri Uli Mas'uliyah Indrawati Wahyu Utaminingrum Widyowati, Ulfi Wiranti Sri Rahayu Yulianingsih, Nur Zainur Rahman Hakim