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All Journal Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Journal of Mathematical and Fundamental Sciences JURNAL PHARMASCIENCE Pharmascience Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Journal of Global Health research Mattawang: Jurnal Pengabdian Masyarakat Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan
Asmiyenti Djaliasrin Djalil
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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PENETAPAN KADAR IBUPROFEN DALAM TABLET SERTA APLIKASINYA PADA PLASMA TIKUS JANTAN WISTAR SECARA IN VITRO DENGAN METODE KCKT Susanti Susanti; Aditya Hanif Evridianto; Ika Diandana Yulia Asmara; Asmiyenti Djaliasrin Djalil
Molekul Vol 9, No 2 (2014)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.822 KB) | DOI: 10.20884/1.jm.2014.9.2.165

Abstract

Telah dilakukan penelitian mengenai pengembangan metode KCKT dalam penetapan kadar tablet ibuprofen dalam plasma darah tikus jantan wistar secara in vitro. Metode  divalidasi berdasarkan parameter linearitas, akurasi, dan presisi. Kondisi KCKT yang digunakan adalah fase terbalik dengan kolom shim pack CLC ODS dan fase gerak asetonitril:bufer fosfat (35:65 v/v), laju alir 0,8 mL/min. Hasil uji linearitas menunjukan nilai r = 0,993 pada kisaran konsentrasi 0,5-5 μg/mL, presisi 0,93 (%RSD), dan perolehan kembali 92,9%. Penentuan ibuprofen dalam tablet generik dan merek pada matriks  plasma tikus jantan wistar menghasilkan persen kadar pada kisaran antara 80-100%. Telah dilakukan penelitian mengenai pengembangan metode KCKT dalam penetapan kadar tablet ibuprofen dalam plasma darah tikus jantan wistar secara in vitro. Metode  divalidasi berdasarkan parameter linearitas, akurasi, dan presisi. Kondisi KCKT yang digunakan adalah fase terbalik dengan kolom shim pack CLC ODS dan fase gerak asetonitril:bufer fosfat (35:65 v/v), laju alir 0,8 mL/min. Hasil uji linearitas menunjukan nilai r = 0,993 pada kisaran konsentrasi 0,5-5 μg/mL, presisi 0,93 (%RSD), dan perolehan kembali 92,9%. Penentuan ibuprofen dalam tablet generik dan merek pada matriks  plasma tikus jantan wistar menghasilkan persen kadar pada kisaran antara 80-100%
Bay leaf essential oils inhibited microbial growth and exerted potential preservation effects on tofu Alwani Hamad; Asmiyenti Djaliasrin Djalil; Eka Yuliani Saputri; Nur Yulianingsih; Dwi Hartanti
Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Vol 3, No 2 (2020)
Publisher : Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.afssaae.2020.003.02.2

Abstract

Cattle manure contains high organic matter, so that this material is commonly used as plant nutrients in a form of organic fertilizer. In order to get a better understanding on the use of cow manure, the objectives of this research are (1) to determine the influence of liquid waste and solid livestock as fertilizer on soil quality and (2) to study the effect of both liquid and solid fertilizer on coffee plant growth. In this research, Completely Randomized Design (CRD) was employed as a research design, while data analysis was conducted using ANOVA. The F statistical test was applied to measure whether all independent variables could influence the dependent variable by using 5% and 1% (Alpha) degrees. The results showed that one time application of livestock wastewater improved C-organic chemical properties, N, P, CEC, Ca and Mg while soil chemical properties of pH, K, Na decreased. Two times application of livestock liquid fertilizer treatment improved soil chemical properties pH, N total, Ca, Mg and saturation bases. As for solid waste, one time treatment increased chemical properties of pH, C organic, N total, Ca and saturation of the base. The two times treatment could improve soil chemical properties of pH, N. total, P, Ca, Mg, base number and base saturation. Liquid waste fertilizer also found to provide significant effect on plant height and coffee plants quality. Additionally, (3) solid waste (compost) was found to have a significant effect on plant height, plant height rate and number of buds.
The Effect of Infusion of Syzygium polyanthum (Wight) Walp. Leaves as Natural Preservative Chicken Meats Hartanti, Dwi; Djalil, Asmiyenti Djaliasrin; Hamad, Alwani; Yulianingsih, Nur
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 1, FEBRUARI 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i1.1100

Abstract

Syzygium polyanthum (Wight) Walp. (Indonesian bay leaf) is known for possessing antimicrobial activity that might be applied for natural food preservative. In this study, we analyzed the constituents of infusion of S. polyanthum leaves and evaluated its potency as the preservative of fresh chicken meats. The infusions were prepared with the method described in Indonesian Pharmacopeia. Phytochemical content of infusion of S. polyanthum leaves was analyzed by qualitative phytochemical screening using colorimetric methods. Its application for preservative of fresh chicken meat was evaluated based on its activity in inhibiting the growth of bacteria on the meats as well as the physical observation of the preserved meats. The infusion of S. polyanthum leaves contained flavonoids, tannins, and saponins. The infusion at the optimum concentration of 10% was capable of inhibiting bacterial growth on chicken meats and extending their shelf life up to 3 days in temperature of 3-7ºC.
DEVELOPMENT OF SUNSCREEN PRODUCTS CONTAINING Stichopus hermanii Semper, 1868 Widyowati, Ulfi; Genatrika, Erza; Djalil, Asmiyenti Djaliasrin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1138

Abstract

Prolonged radiation from UV sunlight has been known to be responsible for skin damage. Sunscreen has been used to limit sun exposure. Sunscreen with natural ingredients has the potential to be developed along with the issue of side effects of synthetic ingredients. This study aimed to develop a zooceuticals sunscreen cream containing a Stichopus hermanii Semper, 1868 extracts. The sunscreen creams were formulated with various ingredients of extract include 0.05 (F1), 0.1 (F2), and 0.2 (F3) %, respectively. The in vitro sun protection factor, organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesion of the creams were evaluated. F3 met the requirements of physical properties. The extract show sun-protective efficacy with SPF value of 2.11 (F1), 3.09 (F2), and 3.46 (F3). Sunscreen containing 0.2% of Stichopus herrmanni extract is the most preferred formulation with minimal protection category.  Keywords: Sea Cucumber, Stichopus hermanii Semper, 1868, Sunscreen.
Isolation, identification, phytochemical screening, and antibacterial activity of Aspergillus sp. MFD-01, an endophytic fungus derived from Mesua ferrea Hartanti, Dwi; Andestia Sinaga, Risda Yunita; Djalil, Asmiyenti Djaliasrin; Wahyuningrum, Retno
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.10009

Abstract

We have successfully isolated and identified endophytic fungi from medicinal plant Mesua ferrea L. grown at Banyumas were for the first time. One of those fungi was MFD-01. In this study, we report the isolation, identification, antibacterial activity, and phytochemical screening of Aspergillus sp. MFD-01. The endophytic fungus was isolated from the leaves of M. ferrea by subsequent inoculation on potato dextrose agar (PDA). The identification was based on its morphology and ITS-DNA sequence. The antibacterial activity was determined by dilution method. The identification of compounds in ethyl acetate extract of it was conducted according to the standart phytochemical screening method. MFD-01 was identified as Aspergillus sp. MFD-01. The ethyl acetate extract of Aspergillus sp. MFD-01 inhibited the growth of both Staphylococcus aureus, and Escherichia coli. At concentration of 1000 ppm, its diameter of inhibitory zone against those bacteria was 10.53 and 11.84, respectively. The extract contained flavonoids, alkaloids, saponins, terpenoids, and tannins, which might responsible for its antibacterial activity against both tested bacteria.
Preservation Potential and Microbial Growth Inhibitory Effect Of Galangal (Alpinia galanga (L.) Willd.) And Lemongrass (Cymbopogon citratus (DC.) Stapf) Oils And Extracts On Chicken (Gallus domesticus) Fillets Hartanti, Dwi; Pradani, Dea Yulinestria; Nurlaeli, Eli; Fadlilah, Intan Nur; Syah Putri, Tina; Djalil, Asmiyenti Djaliasrin; Hamad, Alwani
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.993

Abstract

Galangal (Alpinia galanga (L.) Willd.) and lemongrass (Cymbopogon citratus (DC.) Stapf) are spices known for their antimicrobial activity and potentially developed into a natural food preservative. This study evaluated the potential development of galangal and lemongrass oils and extracts for natural food preservatives. The essential oils and water extracts of galangal and lemongrass were obtained by water and steam distillation and infusion methods, respectively. Chicken fillets were immersed in three concentrations of galangal and lemongrass oils and extracts, with sterile water as the control. The fillets were tightly closed, kept in the refrigerator for 15 days, and evaluated for their preservation potential and microbial inhibitory activity on days 3, 6, 9, 12, and 15. The chicken fillet preservation potential was evaluated by comparing the time spoilage signs started to be observable in the control and treatment groups. The percent of microbial growth inhibition (%MI) was calculated from optical density (OD) and was used as the antimicrobial activity parameter. The %MI was analyzed by two-way ANOVA at α=0.05. Treatment and storage time significantly affected %MI. Galangal extracts at 10 and 20% delayed rancid odor, off-texture, and slime formation for nine days. Microbial growth inhibitory activity was shown by galangal oil at 0.25, 1.25, and 6.25 mg/ml and galangal extract at 20%. In conclusion, galangal extract at 20% was the most promising sample potentially developed into a natural chicken fillet preservative.
REVIEW ON PHOTOSENSITIZER POTENTIAL OF NATURAL DYES FOR ANTIMICROBIALS USING PHOTODYNAMIC INACTIVATION Ayu Mulyani; Ika Yuni Astuti; Djalil, Asmiyenti Djaliasrin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1291

Abstract

Infectious diseases still threaten human life, with incidents continuing to increase every year. The increase in antibiotic resistance in recent years has been one of the causes. This incident triggered research to find alternative antibacterial therapies. One such alternative therapy is Photodynamic Inactivation (PDI). This paper reviews the application of PDI for treating diseases caused by microorganisms, especially dermatitis,  periodontitis, blood transfusions, and foodborne diseases, emphasizing the use of natural dyes as photosensitizers. The source for this article was obtained from several indexed databases, such as the National Center for Biotechnology Information (NCBI), Elsevier, and Google Scholar, from 2002 to 2024. The keywords used included “photodynamic therapy", “photodynamic inactivation (PDI)”, "antimicrobial photodynamic therapy (aPDT)", “laser-activated disinfection”, “photoactive disinfection”, “LED”, “natural photosensitizer”, “curcumin”, “riboflavin”, “hypericin”, “chlorophyll and chlorophyllin. Original (clinical and experimental) studies, case series, case reports, and reviews were also included. Letters to the editor and commentaries are excluded. After reviewing 148 relevant articles, 57 were selected. Full texts were read, and data were extracted and entered into tables. The review demonstrated that natural photosensitizers, such as curcumin, hypericin, riboflavin, and chlorophyll derivatives, have the potential to reduce the number of microorganisms in PDI therapy. Photosensitizers can be obtained from several natural sources. Using the PDI procedure, the ROS produced have been proven to effectively inhibit pathogenic microorganisms and can be widely used to treat diseases caused by microorganisms. Keywords: curcumin, hypericin, riboflavin, chlorophyllin derivatives, PDI, natural dye, antimicrobial.
Assistance in Implementing Hygiene and Sanitation to Promote Halal Certification at UMKM Pabrik Kerupuk in Linggasari Purwokerto Djalil, Asmiyenti Djaliasrin; Utami, Pri Iswati; Suparman; Utaminingrum, Wahyu; Rahayu, Wiranti Sri; Mulyani, Ayu; hasnita
Mattawang: Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2024)
Publisher : Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.mattawang2815

Abstract

Healthy and nutritious food is a basic human necessity. Therefore, it is crucial to ensure that our food is healthy, nutritious, and halal according to Islamic law. This community service activity aimed to support sanitation hygiene requirements for obtaining halal certification at the UMKM Pabrik Kerupuk in Linggasari, Kembaran, Purwokerto. The methods used included observation, interviews, training, and evaluation. The results revealed that while the factory had met several requirements, there were areas for improvement in the use of work clothes and gloves, vector control, and the provision of closed waste bins. The education provided raised awareness among owners and employees about the importance of maintaining product cleanliness and safety. By adhering to reasonable standards, the UMKM can enhance product quality, consumer confidence, and compliance with relevant regulations.
Correlation Between Lead Levels and Percentage of Basophilic Stippling in the Blood of Silver Men Azzahra, Ratu; Dhanti, Kurnia Ritma; Djalil, Asmiyenti Djaliasrin; Sulistiyowati, Retno
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6818

Abstract

The phenomenon of silver men has become increasingly prevalent in recent years. The direct application of metallic paint to the body and the nature of their activities are major factors contributing to potential lead expsure. Elevated blood lead levels can disrupt hematopoiesis, leading to various blood abnormalities, including the presence of basophilic stippling. Basophilic stippling is a distinctive marker indicative of heavy metal toxicity, particularly lead poisoning. This study aims to examine the correlation between blood lead levels and the presence of basophilic stippling in the blood of silver men in Purbalingga Regency and Purwokerto Sub-district. This study employed an observational analytical design with a cross-sectional approach. The research sample consisted of blood specimens from 14 silver men, selected using accidental sampling. Blood samples (3 mL) were collected from the respondents arms into EDTA tubes. Blood lead levels were analyzed using Atomic Absorption Spectrophotometry (AAS), while basophilic stippling was examined through Giemsa-stained blood smears observed under a microscope. The collected data were analyzed using Pearsons correlation test. The Pearson correlation test yielded a p-value of 0.045 (p 0.05) and a correlation coefficient of 0.542, indicating a strong positive correlation. There is a strong correlation between blood lead levels andthe presence of basophilic stippling in silver men. An increase in blood lead levels is accompanied by the occurrence of basophilic stippling, highlighting the potential toxic effects of lead exposure in this population.
Optimasi Fast Disintegrating Tablet Difenhidramin HCl Menggunakan Modifikasi Pati Pisang Kepok Kuning, Crospovidone, dan Microcrystalline Cellulose Rahmawati, Tias Eka; Siswanto, Agus; Djalil, Asmiyenti Djaliasrin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1406

Abstract

Diphenhydramine HCl is an antihistamine drug that is available in conventional tablet form. This study aimed to produce the optimum formula for a diphenhydramine fast disintegrating tablet (FDT) using a modification of starch, crospovidone, and microcrystalline cellulose (MCC) to produce quality tablets that meet the tablet's physical requirements and tablet dissolution. Starch modification was made using a two-step method of starch cross-link, then continued with silica coprecipitation. FDT was prepared by the direct compression method. Optimisation with the simplex lattice design (SLD) model uses three components: co-process starch crosslink-silica, crospovidone, and MCC, which obtained 14 formula designs. The hardness, wetting time, disintegration time, and percent dissolution are optimisation parameters. Equations, contour plots, and desirability values were determined as the optimum formula. Based on the research results, an optimum formula was obtained with the proportion of co-process cross-link starch-silica was 56.185 mg, crospovidone at 6 mg, and MCC at 45.815 mg. The result of hardness was 5 kg, wetting time 51.061 seconds, disintegration time 63.129 seconds, and dissolution was 100.972%. The interaction of the three components reduces hardness and increases disintegration time, wetting time, and percent dissolution.
Co-Authors Aditya Hanif Evridianto Agus Siswanto Alwani Hamad Alwani Hamad Andestia Sinaga, Risda Yunita Andestia Sinaga, Risda Yunita Andry Nur Hidayat Anna Nurlativah Arba, Muhammad Arinda Nur Cahyani Arry Yanuar Ayu Mulyani Azzahra, Ratu Bayu Satria Nugroho Putra Daryono Hadi Tjahjono Dhanti, Kurnia Ritma Dwi Hartanti Dwi Hartanti Dwi Hartanti Dwi Hartanti Eka Yuliani Saputri Eli Nurlaeli, Eli Fadhilah Zahra Nadia Fadlilah, Intan Nur Genatrika, Erza Hartanti, Dwi Hasnita Ika Diandana Yulia Asmara Ika Yuni Astuti Ika Yuni Astuti Ivani, Adhika Rifki Kumala, Rosa Muhammad Sulaiman Zubair Mulyani, Ayu Nur Yulianingsih Nurul Fadhilah Deni Saputri Nurul Fadhilah Deni Saputri, Nurul Fadhilah Deni Pradani, Dea Yulinestria Pri Iswati Utami Rahmawati, Tias Eka Retno Sulistiyowati Retno Wahyuningrum Risda Yunita Andestia Sinaga Sanang Nur Safitri Siti Musyarofah Subagio, Resita Suparman Suparman Suparman Susanti Susanti Syah Putri, Tina Tina Syah Putri Wahyu Utaminingrum Widyowati, Ulfi Wiranti Sri Rahayu Yulianingsih, Nur Zainur Rahman Hakim