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All Journal Jurnal Ilmiah Farmasi Bionatura Farmaka Jurnal Sains Materi Indonesia Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE Pharmascience IDJP (Indonesian Journal of Pharmaceutics) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JFIOnline Majalah Farmasetika Jurnal Locus Penelitian dan Pengabdian Pharmaceutical Sciences and Research (PSR)
Dolih Gozali
Fakultas Farmasi - Universitas Padjadjaran
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health

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PEMANFAATAN KULIT MANGGIS DALAM SEDIAAN SABUN CAIR ANTISEPTIK DI DESA CILIANG KECAMATAN PARIGI KABUPATEN PANGANDARAN Nasrul Wathoni; Tiana Milanda; Dolih Gozali; Dwi Indra Purnomo; Ine Suharyani
Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Vol 12, No 2 (2023): Juni, 2023
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v12i2.41709

Abstract

Program Pengabdian pada Masyarakat (PPM) merupakan salah satu tugas Tri Dharma yaitu suatu bentuk pengabdian dosen kepada masyarakat. PPM periode Juni 2022dilakukan secara terpadu antara kegiatan Riset dan Pengabdian Pada Masyarakat (PPM) Dosen. Kegiatan riset yang dilakukan memberikan hasil berupa pemanfaatan limbah kulit buah manggis. Kulit buah manggis mengandung Xanthone, yang bermanfaat sebagai antiseptik, sehingga dapat dimanfaatkan sebagai alternatif antiseptik yang dapat dibuat dengan mudah dan sederhana, salah satunya adalah bentuk sabun cair dengan zat aktif kulit manggis. Pada kegiatan PPM ini, pengetahuan masyarakat tentang cara pengolahankulit buah manggis dan pemanfaatannya dalam sabun cair antiseptik, diharapkan dapat bertambah.Setelah dilakukan penyuluhan tentang manfaatbuah manggis, kami mendapatkan hasil bahwa pengetahuan masyarakat tentang manggis dan pemanfaatannya dalam sabun antiseptik meningkat, pada pre-test dengan rata-rata jawaban benar sebanyak 78,41%, sementara pada post-test meningkat menjadi 84,72% %. Ketrampilan masyarakat untuk mengolah sabun cair antiseptik dari kulit manggis pun terlihat pada proses pembuatan dihasilkan sabun yang homogen, berbusa dan wangi.
REVIEW: PENGGUNAAN TEKNOLOGI NANOSUSPENSI PADA FORMULASI OBAT HERBAL Fadlilah, Aida Roja; Gozali, Dolih
Farmaka Vol 20, No 1 (2022): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i1.33958

Abstract

AbstrakEfektivitas spesies tanaman obat tergantung pada kandungan senyawa aktifnya. Beberapa konstituen ekstrak yang aktif secara biologis sulit diserap tubuh, karena tidak dapat melintasi membran lipid sel atau memiliki ukuran molekul yang terlalu tinggi, mengakibatkan hilangnya bioavailabilitas dan efektifitas obat-obatan herbal. Berbagai teknologi dan pengembangan dilakukan untuk mengatasi masalah ini, salah satunya teknologi nano. Salah satu teknologi nano untuk drug delivery system adalah nanosuspensi. Nanosuspensi merupakan sistem dispersi koloidal, yang seluruhnya mengandung bahan obat berukuran 10 sampai 1000 nm. Review artikel ini membahas penggunaan teknologi nanosuspensi dan pengaruhnya pada bioavailabilitas obat herbal. Metode yang digunakan adalah studi literature  dari 18 jurnal acuan. Diperoleh hasil bahwa teknologi nanosuspensi dalam formulasi obat herbat dapat digunakan untuk meningkatkan bioavailabilitas, efektivitas, dan stabilitas.AbstractThe effectiveness of medicinal plant species depends on the content of the active compounds. Some of the biologically active constituents of the extract are difficult for the body to absorb, because they cannot cross cell lipid membranes or have too high a molecular size, resulting in loss of bioavailability and effectiveness of herbal medicines. Various technologies and developments have been carried out to overcome this problem, one of which is nanotechnology. One of the nanotechnology for drug delivery system is nanosuspension. Nanosuspension is a colloidal dispersion system, which entirely contains the drug substance in the size of 10 to 1000 nm. This review article discusses the use of nanosuspension technology and its effect on the bioavailability of herbal medicines. The method used is a literature study from 18 journal references. It was found that nanosuspension technology in herbal drug formulations can be used to increase bioavailability, efectivity, and stability. There are several commercial synthetic drug products that use nanosuspension technology in their formulations, but the application in herbal drug formulations is still being researched on a laboratory scale.
REVIEW ARTIKEL: PENINGKATAN KELARUTAN OBAT CARVEDILOL Adiningsih, Nurdiani; Gozali, Dolih
Farmaka Vol 20, No 1 (2022): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i1.33954

Abstract

AbstrakCarvedilol adalah beta bloker non selektif dengan aktivitas penghambat reseptor alfa-1 yang sering diresepkan untuk pengobatan penyakit kardiovaskular.  Carvedilol termasuk ke dalam BCS (Bipharmaceutical Classification System) kelas II dimana memiliki permeabilitas membran yang tinggi tetapi memiliki laju disolusi yang lambat karena kelarutan dalam air yang rendah. Review ini berisi tentang teknik peningkatan kelarutan dari carvedilol dengan melakukan pencarian literatur melalui jurnal nasional dan jurnal internasional.   Berbagai jenis teknik peningkatan kelarutan obat telah diterapkan pada carvedilol seperti dispersi padat dengan berbagai metode preparasinya, c-MCMs, ko-kristalisasi, cyclodextrin inclusion complex, superkritikal karbon dioksida, hidrotropi, polymeric microparticles, pembentukan garam, dan nanopartikel. Dari semua teknik yang diterapkan telah terbukti dapat meningkatkan kelarutan dari carvedilol.ABSTRACTCarvedilol is a non-selective beta blocker with alpha-1 receptor blocking activity that is often prescribed for the treatment of cardiovascular disease. Carvedilol belongs to the BCS (Bipharmaceutical Classification System) class II which has high membrane permeability but has a slow dissolution rate due to low water solubility. This review contains techniques for increasing the solubility of carvedilol by conducting a literature search through national and international journals. Various types of drug solubility enhancement techniques have been applied to carvedilol such as solid dispersion with various preparation methods, c-MCMs, co-crystallization, cyclodextrin inclusion complex, supercritical carbon dioxide, hydrotropy, polymeric microparticles, salting, and nanoparticles. All the techniques have been shown to increase the solubility of carvedilol.
POTENSI KITOSAN DARI CANGKANG RAJUNGAN (Portunus pelagicus) SEBAGAI ZAT ANTIBAKTERI Husni, Patihul; Junaedi, Junaedi; Gozali, Dolih
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 1 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i1.14588

Abstract

Plak gigi merupakan suatu lapisan biofilm yang tersusun atas sel-sel dari koloni mikroorganisme pada permukaan gigi yang berperan sangat dominan dalam pembentukan karies gigi. Salah satu penyebab timbulnya plak adalah bakteri Staphylococcus aureus. Kitosan dari cangkang rajungan (Portunus pelagicus) diketahui memiliki aktivitas antibakteri. Tujuan penelitian ini adalah menguji potensi kitosan dari cangkang rajungan yang diperoleh dari pantai Pasir Putih, Cilamaya, Karawang sebagai zat antibakteri. Uji aktivitas antibakteri kitosan dilakukan terhadap bakteri S. aureus dengan nilai konsentrasi hambat tumbuh minimum (KHTM) pada konsentrasi 0,05–0,1% dan konsentrasi bunuh minimum (KBM) pada konsentrasi 0,1%. Hasil penelitian menunjukkan bahwa aktivitas antibakteri terhadap S. aureus terjadi pada konsentrasi 0,4% dan 0,8% berdasarkan zona hambat. Kesimpulan studi ini adalah kitosan dari cangkang rajungan menunjukkan potensinya sebagai agen antibakteri.
Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV): a Review Study: Pengembangan Teknik dalam Meningkatkan Kelarutan Obat yang Larut Buruk dalam Air (BCS Kelas II dan IV): Studi Review Reza Pahlevi, Muhamad; Sopyan, Iyan; Gozali, Dolih
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.15969

Abstract

Orally active drugs are currently available on the market. API should have adequate solubility and permeability to enhance its therapeutic efficacy when administered orally and obtain optimum bioavailability. Almost 40% of New Chemical Entities had limited solubility or fell into BCS class II and IV. Our review aims to summarize and discuss the development of methods and characterization for increasing the solubility of poorly aqueous drugs from papers published in Google Scholar, NCBI, Science direct, Researchgate, and MDPI. We checked that the methods used such as solid dispersion, cocrystal formation, and coamorphous can increase the solubility of API which has an impact on increasing bioavailability. The successful formation of solid dispersions, cocrystals and coamorphs can be confirmed by the characterization of PXRD, DSC and SEM. In conclusion, drug solubility is an important aspect of pharmacological effects. Drugs with high solubility can provide fast solubility rates and high bioavailability, reducing the dose administered. Solid dispersion, cocrystals, and coamorphous techniques, have succeeded in increasing the solubility of BCS class II and IV drugs.
Study of Formulation, Characteristics, and Evaluation of Self Nanoemulsifying Drug Delivery System (SNEDDS) for Atorvastatin Calcium Silvia, Nurfianti; Rusdiana, Taofik; Gozali, Dolih; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 5, Issue 2, May - August 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.50996

Abstract

A Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a formulation approach used in the pharmaceutical and biotechnology industries to improve the solubility and bioavailability of poorly water-soluble drugs. Atorvastatin calcium has limited water solubility, which can affect its bioavailability when administered orally. Its solubility can be enhanced by various formulation techniques, such as the use of self-nanoemulsifying drug delivery systems (SNEDDS). The purpose of this study is to determine the formulation and characterization of SNEDDS and determine how it affects the bioavailability of atorvastatin calcium. The data were collected from published journals. The carrier components required in the formulation of atorvastatin calcium with SNEDDS formulation include oils (oleic acid, peceol, capyrol 90, and capmul CMC), surfactants (tween 80, tween 20, labrasol, cremophor RH 40) and co-surfactants (brij 30, propylene glycol, transcutol-P, PEG 400, transcutol HP). Characterization of atorvastatin calcium with SNEDDS formulation showed droplet size 21.6-162.2 nm; zeta potential -1.32 - 24.6±6.47 mV; and polydensity index 0.164 - 0.297. SNEDDS formulation increased the percentage of drug release and increased the bioavailability of atorvastatin calcium. Keywords: self-nanoemulsifying drug delivery system, SNEDDS, atorvastatin                      calcium, formulation, characteristics, dissolution, bioavailability
Solid Dispersion Powder of Sargassum cristaefolium extract by solvent evaporation technique Amalia, Eri; Khairunnisa, Nada; Aghnia Khairinisa, Miski; Gozali, Dolih
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.60911

Abstract

Sargassum cristaefolium is one of 782 types of seaweed/macroalgae that grows in Indonesia and is known as one of the macroalgae with bioactive compounds having an important role in the development of nutraceuticals for disease prevention and health maintenance. Sargassum cristaefolium extract (SCE) is known for its various beneficial activities such as antimigraine by reducing levels of CGRP and inhibitor of tyrosinase activity in anti-melanogenetics. Nevertheless, due to its hygroscopic viscous extract consistency and fishy odor, a suitable formulation is required to prepare a powder form of SCE and thus could be applied in a suitable dosage form. Our current study aims to develop the extract into suitable powder raw material by applying a solid dispersion technique.  The solid dispersion of SCE was initially prepared by selecting suitable carrier agents such as Aerosil, Microcrystalline cellulose (MCC) PH 101, maltodextrin, and PVP K30 with the extract in a ratio of 1:1, and continued by the combination of the carrier agents. The best powder formula was characterized by its powder characteristic, solubility and powder flow was assessed by its angle of repose, Carr’s index and Hausner ratio.  The experiment results that the optimum formulation for solid dispersion of SCE was obtained by the combination of SCE:PVP: MCC at a ratio of 1:1:3 with a less fishy smell, and excellent powder properties. The composite mixture was estimated due to the formation of hydrogen bonds between the carbonyl group of PVP and the hydroxyl group of SCE’s compound and MCC. In conclusion, solid dispersion of SCE by employing a combination of PVP and MCC can be an alternative to prepared SCE powder with optimum humidity protection and good flowability thus suitable to proceed as solid dosage form.  Keywords: Sargassum cristaefolium, solid dispersion, PVP K30, Microcrystalline                      cellulose PH101 
MAPPING SUHU GUDANG NARKOTIKA PADA SALAH SATU PEDAGANG BESAR FARMASI (PBF) DI KOTA BANDUNG FADHILAH, FAHRINA NUR; GOZALI, DOLIH
Farmaka Vol 20, No 3 (2022): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i3.43425

Abstract

Sebagai upaya menjaga keamanan, mutu, dan efikasi dari masing – masing obat, kestabilan setiap sediaan obat selama masa penyimpanan harus dijaga dan dipertahankan. Ketidak patuhan terhadap persyaratan kondisi penyimpanan, salah satunya suhu penyimpanan merupakan salah satu penyimpangan yang paling banyak ditemukan di fasililtas penyimpanan obat. Salah satu kegiatan yang dapat dilakukan sebagai upaya pemantauan kondisi suhu penyimpanan adalah pemetaan suhu. Pemetaan suhu dilakukan untuk mengetahui rentang suhu pada ruangan gudang penyimpanan obat, serta mengetahui keberagaman suhu pada masing – masing titik di ruangan gudang penyimpanan obat. Dilakukan pemetaan suhu dengan peletakan dua belas alat pengukur suhu pada empat titik sudut dengan masing – masing tiga ketinggian di Gudang Narkotika salah satu Pedagang Besar Farmasi di Kota Bandung. Dari hasil pengamatan selama 72 jam, diperoleh hasil rentang suhu penyimpanan berada di antara 15oC – 25oC dengan titik kritis pada titik 3 dengan suhu 24,3oC dijadikan sebagai dasar pertimbangan peletakan alat pengukur suhu.Kata kunci: Pemetaan suhu, rentang suhu, titik kritis
EVALUASI SEDIAAN FISIK EMULGEL MENGANDUNG MINYAK ATSIRI RIMPANG TEMU PUTIH (Curcuma zedoaria, (Berg.) Roscoe) Mahdi, Nur; Mudhakir, Diky; Gozali, Dolih
Media Farmasi: Jurnal Ilmu Farmasi Vol. 15 No. 2: September 2018
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v15i2.12657

Abstract

Temu putih atau disebut juga kunir putih merupakan salah satu spesies dari familiZingiberaceae yang telah dikomersilkan penggunaan rimpangnya sebagai tanaman obat.Komponen terbesar dari rimpang temu putih, yaitu minyak atsiri yang mempunyai efekantiinflamasi. Penggunaan rimpang temu putih sebagai antiinflamasi di masyarakatmasih secara empiris, dengan mengoleskan air perahan rimpang temu putih pada kulit.Untuk meningkatkan efektivitas penggunaan minyak atsiri yang terkandung dalam temuputih, dilakukan formulasi emulgel yang mengandung minyak atsiri denganpenambahan PEG 8 beeswax agar didapat sediaan emulgel yang stabil, baik dan amandigunakan. Tahap penelitian yang dilakukan meliputi penyiapan bahan, determinasibahan, skrining fitokimia, destilasi menggunakan uap-air, analisis komponen kimiadengan GC-MS, serta uji kualitatif minyak atsiri dengan sediaan emulgel yangmengandung minyak atsiri, formulasi emulgel mengandung minyak atsiri denganmenggunakan emulsifying wax konsentrasi 6,5%, 7%, 7,5%, dan 8%. Evaluasi sediaanmeliputi pengamatan organoleptik, pH, viskositas, sentrifugasi, serta uji hedoniksediaan. Berdasarkan hasil evaluasi pengamatan organoleptik, pH, viskositas,sentrifugasi, serta uji hedonik sediaan menunjukkan bahwa kestabilan dalam batasrentang yang dibolehkan. Formulasi emulgel yang terbaik ditunjukkan pada formula ke-4 pada konsentrasi PEG 8 beeswax 8%.
Article Review: Glimepiride Solubility Enhancement Strategy as Diabetes Treatment Therapy Fiftianingrum, Valentina; Sopyan, Iyan; Gozali, Dolih
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 5 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i5.4010

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood glucose levels due to impaired insulin secretion. The prevalence of diabetes in Indonesia always increases every year. Glimepiride is a type 2 antidiabetic drug of the sulfonylurea class that works by stimulating insulin secretion of pancreatic beta cells. Glimepiride is given through the oral route of administration and is widely used because it has a longer half-life and can be used as treatment monotherapy. Glimepiride itself has physicochemical properties that can penetrate the stratum corneum with a dose of less than 10 mg, a molecular weight of 490.62 g/mol, a melting point of 207°C, and a lipophilicity value (LogP) of 3.5. However, oral glimepiride in therapy has bioavailability problems due to its poor solubility in the gastrointestinal tract. It has very low solubility values at acidic and neutral pH of approximately less than 0.004 mg/mL (BCS 2). Due to the low aqueous solubility of glimepiride is a major challenge in drug formulation development. This low solubility has an impact on its bioavailability, which is not optimal, thus reducing its therapeutics. Various efforts were made in order to increase the solubility of glimepiride, including the use of formulation techniques such as the preparation of solid dispersion systems, the formation of inclusion complexes, as well as the utilization of nanoparticle technologies such as nanosuspensions, nanoemulgels, and nanoemulsions. In addition, chemical modification approaches and various others are used to improve the solubility of glimepiride. Recent studies have shown that the combination of the latest formulation technologies with suitable carrier materials can significantly improve its solubility and stability, thereby enhancing the therapeutic effectiveness of glimepiride in the management of type 2 diabetes. Thus, innovations in glimepiride formulation are expected to provide better therapeutic solutions for patients with type 2 diabetes.
Co-Authors Adiningsih, Nurdiani Aghnia Khairinisa, Miski alifa nur zaini Amalia, Eri ANASYA RIDHA NURHANIFAH Angga Prawira Kautsar Anis Khoirunisa Anis Khoirunisa, Anis Anis Yohana Chaerunisaa, Anis Yohana Astiningsih Diah Pravitasari CHAIRUNNISA CHAIRUNNISA Diah Siti Fatimah Diky Mudhakir Dwi Indra Purnomo FADHILAH, FAHRINA NUR Fadlilah, Aida Roja Fara Warhead Fara Warhead, Fara Fiftianingrum, Valentina Firman Gustaman FITRI NURJANAH Husein Hernadi Bahti Iyan Sopyan Junaedi Junaedi Junaedi Junaedi Jutti Levita Khairunnisa, Nada Marline Abdassah Mohamad Aprianto Paneo Muchtaridi Muchtaridi Multiani S Latif Mutakin Mutakin Nasrul Wathoni Norisca Aliza Putri Nur Mahdi NURUL FITRI RAHMAWATI PATIHUL HUSNI Patihul Husni Resmi Mustarichie Reza Pahlevi, Muhamad Rini Hendriani Riska Nurul Hidayah Rosa Apriana Apriana SAARAH YURVA SALSABILA LASABUDA SHINTA LESTARI Shofa Shofa Shofa Shofa, Shofa Silvia, Nurfianti Simorangkir, T.P.H. Simorangkir, T.P.H. Siska Sari Marvita Sri Soeryati Suharyani, Ine Sundani N. Soewandhi Taofik Rusdiana TIANA MILANDA Utami, Nadya Firdianna Utami, Nadya Firdianna Veronika Ellena Winda Ratna Pratiwi Winda Ratna Pratiwi, Winda Ratna Yasmiwar Susilawati Yoga Windhu Wardhana Yuni Andriani Yunita Yunita YUSUF PRAKOSO