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STUDI IN-SILICO SENYAWA UMBI LOBAK PUTIH (Raphanus sativus L.) SEBAGAI KANDIDAT ANTI INSOMNIA Noer Fauziah Rahman; Nurzadrina Wahyuddin; Marwati Marwati
Majalah Farmasi dan Farmakologi Vol. 27 No. 4 (2023): MFF SPECIAL ISSUE
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i4.30048

Abstract

Insomnia adalah gangguan tidur yang umum dan tersebar luas yang disebabkan oleh berbagai faktor risiko.Insomnia jangka panjang dapat menyebabkan masalah serius termasuk kecemasan, nyeri kronis, penyakitkardiovaskular, hingga gagal jantung. Pengobatan insomnia konvensional memberikan kemanjuran moderattetapi dapat menyebabkan berbagai efek samping termasuk sedasi, penambahan berat badan, keluhangastrointestinal, insomnia rebound dan efek samping lainnya. Penggunaan bahan alam dipercaya memilikiefek samping minimal sebagai pengobatan alternatif. Salah satu bahan alam yang dipercaya memiliki efeksebagai anti insomnia adalah lobak (Raphanus sativus L.). Penelitian ini bertujuan untuk mengeksplorasisenyawa dari umbi lobak (Raphanus sativus L.) sebagai kandidat obat anti insomnia. Dilakukan penelusuransenyawa melalui studi docking in-silico menggunakan aplikasi AutoDock®. Hasil penambatan senyawa R.sativus menunjukkan semua senyawa dapat berinteraksi dengan sisi aktif reseptor GABA. Interaksi terbaikditunjukkan oleh senyawa 13, 14, dan 16, dengan nilai energi bebas ikatan -9.73, -9.38, dan -7.74 kkal/mol,sedangkan ligan alami diazepam memiliki nilai energi bebas ikatan -8.4 kkal/mol. Interaksi antar molekuldengan residu asam amino yang paling mirip dengan ligan alami adalah Tyr58, Val203, Tyr210, Tyr160, Phe100,Phe77, His102, Ser205. Dapat disimpulkan bahwa ketiga senyawa tersebut diprediksi berpotensi sebagai agenanti insomnia.
HUBUNGAN TINGKAT STRESS DENGAN INSOMNIA PADA MAHASISWA Ruswati Ruswati; Marwati Marwati; Yani Trihandayani
Jurnal Mahasiswa Ilmu Kesehatan Vol. 1 No. 3 (2023): Juli : Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v1i3.107

Abstract

Everyone, including children, adults, and parents, can experience stress. Academic stress is a common type of stress that occurs in a school or educational environment. Students who face high pressure, such as numerous assignments, may experience stress that can lead to insomnia. The purpose of this study is to examine the relationship between stress and insomnia in students. Stress is a negative feeling caused by situations beyond one's control or changes in one's body and mind. Insomnia is the inability to achieve adequate quality and quantity of sleep. A literature review study was conducted, with 5 journals obtained from Google Scholar. The study design was cross-sectional. The results showed a significant relationship between stress and insomnia in college students (p <0.05). This means that stress levels have a moderate positive correlation with insomnia levels. In conclusion, it is important for students to learn how to manage their stress levels to prevent insomnia.
Penyuluhan Kesehatan tentang Kanker Serviks pada Wanita Usia Subur (WUS) di Desa Kertawinangun Kecamatan Kedawung Kabupaten Cirebon Sofiyati Sofiyati; Marwati Marwati
Faedah : Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Vol. 2 No. 3 (2024): Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Publisher : FKIP, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/faedah.v2i3.976

Abstract

Cervical cancer is a primary malignant tumor originating from squamous epithelial cells or cells originating from the vagina and urethra, usually occurring in the cervix or cervix which is located between the uterus and the sexual canal (vagina). According to WHO 2018, cervical cancer is the fourth leading cause of death in women throughout the world, estimated at 570,000, while new cases in 2018 or 6.6% of all cancers in women. Human papilloma virus or commonly called (HPV) is known to cause cervical cancer which can be transmitted through sexual intercourse, infection with several types of viruses, and personal hygiene. Symptoms of cervical cancer can be recognized by the presence of fluid from the birth canal, namely abnormal vaginal discharge, contact bleeding (bleeding during intercourse), and feeling pain during coitus / sexual intercourse as well as bleeding even after entering menopause. Early symptoms of pre-cancerous conditions are generally characterized by the discovery of abnormal cells. These abnormal cells develop into cervical cancer and then the following symptoms of cervical cancer appear; the appearance of pain and bleeding during sexual intercourse (contact bleeding), abnormal vaginal bleeding, such as bleeding outside the menstrual cycle, bleeding between regular menstrual periods, menstrual periods that are longer and more abundant than usual, bleeding after menopause, vaginal discharge excessive and abnormal, if the cancer has spread to the pelvis, the patient will suffer from complaints of pelvic pain, difficulty urinating, and enlarged kidneys. Cervical cancer can be prevented 100% by HPV vaccination, using condoms, avoiding tobacco consumption, and early detection and treatment of precancerous lesions.
UJI ANTI INFLAMASI EKTRAK KOMBINASI TERIPANG PASIR (HOLOTHURIA SCABRA) DAN DAUN KERSEN (MUNTINGIA CALABURA L.) PADA TIKUS (RATTUS NORVEGICUS) Asril Burhan; Marwati Marwati; Besse Hardianti; Waode Ratnasari Hasan
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.204

Abstract

Teripang pasir (Holothuria scabra) dan daun kersen (Muntingia calabura L.) digunakan sebagai obat tradisional yang memiliki aktivitas antiinflamasi. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi dari kombinasi ekstrak etanol teripang pasir dan daun kersen terhadap penurunan udem pada kaki tikus yang telah diinduksi dengan karagenan 1%. Tikus kemudian dibagi menjadi 5 kelompok dan masing-masing kelompok terdiri dari 3 ekor tikus. Kelompok 1 sebagai kontrol positif, kelompok 2 sebagai kontrol negatif, kelompok 3 sebagai kombinasi ekstrak 1:1 (200 mg/kgBB:200 mg/kgBB), kelompok 4 sebagai kombinasi ekstrak 1:2 (200 mg/kgBB:400 mg/kgBB), kelompok 5 sebagai kombinasi ekstrak 2:1 (400 mg/kgBB:200 mg/kgBB), dan masing-masing kelompok diberikan secara peroral. Pada EK 2:1 memiliki efek antiinflamasi yang sama dengan kontrol positif dengan %DAI, yaitu 4,84%. Sedangkan pada EK 1:2 dengan %DAI 4,24% dan EK 1:1 dengan %DAI 1,81%.
SKRINING ANTIOKSIDAN DAN ANTIKANKER EKSTRAK ETANOL DAUN KARAMUNTING (RHONOMYRTUS TOMENTOSA L.) SEBAGAI OBAT ALTERNATIF Marwati Marwati; Mirnawati Salampe; Asril Burhan; Megawati Megawati; Khairuddin Khairuddin; A.Adi Al Ma’aridj Naneng; Nova Oktaviani
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.367

Abstract

Karamunting (Rhodomyrtus tomentosa (Aiton) merupakan salah satu tanaman yang digunakan sebagai obat tradisional yang banyak tersebar diseluruh Indonesia khususnya berasal Toraja, yang berpotensi sebagai antioksidan dan antikanker dengan adanya kandungan senyawa fenolik dan flavanoid. Penelitian ini bertujuan untuk melihat flavonoid total serta aktivitas antioksidan dan toksisitas ekstrak daun karamunting. Simplisia daun karamunting diekstraksi dengan metode maserasi menggunakan etanol 70%, pengujian aktivitas antioksidan diukur menggunakan microplet reader dan diuji toksisitasnya dengan metode BSLT. Hasi penelitian fenolik total 3,496% , Perolehan aktivitas antioksidan nilai IC50 ekstrak etanol daun karamunting sebesar 24,451 bpj dan Perolehan uji toksisitas nilai IC50 ekstrak etanol daun karamunting sebesar 31,80 bpj terhadap larva udang. Berdasarkan hasil tersebut, ekstrak etanol daun karamunting masuk dalam kategori antivitas sangat kuat dengan range <50 % dan dinilai memiliki sifat toksisitas katogori sangant kuat.
Penyuluhan Peran Remaja dalam Mencegah Stunting Melalui Siaran RRI Pro 1 Cirebon Kerja Sama dengan Pimpinan Daerah Aisyiyah Kabupaten Cirebon Marwati Marwati; Sofiyati Sofiyati
Jurnal Kabar Masyarakat Vol. 3 No. 2 (2025): JURNAL KABAR MASYARAKAT
Publisher : Institut Teknologi dan Bisnis Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54066/jkb.v3i2.2974

Abstract

Stunting is a chronic nutritional problem that has a broad impact on children's physical and cognitive development, and contributes to the intergenerational cycle of malnutrition. Teenagers have a strategic role in preventing stunting because they are future parents. This community service activity aims to increase teenagers' knowledge about stunting, the importance of balanced nutrition, as well as risk factors and prevention of stunting. Counseling was carried out via broadcast on RRI Pro 1 Cirebon in collaboration with the Aisyiyah Regional Leadership of Cirebon Regency. The methods used include lectures and question and answer sessions guided by radio broadcasters. The results of the activity show an increase in teenagers' understanding of healthy lifestyles and the importance of balanced nutrition in preventing stunting. Through their role as agents of change, teenagers are expected to be able to disseminate information and contribute to creating a healthier and more productive generation. Involving teenagers in efforts to prevent stunting is a strategic step in improving the quality of public health in a sustainable manner.
Pengaruh Dukungan Sosial, Pengetahuan Ibu Menyusui Terhadap Perilaku Pemberian Air Susu Ibu (ASI) Eksklusif Tahun 2021 di Puskesmas Jombang Kota Cilegon Mitsalina Durrah Judaty; Marwati Marwati; Nuria Fitri Adista
Jurnal Ventilator Vol. 1 No. 1 (2023): Maret : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v1i1.339

Abstract

Breast milk contains various nutrients needed in the process of growth and development of infants. Exclusive breastfeeding, namely that babies are only given breast milk, without any liquid or solid food except vitamins, minerals or drugs in the form of drops or syrup until the age of 6 months. The main obstacle to achieving correct exclusive breastfeeding is the lack of proper knowledge about exclusive breastfeeding for mothers. Objective: A mother must have good knowledge of breastfeeding. The purpose of this study was to reveal the effect of social support on exclusive breastfeeding behavior, the influence of knowledge of breastfeeding mothers on exclusive breastfeeding behavior, as well as the effect of social support, knowledge of breastfeeding mothers on exclusive breastfeeding behavior. Methods: The research method used is quantitative, namely cross sectional analytic survey method. Results:The results of the analysis show that first, the direct effect of social support on exclusive breastfeeding behavior is 34.6% and the remaining 63.4% is influenced by other variables. Second, the effect of social support on the knowledge of breastfeeding mothers is 11.8%, the remaining 88.2% is influenced by other variables. Third, the effect of knowledge of breastfeeding mothers on exclusive breastfeeding behavior is 9.9% and the remaining 90.1% is influenced by other variables. Conclusion: this study is the influence of social support, knowledge of breastfeeding mothers on behavior of giving exclusive breast milk.
Pemanfaatan Daun Kelor untuk Gizi Seimbang pada Anak di Desa Mandalahaji Kecamatan Pacet Kabupaten Bandung Tahun 2025 Maria Octavianti; Bekti Handayani; Marwati Marwati; Trijani Moedjiherwati
Natural: Jurnal Pelaksanaan Pengabdian Bergerak bersama Masyarakat. Vol. 3 No. 4 (2025): November : Natural: Jurnal Pelaksanaan Pengabdian Bergerak bersama Masyarakat
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/natural.v3i4.1806

Abstract

The 2021 Indonesian Nutritional Status Survey (SSGI) shows that 1 in 4 Indonesian children suffers from stunting and 1 in 10 children suffers from malnutrition. Good nutrition is a crucial foundation for optimal growth and development, especially for those growing up in vulnerable environments. According to the WHO, stunting is a failure of growth and development experienced by children due to prolonged inadequate nutritional intake, recurrent infectious diseases, and inadequate psychosocial stimulation. However, on the other hand, children who experience stunting are usually accompanied by developmental delays in various other organs, especially if malnutrition occurs during the first 1000 days of life (HPK). Stunting is defined as a child's length for age (PB/A) or height for age (H/A) that is lower than -2 standard deviations. Therefore, a child with stunting is definitely stunted, but a child who is stunted is not necessarily stunted. Stunting that occurs before a child is 2 years old is an indication of decreased cognitive abilities at a later age if not followed by adequate psychosocial stimulation, thus impacting academic or educational abilities later in life. Providing innovative education such as making moringa pudding is one way to present nutritious and creative food or drinks so that it can be accepted by kindergarten mothers who have toddlers and preschoolers. The content of moringa leaves is a food ingredient that has good nutritional value, especially for preventing stunting in children.
Penyuluhan Kesehatan Gizi sebagai Upaya Pencegahan Osteoporosis pada Lansia di Kalangan Ibu-Ibu Aisyiyah Kabupaten Cirebon Marwati Marwati; Sofiyati Sofiyati
Nusantara: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2026): Februari: NUSANTARA Jurnal Pengabdian Kepada Masyarakat
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/nusantara.v6i1.7932

Abstract

The increasing proportion of the elderly population in Indonesia has led to a rise in degenerative health problems, one of which is osteoporosis. Osteoporosis is a bone disease characterized by decreased bone density, increasing the risk of fractures, particularly among elderly women. Low calcium intake, lack of physical activity, and limited knowledge regarding osteoporosis prevention are major contributing factors. This community service activity aimed to improve the knowledge of Aisyiyah women in Cirebon Regency regarding osteoporosis in the elderly, including its definition, risk factors, impacts, and prevention strategies through proper nutrition and regular physical activity. The activity was conducted from October to December at the Aisyiyah Study Hall in Cirebon Regency, targeting pre-elderly and elderly women. The methods used included health education through lectures and interactive question-and-answer sessions, supported by laptops, LCD projectors, and PowerPoint presentations. Evaluation of participants’ knowledge was carried out using oral pre-tests and post-tests related to the delivered material. The results indicated an improvement in participants’ understanding of osteoporosis, the importance of adequate calcium intake, and the role of physical activity in maintaining bone health. This community service program is expected to contribute to increasing health awareness and reducing the risk and prevalence of osteoporosis among the elderly.
Penyuluhan Kesehatan Manfaat Pemberian ASI untuk Pencegahan terjadinya Stunting pada Anak Kepada Ibu-Ibu Pengajian Aisyiyah Cabang Klangenan Kabupaten Cirebon Marwati Marwati; Sofiyati Sofiyati
Jurnal Informasi Pengabdian Masyarakat Vol. 4 No. 2 (2026): Mei :Jurnal Informasi Pengabdian Masyarakat
Publisher : Institut Nalanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47861/jipm-nalanda.v4i2.2179

Abstract

Stunting remains a major chronic nutritional problem in Indonesia, as it affects physical growth, cognitive development, and the quality of human resources in the future. One effective strategy to prevent stunting is the provision of exclusive breastfeeding during the first six months of life as part of interventions in the first 1,000 days of life. This community service activity aimed to improve the knowledge of mothers in the Aisyiyah Islamic study group, Klangenan Branch, Cirebon Regency, regarding the importance of breastfeeding, adequate nutrition, and the role of the first 1,000 days of life in preventing stunting in children. The method used was health education through lectures, discussions, and question-and-answer sessions. The results showed an increase in participants’ understanding of the benefits of exclusive breastfeeding, appropriate infant feeding practices, and the importance of fulfilling nutritional needs from pregnancy until the child reaches two years of age. With improved maternal knowledge, positive behavioral changes in breastfeeding practices and child nutrition are expected. This activity contributes to promotive and preventive efforts to reduce stunting rates, particularly in Cirebon Regency.