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Journal : Bulletin of Electrical Engineering and Informatics

Profiling DNA Sequence of SARS-Cov-2 Virus Using Machine Learning Algorithm Lailil Muflikhah; Muh. Arif Rahman; Agus Wahyu Widodo
Bulletin of Electrical Engineering and Informatics Vol 11, No 2: April 2022
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/eei.v11i2.3487

Abstract

Corona virus disease-19 (COVID-19) is growing rapidly because it is an infectious disease. This disease is caused by a virus belonging to the type of DNA virus with very diverse genetics. This study proposes a feature extraction method using k-mer to obtain nucleotide frequencies in protein coding. In profiling viral DNA sequences, this study proposes to obtain similarity by country using hierarchical k-means, where the results are averaged by the hierarchical clustering method and then find the initial cluster center. The experimental results show that the silhouette, purity, and entropy are 0.867, 0.208, and 0.892, respectively. Then, we apply the Gini index feature selection to find the important components as characteristics in each country. The selected components are implemented using the ensemble method, Random Forest, to evaluate their performance. The experimental results showed high performance, including sensitivity, accuracy, specificity, and area under the curve (AUC).
Co-Authors A Alfan Jauhari Abdullah Hamid Agi Putra Kharisma, Agi Putra Agus Wahyu Widodo Agus Wahyu Widodo, Agus Wahyu Aida Sartimbul Ali Muntaha Andi Khofifah Nurfadillah Andreas Pardede Arief Andy Soebroto Bagus Priambodo Berton, Freddy Toranggi Citra Satrya Utama Dewi Daduk Setyohadi Darmawan Ockto Sutjipto Debby Aranindy Putri Wangi Defri Yona Dewa Gede Raka Wiadnya Dewa Gedhe Raka Wiadnya Dian Eka Ratnawati Edy Santosa Eko Sulkhani Yulianto Farys, Sholeh Al Fawwaz Haryono, M. Naufal Feni Iranawati Fransisca Sariuli Tobing Fransiskus Cahyadi Putra Pranoto Gatut Bintoro Geoffrey Manurung, Daniel Iis Nur Rodliyah, M.Ed Imam Cholissodin Imam Subali Jonemaro, Eriq Muhammad Adams Juan, Patrick Kurnianingtyas, Diva Lailil Muflikhah Ledhyane Ika Harlyan Mihrobi Khalwatu Rihmi Mr Sunardi Muhammad Rafi Farhan Nanda Dwi Putra Miskarana Ade Nindi Nur Wulandari Nita Hellis Setyowati Novanto Yudistira Nugroho, Muhammad Alifyan Satrio Nurin Hidayati Nurin Hidayati Prakoso, Gideon Aji Pramana Putra, Jody Priyanka Mondal Putra Pandu Adikara Putri, Safinatunnajah Mutiara Rahmansyah, Muhammad Dzikri Riska Oktaviana Rr Dea Annisayanti Putri Safitri Widya Ningtias Shobriyyah Afifah Nabilah Shofiatul Kholishoh Solimun, Solimun Sunardi Sunardi Sunardi, Sunardi Supapong Pattarapongpan SUTRISNO Syarifah Hikmah Julinda Sari Syarifah Hikmah Julinda Sari Syarifah Hikmah Julinda Sari Tri Djoko Lelono Tsania Humairoh Vita Rumanti Kurniawati Wahida Kartika Sari Wakhit Rhomadona Wayan Firdaus Mahmudy