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All Journal Jurnal Surya Medika Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Reswara: Jurnal Pengabdian Kepada Masyarakat Indonesia Berdaya Borneo Journal Of Pharmascientech Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Farmasis: Jurnal Sains Farmasi Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Journal of Pharmaceutical Care and Sciences Sains Medisina
Noval Noval
Universitas Sari Mulia
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Journal : Jurnal Surya Medika

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Pengaruh Kombinasi Polimer Polivinil Pirolidon dan Etil Selulosa terhadap Karakteristik dan Uji Penetrasi Formulasi Transdermal Patch Ekstrak Bawang Dayak (Eleutherine palmifolia (L) Novia Novia; Noval Noval
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2653

Abstract

The transdermal patch can deliver the active substance with good bioavailability, then made formulations of such preparations from dayak onion extract, which has a compound content of flavonoids, with a combination of polymer PVP K30 and ethyl cellulose to produce transdermal patches with good physical evaluation and penetration. The research aims to carry out the effect and ideal formulation of transdermal patches of dayak onion extract with a combination of polymers PVP K30 and ethyl cellulose based on physical evaluation and penetration—manufacture of transdermal patches using the solvent evaporation method. Physical evaluation includes organoleptic testing, weight uniformity, thickness, folding resistance, and moisture testing. Then evaluate the penetration of the active substance using Franz diffusion cells. Analyze data with One Way ANOVA. The physical evaluation results of weight uniformity, patch thickness, folding resistance, and moisture test of transdermal patches on F1, F2, F3, and F4 meet the requirements. As for the results of penetration tests, F1, F2, F3, and F4 can be penetrated from 120 minutes to 180 minutes with the concentration of active substances that are linearly penetrated. The combination of polymers PVP K30 and ethylcellulose has affected the physical evaluation of transdermal patches of dayak onion extract. Based on the physical evaluation and penetration test in vitro obtained, the most optimal formula results are F3 with comparison PVP K30 and ethyl cellulose (100:300).
Uji Aktivitas Teh Celup Fraksi Metanol Rimpang Temu Mangga (Curcuma mangga Valeton and Zijp) sebagai Antihiperlipidemia Dyan Fitri Nugraha; Noval Noval; Kunti Nastiti
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.3199

Abstract

The high number of deaths from cardiovascular disease in the world makes cardiovascular drugs, such as antihyperlipidemic or dyslipidemia often used by patients in the whole world. Statins are first-line drugs that are often used, but have various side effects, such as myalgia, rhabdomyolysis, and are considered to trigger diabetes mellitus. Meanwhile, the use of traditional medicines such as the Temu mangga’s rhizome (Curcuma mangga Valeton and Zijp) is often used by the community as antihyperlipidemic therapy. The purpose of this study was to scientifically prove the antihyperlipidemic activity of teabags from the methanol fraction of Temu Mangga’s rhizome in reducing lipid profiles, namely total cholesterol, triglycerides, and LDL, as well as increasing HDL. This research method is experimental by measuring the parameters of total cholesterol, triglycerides, LDL, and HDL as well as the bodyweight of the test animals as additional parameters. The test group was divided into 3 doses, namely 0.35 mg, 0.7 mg, and 1.4 mg per 200 grams of test animals. The results showed that there was no significant difference between all groups, both in lipid profile and bodyweight of the test animals. However, a dose of 1.4 mg had better triglyceride lowering activity than the positive control, and the activity of the methanol fraction of the Temu Mangga’s rhizome was predicted to be similar to statins.
Formulasi dan Evaluasi Tablet Effervescent dari Ekstrak Buah Tampoi (Baccaurea macrocarpa) Ika Avrilina Haryono; Noval Noval
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.3201

Abstract

Tampoi is one of the many plants found in East Kalimantan, has secondary metabolic content in the form of saponins, flavonoids, and alkaloids, and has antioxidant activity. The antioxidants produced by the human body are not sufficient to fight free radicals, therefore the body requires the intake of antioxidants from the outside, so to help increase public interest in consumption, researchers are interested in making preparations in the form of extracts and formulated as effervescent tablets from tampoi fruit extract which are useful as antioxidants and increase immunity. The purpose of this study was to determine a good formula for making effervescent tablets from tampoi fruit extract with variations of PVP K30 as a binder. Making tablets using direct compression method with an evaluation of effervescent powder including the angle of repose test, flow rate, setting, compressibility, and moisture of the powder. Evaluation of effervescent tablets included organoleptic test, weight uniformity test, tablet friability test, tablet hardness test, and tablet dissolving time test. The results obtained in the evaluation of the effervescent powder, the angle of repose test has met the requirements, while the test for flow velocity, sizing, compressibility, and moisture of the powder has not met the requirements. The results of the physical evaluation of the tablet weight uniformity test on F1 and F2 were in accordance with the requirements, the tablet friability test on F3 and F4 had met the requirements, the F3 tablet hardness test had met the requirements, and the tablet dissolving time test resulted that all formulas met the requirements with the best formula namely F1 which has the fastest tablet dissolution time. The conclusion of the study from the evaluation of the dissolving time which is the main parameter of the effervescent tablet preparation of tampoi fruit extract, the best formula was obtained, namely F1 with a PVP K30 concentration of 0.5 mg resulting in a tablet dissolving time of 01.99 minutes.
Penggunaan Tanaman Sebagai Obat pada Masyarakatan Suku Banjar, Dayak, dan Bugis di Kalimantan Selatan: The Use of Plants as Medicine in the People of Banjar, Dayak, and Bugis Tribes in South Kalimantan Melviani Melviani; Rohama Rohama; Noval Noval
Jurnal Surya Medika (JSM) Vol. 8 No. 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i2.3882

Abstract

The development of science and technology in the development of pharmaceutical products that are going fast does not make society switch completely to modern medicine; it can be seen from how some of society for generations still utilize the potential of plants for treatment. This research is useful to find out the picture of plants used as medicine in the Banjar Tribe, Dayak Tribe, and Bugis tribe in South Kalimantan. This research method is an observational research design with a cross-sectional approach, using convenience sampling techniques. The results obtained there are 44 types of plants used, with the largest percentage being ginger which serves as body warmth and guava to treat stomach pain (12.0%), betel leaves to reduce body odor (9.0%), turmeric, Dutch jackfruit leaves or soursop leaves and cat whiskers (5.0%), sungkai (4.0%), bay leaves (3.0%) and other plants with a percentage (45%). The type of plant used is herbaceous (40.0%). The largest part of the plant is the leaves (55.0%) processed by boiling (65.0%).
Karakterisasi dan Formulasi Nanopartikel Ekstrak Tanaman Bundung (Actinoscirpus grossus) dengan Variasi Konsentrasi Basis Kitosan dan Na-TPP Menggunakan Metode Gelasi Ionik: Characterization and Formulation of Nanoparticles Extract of Bundung Plant (Actinoscirpus grossus) with Variations in Concentration of Chitosan and Na-TPP Bases Using the Ionic Gelation Method Yuditha Mutia Windy; Khaliza Natasya Dilla; Jesika Claudia; Noval Noval; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.4495

Abstract

Bundung plant extract contains flavonoid secondary metabolite compounds that have the potential to kill Staphylococcus aureus bacteria and inhibit the fungus Candida albicans. Its utilization uses nanoparticle technology because the ability to penetrate cell walls can be penetrated by the size of colloidal particles. Nanoparticles are technologies that have a size of 10-1000 nm. The formation of nanoparticles using chitosan polymer and Na-TPP can produce preparations with good stability. This study aims to determine the characterization and formulation of nanoparticles and the effect of the concentration of chitosan and Na-TPP on the characterization of nanoparticles of plant extracts. This research is an experimental laboratory with a quasi-experimental design method and a one-group posttest-only research design. Bundung plant extracts formulated into nanoparticles with various concentrations of formula 1 (chitosan 0.1% and Na-TPP 0.2%), formula 2 (chitosan 0.15% and Na-TPP 0.15%), and formula 3 (chitosan 0.2% and Na-TPP 0.1%). Then organoleptic and characterization tests were carried out in particle size tests, zeta potential, and data were analyzed by ANOVA. All formulas showed nanoparticle size. The results of the nanoparticle characterization of the extract of the Bundung plant showed that F2 was the formula with the smallest particle size of 328.8 nm, but for the zeta potential value, the stable formula was F3 because it had a zeta potential value close to +/-30mV, i.e., 10.4mV. The statistical results of One Way ANOVA show that the significance value is <0.05, which means that there is an effect of variations in the concentration of chitosan and Na-TPP. Variations in the concentration of chitosan and Na-TPP in each formula can affect the particle size and zeta potential value.
Optimasi Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Kalangkala (Litsea angulata) sebagai Antioksidan Menggunakan Metode SLD (Simplex Lattice Design): Optimization of Effervescent Tablets Formulation From Ethanol Extract of Kalangkala Plant (Litsea angulata) as Antioxidant Using SLD (Simplex Lattice Design) Method Rohama Rohama; Melviani Melviani; Noval Noval
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.4496

Abstract

Free radicals trigger various diseases, such as respiratory disorders and cancer. Aware of the bad potential of free radicals, many people consume antioxidants to tackle free radicals. One of them is Kalangkala Plant (Litsea angulata), which contains flavonoids. The potential of Kalangkala plants as antioxidants is formulated in effervescent tablets. The effervescent tablet was evaluated using the Simplex Lattice Design (SLD) method to determine the most optimal formulation. The results showed that the most optimal preparation from the evaluation of powders was F2, while the results of the evaluation of tablets using the SLD method were the most optimal was F3. In addition, the antioxidant activity test using the DPPH method showed that Kalangkala Leaf extract had strong antioxidant activity.
Karakterisasi Nanokapsul Ekstrak Daun Serunai (Chromolaena odorata L.) dengan Variasi Kitosan-Alginat Menggunakan Metode Emulsi-Difusi: Characterization of Nanocapsules of Serunai Leaf Extract (Chromolaena odorata L.) with Chitosan-Alginate Variations Using the Emulsion-Diffusion Method Roosma Hatmayana; Noval Noval; Dede Mahdiyah; Rizki Adhie Ramadhani; Nurul Auliyani
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.4512

Abstract

Serunai (Chromolaena odorata L.) is a plant that has been widely used in medicine, one of which is as an antidiabetic. But treatment using plant extracts has drawbacks to the solubility of the active substance and its bioavailability in the body. Nanocapsules are one of the systems in particle technology that can solve this problem by utilizing a polymer that will encapsulate the active substance and release it slowly at the intended target. To achieve this, the manufacture of nanocapsules must meet several characteristic requirements such as particle size, potential zeta, absorption efficiency, and emulsion stability. This study was conducted to identify the nanocapsules characteristics of Serunai leaf extract (Chromolaena odorata L.) with chitosan-alginate variations and identify the influence of chitosan-alginate variations on the characteristics of nanocapsules. This study is a laboratory experimental study with a one-group posttest-only design. The manufacture of Serunai leaf extract nanocapsules using the emulsion-diffusion method, which is then characterized including particle size determination, potential zeta determination, absorption efficiency test (%EE), and emulsion stability test. The results obtained from the determination of the particle size of Formula I 196.4 nm, Formula II 264.2 nm, and Formula III 207.4 nm, potential zeta Formula I -36.1 mV, Formula II -40.1 mV, and Formula III -36.5 mV, the formula I %EE values 99.7%, Formula II 99.8%, and Formula III 99.7%, as well as all formulas indicating the emulsion type m/a. Three formulas have met the requirements of nanocapsules characteristics. The formula is best obtained in Formula II with a chitosan concentration of 0.3% and alginate of 0.6%, so chitosan-alginate variations influence the characteristic results.
Pengaruh Perbedaan Jenis Pelarut Terhadap Kadar Flavonoid Total Ekstrak Daun Sirsak (Annona muricata L.): The Effect of Different Types of Solvents on Total Levels of Flavonoid Extract (Annona muricata L.) Ni Ketut Linda Puspa Yani; Kunti Nastiti; Noval Noval
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5131

Abstract

One of the plants that is efficacious to prevent a disease is the leaf Annona muricata L. This plant contains contains saponins, terpenoids, steroids, flavonoids, tannins and alkaloids. Compounds that have the most role in causing pharmacological effects are flavonoid compounds as a source of antioxidants. The level of polarity of the solvent in the study will affect the content of the compound extracted based on the principle of like dissolves like. This study was conducted to determine the total flavonoid content at different levels of solvent types and the effect of different solvents of 96% ethanol, ethyl acetate and n-hexane on total flavonoid content. In addition, qualitative tests were carried out to determine the flavonoid compounds. The type of research used is pre-experimental, extraction with controlled maceration method of temperature, light, length of time and stirring. Qualitative analysis with color correction test and Thin Layer Chromatography. Assay using UV-Vis spectrophotometry. The results of the research on identification by color test and Thin Layer Chromatography on the extract Annona muricata L. using 96% ethanol, ethyl acetate and n-hexane as solvents were positive for flavonoids and the results of the determination of flavonoid levels in each solvent were 68,9048 mgQE/g, 97,2381 mgQE /g and 73,6667 mgQE/g. ANOVA statistical analysis in each group had a significant difference with p= <0.001 (<0.05). Flavonoid compounds are influenced by the level of solvent polarity, there are significant differences between treatment groups with different types of solvents on total flavonoid levels. The highest flavonoid content was found in ethyl acetate followed by n-hexane and 96% ethanol.
Optimasi Formulasi Tablet Lepas Lambat Ekstrak Seledri (Apium graveolens L.) Menggunakan Polimer Xanthan Gum dan Lubrikan Magnesium Stearat dengan Metode Simplex Lattice Design (SLD): Optimization of Celery Extract (Apium graveolens L.) Sustained Release Tablet Formulation Using Xanthan Gum Polymer and Magnesium Stearate Lubricant with Simplex Lattice Design (SLD) Method Nur Azizah; Noval Noval; Putri Vidiasari Sudarsono
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5165

Abstract

Antihypertensive drugs undergo first-pass metabolism and therefore have low oral bioavailability. It causes an increase in the frequency of drug use and concentration fluctuations that affect patient comfort. The sustained release tablet formulation was chosen because it can deliver the active substance with good bioavailability. An active antihypertensive substance that can be used is celery extract because it contains flavonoids, so a sustained release tablet formulation was made using xanthan gum and magnesium stearate to produce a constant and controlled release rate. This study aims to knowing the results of celery extract sustained release tablet evaluation using different concentrations of xanthan gum and magnesium stearate, and also obtains the optimal formulation. The manufacture of tablets uses the direct compression method. Powder evaluations include flow property through a funnel, angle of repose, compressibility index, and moisture content. Tablet evaluations include organoleptic, weight uniformity, size uniformity, hardness, friability, disintegration time, and dissolution tests. The evaluation results data were analyzed using Simplex Lattice Design. The powder evaluation result of all formulations meets the requirements of flow property through a funnel, angle of repose, compressibility index, and moisture content. Physical evaluation of the tablets shows all formulations meet the requirement of weight uniformity, hardness, and friability tests. On the size uniformity test, all formulations do not meet the requirement. The disintegration time test results show that F1 does not meet the requirement. Meanwhile, the dissolution test results show that F4 is the best formula because it shows constant and controlled release rate. Based on analyzed using Simplex Lattice Design, the F4 is the most optimal formula with xanthan gum 52 mg and magnesium stearate 3 mg.
Co-Authors Adam Ferdian Sigit Pratama Ahmad Faisal Ali Rakhman Hakim Amalia Safitri Bayu Nugraha Dahlia Syahrina Darini Kurniawati Darini Kurniawati Dede Mahdiyah Deni Setiawan Dyan Fitri Nugraha Dyan Fitri Nugraha Faisal Rahman Giovanni Ulima Nibras Giovanni Gunawan Gunawan Haryono, Ika Avrilina Husda Oktaviannoor Ilham Kuncahyo, Ilham Iwan Yuwindry Jesika Claudia Khaliza Natasya Dilla Khusnul Berty Indartantri Kunti Nastiti Kunti Nastiti Liling tryasmono M. al Gifari Martinah Martinah Melviani Mia Audina Nadya Novianty Ni Ketut Linda Puspa Yani Novia Novia Nur Azizah Nur Hidayah Nurul Auliyani Onny Ziasti Fricillia Putri Vidiasari Darsono Rahmadani Rahmadani Raihana Raihana Raihanah Raihanah Rizka Appriliani Rizki Adhie Ramadhani Rohama Rohama Roosma Hatmayana Rosyifa Rosyifa Safti Aryzki Samsul Hadi Sept Enno Putri Setia Budi Siti Malahayati Siti Malahayati Syafira Nabillah Syafira Nabillah Tumanggor, Agustina Hotma Uli Tuti Alawiyah Wijaya, Eka Setya Yuditha Mutia Windy Yulia Puteri Rahmida Yusri Yusri