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All Journal Berkala Kedokteran Jurnal Surya Medika Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat JURNAL PENDIDIKAN MIPA Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Riset Kefarmasian Indonesia Science Midwifery International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Reswara: Jurnal Pengabdian Kepada Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indonesia Berdaya Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Journal of Pharmaceutical Care and Sciences Sains Medisina International Journal of Health Science
Kunti Nastiti
Universitas Sari Mulia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Pelarut Etanol 70% Dan Metanol Terhadap Kadar Flavonoid Total Ekstrak Daun Sirsak (Annona muricata Linn): Pengaruh Pelarut Etanol 70% Dan Metanol Terhadap Kadar Flavonoid Total Ekstrak Daun Sirsak (Annona muricata Linn) Juliance Yolanda Putri; Kunti Nastiti; Nurul Hidayah
Jurnal Pelayanan Kefarmasian dan Sains Vol 3 No 2 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v3i2.235

Abstract

Background: Annona muricata leaf are empirically used to treat a wide variety of diseases. One of the potentials of leaf as antioxidants because they contain flavonoid compounds. This study used a polar solvent, ethanol 70% and methanol to extract flavonoid compounds in leaf, the use of different types of solvents will affect the total flavonoid levels produced. Objective: Knowing the effect of differences in the type of solvent ethanol 70% and methanol on the total flavonoid levels of leaves and qualitative detection of flavonoid compounds. Methods: The study used a pre-experimental method, making Annona muricata leaf extract using the maceration method by comparing 70% ethanol solvent and methanol then flavonoid compounds were detected qualitatively using color reagents and thin layer chromotreography then determination of flavonoid levels with UV-Vis Spectrophotometry and data analyzed with the One Way Anova test. Results: The results of the qualitative detection test showed positive results of flavonoid compounds and the total flavonoid levels produced by ethanol extract were 70% and methanol were 6.79 mg QE / g and 9.25 mg QE / g. The results of the One Way Anova test analysis showed that the difference in the type of solvent had a significant effect on the total flavonoid levels of Annona muricata leaf extract. Conclusion: Differences in solvent types have a significant effect on the total flavonoid levels of Annona muricata leaf extract with the highest levels produced by methanol solvents of 9.25 mg QE/g.
Uji Aktivitas Antibakteri Fraksi N-Heksan Kayu Bajakah (Uncaria tomentosa) Terhadap Bakteri Escherichia coli: Uji Aktivitas Antibakteri Fraksi N-Heksan Kayu Bajakah (Uncaria tomentosa) Terhadap Bakteri Escherichia coli Firda Nirmalasari; Kunti Nastiti; Mia Audina
Jurnal Pelayanan Kefarmasian dan Sains Vol 3 No 2 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v3i2.239

Abstract

Background: Diarrhea is an infectious disease which is still the highest case in Indonesia. Drug therapy currently used as the drug of choice in diarrheal diseases is chloramphenicol class of antibiotics. It is known that treatment using chemicals is more prone to causing unwanted side effects. To deal with this problem, efforts need to be made in the form of exploring the latest therapies to kill bacteria. New therapeutic sources that can be found from plants that have the potential as antibacterial. Objective: This study aimed to determine the antibacterial activity of the n-hexane fraction in the extract of bajakah wood (Uncaria tomentosa) by testing its inhibition and killing power by observing the minimum inhibition and minimum killing of Escherichia coli bacteria. Methods: This study used a true experimental type of research in the manufacture of extracts using the maceration method and the antibacterial activity test method used the disc diffusion method and continued with the dilution method with concentrations of 100,50,25,12,5, and 6,25 ppm and the inhibition concentration was determined. minimum and minimum kill concentration. Analysis of this data using the Kruskal-Wallis and Mann Whitney test. Results: The results of the antibacterial activity of the n-hexane fraction of bajakah wood (Uncaria tomentosa) against Escherichia coli bacteria with an inhibition zone of 7.72 mm. The results of the analysis showed that there was a significant difference with a p value of 0.005 at Kruskal-Wallis and at Mann Whitney showing a p value of 0.05. minimum inhibitory concentration (MIC) showed clarity at a concentration of 50 ppm. Conclusion: The n-hexane fraction of pirated wood against Escherichia coli bacteria has a minimum inhibitory concentration (MIC) at a concentration of 50 ppm. However, it does not have a minimum kill concentration (MKC).
Pengetahuan Masyarakat Terhadap Tanaman Obat Keluarga (TOGA) di Kelurahan Pemurus Luar : Pengetahuan Masyarakat Terhadap Tanaman Obat Keluarga (TOGA) di Kelurahan Pemurus Luar Ghina Zhahera; Melviani Melviani; Kunti Nastiti
Jurnal Pelayanan Kefarmasian dan Sains Vol 3 No 2 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v3i2.253

Abstract

Background: The development of knowledge in the medical field that gave birth to various types of drugs containing chemicals, public confidence in the ability of herbal medicines is decreasing. One of the factors that causes the loss of public confidence in the efficacy of traditional medicines is the loss of knowledge about traditional medicines owned by the ancestors of the Indonesian nation. Knowledge about this family medicinal plant needs to be continuously developed so that the process of creating knowledge continues among the community groups that develop it. Objective: To know the public's knowledge of Family Medicinal Plants (TOGA). Methods: Descriptive research with Univariate analysis. Sampling with purvosive sampling technique. The sample of the study was 97 respondents. data obtained from questionnaires distributed to the public. Results: Community knowledge on the types of family medicinal plants 49% in good category, about the benefits of family medicinal plants 84% ​​in good category, about processing methods for family medicinal plants 45% in good category, and community on how to use family medicinal plants 48% quite good category. The use of family medicinal plants in the community there are 27 family medicinal plants. Conclusion: Public knowledge of family medicinal plants in Pemurus Luar Village is on average with good knowledge. Keywords : Knowledge, Family Medicinal Plants
Activity predication of rhodomyrtus tomentosa (Aiton) hassk against ace1 inhibitors Samsul Hadi; Kunti Nastiti
Science Midwifery Vol 11 No 2 (2023): June: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i2.1271

Abstract

ACE is a peptidyl-dipeptidase enzyme that catalyzes the conversion of substrates from angiotensin I to angiotensin II. These changes cause constriction of blood vessels so that blood pressure increases (hypertension), so This study aims to find compounds that have the potential to reduce blood pressure through the pathway of ACE1 enzyme inhibition. The method used is docking, the material used is a compound contained from Rhodomyrtus tomentosa and. The ACE1 protein was obtained from RCSB with the code 1UZF. The equipment used was an online pass webserver, PLNTS software and discovery studio. This research was started by redocking the native ligand to determine the coordinates and radius, followed by validating the docking results. The results of the early stage screening obtained 4 compounds with a threshold value above 0.3, these four compounds were continued with the docking test. The docking scores obtained were Afrormosin (-59.620); Pedunculagin (-45.205); Tomentosine (-70.986); Desgalloylstachyurin (-54.374). The conclusion obtained is that the Tomentosine compound binds most easily to ACE1
Pengaruh Perbedaan Jenis Pelarut Terhadap Kadar Flavonoid Total Ekstrak Daun Sirsak (Annona muricata L.): The Effect of Different Types of Solvents on Total Levels of Flavonoid Extract (Annona muricata L.) Ni Ketut Linda Puspa Yani; Kunti Nastiti; Noval Noval
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5131

Abstract

One of the plants that is efficacious to prevent a disease is the leaf Annona muricata L. This plant contains contains saponins, terpenoids, steroids, flavonoids, tannins and alkaloids. Compounds that have the most role in causing pharmacological effects are flavonoid compounds as a source of antioxidants. The level of polarity of the solvent in the study will affect the content of the compound extracted based on the principle of like dissolves like. This study was conducted to determine the total flavonoid content at different levels of solvent types and the effect of different solvents of 96% ethanol, ethyl acetate and n-hexane on total flavonoid content. In addition, qualitative tests were carried out to determine the flavonoid compounds. The type of research used is pre-experimental, extraction with controlled maceration method of temperature, light, length of time and stirring. Qualitative analysis with color correction test and Thin Layer Chromatography. Assay using UV-Vis spectrophotometry. The results of the research on identification by color test and Thin Layer Chromatography on the extract Annona muricata L. using 96% ethanol, ethyl acetate and n-hexane as solvents were positive for flavonoids and the results of the determination of flavonoid levels in each solvent were 68,9048 mgQE/g, 97,2381 mgQE /g and 73,6667 mgQE/g. ANOVA statistical analysis in each group had a significant difference with p= <0.001 (<0.05). Flavonoid compounds are influenced by the level of solvent polarity, there are significant differences between treatment groups with different types of solvents on total flavonoid levels. The highest flavonoid content was found in ethyl acetate followed by n-hexane and 96% ethanol.
Autentikasi Bunga R.tomentosa dari Resiko Adulterasi M. Candidum dengan Metode Spektrofotometri UV-VIS Kombinasi Khemmometrik: Authentication of R.tomentosa Flowers From the Risk of M. Candidum Adulteration Using Chemometric Combination UV-VIS Spectrophotometry Method Samsul Hadi; Kunti Nastiti
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5140

Abstract

R. tomentosa flowers have various activities and these activities are different from M. candidum flowers, but have similar flowers so the risk of mixing is very high. Therefore, this study aims to prevent the occurrence of mixtures using UV-VIS spectrophotometry method combined with chemometrics. The method used in this study was the extracts of the two species were dissolved with methanol p.a and scanned the spectra at a wavelength of 200-400 nm, data analysis using partial least squares. The results obtained in the authentication of Bunga R.tomentosa produced various models, at 248.14-222.5 nm scanning resulted in data RMSEC: 2.61, R2: 0.9971, RMSEP:5.78, R2: 0.9951 and RMSECV:9.19, R2: 0.9655, On scanning 298.43- 56.36nm produces data RMSEC:0.929, R2: 0.9996, RMSEP:3.54, R2: 0.9956 and RMSECV:10.5,R2:0.9591, by looking at the two data, the lowest RMSE value and the highest R2 value are selected. The conclusion in this study is that the best model for R.tomentosa authentication is the second derivatization with a wavelength of 298.43-256.36nm.
Aktivitas Anti Dislipidemia Ekstrak Etil Asetat Rimpang Temu Mangga (Curcuma mangga Valeton and Zijp): Antidyslipidemic Activity of Ethyl Acetate Extract of Temu Mangga Rhizome (Curcuma mangga Valeton and Zijp) Dyan Fitri Nugraha; Kunti Nastiti; Rahmayani Rahmayani
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5193

Abstract

Statins are first-line drugs that are often used in the treatment of cardiovascular disease. It is noted that statins have various side effects, such as myalgia, rhabdomyolysis, and are considered to trigger diabetes mellitus. Meanwhile, the use of natural ingredients such as the rhizome of Intersection mango (Curcuma mango Valeton and Zijp) is often used empirically by the community in the treatment of dyslipidemia. The purpose of this study was to determine the effectiveness of anti-dyslipidemia and the dose of ethyl acetate extract of the temu mango rhizome which was effective as anti-dyslipidemia. This research method is a true experimental design with a pre-post test with control group on test animals with 5 test groups induced by cooking oil for 14 days, then given treatment for 14 days. Measurement of total cholesterol, triglyceride, LDL, and HDL parameters as well as body weight of test animals as additional parameters. The test group was divided into 3 doses, namely 90 mg, 180 mg, and 360 mg per 200 grams of test animals. The results showed that there was no significant difference between the extract groups, both in lipid profile and body weight of the test animals. However, a dose of 360 mg had the best activity, being able to lower cholesterol, triglycerides, and LDL, but was able to increase HDL levels.
Identifikasi Senyawa Aktif Antibakteri dari Ekstrak Bajakah (Spatholobus Littoralisk Hask) dengan GCMS (Gass Chromatography Mass Spectroscopy): Identification of Active Antibacterial Compounds from Spatholobus Littoralisk Hask Extract With GCMS (Gass Chromatography Mass Spectroscopy) Kunti Nastiti; Dyan Fitri Nugraha; Darini Kurniawati
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5195

Abstract

Bajakah wood (Spatholobus Littoralisk Hask) is empirically used by the community to treat stomach pain, diarrhea and is even believed to be able to treat cancer. Several studies have shown its activity as an antibacterial. The purpose of this study was to identify compounds with antibacterial properties using Gas Chromatography Mass Spectroscopy (GCMS). The method used in this research is the experimental method. Bajakah plants were obtained from seven different areas, then extracted and fractionated. The fraction identified in this study was the n-hexan fraction. Preliminary tests were carried out using thin layer chromatography (TLC) bioautography for compounds that have the potential as antibacterial. Compounds in the n-Hexan fraction were further identified using Gass Chromatography Mass Spectroscopy (GCMS). The results showed Bajakah wood from seven regions had antibacterial activity seen from the formation of inhibition zones on compound spots on TLC that had been planted in agar media. There are 23 types of compounds identified by GCMS in this n-hexan fraction. In this study, the dominant compound seen from the largest area was Stigmast-5-en-3-ol, (3.beta.,24S)- (CAS) Clionaster (26.74%). The results of TLC bioautography of the n-Hexan fraction showed antibacterial activity and the dominant compound was Stigmast-5-en-3-ol, (3.beta.,24S)- (CAS) Clionaster.
The Potential of Bajakah Endophytic Fungus (Spatholobus littoralis Hassk) Against Staphylococcus aureus Bacteria Putri Nadila Utami; Kunti Nastiti; Melviani Melviani; Dede Mahdiyah
International Journal Of Health Science Vol. 5 No. 3 (2025): November : International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i3.6230

Abstract

A plant that has great potential as a source of traditional medicine is Spatholobus littoralis Hassk, or better known as bajakah. The research aims to analyze the Potential of Bajakah Endophytic Fungi (Spatholobus littoralis Hassk) Against Staphylococcus aureus Bacteria. This research was conducted at the Pharmaceutical Microbiology Laboratory, Faculty of Health, Sari Mulia University, Banjarmasin. The study used endophytic fungi on Bajakah wood (Spatholobus littoralis Hassk). The research design used was a True Experimental design with the aim of identifying the antibacterial activity of Bajakah endophytic fungi (Spatholobus littoralis Hassk) and testing the inhibitory power of Bajakah endophytic fungi (Spatholobus littoralis Hassk) against Staphylococcus aureus bacteria. Three isolates of endophytic fungi from Bajakah stems (Spatholobus littoralis Hassk) showed antibacterial activity against Staphylococcus aureus bacteria with varying levels of potency. Isolate (JEB 1) which is estimated to originate from Aspergillus sp showed very strong antibacterial activity with an inhibition zone diameter of 27.18 ± 0.725 mm. Isolate (JEB 1) has a Minimum Inhibitory Concentration (MIC) value at a concentration of 5 x 106 ppm and the best Minimum Bactericidal Concentration (MBC) at a concentration of 5 x 106 ppm. These findings indicate that endophytic fungi, especially from Aspergillus sp, have potential as natural antibacterial agents that can be further developed as candidates for new antibacterial materials based on local natural resources.
Co-Authors Ana Maulana Ana Muliana Arif Subekti Citra Agustiani Kusuma Darini Kurniawati Darini Kurniawati Darini Kurniawati Dede Mahdiyah Desiya Ramayanti Azhara Diah Aulia Rosanti Dian Ekowati Dyan Fitri Nugraha Dyan Fitri Nugraha Dyan Fitri Nugraha Dyan Fitri Nugraha Faisal Rahman Firda Nirmalasari Ghina Zhahera Ihda Syifa El Rahma Juliance Yolanda Putri Mambang Maria Dwi Ayu Listiawati Melviani Melviani Melviani Melviani Melviani Melviani Melviani Melviani Melviani Mia Audina Mia Audina Muhammad Noor Ni Ketut Linda Puspa Yani Noval Noval Nur Syifa Nurul Hidayah Putri Nadila Utami Putri Vidiasari Darsono Rahmadani Rahmadani Rahmayani Rahmayani Samsul Hadi Setia Budi Setia Budi Siti Malahayati Siti Malahayati Tuti Alawiyah Umi Kalsum Yanti Saubari Yanti Saubari