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Uji Farmakognostik dan Identidikasi Senyawa Pada Beberapa Tingkatan Fraksi Ekstrak Etanol Daun Lengkuas (Alpinia Galanga) Yanti Saubari; Kunti Nastiti; Mambang Mambang
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

ABSTRACT Background:Galangal Leaves (Alpinia Galanga) is a plant that grows in Indonesia. This plant is used as a cleaning wound after childbirth, bathing water for rheumatism sufferers, and as stimulation. Objective: To find out about the results of Pharmacognostic Tests and Identification of Compounds at Several Levels of The Ethanol Extract Fractions of Galangal Leaves (Alpinia Galanga) Method: extraction process using maceration method with 70% ethanol solvent was carried out for 3 x 24 hours, evaporated with rotary vacuum evaporator until thick extract was then fractionated with different solvents and detected by secondary metabolites using color test and KLT method Results: Macroscopic tests included a slippery green color with a length of 40cm, width 8cm, flat edge, pointed tip, blunt leaf base, and crossing. Microscopic test is the presence of epidermis, parenchyma, and stomata. Results Physico-chemical parameters of drying shrinkage were 0.23%, extracts of solvents with certain solvents were water-soluble and ethanol-soluble were 0.405% and 0.395%. Phytochemical screening results of the compounds obtained in the n-hrxane fraction, ethyl acetate fraction, and methanol fraction are steroids, tannins, phenolics, terpanoids, alkaloids, saponins, and flavanoids. KLT results for the n-hexane fraction with a mobile phase of methanol: ammonium (5: 0.25) with a spray of red brick (alkaloid). Conclusion: pharmacognostic testing meets the requirements and extracts of Galangal Leaves (Alpinia Galanga)

The Potential Content of Karamunting (Rhodomyrtus tomentosa) in Binding With HMG-CoA Reductase Kunti - Nastiti; Samsul Hadi
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 2 (2021): Journal Pharmaceutical Care and Sciences
Publisher : LPPM Universitas Sari Mulia

Background : Hyperlipidemia is the medical term for abnormally high levels of fats (lipids) in the blood. The two types of lipids found in the blood are triglycerides and cholesterol. The enzyme that plays a role in cholesterol regulation is HMG-CoA reductase. Objective : The purpose of this study was to find the content of karamunting compounds that have stability in interactions with HMG-CoA reductase. Method : The research method is to see the probability of activity with webservices, protein-compound interactions with PLANTS, visualization with Discovery studio. Results : The results of this study have a minimum activity probability of 0.5, namely -tocopherol-quinone, naringenin, quercetin, -tocopherol A, verimol K. The docking score is at least 80% against the reference ligand, namely -tocopherol-quinone (100%), blumeatin (82%), rhodomyrtosone C (80%), tetrahydroxyflavanone (81%), -tocopherol A (86%). Conclusion: The conclusion of this study is the probability of activity of the most potent compound is -tocopherol A and the interaction stability result is -tocopherol-quinone.

Etnofarmakologi: Pengetahuan Khusus Yang Umum Dyan Fitri Nugraha; Kunti Nastiti; Faisal Rahman
Jurnal Pelayanan Kefarmasian dan Sains Vol 2 No 2 (2022): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Background: The use of traditional medicine in the community is increasing every year. Along with the development of information technology and the urgency of a pandemic, making people realize the need for traditional medicine. The development of information circulating on social media regarding the identification, efficacy, and processing of traditional medicines is not entirely correct. Objective: The high consumption and flow of information in cyberspace, especially by young people, causes the need for an analysis of the level of truth of knowledge related to traditional medicine. This is the aim of this research. Methods: Using a survey method with quantitative descriptive analysis based on online questionnaires via google form to young students (18-24 years old). The survey includes the identification, efficacy and processing of traditional medicines. Results: The average level of knowledge on identification, efficacy, and processing of traditional medicines with different levels of popularity of traditional medicines was <60%. The majority of respondents only know about traditional medicines that are commonly known, while information on the potential of other local natural resources is still not well distributed. Conclusion: The low level of respondents' knowledge of traditional medicine is a challenge for regulators, academics, and practitioners to be able to ground information about ethnopharmacology. In other words, disseminating special knowledge so that it becomes common.

Skrining Fitokimia Dan Uji Aktivitas Antioksidan Bunga Lai (Durio kutejensis) Setia Budi; Kunti Nastitia
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.9076

ABSTRAKPenelitian ini bertujuan untuk mengidentifikasi/ skrining fitokimia dan uji aktivitas antioksidan Bunga Lai (Durio kutejensis). Bunga Lai memiliki potensi untuk dapat dikembangkan menjadi salah satu produk sedian farmasi, namun Bunga Lai masih kurang dikenal jika dibandingkan dengan jenis tanaman Durio zibethinus. Dalam penelitian ini, peneliti menggunakan menggunakan metode kualitatif dan kuantitatif yang bersifat eksperimental. Pada pengujian skrining fitokomia menggunakan metode kualitatif dan uji aktivitas antioksidan menggunakan metode kuantitatif. Metode skrining fitokimia dilakukan dengan melihat reaksi pengujian warna dengan menggunakan suatu pereaksi warna dan uji aktivitas antioksidan menggunakan metode DPPH yaitu dengan cara mengukur penangkap radikal sintetik dalam pelarut polar. Metode DPPH (Difenil pikrilhidrazil) untuk mengukur daya peredaman sampel (ekstrak) terhadap radikal bebas DPPH yang akan bereaksi dengan atom hidrogen dari senyawa peredaman radikal bebas membentuk DPPH yang lebih stabil. Pada pengujian antioksidan bunga lai (Durio kutejensis) dengan menggunkan ekstrsk kental dengan kosentrasi berbeda beda yaitu : 10 mg/L, 20 mg/L, 40 mg/L, 80 mg/L, 100 mg/L, 150 mg/L. Didapatkan hasil % inhibisi Ekstrak Bunga Lai berturut-turut 68,16% untuk formula I, 56,25% untuk formula II, dan 41,21% untuk formula III, sedangkan nilai IC50 sebesar 2,38 ppm. Berdasarkan hasil penelitian, aktivitas antioksidan ekstrak bunga Lai memiliki nilai IC50 yang lebih rendah dibandingkan vitamin C. Hal ini menunjukkan bahwa aktivitas antioksidan pada bunga Lai lebih tinggi dibandingkan dengan Vitamin C. Dapat disimpulkan, dilihat dari aktivitas antioksidannya ekstrak bunga Lai sangat berpotensi sebagai alternatif bahan antioksidan alami. Kata kunci : Durio; Kutejensis; Lai; Bunga Durian. ABSTRACTThis study aims to identify/screen phytochemicals and test the antioxidant activity of Flower Lai (Durio kutejensis). Flower Lai has the potential to be developed into a pharmaceutical product, but Flower Lai is still less well known when compared to Durio zibethinus. In this study, researchers used qualitative and quantitative methods that were experimental. The phytochemical screening test used qualitative methods and the antioxidant activity test used quantitative methods. The phytochemical screening method was carried out by observing the color test reaction using a color reagent and the antioxidant activity test using the DPPH method, namely by measuring synthetic radical scavengers in polar solvents. The DPPH (Diphenyl picrylhydrazil) method is used to measure the reducing power of the sample (extract) against DPPH free radicals which will react with hydrogen atoms of free radical scavenging compounds to form more stable DPPH. Free radical scavenging compounds that react with DPPH will become new radicals that are more stable or non-radical compounds. In testing the antioxidants of other flowers (Durio kutejensis) using a thick extract with different concentrations, namely: 10 mg/L, 20 mg/L, 40 mg/L, 80 mg/L, 100 mg/L, 150 mg/L. The results of the % inhibition of Flower Lai Extract were 68.16% for formula I, 56.25% for formula II, and 41.21% for formula III, while the IC50 value was 2.38 ppm. Based on the results of the study, the antioxidant activity of Lai flower extract has a lower IC50 value than vitamin C. This indicates that the antioxidant activity of Lai flower is higher than that of Vitamin C. Judging from its antioxidant activity, Lai flower extract has the potential as an alternative natural antioxidant. Keywords : Durio; Kutejensis; Lai; Flower Lai.

Autentikasi G.mangostana terhadap Adulterasi G. tinctoria dengan Metode Spectrofotometri UV-VIS Kombinasi Khemometrik Samsul Hadi; Kunti Nastiti
JURNAL PENDIDIKAN MIPA Vol 12 No 3 (2022): JURNAL PENDIDIKAN MIPA
Publisher : Pusat Publikasi Ilmiah, STKIP Taman Siswa Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37630/jpm.v12i3.642

G. mangostana telah banyak dilakukan penelitian mengenai bagian pericarp buah. Uji aktivitas yang telah dilakukan mulai dari ektrak, fraksi sampai ditemukan senyawa aktif. Berbagai macam uji untuk membuktikan khasiat Garcina mangostana telah dilakukan baik secara insilico,invitro atau invivo. Sehingga untuk menjaga kualitas dari G. mangostana terhadap resiko tercampurnya dengan spesies lain, maka diperlukan penelitian autentikasi G. mangostana terhadap G. tinctoria. Metode yang dipergunakan dalam penelitian ini dengan melihat data spektrum UV-VIS dari berbagai komposisi sampel dikombinasikan dengan kemometrik menggunakan PLS. Hasilnya didapatkan dua daerah panjang gelombang yaitu 249.71-223.87 nm dan 300.2-266.73 nm. Pada 249.71-223.87 nm derivatisasi pertama diperoleh RMSEC 2,25; R2 0.9978; RMSEP 4,1; R20.9945; RMESCV 11,6; R2; 0,9469. Pada 300.2-266.73 nm normal diperoleh RMSEC 0,941; R2 0,9996; RMSEP 2,64; R2 0.9971; RMSECV 18,7; R2 0,8736. Sehingga dari kedua daerah panjang gelombang tersebut model normal 300.2-266.73 nm merupakan model terbaik untuk autentikasi G. mangostana ketika tercampur dengan G. tinctoria.

Anti-Inflammatory Test Macaranga gigantea with Interleukin Inhibitor approach In Silico samsul hadi; kunti nastiti
Science Midwifery Vol 10 No 5 (2022): December: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v10i5.869

Inflammation is condition inflammation accompanied by pain and fever . _ In general drug anti-inflammatory work with hinder enzyme cyclooxygenase , both COX-1 and COX-2, which play a role in synthesize inflammatory mediators such as prostaglandins and thromboxane . Various study developed for look for agent more therapy effective and have more risk low good symptom inflammation I or consequence period long from disease inflammation chronic . One of the approach taken is develop IL1β inhibitors. Method used is compound screening active using in silico. Docking software used in study this is autodock 4.2 and visualization interaction using discovery studio , materials used in study this is the compounds contained in M. gigantea. Result of research this is the value of delta G is negative below -4 kcal / mol, so reaction yanga occur between the ligand and the protein will walk spontaneous . Conclusion in study this obtained four ligands with lowest G value that is glycasperin A; broussoflavonol F; 5,7,3 ',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone; meliternatin .

Uji Farmakognostik dan Identidikasi Senyawa Pada Beberapa Tingkatan Fraksi Ekstrak Etanol Daun Lengkuas (Alpinia Galanga) Yanti Saubari; Kunti Nastiti; Mambang Mambang
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v1i1.27

ABSTRACT Background:Galangal Leaves (Alpinia Galanga) is a plant that grows in Indonesia. This plant is used as a cleaning wound after childbirth, bathing water for rheumatism sufferers, and as stimulation. Objective: To find out about the results of Pharmacognostic Tests and Identification of Compounds at Several Levels of The Ethanol Extract Fractions of Galangal Leaves (Alpinia Galanga) Method: extraction process using maceration method with 70% ethanol solvent was carried out for 3 x 24 hours, evaporated with rotary vacuum evaporator until thick extract was then fractionated with different solvents and detected by secondary metabolites using color test and KLT method Results: Macroscopic tests included a slippery green color with a length of 40cm, width 8cm, flat edge, pointed tip, blunt leaf base, and crossing. Microscopic test is the presence of epidermis, parenchyma, and stomata. Results Physico-chemical parameters of drying shrinkage were 0.23%, extracts of solvents with certain solvents were water-soluble and ethanol-soluble were 0.405% and 0.395%. Phytochemical screening results of the compounds obtained in the n-hrxane fraction, ethyl acetate fraction, and methanol fraction are steroids, tannins, phenolics, terpanoids, alkaloids, saponins, and flavanoids. KLT results for the n-hexane fraction with a mobile phase of methanol: ammonium (5: 0.25) with a spray of red brick (alkaloid). Conclusion: pharmacognostic testing meets the requirements and extracts of Galangal Leaves (Alpinia Galanga)

P POTENSI KANDUNGAN KARAMUNTING (Rhodomyrtus tomentosa) DALAM BERIKATAN DENGAN HMG-CoA REDUKTASE Kunti - Nastiti; Samsul Hadi
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 2 (2021): Journal Pharmaceutical Care and Sciences
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v2i1.76

Background : Hyperlipidemia is the medical term for abnormally high levels of fats (lipids) in the blood. The two types of lipids found in the blood are triglycerides and cholesterol. The enzyme that plays a role in cholesterol regulation is HMG-CoA reductase. Objective : The purpose of this study was to find the content of karamunting compounds that have stability in interactions with HMG-CoA reductase. Method : The research method is to see the probability of activity with webservices, protein-compound interactions with PLANTS, visualization with Discovery studio. Results : The results of this study have a minimum activity probability of 0.5, namely -tocopherol-quinone, naringenin, quercetin, -tocopherol A, verimol K. The docking score is at least 80% against the reference ligand, namely -tocopherol-quinone (100%), blumeatin (82%), rhodomyrtosone C (80%), tetrahydroxyflavanone (81%), -tocopherol A (86%). Conclusion: The conclusion of this study is the probability of activity of the most potent compound is -tocopherol A and the interaction stability result is -tocopherol-quinone.

Etnofarmakologi: Pengetahuan Khusus Yang Umum Dyan Fitri Nugraha; Kunti Nastiti; Faisal Rahman
Jurnal Pelayanan Kefarmasian dan Sains Vol 2 No 2 (2022): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v2i2.189

Background: The use of traditional medicine in the community is increasing every year. Along with the development of information technology and the urgency of a pandemic, making people realize the need for traditional medicine. The development of information circulating on social media regarding the identification, efficacy, and processing of traditional medicines is not entirely correct. Objective: The high consumption and flow of information in cyberspace, especially by young people, causes the need for an analysis of the level of truth of knowledge related to traditional medicine. This is the aim of this research. Methods: Using a survey method with quantitative descriptive analysis based on online questionnaires via google form to young students (18-24 years old). The survey includes the identification, efficacy and processing of traditional medicines. Results: The average level of knowledge on identification, efficacy, and processing of traditional medicines with different levels of popularity of traditional medicines was <60%. The majority of respondents only know about traditional medicines that are commonly known, while information on the potential of other local natural resources is still not well distributed. Conclusion: The low level of respondents' knowledge of traditional medicine is a challenge for regulators, academics, and practitioners to be able to ground information about ethnopharmacology. In other words, disseminating special knowledge so that it becomes common.

Pengaruh Pengaruh Perbedaan Jenis Pelarut Terhadap Kadar Fenolik Ekstrak Daun Sirsak (Annona Muricata L.): Pengaruh Perbedaan Jenis Pelarut Terhadap Kadar Fenolik Ekstrak Daun Sirsak (Annona Muricata L.) Maria Dwi Ayu Listiawati; Kunti Nastiti; Mia Audina
Jurnal Pelayanan Kefarmasian dan Sains Vol 3 No 1 (2022): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v3i1.234

Backgraund: Annona muricata L leaves are used as anticancer drugs by the public because Annona muricata L leaves have a high content of phenolic compounds that have antoxid activity that can ward off free radicals that cause cancer. Phenolic compounds have polar properties so that to obtain this compound the same polar solvents are used, namely ethanol 70%, ethanol 96% and Methanol where the use of different types of solvents will affect the resulting phenolic level. Objective: Knowing what are the levels and influences of differences in phenolic levels of leaves Annona Muricata L. leaves based on differences in solvent types Methods: This study used a pre-experimental method with a randomized design by conducting a maceration extraction method and then a Thin Layer Chromatography test was carried out to identify phenolic compounds. Then the determination of total phenolic levels using UV-Vis spectrophotometry. Results: Effect of differences in solvent type from phenolic levels with One Way ANOVA parametric test. The total phenolic content of Annona muricata L leaves of Ethanol extract was 70%, Ethanol 96% and Methanol obtained were 5,753 mg GAE/g, 4,022 mg GAE/g and 7,179 mg GAE/g. Differences in solvent type had a significant effect of 0,000 (p<0,05) on the phenolic levels of Annona Muricata L leaf extract. Conclusions: Based on the results of the study, it was concluded that methanol is effective in irradiating phenolics compared to other types of solvents.

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