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All Journal Jurnal Gizi dan Pangan Jurnal Kesehatan Masyarakat Althea Medical Journal Nexus Kedokteran Komunitas Nexus Biomedika Jurnal Media Gizi Indonesia (MGI) Journal of Maternal and Child Health MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Nusantara Science and Technology Proceedings Journal of Health and Nutrition Research Media Penelitian dan Pengembangan Kesehatan
Ratih Puspita Febrinasari
Faculty of Medicine, University of Sebelas Maret
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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A Systematic Review of NT-proBNP as Prognostic Biomarker for Preeclampsia Complications Bachnas, Muhammad Adrianes; Asaduddin, Aiman Hilmi; Ali, Agni Shalha; Indarta, Ardhia Fefrine; Anshari, Shafira Yasmine; Febrinasari, Ratih Puspita; Widyaningsih, Vitri
Journal of Maternal and Child Health Vol. 9 No. 2 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2024.09.02.06

Abstract

Background: Preeclampsia can lead to maternal and fetal complications due to its ability to cause multiple organ disorders. Interestingly, N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels were higher in preeclampsia than in non-preeclampsia, representing cardiovascular mal¬function as the potential cause. Moreover, NT-proBNP also has a potential role in predicting complications that will arise in preeclampsia. This systematic review was performed to determine the role of NT-proBNP plasma levels in predicting maternal and fetal complications in preeclampsia.Subjects and Method: This systematic review was conducted based on PRISMA-P by previous observational study from scientific databases, namely Hinari, Cochrane Library, ScienceDirect, Scopus, and grey literature in OCLC’s OAISTER between 2006 and 2021. The search keyword used were ((NTproBNP) OR (NT-proBNP) OR (N-terminal pro-BNP) OR (N-terminal pro-Brain Natriuretic Peptide)) AND ((preeclampsia) OR (pre-eclampsia)) AND (pregnancy complications). Newcastle - Ottawa Quality Assessment Scale (NOS) was used to assess quality of included studies.Results: After study selection, five studies from 156 studies were considered eligible and selected in this systematic review. The results showed that pre-eclampsia complications occurred with NT-proBNP levels above 500 mg/dL, which cardiovascular complications may occurred above 700 mg/dL. NT-proBNP levels were higher in women with maternal complications such as placental abruption, HELLP (Hemolysis, elevated liver enzyme levels, and low platelet levels) syndrome, eclampsia, pulmonary oedema, congestive heart failure, cerebrovascular accident, renal dysfunction, and hypertensive retinopathy. Furthermore, increased NT-proBNP levels were associated with fetal growth restriction, resulting in low birth weight. NT-proBNP was significantly higher in pregnant women due to a combination of pre-existing volume overload and NT-proBNP clearance dysfunction in kidney. Conclusion: NT-proBNP levels were associated with adverse outcomes in preeclampsia. NT-proBNP serum levels could be used to predict maternal-fetal complications in preeclampsia.
Acceptability and Nutritional Value of Mackerel Fish Nugget with Additions of Moringa Leaves Flour for Stunting Children Under-Five Years in West Nias Regency Haruni, Diah Sekar; Nuhriawangsa, Adi Magna Patriadi; Febrinasari, Ratih Puspita
Nusantara Science and Technology Proceedings The 1st International Conference Muhammadiyah Yogyakarta – Hospital & Healthcare Management
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4209

Abstract

Stunting is one of a nutritional problems. Mackerel contains high protein which is important for growth. Moringa leaves contain high calcium and iron to overcome stunting. However, these two ingredients are very low in utilization as food ingredients so food diversification is carried out by making nuggets that are popular with children. The goal of this study was to determine the acceptability and nutritional value of mackerel nuggets with the addition of moringa leaf flour for stunting children in West Nias Regency. This type of research was experimental with organoleptic and proximate test. The treatment is moringa flour addition of 3%, 5%, 7%. Data were analyzed with One Way ANOVA followed by Duncan's and using Kruskal Wallis followed by the Mann-Whitney test if the data did not meet one of the conditions for the Anova test. The hedonic test results showed that there was a significant difference in aroma (p=0.033), taste (p=0.001), and texture (p=0.043) but no effect on color (p=0.639). The nutritional value test results showed that there was an effect of moringa leaf addition on the moisture content (p=0.016), ash (p=0.001), protein (p=0.001), fat (p=0.001), carbohydrate (p=0.024), calcium (p=0.001), and iron (p=0.001) of mackerel nuggets. Moringa flour addition influenced the liking of aroma, taste, and texture but had no effect on aroma and was well received by children's panelists in the category of “like” with F1 with the highest acceptance. Moringa flour addition influenced the protein, calcium, and iron levels with the highest levels in F3.
Formulation of Soygurt Mung Bean with Date Juice as Adjuvant Therapy for Diabetes Mellitus Jannah, Miftakhul; Rahardjo, Setyo Sri; Febrinasari, Ratih Puspita
Nusantara Science and Technology Proceedings The 1st International Conference Muhammadiyah Yogyakarta – Hospital & Healthcare Management
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4210

Abstract

One innovative nutritional therapy approach for diabetic mellitus (DM) is modulating the gut microbiota by administering probiotics. Soygurt is a probiotic functional food made from fermenting soy milk with lactic acid bacteria (LAB), which includes bioactive peptides and antioxidants. The use of soybean, mungbean, and date juice as sweeteners is expected to increase the product's physicochemical quality as well as the presence of lactic acid bacteria, maximizing its benefits as a functional meal for DM. This study was an experiment that used a completely randomized design with three treatment formulas comparisons of soybeans and mungbean's (% : %) as follows F1 (25:75), F2 (50:50), and F3 (75:25). Protein content was determined using the biuret method, fat content was identified using the mojonieur method, the reduced sugar content was analyzed using the Nelson Smogyi method, crude fiber content was identified using the gravimetric, and LAB were determined using the Total Plate Count (TPC). The best formula was continued for clinical trials on animals. The result of F3 produced protein of 5.46%, fat of 2.36%, reduced sugar of 4.66%, crude fiber of 3.81%, and a pH of 4.139. The lactic acid bacteria (LAB) count in F1 was 1.9 x 108 CFU/mL. It concluded that soygurt mung bean with date juice can potentially control blood glucose levels due to its high protein and low-fat content.
Scoping Review: Potential of Bekul Fruit (Ziziphus jujube Mill.) as an Antidiabetic Agent in Patients with Type 2 Diabetes Mellitus Windayani, Komang; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita
Nusantara Science and Technology Proceedings The 1st International Conference of Health Institut Kesehatan Mitra Bunda 2024
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4301

Abstract

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (hyperglycemia) caused by damage or abnormalities in insulin production. Pharmacological therapy used as a treatment for diabetes mellitus in some patients has adverse side effects on the body, thus encouraging exploration to use natural ingredients as an alternative therapeutic source in reducing blood glucose. Therefore, a thorough review is needed to summarize scientific data and investigate the potential use of natural ingredients bekul fruit (Ziziphus jujube Mill.) in its role as an antidiabetic agent. This study used a scoping review with 4 databases: Pubmed, ScienceDirect, DOAJ and Google Scholar. The results of the scoping review of 5 scientific articles found that bekul fruit (Ziziphus jujube Mill.) is proven to have bioactive content that is rich in antioxidants such as phenolic/polyphenolic compounds (ferulic acid, caffeic acid, chlorogenic acid), flavonoids (quercetin, rutin, catechin), phytosterols, and inulin which have the potential as antidiabetic agents with different mechanisms of action in reducing blood glucose levels. Conclusion: bekul fruit (Ziziphus jujube Mill.) has the potential to be an alternative nutraceutical diet therapy in patients with diabetes mellitus.
THE EFFECT OF EDUCATION USING DIGITAL COMIC MEDIA ON HEALTHY FOOD CHOICES IN ADOLESCENT GIRLS WITH PRIMARY DYSMENORRHEA Shinta, Shinta; Tamtomo, Didik Gunawan; Febrinasari, Ratih Puspita
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 3 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i3.2097

Abstract

Remaja merupakan masa peralihan dari anak-anak menuju dewasa ditandai dengan terjadinya menstruasi pada wanita. Sebagian besar remaja merasakan nyeri menstruasi yaitu dismenorea primer. Prevalensi dismenorea di dunia tertinggi terdapat pada remaja putri yaitu sekitar 20-90% dan di Indonesia sebesar 60-75%.Kurangnya pengetahuan gizi dan kecenderungan untuk mengikuti faktor emosional dan sosial menyebabkan remaja  memilih makanan yang kurang sehat dan bergizi, sehingga berdampak pada asupan gizi. Penelitian ini bertujuan untuk menganalisis pengaruh komik digital terhadap pemilihan makanan sehat terhadap remaja yang menderita dismenorea primer. Penelitan ini menggunakan metode campuran (R&D dan true eksperimen dengan rancangan pre-post test with control group). Penelitian ini melibatkan tiga validator ahli yaitu ahli materi, ahli bahasa dan ahli med­ia. Pengumpulan data melalui kuesioner penilaian media dan wawancara. Subjek penelitian 100 remaja putri di sekolah sasaran penelitian yang memenuhi kriteria inklusi yaitu siswi SMA Negeri Kelas X dan XI, riwayat menstruasi teratur selama 6 bulan terakhir, usia 15-18 tahun, memiliki smartphone pribadi dan belum pernah mendapatkan edukasi terkait dismenorea. Kriteria eksklusi yaitu tidak hadir saat penelitian dan tidak mengisi kuesioner secara lengkap. Pengambilan sampel menggunakan multistage random sampling terdiri dari 2 tahap yaitu cluster random sampling dan proportional random sampling. Instrumen data pemilihan makanan sehat menggunakan formulir healthy food choices quetionarre. Hasil uji Wilcoxon menunjukkan pada kelompok intervensi didapatkan nilai p-value = <0,001 dan pada kelompok kontrol didapatkan nilai p-value = <0,001. Hasil ini menunjukkan komik digital yang dirancang memiliki pengaruh terhadap skor pemilihan makanan sehat.
A COMBINATION OF APPLE AND CINNAMON EXTRACTS REDUCES BLOOD GLUCOSE AND INCREASES INSULIN LEVELS OF T2DM MODEL RATS Hamka, Dwi Wulandari Aaas; Harioputro, Dhani Redhono; Febrinasari, Ratih Puspita
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 4 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i4.1772

Abstract

Prevalensi penyandang penyakit diabetes melitus (DMT2) terus meningkatan akibat kenaikan kadar glukosa darah dan resisten insulin oleh sel β pancreas. Hiperglikemia pada DMT2 dapat menyebabkan stress oksidatif. Pemberian kombinasi ekstrak apel dan kayu manis memiliki potensi untuk menurunkan kadar glukosa darah karena mengandung senyawa flavonoid dan antioksidan yang mencegah stress oksidatif. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian Kombinasi Ekstrak Apel dan Kayu manis (KEAK) terhadap kadar GDP dan insulin pada tikus DMT2. Jenis penelitian ini adalah eksperimental laboratorik dengan rancangan randomized pre-post test control group design. Penelitian ini menggunakan 36 tikus Rattus norvegicus Jantan, dibagi menjadi 6 kelompok: KN tikus dikondisikan normal, K- tikus DMT2 tanpa perlakuan, K+ tikus DMT2 yang diberikan obat metformin, kelompok KP1 (9,14+45 mg/200 gramBB), KP2 (18,36+30 mg/200 gramBB) dan KP3 (27,42+15mg/200gramBB) yaitu tikus DMT2 yang di berikan KEAK selama 21 hari. Analisis data menggunakan uji One-way Anova. Setelah 21 hari intervensi KP1 mengalami penurunan kadar GDP (Δ -177,88 ± 4,61) dan kenaikan kadar insulin tertinggi (Δ 81,83 ± 9,37) dibandingkan dengan perlakuan yang lain. KP2 mengalami penurunan kadar GDP (Δ -167,41 ± 4,13) dan kenaikan kadar insulin (Δ 62,82 ± 9,37) yang hampir sama dengan kelompok perlakuan yang diberikan obat metformin (K+) dengan penurunan kadar GDP (Δ -167,80 ± 4,96) dan kadar insulin (Δ 56,23 ± 8,54). Pemberian kombinasi ekstrak apel dan kayu manis berpengaruh dalam menurunkan kadar GDP dan meningkatkan kadar insulin. Kombinasi ekstrak apel dan kayu manis dapat dipertimbangkan untuk menurunkan GDP dan meningkatkan kadar insulin.
The Effect of Combined Extracts of Sappan Wood (Caesalpinia sappan L.) and Gotu Kola (Centella asiatica L.) in Improving Diabetic Condition in Rats Binti Maulina; Wasita, Brian; Febrinasari, Ratih Puspita
Jurnal Gizi dan Pangan Vol. 17 No. 1 (2022)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.931 KB) | DOI: 10.25182/jgp.2022.17.1.37-46

Abstract

This study aimed to determine the efficacy of combination of sappan (secang) wood and gotu kola extracts in reducing insulin resistance and Malondialdehyde (MDA) levels in diabetic rats induced by Streptozotocin (STZ) 65 mg/kg Body Weight (BW) and Nicotinamide (NA) 230 mg/kg BW. Forty-two male Sprague Dawley rats weighing ±200 g were divided into 7 groups: 1) control, 2) glibenclamide 0.45 mg/kg BW, 3) sappan wood extract (CS) 250 mg/kg BW, 4) gotu kola extract (CA) 500 mg/kg BW, 5) 1st combination of extracts of sappan wood and gotu kola (CSCA1) 125 mg/kg BW + 750 mg/kg BW, 6) 2nd combination (CSCA2) with 250 mg/kg BW + 500 mg/kg BW, and 7) 3rd combination (CSCA3) with 375 mg/kg BW + 250 mg/kg BW. The insulin resistance levels were measured using the HOMA-IR index based on fasting blood glucose and insulin. The Thiobarbituric Acid Reactive Substance (TBARs) method was used to measure MDA levels. All measurements were taken before treatment, 14 days after treatment, and 21 days after treatment. The group receiving CSCA3 showed significant reduction in insulin resistance (-3.32±0.05) and MDA levels (-2.04±0.37 nmol/ml) on Day 21 after treatment. The CSCA3 treatment did not show statistically different result compared to glibenclamide treatment (p>0.05). Hence, CSCA3 treatment was considered as the best proportion of sappan wood and gotu kola extracts mixture and the result is comparable to glibenclamide. This study shows that the combination of sappan wood and gotu kola extracts has the potential to be developed as a functional drink for people with diabetes.
Utilizing TikTok Animation for Nutrition Education: A Feasibility and Preliminary Efficacy Study among Mothers Underweight of Toddlers Lestari, Dian; Sari, Yulia; Febrinasari, Ratih Puspita
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.384

Abstract

Underweight is a condition of body weight based on the toddler's age (BW/A) with a Z-score value <2SD. This study aims to develop TikTok animated videos to help toddlers overcome being underweight. The type of research uses Research and Development (R&D) with the ADDIE model, including Analysis, Design, Development, Implementation, and Evaluation. However, this study is only up to the development stage. Video validation involved three experts, namely material, language, and media experts, with an average result of 80.3 (feasible category, minor revision). Furthermore, trials were carried out on prospective users (n=10) selected by purposive sampling. The results of the product assessment by prospective users were 91.08 (very feasible category, no need to revise). The impact of using the video was measured by a knowledge questionnaire (reliability = 0.743). The results of the knowledge score based on the pretest and posttest on mothers of toddlers obtained an average N-Gain score of 0.84 with a high category. Developing the TikTok animated video product is feasible based on the results of the analysis. It can be applied as educational media to increase the knowledge of mothers of toddlers and overcome the problem of underweight toddlers.
Validity and Reliability of Indonesian Version of Diabetes Quality of Life Brief Clinical Inventory in Patients with Type 2 Diabetes at Primary Care Azmiardi, Akhmad; Febrinasari, Ratih Puspita
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 2 (2025): AUGUST
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.2.2025.124-132

Abstract

Background:  Type 2 diabetes (T2DM) has a significant impact on patients' quality of life (QoL), including physical, psychological, social, and economic aspects. However, a culturally and linguistically adapted Diabetes Quality of Life Brief Clinical Inventory (DQoL-BCI) for Indonesian patients remains limited. A validated Indonesian version of this instrument is necessary to ensure accurate assessment and effective interventions for diabetes management.Objective: This study aimed to assess the validity and reliability of the Indonesian version of the Diabetes Quality of Life Brief Clinical Inventory (DQoL-BCI) among patients with T2DM in primary care.Methods: A cross-sectional study was conducted among 30 T2DM patients at a primary health care center in Singkawang City, West Borneo, Indonesia. Data were collected through interviews. The DQoL-BCI, a 15-item questionnaire, was used to measure QoL, with responses rated on a 5-point Likert scale. Construct validity and internal consistency were assessed using Pearson’s r and Cronbach’s alpha.Results: All items showed Pearson’s r values greater than 0.361, indicating an adequate correlation with the overall scale and thus validating the items. The highest Pearson’s r values were for satisfaction with the time to determine sugar levels (0.688) and sex life (0.680). The Cronbach’s alpha coefficient for all items was 0.887, exceeding the minimum requirement of 0.70, demonstrating excellent internal consistency.Conclusion: The Indonesian version of the DQoL-BCI is a valid and reliable instrument for measuring the QoL in individuals with T2DM in primary care settings.
Therapeutic Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Hikmayani, Nur Hafidha; Febrinasari, Ratih Puspita; Satwika, Ariq Ratya
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4209

Abstract

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel class of medications for managing dyslipidemia. Although previous meta-analyses have confirmed their efficacy in lowering low-density lipoprotein cholesterol (LDL-C), few have evaluated their effects on broader lipid parameters. Moreover, most studies focus on the general dyslipidemic population, provided limited insight into specific subgroups. This study specifically investigated the effects of PCSK9 inhibitors on multiple lipid parameters in individuals with dyslipidemia who were statin-intolerant, statin-resistant, or required intensified lipid-lowering treatment.Methods: This study systematically searched PubMed, ScienceDirect, and the Cochrane Library for phase 3 randomized controlled trials (2013-2023), evaluating PCSK9 inhibitors against placebo or non-statin standard care in dyslipidemic patients aged ≥18 years. The main outcome was the changes from baseline in lipid parameters. Random-effects meta-analyses were conducted using RevMan. Results: Eight studies involving 2,343 participants met eligibility criteria. PCSK9 inhibitors significantly reduced LDL-C (MD -46.8, 95% CI [-53.2; -40.4]), non-HDL-C (MD -41.1 [-46.9; -35.3]), total cholesterol (MD -31.5 [-37.8; -25.2]), triglycerides (MD -11.7 [-15.0; -8.4], Lp(a) (MD -19.2 [-25.7; -12.6]), and ApoB (MD -39.4 [-45.0; -33.7]). PCSK9 inhibitors also significantly increased HDL-C (MD 6.3 [4.7; 7.9]) and ApoA-I (MD 4.1 [2.8; 5.5]).Conclusion: PCSK9 inhibitors significantly improve a broad spectrum of lipid parameters, including non-traditional markers such as non-HDL-C, ApoA-I, ApoB, and Lp(a), underscoring their potential role in managing dyslipidemia, particularly in patients inadequately controlled with standard therapies.
Co-Authors . Suyatmi . Widardo A.A. Ketut Agung Cahyawan W Adi Magna Patriadi Nuhriawangsa Akhmad Azmiardi Ali, Agni Shalha Anshari, Shafira Yasmine Asaduddin, Aiman Hilmi Asih Anggraini Bachnas, Muhammad Adrianes Binti Maulina Brian Wasita Dedi Febriandaru DIAN LESTARI Didik Gunawan Tamtomo Dilma’aarij, Dilma’aarij Dyonisa Nasirochmi Pakha Hamka, Dwi Wulandari Aaas Hanif Mustikasari Harioputro, Dhani Redhono Haruni, Diah Sekar Indarta, Ardhia Fefrine Laksmi Wardhani, Tri Martya Ningrum Lilik Wijayanti MIFTAKHUL JANNAH Mustiqa Febriniata Nur Hafidha Hikmayani Paramasari Dirgahayu Rahardjo, Setyo Sri Rio Nanda Pratama Riris Arizka Wahyu Kumala, Riris Arizka Wahyu RR. Ella Evrita Hestiandari Satwika, Ariq Ratya Shinta Shinta Solikah, Tri Agusti Vitri Widyaningsih Widardo . Windayani, Komang Yulia Lanti Retno Dewi