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All Journal HAYATI Journal of Biosciences Damianus Journal of Medicine Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Jurnal Ilmu Kedokteran dan Kesehatan Acta Biochimica Indonesiana Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Biologi UMA (JIBIOMA) Jurnal Kesehatan Tambusai Bioscientist : Jurnal Ilmiah Biologi EduNaturalia: Jurnal Biologi dan Kependidikan Biologi Jurnal Sehat Indonesia (JUSINDO) Tarumanagara Medical Journal Jurnal Sosial dan Sains Ebers Papyrus Jurnal Muara Medika dan Psikologi Klinis Cermin Dunia Kedokteran
Frans Ferdinal
Department Of Biochemistry And Molecular Biology, Faculty Of Medicine, Tarumanagara University, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : HAYATI Journal of Biosciences

 1 
Expression of Hypoxia-Inducible Factor-1α and Myoglobin in Rat Heart as Adaptive Response to Intermittent Hypobaric Hypoxia Exposure Margaretha Herawati; . Wardaya; Wawan Mulyawan; Fanny Septiani Farhan; Frans Ferdinal; Sri Widia A. Jusman; Mohamad Sadikin
HAYATI Journal of Biosciences Vol. 24 No. 3 (2017): July 2017
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (826.933 KB) | DOI: 10.4308/hjb.24.3.131

Abstract

The aim of this study was to investigate the influence of intermittent hypobaric hypoxia on the expression hypoxia adaptation proteins, namely hypoxia inducibla factor-1a (HIF-1a) and myoglobin (Mb). Twenty five male Sprague-Dawley rats were exposed to intermittent hypobaric hypoxia in a hypobaric chamber in Indonesian Air Force Institute of Aviation Medicine, for 49.5 minutes at various low pressure, 1 week interval for 4 times (day 1, 8, 15 and 22). HIF-1α and Mb protein were measured with ELISA. mRNA expression of Mb was measured with one step real time RT-PCR. HIF-1α protein levels increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0437). mRNA expression and protein of Mb increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0283; 0.0170), and both are strongly correlated (Pearson, r = 0.6307). The heart of rats adapted to intermittent hypoxia conditions by upregulation the expression of HIF-1a and myoglobin and then both return to normal level.
Co-Authors . Wardaya Alphanto, Alfred H Alvionica, Selina Ani R. Prijanti Ani Retno Prijanti Annisaa Nurrahma Ardyati Asyraf, Muhammad Zain Alwi Audina Leonita Bethy S. Hernowo Cinthia Catherine Clareta Vero Patricia Widya Darlene Zaneta David Limanan Dewi, Mietha Apriyanti E Efrany E Yulianti Elhapidi, Nafisa Zulpa Eloydia Vintari, Clarista Enny Yulianti, Enny Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti, Eny Erics Efrany Ezra, Pasuarja Jeranding F Wandy Fanny Septiani Farhan Febriana C. Iswanti Felix Felix Ferdian Ferdian Fernando Yosafat Franciscus D. Suyatna Frankson, Desvin Frans D Suyatna Gaofman, Brian Albert Gita Manerlin Kasihita Simatupang H R Helmi Habibah, Rizka Azahra HANS-JOACHIM FREISLEBEN Hartono, Daniswara Aliya Helmi, Helmi Rizal Hilmi, Fakih Iksanti, Azra Morley Jessica Geselda Salim Julianty, Eny Karinnia Karinnia Kusuma, Andrea Bianca Castafiore M Lirendra Maharani, Karennina Larissa Malano, Zahra Khoirunissa Malihah, Ely Marcella, Agnes Maria Christina Dwiyanti Mellenia, Kelnia Michael Chen Mohamad Sadikin Mohamad Sadikin Najukha, Yusrifa Natasha Olivia Christian Ngestinuari Salim NO Christian Noer Saelan Tadjudin Novelee Irawan Putri Putri, Nawaika Shafira Putri, Viola Ananda Jerika R Benettan Rizky Audryan Rizky Putri Agustina Rostika Flora Rudianti, Selly Herlia Rumengan, Peterjohn Andrew Benhard Saerang, Stefanus Handy Salim, Melanie Santoso, Stanley Sentosa, Belinda Septelia I. Wanandi Setiady, Brandon Alexander Siufui Hendrawan Siufui Hendrawan Soebrata, Linginda Sri W.A. Jusman Sri Widia A Jusman Sri Widia A. Jusman Swantari, Ni Made Tamba, Monica Diva Maharani Tanowijono, Gabriella Frederica Tanuhariono, Ardhita Felicia Thalia Gabriella Siriwa Verita, Chaeza Nara Wawan Mulyawan Wijayadi, Linda Julianti William Lukman