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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Berkala Ilmu Kesehatan Kulit dan Kelamin IJEMS (Indonesian Journal of Environmental Management and Sustainability) Biosaintifika: Journal of Biology & Biology Education Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Media Medika Muda Medica Hospitalia PREPOTIF : Jurnal Kesehatan Masyarakat Medica Arteriana (Med-Art) Jurnal Health Sains Journal of Social Research Eduvest - Journal of Universal Studies
Renni Yuniati
Dept Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Diponegoro
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Adjuvant Therapy Effect of Curcuma Longa Rhizome Extract On TGF-β Serum Levels in Leprosy Ulcer Patients Alfarizi, Rizki; Yuniati, Renni; Mundhofir, Farmaditya Eka Putra; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1300

Abstract

Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy. Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy.
Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients Putri, Syifa Nurisma; Mundhofir, Farmaditya Eka Putra; Yuniati, Renni; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1301

Abstract

Type 1 leprosy reaction / Reversal reaction (RR) is an inflammatory episode in existing leprosy lesions and aggravates the pain rate. Long-term therapy with steroids causes a variety of side effects, so an adjuvant therapy alternative is needed to alleviate steroid use. Curcuma longa rhizome extract has become an anti-inflammatory therapy choice in various previous inflammatory diseases. This study aims to determine the anti-inflammatory effect of Curcuma longa rhizome extract as an adjuvant therapy for reversal reaction patients by analyzing serum levels of IL-6 as a marker of inflammation. The pre and post-test randomized single-blinded controlled trial was conducted on two groups, namely control (RR patients with steroid therapy & placebo) and treatment (steroid therapy & Curcuma longa rhizome extract 1 gram/day). IL-6 serum levels were analyzed from sampling before and after the intervention for one month. The serum levels of IL-6 post-test in the control group were significantly higher than those of the pre-test. The treatment group showed lower serum levels of IL-6 post-test compared to pre-test, although there was no significant difference. Curcuma longa rhizome extract 1 gram/day for one month as adjuvant therapy for patients with type 1 leprosy reaction did not significantly reduce serum IL-6 levels.
Pengaruh waktu pemanasan dan pengasaman terhadap kadar albumin ekstrak ikan gabus : The effect of long heating and aciditing time on albumin levels in snakehead fish extract Yuniati, Renni; Nurtari, Rahma Yulia; Annaafi, Alviona Denti; Priguna, Tangkas Mukti; Anggita, Vinka Dwi; Kusumaningrum, Novi; Saraswati, Indah; Muslimin, Muslimin; Putra, Farmaditya Eka; Hardian, Hardian
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 27 No. 2 (2024): Jurnal Pengolahan Hasil Perikanan Indonesia 27(2)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v27i2.46448

Abstract

Snakehead fish, specifically the Channa striata species, are known to have an abundance of albumin. However, there is limited information available regarding alterations in the properties of snakehead fish extracts that have undergone high heat and acid treatment. This presents a compelling research area for further exploration and study. The aim of this study was to determine the optimal portion of the fish and to examine the effect of heating and acidification time on albumin concentration in snakehead fish. The method employed in this study involved heating samples at 70 °C for 0, 15, and 30 min and subjecting them to acidification at pH 1, 4, and 7. The extraction process was conducted using centrifugation at a speed of 6,000 rpm for 60 minutes, followed by absorbance measurement at a wavelength of 280 nm using a UV-Vis spectrophotometer to evaluate the properties of protein extracts.The relationship between albumin levels and protein levels is one of direct proportionality.According to recent studies, snakehead fish extract is a safe and effective topical treatment for skin conditions, with a pH level ranging from 4.5 to 6.5. Furthermore, snakehead meat is a rich source of albumin, containing approximately 22.4 mg of protein per 100 g. The absorbance exhibited a more substantial rise at a temperature of 70oC over a 15-minute period and in a highly acidic environment (pH 1.0). Snakehead fish protein extract is less stable and more susceptible to denaturation than standard bovine serum albumin (BSA).
Co-Authors Abdul Hakam Agnes Sri Siswati Alfarizi, Rizki An Nidha, Amalia Anggita, Vinka Dwi Annaafi, Alviona Denti Anum, Qaira Arifin S Bagus Haryo Kusumaputra Bambang Sulardiono Cita Rosita Sigit Prakoeswa Dea May Fitry Dhelya Widasmara Dimarti, Safira Chairani Farmaditya Eka Putra Farmaditya EP Mundhofir, Farmaditya EP Fifa Argentina Handojo, Djoko Hardian Hardian Hario Seno, Heri Nugroho I Gusti Nyoman Darmaputra Indah Saraswati Intan Nurmawati Putri Jayawarsa, A.A. Ketut Kosasih, Enrique Vicenzo Kusuma, Nauval Marta Kusumaningrum, Hermin Kusumaningrum, Novi Lubis, Ramona Sari Luh Made Mas Rusyati M. Yulianto Listiawan Mamuaja, Enricco Hendra Medhi Denisa Alinda, Medhi Denisa Muanjatun, Dahin Muchtar, Vitayani Muhammad Zainuri Mulianto, Nur Rachmat Mundhofir, Farmaditya Eka Putra Muniroh, Muflihatul Muslimin Muslimin Najatullah, Najatullah Nani Maharani Neni Susilaningsih Noor Wijayahadi Nurtari, Rahma Yulia Priguna, Tangkas Mukti Putri, Ajeng Kurniasari Putri, Syifa Nurisma Regitta Indira Agusni Riawan W Riski Dwi Utami Sidauruk, Rollin Hansen Sri L. Menaldi Sugianto, Sylvia Christiana Surbakti, Herry Maha Putra Syaropi Simanjuntak, Victor Jeremia Tri Nur Kristina Utami, Arini Widasmara D Yan Wisnu Prajoko Yora Nindita