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All Journal Farmaka Indonesian Journal of Applied Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Pharmacology and Clinical Pharmacy Research KACANEGARA Jurnal Pengabdian pada Masyarakat Journal of Maternal and Child Health Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Farmako Bahari Indian Journal of Forensic Medicine & Toxicology Medical Sains : Jurnal Ilmiah Kefarmasian Sciences of Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian

Keri Lestari

Fakultas Farmasi, Universitas Padjadjaran

Author-ID : 2695911

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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HUBUNGAN MANFAAT PENGGUNAAN STATIN PADA PASIEN CORONAVIRUS DISEASE 2019 (COVID-19): SEBUAH REVIEW Arsenila Dewi Pramanti; Melisa I Barliana; Keri Lestari
Jurnal Ilmiah Farmako Bahari Vol 14, No 1 (2023): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v14i1.2051

Coronavirus Disease 2019 (Covid-19) merupakan penyakit sindrom pernafasan akut parah dengan tingkat morbiditas dan mortalitas yang tajam di seluruh dunia. Statin merupakan salah satu obat yang digunakan dalam pengobatan hiperkolesterol. Beberapa penelitian menyatakan bahwa statin dapat mengurangi tingkat keparahan penyakit infeksi COVID-19. Ulasan ini menguraikan manfaat penggunaan statin pada pasien COVID-19. Desain penulisan ini adalah study literature review. Beberapa hasil penelitian menyatakan bahwa penggunaan statin sebelum dan selama pengobatan di Rumah Sakit karena COVID-19 berkaitan dengan penurunan kematian. Karena selain menurunkan kadar serum lipid dengan menghambat HMG-CoA reduktase, statin juga memiliki efek lain seperti antiinflamasi.

Implementasi Kepatuhan Pelaksanaan Cara Distribusi Obat yang Baik Terkait Produk Khusus Psikotropika dan Obat Mengandung Prekursor Farmasi di PBF PT “X” di Kota Tasikmalaya Melisa Fuji Faujiah Dwi Putri; Keri Lestari Dandan
Majalah Farmasetika Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v8i3.44089

Penggunaan psikotropika dan obat mengandung prekursor farmasi (OMPF) tanpa petunjuk atau resep dokter merupakan tindakan di luar indikasi medis yang dapat menyebabkan pengguna mengalami ketergantungan dan menimbulkan gangguan dalam aktivitas sehari-hari akibat pemakaian yang bersifat patologik (menimbulkan kelainan). Oleh karena itu, diperlukan pengawasan terhadap penangan dan penyaluran produk khusus psikotropika dan OMPF salah satunya oleh Pedagang Besar Farmasi (PBF). PBF merupakan suatu perusahaan berbadan hukum yang memperoleh izin dalam proses pengadaan, pelaksanaan penyimpanan, hingga proses penyaluran obat dan/atau bahan obat dengan jumlah yang besar sesuai ketentuan peraturan perundang-undangan. Cara Distribusi Obat yang Baik (CDOB) merupakan pedoman dalam melaksanakan proses penyaluran dan pendistribusian obat atau bahan obat sehingga mutu poduk dapat terjamin sepanjang jalur distribusi. Tujuan: untuk mengetahui kepatuhan pelaksanaan CDOB berdasarkan regulasi pemerintah dan regulasi internal terkait penanganan dan penyaluran produk khusus psikotropika dan OMPF di PBF PT “X” di Kota Tasikmalaya. Metode: Penelitian ini dilakukan secara observasional deskriptif yaitu menggunakan metode observasi langsung dan wawancara dengan menggunakan daftar ceklis kuisioner. Hasil: Perolehan kepatuhan penerapan CDOB terkait produk khusus Psikotropika dan OMPF dari kuisioner yang berjumlah 19 pertanyaan, PBF PT “X” telah memenuhi semua aspek CDOB. Kesimpulan: Berdasarkan hasil observasi, dan wawancara langsung didapatkan kesimpulan penerapan Cara Distribusi Obat yang Baik di PBF PT “X” di Kota Tasikmalaya telah terlaksana dengan sangat baik.

Effect of Stunting Education Counseling with Booklet Media on Parental Knowledge and Attitude As an Effort to Overcome Stunting Triatmaja, Dendy; Lestari, Keri; Setiabudiawan, Budi
Journal of Maternal and Child Health Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: Stunting is developmental disorders experienced by children due to poor nutrition, repeated infections, and inadequate psychosocial stimulation. The problem of stunting in children under five shows an average rate of 35.3% in West Java. Stunting is a problem because it is associated with an increased risk of disease and death, suboptimal brain development, which results in delayed motor development and stunted mental growth. Jamika sub-district has a high prevalence of stunting under five in West Java, which is 23.7%. Pharmacists as Agents of Change can also optimize their role by providing information and education on stunting prevention. Subjects and Method: This study uses a design Pretest-posttest control group design at the Posyandu, Jamika Village, from February to April 2022. The total sample in this study was 30 people who were taken from mothers who had toddler 0-24 months of age. Samples were obtained by simple random sampling. The dependent attitudes of parents. The independent variable was knowledge. The data that has been collected is then analyzed using chi square test and odds ratio (OR). Results: Good knowledge increased the attitude of parents in efforts to overcome stunting at Posyandu, Jamaika village. Parents with good knowledge increased attitude by 1.40 times to have a positive attitude in efforts to overcome stunting, and this result is statistically significant (OR= 1.40; 95% CI= 0.87 to 2.23; p= 0.008). Conclusion: There was a relationship between good knowledge with attitude of parents as an effort to overcome stunting in the Posyandu, Jamika village with booklet media. Keywords: stunting, booklet, knowledge, attitudes, parents. Correspondence:Dendy Triatmaja. Master of Clinical Pharmacy Study Program. Universitas Padjadjaran. Jl. Raya Bandung Sumedang KM 21, Jatinangor 45363. Email: dendy20001@unpad.ac.id. Mobile: 082250888878.

Kajian Farmasi Klinis Penggunaan Obat Batuk “X” Dengan Kandungan Bromheksin HCl Untuk Pengencer Dahak Pada Anak Lisna Nur Imani; Keri Lestari; Wida Mulyaningsih
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Cough is a physiological reflex that occurs to protect the lungs from mechanical trauma or a natural defense process to maintain the respiratory tract by preventing the ingress of foreign bodies in the respiratory tract. Children are particularly susceptible to a wide variety of diseases such as acute respiratory infections. There are 3 types of cough medicines sold freely in Indonesia, namely for coughing up phlegm, dry cough and allergic cough, where the drug content in each type of cough medicine is different. Cough medicine X is a sputum-thinning cough medicine containing bromhexine HCl that works to dilute sputum in the respiratory tract. This article contains clinical pharmaceutical studies related to cough medicine X with the active substance bromhexine HCl. Based on the results of clinical pharmaceutical studies, cough x medicine can be used as a treatment for cough phlegm in children.

REVIEW: TONIC POTENCY OF ZINGIBERACEAE FAMILY HERBAL PLANTS IN IMPROVING BODY WELLNESS Nabilah Azka Nihlah; Imam Adi Wicaksono; Keri Lestari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.846

Body wellness is closely related to health; it is the ability of a person to perform activities without fatigue. Herbal plants can be used to help improve body health and endurance. The Zingiberaceae family is widely found and used by the Indonesian people. This family is widely used as an ingredient in herbal medicines and seasonings. Herbal plants with the potential to improve body wellness can be seen in their tonic effects. Testing the tonic effect can use several methods, namely, the natatory exhaustion test, hanging test, sleep induction test, and rotarod test in mice. Among these, the natatory exhaustion method is the simplest and can be performed quickly. The method used in preparing this article is to collect and understand the primary literature from online databases, such as Google Scholar. This review article aims to provide scientific information to the public regarding herbal plants from the Zingiberaceae family, which have the potential to help maintain a healthy body. Plants that can be used as health enhancers include Red Ginger, Gajah Ginger, Temu Kunci, Temu Giring, Lempuyang Gajah, and Cardamom. Keywords: Herbal Plant, Zingiberaceae, Tonicum, HealthÂ

Dendritic Cell as Potential Immunotherapy for Nasopharyngeal Cancer: A Review Albertus Budi Sulistya; Rima Haifa; Geofanny Facicilia; Kristin Talia Marbun; Marsya Nilam Kirana; Yussy Afriani Dewi; Cynthia Retna Sartika; Andi Wijaya; Keri Lestari Dandan
The Indonesian Biomedical Journal Vol 15, No 5 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i5.2389

BACKGROUND: Dendritic cell (DC)-based cancer therapy is a promising adjuvant therapy for nasopharyngeal cancer (NPC) after chemoradiation. Owing to low immunity after chemoradiation, DC therapy activates immune responses. Moreover, DC-based cancer therapy can decrease tumor progression, prolong lifespan, and increase the quality of life of patients. Various studies regarding the use of DC therapy for NPC have been reported, however there are limited reviews on the implementation and foundation of DC immunotherapy to expand this technology.METHODS: A literature search was performed on EMBASE, ScienceDirect, PubMed (MEDLINE), and Cochrane Library, with the term dendritic cells therapy for nasopharyngeal cancer, dendritic cell immunotherapy in nasopharyngeal cancer patients, and DC therapy in NPC, as the search keywords.RESULTS: A total of 199 literatures were reviewed, and four clinical trials were identified as relevant for this review. DC vaccines can be processed with various maturation and activation processes. Selected literatures reported antigens used when incubating the DC are latent membrane protein (LMP) 1, LMP2, and Epstein–Barr virus nuclear antigen 1 (EBNA1). Although DC therapy was produced from different pathways, it has been reported that there are increases of cluster of differentiation (CD)8+ T cells, CD4+ T cells, and the progression free survival (PFS) rate in DC immunotherapy patients than the radiochemotherapy patients.CONCLUSION: It can be concluded that DC could be used as an adjuvant therapy alongside the standard therapy of NPC, which prolongs NPC patient survival.KEYWORDS: adjuvant cell therapy, nasopharyngeal cancer therapy, dendritic cells

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.846

Efficacy of Quinine Sulfate in Patients with Mild-To-Moderate COVID-19: A Randomized Controlled Trial Irma Rahayu Latarissa; Melisa Intan Barliana; Anna Meiliana; Ida Paulina Sormin; Erizal Sugiono; Cissy Bana Kartasasmita; Irmansyah Irmansyah; Keri Lestari
The Indonesian Biomedical Journal Vol 15, No 6 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i6.2543

BACKGROUND: Before WHO revoked the emergency use authorization for Chloroquine (CQ) and Hydroxychloroquine (HCQ) because of their side effects, it was suggested to use these two drugs for COVID-19 therapy. In addition, another derivate of quinine, namely Quinine Sulfate (QS), showed good in silico and in vitro antiviral activity against SARS-CoV-2. Prior the WHO revocation, this study was conducted to evaluate the efficacy of QS in mild-to-moderate COVID-19 patients.METHODS: This was an adaptive, controlled, multicenter, randomized, double-blind clinical trial involving mild-to-moderate COVID-19 patients in Indonesia. The participants were divided into 2 groups: the control group (standard COVID-19 treatment + placebo) and the treatment group (standard COVID-19 treatment + QS). The primary outcome was the efficacy of QS based on clinical status using a 7-point ordinal scale. The secondary outcomes were the efficacy of QS in terms of the incidence and duration of oxygen supplementation, incidence of mechanical ventilation, and length of stay.RESULTS: No significant difference in the efficacy parameters studied was found between the control group and the treatment group. The difference in the mean oxygen saturation was also measured and the results showed a significant difference where the treatment group had higher mean oxygen saturation than the control group (p=0.001).CONCLUSION: Although not significant, the treatment group showed better therapy outcomes compared to the control group.KEYWORDS: clinical trials, efficacy, quinine, chloroquine, hydroxychloroquine

Higher Nrf2 Level is Correlated with Metabolic Parameters in Type 2 Diabetes Mellitus Rina Triana; Indriyanti Rafi Sukmawati; Mas Rizky Anggun Adipurna Syamsunarno; Keri Lestari
The Indonesian Biomedical Journal Vol 15, No 6 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i6.2656

BACKGROUND: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder associated with oxidative stress and chronic inflammation. Understanding the regulatory mechanisms related to the role of nuclear factor erythroid 2 (Nrf2), a master regulator of cellular antioxidant defenses, in individuals with T2DM, is essential. Therefore, in-depth investigation regarding the associations between Nrf2 levels, and metabolic parameters, such as waist circumference, fasting glucose levels, HbA1C, and serum inflammatory markers expressions is needed to elucidate the mechanisms driving T2DM and its metabolic disturbances.METHODS: This was a cross-sectional study including 90 T2DM and 25 healthy subjects. Nrf2 level; serum inflammatory markers levels, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, interferon (IFN)-α2, IFN-g, monocyte chemoattractant protein (MCP)-1, IL-10, IL-12p70, IL-17A, IL-18 and IL-23; as well as waist circumference; fasting glucose levels; and HbA1C were measured. Nrf2 concentrations in peripheral blood mononuclear cells were determined using enzyme-linked immunosorbent assay (ELISA), while serum inflammatory markers concentrations were quantified with flowcytometry.RESULTS: Nrf2, TNF-α, and IL-17A levels were significantly higher in the T2DM group, while IL-1β, IFN-α 2, IL-10, IL-12p70, and IL-23 levels were elevated in healthy controls Nrf2 exhibited positive correlations with waist circumference, fasting glucose, HbA1C, and TNF-α. Conversely, an inverse correlation of Nrf2 was observed with IL-1β, IL-12p70 and IL-17A.CONCLUSION: Correlations between Nrf2 and metabolic clinical parameters suggest its role in regulating glucose metabolism and adiposity. Elevated Nrf2 levels observed in T2DM patients may present novel therapeutic avenues for enhancing endogenous antioxidant defenses.KEYWORDS: type 2 diabetes mellitus, Nrf2, oxidative stress, inflammation, metabolic regulation, therapeutic strategies

Kajian Farmasi Klinis Kombinasi Pseudoefedrin HCl dan Guaifenesin Pada Obat Merk “X” Sebagai Penggunaan Obat Batuk dan Pilek Putri, Adinda Naswa; Lestari, Keri
Farmaka Vol 21, No 3 (2023): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i3.46904

Batuk dan hidung tersumbat merupakan refleks fisiologi untuk dapat melindungi saluran pernafasan dari rangsangan mekanik atau kimia atau masuknya benda asing untuk masuk. Anak merupakan usia yang rentang terkena penyakit saluran nafas akut dan rentan juga mengalami efek samping yang tidak diinginkan terhadap penggunaan obat. Obat batuk dan hidung tersumbat dalam bentuk siruk untuk anak terjual bebas di Indonesia salah satunya jenis ekspektoran dan dekongestan. Obat X ini memiliki kandungan Guaifenesin sebagai Ekspektoran dan Pseudoefedrin HCl sebagai deongestan. Artikel ini memuat tentang akjian farmasi klinis terkait obat X tersebut. Dan berdasarkan kajian farmasi klinis, obat X ini dapat dipergunakan sebagai obat batuk dan hidung tersumbat pada anak

Co-Authors Abdurahman Ridho ADIRA RAHMAWATY Adit Taufik Ahmad Muhtadi Ajeng Diantini, Ajeng Albertus Budi Sulistya Anas Subarnas Andi Wijaya ANISA MARIETA Anna Meiliana Anna Meiliana Arifin, Arief Riadi Arsenila Dewi Pramanti Asti Y. Rindarwati Aulia, Gina Auliya A. Suwantika Babikian, Haig Barliana, Melisa I. BERLIAN HANUTAMI N.P. Bryan J. Siagian Budi Setiabudiawan Catharina A. P. Utami Chandra Agung Purnama Cissy Bana Kartasasmita Cynthia Retna Sartika Destiani, Dika P. Desyandri Desyandri Dika P. Destiani DILA TRIARINI, DILA Dradjad - Priambodo Dwi Lestari Sulistyaningsih Eli Halimah, Eli Erizal Sugiono Erizal Sugiono, Erizal Fadila Nur Annisa Fadlilah, Aida Roja Fajriansyah Fajriansyah FATHYA ULFA Ferdy Ferdian Fitriah Nurhayani Florencia, Carla Furqani, Winda H. Ganis Fitria Fauziyyah Geofanny Facicilia Ghassani, Salma K. Gina Aulia Herdaningsih, Sulastri Herdaningsih, Sulastri Iceu Dimas Kulsum Ida Paulina Sormin Ida Paulina Sormin Iis Rukmawati Iis Rumawati Imam Adi Wicaksono Indriyanti Rafi Sukmawati Insani, Widya N. Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Irma Rahayu Latarissa Irmansyah Irmansyah Iskandarsyah, Aulia Ismail, Efriadi Jutti Levita Khaerani, Fitri Azlia Khoirunnisa, Izzatul Kristin Talia Marbun Kusnendar, Ahmad Nada Lisna Nur Imani Magdarita Riwu Maharani, Devita Salsa Marsya Nilam Kirana Mas Rizky Anggun Adipurna Syamsunarno Meilani Jayanti Melisa Fuji Faujiah Dwi Putri Melisa I Barliana Melisa I. Barliana Melisa Intan Barliana MICHELLE FERDINAND Miswar Fattah Mulyana Mulyana Mulyanto, Sangkan Mutakin Mutakin Nabilah Azka Nihlah Nabilah Nadhif Nabilah Nadhif Nimas T. I. Tarina Norisca A. Putriana Nuning Nurcayani Nyai Ayu Sylfia Stannia Puspitasari Helmi Oktavelia, Wanda Pradana, Eky Septian Prayudi Santoso Putri Kholilah Maulida Putri, Adinda Naswa Putri, Norisca A. Putri, Norisca A. Putriana, Norisca A. Ramadhan, Iqbal Sujida Rano K. Sinuraya Rima Haifa Rina Triana Rindarwati, Asti Y. Rini Hendriadi Rizky Abdulah Rizky H. Rambe Salma K. Ghassani Setiawan Setiawan Siagian, Bryan J. Sinuraya, Rano K. Siti Saidah Siti Saidah Soemita, Nanang Sumalim, Yelsen Taofik Rusdiana Taufik, Adit TIANA MILANDA Triatmaja, Dendy Vani Rahmasari Wahyu P. Sari Wida Mulyaningsih Widya N. Insani Winda H. Furqani Yova Amijaya Fitri Yovita Hartantri Yussy Afriani Dewi YUSUF, RAMAYANI Zaerani, Rani Zelika Mega Ramadhania Zulfahmidah, Zulfahmidah Zulfan Zazuli

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