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All Journal Farmaka Indonesian Journal of Applied Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Pharmacology and Clinical Pharmacy Research KACANEGARA Jurnal Pengabdian pada Masyarakat Journal of Maternal and Child Health Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Indian Journal of Forensic Medicine & Toxicology Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian

Keri Lestari

Universitas Padjadjaran

Author-ID : 2695911

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Antibacterial Activity of Parijoto (Medinilla speciosa Blume) Fruit Against Serratia marcescens and Staphylococcus aureus Tiana Milanda; Keri Lestari; Nimas T. I. Tarina
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.32166

Parijoto (Medinilla speciosa Blume) is a plant found in Mount Muria, Kudus, Central Java. The local community often uses its fruit to treat various diseases, as well as antibacterial, anti-inflammatory, antioxidant, and anti-cancer. This study aimed to determine the antibacterial activity of n-hexane, ethyl acetate and methanol extract from parijoto fruit against Staphyococcus aureus ATCC 29213 and Serratia marcescens clinical isolates. Gradual maceration of simplicial and antibacterial activity testing of the extracts was performed, followed by determining the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and comparative antibacterial activity most active extract against ampicillin and cefadroxil. The results showed that all extracts exhibited activity against S. aureus ATCC 29213, but only ethyl acetate and methanol extracts had activity against S. marcescens clinical isolates. The highest antibacterial activity was shown by the methanol extract, which was more effective against S. aureus ATCC 29213, having the largest inhibition diameter and lowest MIC and MBC values (6.25 and 12.5 mg/mL). The comparative analysis indicated that the methanol extract demonstrated lower antibacterial activity against S. aureus ATCC 29213 than cefadroxil (72,511: 1). This antibacterial activity is presumed to be generated from alkaloids, polyphenols, tannins, flavonoids, quinones and saponina in the extract.Keywords: Amoxicillin, Cefadroxil, MIC, MBC

Korelasi Faktor Usia, Cara Minum, dan Dosis Obat Metformin terhadap Risiko Efek Samping pada Penderita Diabetes Melitus Tipe 2 Magdarita Riwu; Anas Subarnas; Keri Lestari
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Universitas Padjadjaran

Metformin merupakan obat antidiabetes oral yang umumnya direkomendasikan sebagai pengobatan lini pertama pada diabetes melitus tipe 2 apabila kadar glukosa darah tidak terkontrol dengan modifikasi gaya hidup. Pada penggunaan metformin sebagai kontrol glikemia sering terjadi reaksi obat yang merugikan (ROM) berupa gangguan gastrointestinal seperti diare, mual, dan perut kembung. Penelitian ini bertujuan untuk menganalisis korelasi faktor usia, cara minum, dan dosis metformin terhadap risiko efek samping gangguan gastrointestinal pada penderita rawat jalan BPJS Kesehatan yang baru terdiagnosis diabetes melitus tipe 2 di RSAU Dr. M. Salamun Bandung. Penelitian ini adalah analitik observasional dengan desain potong lintang. Data dikumpulkan dari bagian poliklinik penyakit dalam, rekam medis, dan form check penderita yang mendapat pengobatan dengan metformin yang dilakukan sejak April–Juni 2014. Jumlah penderita yang memenuhi kriteria penelitian sebanyak 65 orang dengan rentang usia rata-rata 48 tahun. Keluhan efek samping yang dialami penderita berupa kembung (58,46%) dan mual (41,54%). Cara minum dan dosis metformin berkorelasi terhadap risiko efek samping berupa mual dan kembung pada penderita diabetes melitus tipe 2 (p<0,05) sedangkan faktor usia tidak berkorelasi (p>0,05). Penggunaan metformin dianjurkan sesudah makan dan dengan dosis awal rendah yang dititrasi perlahan untuk mengurangi dan menghindari terjadinya efek samping mual dan perut kembung pada penderita diabetes melitus tipe 2.Kata kunci: Diabetes melitus tipe 2, efek samping, metforminThe Correlation of Age Factor, Administration, and Metformin Dose Against Risk of Side Effect on Type 2 Diabetes MellitusMetformin is an antidiabetic oral medicine commonly recommended as first line treatment on type 2 diabetes mellitus. Metformin can caused drug related problems (DRPs) such as gastrointestinal disorders, e.g. diarrhea, nausea, and flatulence. This study aimed to analyze correlation profiles on age, administration, and metformin dosage factors against risk of gastrointestinal disorders among newlydiagnosed diabetic outpatients of National Health Insurance in RSAU Dr. M. Salamun Bandung. This study was an analytic observational study with a cross sectional method. The study was carried out in the internal medicine outpatient clinic and data were extracted from patients medical records from April to June 2014. Metformin-treated patients were interviewed using a form check. The number of patients were 65 with the median rate was 48 years old. Side effect reported were flatulence (58.46%) and nausea (41.54%). Administration and metformin dosage factors were correlated to the risk of side effects such as nausea and flatulence on type 2 diabetes mellitus (p<0.05), while age was not correlated (p>0.05). The administration of metformin is recommended after meals and with a lower initial dose titrated slowly to reduce and avoid the side effects of nausea and flatulence in patients with type 2 diabetes mellitus.Keywords: Metformin, side effect, type 2 diabetes mellitus

Pengaruh Konseling Apoteker terhadap Pengetahuan dan Persepsi Pasien Penyakit Jantung Terapi Warfarin di RSUP Dr. Hasan Sadikin Bandung Norisca A. Putriana; Melisa I. Barliana; Keri Lestari
Indonesian Journal of Clinical Pharmacy Vol 6, No 4 (2017)
Publisher : Universitas Padjadjaran

Warfarin merupakan turunan dari kumarin, yang sudah biasa diresepkan sebagai antikoagulan oral untuk mengobati atau mencegah penyakit-penyakit trombotik. Tujuan dari penelitian ini yaitu untuk menganalisis pengaruh konseling apoteker terhadap pengetahuan dan persepsi pada pasien penyakit jantung pengguna warfarin. Penelitian ini dilaksanakan pada bulan Juli 2012–Februari 2014 di Poli Jantung RSUP Dr. Hasan Sadikin, Bandung. Desain penelitian berupa mixed method. Data kualitatif digunakan untuk mendukung data kuantitatif, dengan metode kualitatif berupa analisis konten dengan cara wawancara. Metode kuantitatif berupa quasi-eksperimental dengan kelompok kontrol pre-post test design. Analisis data penelitian menggunakan uji Wilcoxon dan uji Mann-Whitney dengan level signifikansi p≤0,05 dan analisis multivariat. Hasil penelitian menunjukkan bahwa terdapat pengaruh konseling apoteker terhadap pengetahuan (p<0,05) dan persepsi (p<0,05). Konseling apoteker dapat memperbaiki pengetahuan dan persepsi pasien terapi warfarin.Kata kunci: Konseling, pengetahuan, persepsi, warfarin The Influence of Pharmacist’s Counseling on Knowledge and Perception on Cardiac Patient Warfarin Management at Dr. Hasan Sadikin Hospital BandungWarfarin is a derivate of coumarin, which is usually prescripted as an oral anti-coagulant for treatment and prevention of thromboembolic disorders. The aim of this research was to analyse the influence of pharmacist’s counseling on knowledge and perception on warfarin management. This research was conducted from July 2012 until February 2014 in Cardiac Polyclinic Dr. Hasan Sadikin General Hospital, Bandung. This research used mixed method design. Qualitative data was obtained using content analysis with interview method and used to complete quantitative data. Quantitative method used a quasi-experimental method with control groups and pre-post test design. Data was collected by prospective method and analysed using Wilcoxon and Mann-Whitney test at significance level p≤0.05 and multivariate analysis covariate. The result of this research is pharmacist’s counseling affected knowledge (p<0.05) and perception (p<0.05). Pharmacist’s counseling can improve knowledge and perception on warafarin therapy.Keywords: Counseling, knowledge, perception, warfarin

Permasalahan Terkait Obat (Drug Related Problems/DRPs) pada Penatalaksanaan Penyakit Ginjal Kronis dengan Penyulit Penyakit Arteri Koroner Winda H. Furqani; Zulfan Zazuli; Nabilah Nadhif; Siti Saidah; Rizky Abdulah; Keri Lestari
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Masalah terkait obat (DRPs) didefinisikan sebagai setiap kondisi dalam penatalaksanaan terapi pasien yang menyebabkan atau berpotensi menyebabkan tidak tercapainya hasil terapi yang optimal. Penelitian ini dilakukan di salah satu rumah sakit di Kota Cimahi pada bulan Mei 2014. Pada penelitian ini dilakukan identifikasi DRPs pada pasien wanita berusia 59 tahun yang didiagnosis penyakit ginjal kronis dengan penyulit penyakit arteri koroner dan gangren di tangan kiri (jari ke-3). Pasien diketahui mempunyai riwayat diabetes melitus sejak dua hingga tiga tahun yang lalu. Melalui kajian DRPs ditemukan permasalahan terkait obat, yaitu adanya terapi obat yang tidak diperlukan (pemberian kalsium polistiren sulfonat), ketidaktepatan pemilihan antibiotik, Ketidaktepatan dosis (pemberian amoksisilin dan kaptopril), dan risiko interaksi obat-obat merugikan (interaksi kaptopril–furosemid, kaptopril–isosorbid dinitrat, dan kaptopril–natrium bikarbonat). Pasien penyakit ginjal kronis dengan penyulit penyakit arteri koroner menerima terapi obat yang kompleks sehingga meningkatkan risiko terjadinya DRPs. Keterlibatan apoteker klinis di rumah sakit dalam penatalaksanaan penyakit yang kompleks diperlukan untuk mengoptimalkan terapi, meminimalisir risiko DRPs, dan meningkatkan kualitas hidup pasien.Kata kunci: Drug related problems, penyakit ginjal kronis, penyakit arteri koronerDrug Related Problems in the Management of Chronic Kidney Disease with Coronary Artery DiseaseDrug related problems were defined as conditions on patient’s therapy management that caused, or potentially caused unsuccessful therapy. This study was conducted at a hospital in Cimahi City in May 2014. In this study, DRPs were identified on a 59 years old woman who was diagnosed with chronic kidney disease and coronary artery disease with gangrene on the left hand (the third finger). The patient also had a diabetes mellitus for two until three years ago. Drug related problems (DRPs) were found in this patient. Unnecessary drug therapy (administration of calsium polystirene sulfonate), inappropriate choosen antibiotic, inappropriate dosing (administration of amoxicillin and captopril), and risks drug interactions (captopril–furosemide, captopril–isosorbide dinitrate, and captopril–sodium bicarbonate). Patients with chronic kidney disease and coronary artery disease received complex drug therapy. These condition lead to higer risk of DRPs. The involvement of clinical pharmacist in interdisciplinary team for management of complex diseases was needed to monitor drug therapy to optimizing the therapy, minimalizing the risk of DRPs, and improving patient’s quality of life.Key words: Chronic kidney disease, coronary artery disease, drug related problems

Pengukuran Tingkat Pengetahuan tentang Hipertensi pada Pasien Hipertensi di Kota Bandung: Sebuah Studi Pendahuluan Rano K. Sinuraya; Bryan J. Siagian; Adit Taufik; Dika P. Destiani; Irma M. Puspitasari; Keri Lestari; Ajeng Diantini
Indonesian Journal of Clinical Pharmacy Vol 6, No 4 (2017)
Publisher : Universitas Padjadjaran

Hipertensi merupakan penyebab umum dalam peningkatan angka mortalitas dan mobiditas di masyarakat. Selain merupakan silent killer, prevalensi penyakit ini semakin meningkat di seluruh dunia. Prevalensi hipertensi di Indonesia 25,8% dan Jawa Barat berada di peringkat keempat dengan prevalensi 29,4%. Penelitian ini bertujuan untuk mengukur tingkat pengetahuan pasien hipertensi terkait penyakit yang dideritanya. Studi ini merupakan penelitian observasional menggunakan rancangan potong lintang dan dilakukan pada bulan Juni–Oktober 2017 di Apotek Pendidikan Universitas Padjadjaran, Kota Bandung. Sejumlah seratus lima puluh responden mengisi kuesioner yang telah divalidasi setelah menandatangani informed consent terlebih dahulu. Hasil penelitian menunjukkan bahwa sebanyak 56,7% dari responden memiliki tingkat pengetahuan baik, 40% dari responden memiliki tingkat pengetahuan cukup, dan 3,3% dari responden memiliki tingkat pengetahuan kurang. Data kemudian diolah secara statistik sehingga diperoleh hasil bahwa tidak terdapat perbedaan bermakna (p>0,05) antara setiap kelompok responden terhadap sosiodemografi dan karakteristik klinis pasien. Hanya sekitar 50% responden yang memiliki tingkat pengetahuan baik, pasien yang memiliki tingkat pengetahuan cukup dan kurang umumnya adalah pasien dengan tingkat pendidikan rendah dan menderita hipertensi kurang dari lima tahun.Kata kunci: Fasilitas kesehatan primer, hipertensi, tingkat pengetahuan Assessment of Knowledge on Hypertension among Hypertensive Patients in Bandung City: A Preliminary StudyHypertension is a common health problems that can increase the mortality and mobility rate in the community. As a silent killer, the prevalence of this disease is increasing worldwide. The prevalence of hypertension in Indonesia is 25.8% and West Java is ranked at top four with prevalence of 29.4%. This study aimed to measure the level of knowledge of hypertensive patients about their disease. This study was an observational study using cross-sectional design in June–October 2017 at Apotek Pendidikan Universitas Padjadjaran, Bandung City. A total of one hundred and fifty respondents completed a validated questionnaire after signing informed consent. The results showed that 56.7% of respondents have “good” level of knowledge, 40% of respondents have “moderate” level of knowledge, and 3.3% of respondents have “poor” level of knowledge. Data were analyzed statistically, the results showed that there was no significant difference (p>0.05) between each group of respondents to sociodemographic and clinical characteristics of the patients. Only fifty percent of respondents have “good” level of knowledge, patients who have “moderate” and “poor” level of knowledge generally are patients with low levels of education and suffer from hypertension less than five years.Keywords: Hypertension, level of knowledge, primary health care

Pengaruh Pelayanan Informasi Obat terhadap Keberhasilan Terapi Pasien Diabetes Melitus Tipe 2 Widya N. Insani; Keri Lestari; Rizky Abdulah; Salma K. Ghassani
Indonesian Journal of Clinical Pharmacy Vol 2, No 4 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.955 KB)

pemahaman mengenai instruksi pengobatan merupakan permasalahan utama dalam pengobatan DMT2. Ketidakpatuhan pasien terhadap regimen obat hipoglikemik oral yang kompleks serta ketidaktepatan dalam cara dan waktu pengonsumsiannya merupakan barrier tercapainya keberhasilan terapi DMT2. Hal ini sangat berkaitan dengan kualitas pelayanan kefarmasian yang diberikan kepada pasien, khususnya pelayanan informasi obat. Penelitian ini bertujuan untuk mengevaluasi pengaruh intervensi pelayanan informasi obat terhadap parameter keberhasilan terapi diabetes yaitu glukosa 2 jam postprandial, HDL dan trigliserida. Penelitian ini merupakan nonrandomized concurrent control trial secara prospektif. 14 subjek uji direkrut selama 4 bulan selama Mei–Agustus 2013 kemudian dibagi menjadi dua grup. Kedua grup mendapat terapi pengobatan diabetes berupa hipoglikemik oral. Grup intervensi mendapatkan pelayanan informasi obat dan edukasi mengenai diabetes, sedangkan grup kontrol tidak mendapatkannya. Data dianalisis menggunakan uji t independen dengan α 0,05. Walau belum berbeda signifikan, nilai keberhasilan terapi dengan intervensi pelayanan informasi obat pada parameter glukosa 2 jam postprandial, HDL dan trigliserida memberikan hasil yang lebih tinggi 17,01%; 6,73%; dan 6,31% untuk masing-masing parameter dibandingkan terapi tanpa pelayanan kefarmasian tersebut.Kata kunci: Pelayanan informasi obat, diabetes, obat hipoglikemik oral Effect of Pharmaceutical Information Care on Clinical Outcomes of Patients With Type 2 Diabetes MellitusPoor adherence to medication and lack of understanding about medication instructions are the main problems in the treatment of type 2 diabetes mellitus. Poor adherence to oral hypoglicemic drugs which have complex regiment and unappropriate consumption of them are the obstacles to reach good clinical outcomes. These problems are highly related to the quality of pharmaceutical care given to patients. The aim of this study was to evaluate the effect of pharmaceutical information care towards the outcome of type 2 diabetes mellitus including 2 hours postprandial glucose, HDL and tryglicerides. This study used nonrandomized concurrent control trial prospectively. 14 subjects were recruited during 4 months from May–August 2013 and were divided into two groups. Both of group were given oral hypoglycemic drugs. The intervention group received pharmaceutical information care and diabetes education, whilecontrol group did not receive these. Data were then analysed with independent t test using α 0,005. Although the difference were not significant yet, pharmaceutical information care intervention on diabetes treatment gave higher improvement by 17,01%; 6,73%; and 6,31% respectively in 2 hours postprandial glucose, HDL and tryglicerides parameters, compared with the treatment without pharmaceutical care.Key words: Pharmaceutical information care, diabetes, oral hypoglicemic drugs

Stevia rebaudiana Bertoni Leaves Extract as a Nutraceutical with Hypoglycemic Activity in Diabetic Rats Keri Lestari; Abdurahman Ridho; Nuning Nurcayani; Zelika Mega Ramadhania; Melisa Intan Barliana
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.686

BACKGROUND: The prevalence of diabetes mellitus is growing every year, including in Indonesia. Medicinal herbs were used empirically for lowering blood glucose. One of potential herb to have hypoglycemic activity is Stevia. Stevia rebaudiana Bertoni leaves contain stevoside, a natural, low-calorie sweetener that is 300 times sweeter than saccharose. In this study, we aimed to explore the hypoglycemic activity of S. rebaudiana Bertoni leaves extract in a rat model of type 2 diabetes mellitus (T2DM). METHODS: Male Wistar rats were feed high-fat, high-carbohydrate feed and sugar solution for 74 days to induce a diabetic rat model. The animals were then divided into five groups consisting of a negative control group treated with 2% Pulvis Gom Arabicum; a positive control group treated with Metformin 45 mg/kg body weight (BW); and three test groups treated with aqueous extract of S. rebaudiana Bertoni leaves at doses of 3.125, 6.25 and 12.5 mg/kg BW for 36 days. Blood glucose was measured on days 14, 28 and 36.RESULTS: The results showed that blood glucose levels over 36 days were significantly (p=0.043) lower in the group treated with S. rebaudiana Bertoni leaves extract. Further Newman-Keuls analysis suggested that the hypoglycemic activity of S. rebaudiana Bertoni leaves extract was dose-dependent. CONCLUSION: Our results indicate that S. rebaudiana Bertoni leaves extract has a potential role as a hypoglycemic agent in the treatment of T2DM.KEYWORDS: Stevia rebaudiana Bertoni, nutraceuticals, hypoglycemic, diabetic rats

Apoptosis and Efferocytosis in Inflammatory Diseases Chandra Agung Purnama; Anna Meiliana; Melisa Intan Barliana; Keri Lestari Dandan; Andi Wijaya
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1608

BACKGROUND: Millions of cells in multicellular organisms regenerate every day to replace aged and died cells. Effective cell clearance (efferocytosis) is critical for tissue homeostasis, as the human body recycles its cellular components. We summarize what is known about the mechanisms of efferocytosis and how it impacts the physiology of the organism, effects on inflammation and the adaptive immune response, as well as the consequences of defects in this critical homeostatic mechanism in this review.CONTENT: Cell death is the process by which the human body replaces aged or damaged cells with new ones. It can be triggered by genetically encoded machinery or regulated cell death, or by specific pharmacologic or genetic interventions, resulting in accidental cell death. Dying cells release signals that entice phagocytes to engulf them in a process known as efferocytosis. Efferocytosis is a multistep process involving the release of “find me” and “eat me” signals and destruction of death cells by phagocytes. Different types of cell death including apoptosis and necroptosis can express pro- or anti-inflammatory signals via macrophage activity modulation.SUMMARY: Failed or ineffective efferocytosis can result in disruption of tissue homeostasis, which can contribute to the development of chronic inflammatory diseases such as atherosclerosis, obesity, diabetes, and heart failure. Therefore, any therapeutic strategy that enhances efferocytosis will have a beneficial effect on the treatment of these metabolic disorders.KEYWORDS: apoptosis, necroptosis, phagocytosis, efferocytosis, macrophage.

Pharmaceutical Counseling Has a Positive Impact on Quality of Life of Hypertension Patients Gina Aulia; Eli Halimah; Keri Lestari
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Pharmacists play a major role in educating patients regarding drug therapy, in order to achieve optimal health outcomes. The aim of this study was to investigate the effect of pharmaceutical counseling on quality of life (QoL) of hypertensive patients with renal impairment at one of public hospital in Bandung, Indonesia. This study used a prospective experimental design with pretest-posttest design for 2 months. Inclusion criteria in this study were hypertensive patients with renal impairment who received antihypertensive drugs, aged >18 years, and signed the informed consent. Exclusion criteria were patients who were not able to fill in the questionnaire, patients with end stage renal diseases, diabetes, and pregnant or lactating patients. Pharmaceutical counseling was given during 2 months of the therapy. Pharmaceutical counseling consisted of education on the appropriate use of drugs and disease management. Schedule of their own medication and leaflet containing educational information were given to the subjects. QoL was assessed using a previously validated Mini-Questionnaire of QoL in Arterial Hypertension (MINICHAL). The questionnaire consisted of 16 two dimensions questions, i.e., mental health and somatic manifestation. We found that the mean increase in mental health status (49.5±5.3) was higher than that of somatic dimension (32.7±3.6). Both dimensions had statistically significant improvement (P value <0.05). In conclusion, pharmaceutical counseling is beneficial to improve QoL of hypertension patients.Keywords: hypertension, renal impairment, quality of life

Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children Asti Y. Rindarwati; Ajeng Diantini; Keri Lestari
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.Keywords: deferasirox, deferiprone, ferritin, thalassemia major

Co-Authors Abdurahman Ridho ADIRA RAHMAWATY Adit Taufik Ahmad Muhtadi AJENG DIANTINI Ajeng Diantini, Ajeng Anas Subarnas Andi Wijaya ANISA MARIETA Anna Meiliana Arifin, Arief Riadi Asti Y. Rindarwati Aulia, Gina Auliya A. Suwantika Babikian, Haig Barliana, Melisa I. BERLIAN HANUTAMI N.P. Bryan J. Siagian Budi Setiabudiawan Catharina A. P. Utami Chandra Agung Purnama Destiani, Dika P. Desyandri Desyandri DIANTINI, AJENG - Dika P. Destiani DILA TRIARINI, DILA Dwi Lestari Sulistyaningsih Eli Halimah Eli Halimah, Eli Erizal Sugiono, Erizal Fadila Nur Annisa Fadlilah, Aida Roja Fajriansyah Fajriansyah FATHYA ULFA Ferdy Ferdian Fitriah Nurhayani Florencia, Carla Furqani, Winda H. Ganis Fitria Fauziyyah Ghassani, Salma K. Gina Aulia Herdaningsih, Sulastri Herdaningsih, Sulastri Iceu Dimas Kulsum Ida Paulina Sormin Iis Rukmawati Iis Rumawati Imam Adi Wicaksono Insani, Widya N. Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Iskandarsyah, Aulia Ismail, Efriadi Jutti Levita Khaerani, Fitri Azlia Khoirunnisa, Izzatul Kusnendar, Ahmad Nada Magdarita Riwu Maharani, Devita Salsa Meilani Jayanti Melisa I. Barliana Melisa Intan Barliana Melisa Intan Barliana MICHELLE FERDINAND Miswar Fattah Mulyana Mulyana Mulyanto, Sangkan Mutakin Mutakin Nabilah Azka Nihlah Nabilah Nadhif Nabilah Nadhif Nimas T. I. Tarina Norisca A. Putriana Nuning Nurcayani Nyai Ayu Sylfia Stannia Puspitasari Helmi Oktavelia, Wanda Pradana, Eky Septian Prayudi Santoso Putri Kholilah Maulida Putri, Adinda Naswa Putri, Norisca A. Putri, Norisca A. Putriana, Norisca A. Ramadhan, Iqbal Sujida Rano K. Sinuraya Rindarwati, Asti Y. Rini Hendriadi Rizky Abdulah Rizky H. Rambe Salma K. Ghassani Setiawan Setiawan Siagian, Bryan J. Sinuraya, Rano K. Siti Saidah Siti Saidah Soemita, Nanang Sumalim, Yelsen Taofik Rusdiana Taufik, Adit TIANA MILANDA Triatmaja, Dendy Vani Rahmasari Wahyu P. Sari Widya N. Insani Winda H. Furqani Yovita Hartantri YUSUF, RAMAYANI Zaerani, Rani Zelika Mega Ramadhania Zulfan Zazuli

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