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Potential Analysis of Quercetin and Its Derivatives as Inhibitors of Hendra Virus (HeV) Rosyiidah, Nur Anisa; Setiarso, Pirim; Sanjaya, I Gusti Made
Indonesian Journal of Chemical Science and Technology (IJCST) Vol 7, No 1 (2024): JANUARY 2024
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v7i1.56448

Abstract

This study aims to determine the inhibitory potential of quercetin and its derivatives on the activity of Hendra virus (HeV) 6BK6 protein with its comparator N-Acetyl-D-[1-13C] Glucosamine. This research was carried out using the molecular docking method in order to obtain information related to binding affinity values, inhibition constants, and amino acid residues in the ligand-receptor hydrogen bonds. It was found that the compound quercetin 3-O-xyloside had the lowest binding affinity among the other compounds, namely -6.92 kcal/mol with an inhibition constant of 8.44 µM. In addition, there are four types of amino acid residues in the ligand-receptor hydrogen bonds including ASP304 (1,90 Å), SER301 (2,47 Å), ARG191 (3,18 Å), and MET188 (4.34 Å). In this case it can be concluded that the compound quercetin 3-O-xyloside has been shown to have the potential to inhibit the activity of the HeV 6BK6 protein.
Implementasi Pendekatan CRT untuk Meningkatkan Motivasi Dan Hasil Belajar Peserta Didik Kelas VIII SMPN 13 Madiun Mardiyanti, Nur Eka Agusti; Kurdaningsih, Kurdaningsih; Sanjaya, I Gusti Made
PendIPA Journal of Science Education Vol 8 No 2 (2024): June
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.8.2.126-130

Abstract

This research aimed to increase student motivation and learning outcomes. This type of research is Classroom Action Research over 2 learning cycles, which lasts for two meetings, where in one cycle there is one meeting which includes planning, implementation, observation and reflection activities. The research subjects were 31 students from class VIII B at SMPN 13 Madiun. Data collection was carried out using questionnaires, observations and evaluations. The data from this research were processed and analyzed, which showed that the highest student motivation was in the process indicators that were interesting, the learning activity process ran interestingly, and increased students' learning motivation. The learning outcomes of students in cycle 1 obtained an average score of 88.57 and a completeness level of 75%, cycle 2 obtained an average score of 96.07 with a completeness level of 89.29%. The results obtained from cycles 1 and 2 using the CRT approach can be used as input for teachers to increase students' motivation and learning outcomes in learning activities.
PELATIHAN MENDESAIN PEMBELAJARAN BERBASIS PROYEK UNTUK GURU KIMIA DI KOTA MOJOKERTO Suyatno Sutoyo; I Gusti Made Sanjaya; Sophia Allamin; Zainul Arifin Imam Supardi; Beni Setiawan; Ika Ambarwati
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pembelajaran berbasis proyek (Project based learning) merupakan salah satu model pembelajaran yang direkomendasikan dalam kurikulum merdeka karena mampu membekali siswa dengan keterampilan abad 21 serta mewujudkan profil pelajar Pancasila. Tingkat pemahaman dan kemampuan guru kimia di Kota Mojokerto dalam mendesain pembelajaran berbasis proyek masih kurang sehingga diperlukan pelatihan untuk mengatatasi permasalahn mitra tersebut. Kegiatan pelatihan dilaksanakan di SMAN 3 Mojokerto, pada hari Sabtu, 28 September 2024, diikuti oleh 25 orang guru kimia. Kegiatan diawali dengan penyajian materi pelatihan oleh Tim PKM, dilanjutkan dengan pendampingan pembuatan desain pembelajaran berbasis proyek melalui diskusi dan presentasi. Pada akhir kegiatan dilakukan refleksi dan pemberian angket. Berdasarkan hasil penilaian terhadap produk desain pembelajaran berbasis proyek yang dihasilkan melalui penugasan secara mandiri, peserta pelatihan telah memiliki kemampuan dalam menyusun desain pembelajaran berbasis proyek dengan kategori baik dengan skor rata-rata 85,40. Hasil analisis angket menunjukkan bahwa peserta memberikan respon respon yang sangat baik terhadap pelatihan yang telah dilaksanakan.
PELATIHAN PEMBUATAN HAND SANITIZER BERBASIS BAHAN ALAM RAMAH LINGKUNGAN DI WILAYAH LOCERET KABUPATEN NGANJUK Nur Hayati; Suyatno Suyatno; Nita Kusumawati; I Gusti Made Sanjaya; Maria Monica Sianita; Samik Samik
RESONA : Jurnal Ilmiah Pengabdian Masyarakat Vol 7, No 2 (2023): December
Publisher : Lembaga Penerbitan dan Publikasi Ilmiah (LPPI) Universitas Muhammadiyah Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35906/resona.v7i2.1325

Abstract

Era endemi Covid-19 menuntut masyarakat untuk menjaga protokol  kesehatan sesuai dengan SOP kesehatan agar terhindar dari penularan Covid-19  dan penyakit menular lainnya. Kebutuhan untuk melakukan 5M salah satunya  mencuci tangan dengan sabun atau dengan menggunakan hand sanitizer sangat  besar. Untuk itu ketersediaan hand sanitizer yang murah dan efektif untuk digunakan dalam berbagai kepentingan dapat membantu masyarakat menerapkan  protokol kesehatan. Untuk itu, Tim PKM bermaksud untuk memberikan pelatihan pembuatan  produk   hand sanitizer berbasis bahan alam bagi masyarakat desa Ngepeh Kec Loceret Kab Nganjuk. Hand sanitizer ini menggunakan bahan alami yang tersedia di lingkungan tempat tinggal mereka, yakni daun sirih dan jeruk nipis. Namun, sebagian masih menggunakan bahan kimia seperti gliserin dan hidrogen peroksida. Dari kegiatan PKM produksi Hand Sanitizer Non-Alkohol berbahan alam ini diharapkan: (1) masyarakat desa Ngepeh Kec Loceret Kab Nganjuk memiliki keterampilan dalam membuat hand sanitizer berbahan tanaman toga, (2) meringankan beban mereka dalam pembelian hand sanitizer, (3) meningkatkan peran warga untuk ikut berpartisipasi di masyarakat dalam membantu memberikan hand sanitizer berbahan alami. Hasil kegiatan menunjukkan bahwa pelatihan yang diberikan terkait pembuatan handsanitizer memberikan perubahan pengetahuan khalayak sasaran (kelompok mitra). pengabdian, dan hasil.  Abstract. The Covid-19 endemic era requires the public to maintain health protocols in accordance with health SOPs to avoid transmission of Covid-19 and other infectious diseases. The need to do the 5Ms, one of which is washing hands with soap or using hand sanitizer, is very large. For this reason, the availability of cheap and effective hand sanitizers for use for various purposes can help people implement health protocols. For this reason, the PKM Team intends to provide training in making hand sanitizer products based on natural ingredients for the people of Ngepeh village, Loceret District, Nganjuk District. This hand sanitizer uses natural ingredients that are available in the environment where they live, namely betel leaves and lime. However, some still use chemicals such as glycerin and hydrogen peroxide. From the PKM activity of producing Non-Alcoholic Hand Sanitizers made from natural ingredients, it is hoped that: (1) the people of Ngepeh village, Loceret District, Nganjuk Regency will have the skills to make hand sanitizers made from the toga plant, (2) lighten their burden in purchasing hand sanitizers, (3) increase their role residents to participate in the community in helping provide natural hand sanitizers. The results of the activity showed that the training provided regarding making hand sanitizer resulted in changes in the knowledge of the target audience (partner group).
Validitas Lembar Kerja Peserta Didik (LKPD) Berbasis Inkuiri Untuk Melatihkan Literasi Sains Peserta Didik SMA Pada Materi Perubahan Iklim Agustin, Zulfani Nurdiana; Sanjaya, I Gusti Made
JURNAL PENELITIAN PENDIDIKAN MATEMATIKA DAN SAINS Vol. 8 No. 2 (2024): JPPMS Vol. 8 No. 2 Tahun 2024
Publisher : Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jppms.v8n2.p60-68

Abstract

This study aims to describe the validity of inquiry-based LKPD to train science literacy of high school students on climate change material. This research uses a type of development / Research and Development (R&D) with a 4D model (Define, Design, Develop, Disseminate). When the define stage begins by analyzing the initial problem by means of literature study. Next is the design at this stage is the process of preparing learning tools developed in the form of Student Worksheets (LKPD). At the development stage, it is to conduct a validation test of the LKPD learning tool to expert validators and a trial to students. The dissemination stage is not carried out, only until it is carried out by disseminating the research results in the form of scientific articles containing research on the development of published learning tools. The validity of the worksheet was assessed with 13 aspects on the validator assessment sheet. Based on the assessment aspects carried out by 2 expert validators, it was found that the validity of the LKPD developed obtained a validity of 0.87, reliability of 0.87, and homogeneity of 0.96. The results of the validation show that the LKPD developed is declared valid and reliable, so it is suitable for use in learning activities to improve students' science literacy on climate change material.
Potential of Fruit Extract from Green-Stemmed Binahong (Anredera cordifolia) as a Natural Chromophore for Solar Cell Development Damayanti, Ni Noman Triyani; Sanjaya, I Gusti Made
Jurnal Pijar Mipa Vol. 20 No. 5 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i5.9442

Abstract

The increasing demand for clean and renewable energy has driven the exploration of alternative materials for solar cell development. In this context, natural chromophores derived from plants offer an eco-friendly and sustainable solution due to their availability, low toxicity, and diverse molecular structures. This study investigates the chromophoric potential of the green-stemmed binahong (Anredera cordifolia) fruit and evaluates natural compounds that can be efficient light-absorbing materials in solar energy applications. Extracts of the binahong fruit were analyzed using Liquid Chromatography–Mass Spectrometry (LC-MS), revealing 66 distinct molecular peaks. Each compound was subjected to quantum chemical simulations using Time-Dependent Density Functional Theory (TD-DFT) following initial geometry optimization through Density Functional Theory (DFT) calculations. The simulations were conducted using the ORCA software, with molecular input prepared via the ChemCompute and Avogadro platforms. Parameters such as HOMO–LUMO energy levels and bandgap values were determined for all detected compounds. From these, 17 compounds exhibited favorable electronic characteristics, including bandgap values ranging from 1.3 to 4.4 eV and well-delocalized frontier orbitals. Notably, betalain compounds such as betanin and indicaxanthin showed strong visible light absorption and low energy gaps, while flavonoids and phenolic acids offered structural stability and tunable electronic properties. This research presents a novel computational approach to screening plant-based chromophores from non-model species, integrating LC-MS and TD-DFT data to highlight their light-harvesting capabilities. In conclusion, green-stemmed binahong is shown to be a promising source of natural chromophores for use in environmentally friendly solar technologies. The selected chromophores, especially those with optimal electronic configurations, are expected to be applied in future organic photovoltaic materials or integrated into green chemistry education as part of renewable energy awareness.
Co-Authors Abdul Kodir Achmad Lutfi AFAF BAKTIR Agustin, Zulfani Nurdiana Aprido Bernando Simamora Asfiyah, Sofi Nur B. Jatmiko Bagus Rahmat Basuki Beni Setiawan Bertha Yonata Budi Jatmiko Damayanti, Ni Noman Triyani Dian Novita Dina Kartika Maharani ENDANG SUSANTINI Endang Susantini Firlia Nur Fadila Firman Adji Nur Hidayat Gatot Suparno1 Hakimah, Nurul Lathifatul Hanifa Rachmah Kamila Hariyono, Eko Ika Ambarwati Indarwati, Rosi Ishma, Ervina Fadhilatul ISMONO ISMONO Isnawati1 Julia Astutik Julian Sagus Bramasta Kardi, Soeparman Karimah, Iffah Kholifatur Rosyidah* Koestiari, Toeti Koestiari Kurdaningsih, Kurdaningsih Kurniawati, Laili Kusumawati Dwiningsih L. R. Jannah Lukas S. Budipramana1 Madlazim Madlazim Madlazim Madlazim Mardiyanti, Nur Eka Agusti Maria Monica Sianita Muchlis Muchlis Mufid, Mohammad Fakhrul Muhammad Nasir Murniati, Diani Rachmanita Nafisa Cahyani Ngandoh, Satwika Trianti Nita Kusumawati Nita Kusumawati Nur Hayati Pirim Setiarso Rosyiidah, Nur Anisa S. Oktaviyanti S. R. Yunus Samik Samik Samik Samik Samik Samik Sari Edi Cahyaningrum Satwika Trianti Ngandoh Selvi Marcellia Soeparman Kardi Solly Aryza Sophia Allamin Sri Poedjiastoeti Sri Poedjiastoeti Sutrisno Sutrisno Sutrisno, Sutrisno Suyatno Sutoyo SUYONO Syahdiani Syahdiani Syahdiani, Syahdiani Syahrani, Achmad Titik Taufikurohmah Toeti Koestiari Koestiari Trisanti, Diah Candra Tukiran Tukiran Tukiran Tukiran Tukiran Tukiran Viyana Choyrunisa, Ratrie Wahono Widodo Wanita, Defitiana WIELIYANI, ARI YUNI SRI RAHAYU ZAINUL ARIFIN IMAM SUPARDI Zeinur Rochma Fandis Romadhon