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All Journal JPMS (Jurnal Pendidikan Matematika dan Sains) Jurnal Penelitian Fisika dan Aplikasinya (JPFA) Jurnal Matematika & Sains Jurnal Sumberdaya Alam dan Lingkungan Science and Technology Indonesia Emerging Science Journal ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Analis Kesehatan ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Abdi Insani Sinar Sang Surya: Jurnal Pusat Pengabdian kepada Masyarakat Analit: Analytical and Environmental Chemistry

Sutopo Hadi

Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Lampung, Bandar Lampung, 35145, Indonesia

Author-ID : 272268

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Social Sciences

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Reactions of The First Cisplatin Hydrolytes cis-[PtCl(15NH3)2(H2O)]+ with N-Acetylcysteine Sutopo Hadi
Jurnal Matematika & Sains Vol 11, No 4 (2006)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

The interactions between cis-[PtCl(15NH3)2(H2O)]+ and N-acetylcysteine (H3accys) in aqueous solution was investigated. In this reaction, polymeric solid was not formed and the amine liberation was slower than that of cis-[Pt(15NH3)2(H2O)2]2+. Initially, the only product observed in the reaction of cis-[PtCl(15NH3)2(H2O)]+ with a variety of thiols was a platinum(II) species with chloride and the thiolate ligand bound monodentate through sulphur, although different final product was obtained in each reaction. In this reaction, after the formation of a species with thiolate bound monodentate cis-[PtCl(15NH3)2(H2accys-S), two new platinum products were observed, namely a four-membered ring dinuclear platinum(II) complex, cis-[{Pt(15NH3)2)2}2( Âµ-Cl) ( Âµ-H2accys-S)]2+ and a six-membered -S,O- chelate ring complex, cis-[Pt(15NH3)2(Haccys-S,O), while dinuclear sulphur-bridged complex cis-[{Pt(NH3)2}2(H2accys- Âµ-S)2)]2+, giving a broad peak in 15N NMR, was only present in very tiny amounts in this reaction.

The Effect of Zeolite/Chitosan Hybrid Matrix for Thermal-stabilization Enhancement on the Immobilization of Aspergillus fumigatus α-Amylase Yandri Yandri; Hendri Ropingi; Tati Suhartati; John Hendri; Bambang Irawan; Sutopo Hadi
Emerging Science Journal Vol 6, No 3 (2022): June
Publisher : Ital Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28991/ESJ-2022-06-03-06

In this paper, the A. fumigatus α-amylase had been immobilized onto zeolite/chitosan hybrid to improve its thermal-stabilization for industrial needs. The methods applied enzyme production, isolation, partial purification, immobilization, and characterization. The optimum temperatures of the native and immobilized enzymes were 50 and 55˚C, respectively. The native enzyme has KM of 3.478 ± 0.271 mg mL-1 substrate and Vmax of 2.211± 0.096 µmole mL-1 min-1, while the immobilized enzyme has KM value of 12.051 ± 4.949 mg mL-1 substrate and Vmax of 1.602 ± 0.576 µmole mL-1 min-1. The residual activity of the immobilized enzyme retained up 10.97% after fifth reuse cycles. The native enzyme has ΔGi of 104.35 ± 1.09 kJ mole-1 and t½ of 38.75 ± 1.53 min, while the immobilized enzyme has ΔGi of 108.03 ± 0.05 kJ mole-1 and t½ of 180.03 ± 3.31 min. According to the increase in half-life (t½), stability improvement of the A. fumigatusα-amylase was 4.65 times greater than the native enzyme. Thus, the zeolite/chitosan hybrid is used as a new supporting matrix for further enzyme immobilization to stabilize the enzymes. Doi: 10.28991/ESJ-2022-06-03-06 Full Text: PDF

Reactions of cis-[PtCl(15NH3)2(H2O)]+, The First Cisplatin Hydrolytes with Thiols. 3: Reactions with Glutathione Sutopo Hadi
Jurnal Pendidikan Matematika dan Sains No 1 (2006): Jurnal Pendidikan Matematika dan Sains Tahun XI
Publisher : Faculty of Mathematics and Natural Sciences, Universitas Negeri Yogyakarta

Interaksi antara senyawa kompleks cis-[PtCl(15NH3)2(H2O)]+ (2) dengan glutation (GSH) telah dilakukan pada larutan berair. Pada reaksi ini, padatan yang berbentuk polimer tidak terbentuk dan pelepasan ligan amina lebih lambat dibanding reaksi sejenis untuk kompleks cis-[PtCl(15NH3)2(H2O)]2+ (3). Dalam seri penelitian ini juga diamati bahwa walaupun reaksi yang terjadi antara kompleks 2 dengan berbagai tiol memberikan hasil yang akhir yang berbeda, akan tetapi pada tahap awal reaksi, senyawa yang terbentuk adalah sama yaitu terbentuknya spesi platina (II) dengan ligan klorida dan tiolat yang terikat secara mondentat melalui atom sulfur. Pada reksi ini, setelah terbentuk hasil awal yaitu kompleks platina dengan glutation terikat secara monodentat cis-[PtCl(15NH3)2(SG)] (7), tidak ada senyaw komplek lain yang teramati. Seperti pada reaksi kompleks 3 dengan GSH, senyawa bistiolat cis-[Pt(NH3)2(SG2)] (8) selalu teramati dalam reaksi ini. Sedangkan, kompleks sulfur dua inti berjembatan yang memberikan serapan lebar pada 15N NMR hanya teramati dalam jumlah yang sangat sedikit.Kata kunci: 15N NMR, glutation, hidrolisat cisplatin

Peningkatan Kestabilan Enzim Lipase Dari Pseudomonas aeruginosa ATCC 27853 Dengan Amobilisasi Menggunakan Bentonit NOPIANI NOPIANI; YANDRI AS; SUTOPO HADI
Jurnal Analis Kesehatan Vol 5, No 1 (2016): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Pada penelitian ini telah dilakukan amobilisasi enzim lipase dari Pseudomonas aeruginosa ATCC 27853 menggunakan bentonit untuk meningkatkan kestabilan enzim. Tahapan prosedur yang dilakukan pada penelitian ini meliputi: kondisi pertumbuhan optimum, produksi, isolasi, pemurnian, amobilisasi dan karakterisasi enzim lipase hasil pemurnian sebelum dan sesudah amobilisasi. Aktivitas enzim lipase ditentukan dengan metode Titrimetri. Kadar protein ditentukan dengan metode Lowry. Hasil penelitian menunjukkan kondisi optimum pertumbuhan Pseudomonas aeruginosa ATCC 27853 menghasilkan enzim lipase dengan aktivitas tertinggi pada pH 7, temperatur 35°C dan waktu inkubasi selama 48 jam. Aktivitas spesifik enzim hasil pemurnian sebesar 520,000 U/mg, meningkat kemurniannya 9,2 kali dibandingkan ekstrak kasar enzim lipase dengan aktivitas spesifik sebesar 56,491 U/mg. Enzim lipase hasil pemurnian mempunyai suhu optimum 35°C, KM 86,177 mgmL-1 substrat, Vmaks 35,714 μmol mL-1 menit-1, ki = 0,023 menit-1, t1/2 = 30,130 menit, dan ∆Gi = 95,669 kJ mol-1. Enzim lipase hasil amobilisasi mempunyai suhu optimum 35 °C, KM 4,742 mgmL-1 substrat, Vmaks 4,854 μmol mL-1 menit-1, ki = 0,018 menit-1, t1/2 = 38,500 menit, dan ∆Gi = 96,296 kJ mol-1. Berdasarkan penelitian yang telah dilakukan diketahui bahwa amobilisasi enzim lipase menggunakan matriks bentonit dapat meningkatkan kestabilan enzim dibandingkan dengan enzim tanpa amobilisasi.

Peningkatan Kestabilan Enzim Protease dari Bacillus subtilis ITBCCB148 dengan Modifikasi Kimia Menggunakan Sitrakonat Anhidrida NANIK SUWARSO; YANDRI AS; SUTOPO HADI
Jurnal Analis Kesehatan Vol 5, No 1 (2016): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Protease merupakan enzim ekstraseluler yang dapat memecah molekul protein menjadi asam amino dan banyak digunakan pada proses industri dalam keadaan yang stabil pada suhu dan pH yang ekstrim. Tujuan penelitian ini untuk meningkatkan stabilitas enzim protease dari bakteri Bacillus subtilis ITBCCB148 dengan modifikasi kimia menggunakan sitrakonat anhidrida. Hasil penelitian menunjukkan bahwa aktivitas spesifik enzim protease hasil pemurnian 1.006,648 U/mg, meningkat 14 kali dibandingkan dengan ekstrak kasar enzim yang mempunyai aktivitas spesifik 70,352 U/mg. Enzim hasil pemurnian ini mempunyai pH optimum 6,5; suhu optimum 50oC; KM = 23,565 mg/mL substrat; Vmaks = 434,783 μmol/mL.menit; ki = 0,085 menit-1; t1/2 = 8,153 menit dan ΔGi = 96,944 kJ/mol. Enzim hasil modifikasi menggunakan sitrakonat anhidrida dengan derajat modifikasi 65; 70 dan 75% mempunyai pH optimum 7,0; suhu optimum 55oC; KM berturut-turut sebagai berikut: 11,658; 13,300 dan 14,571 mg/mL substrat; Vmaks berturut-turut sebagai berikut: 243,902; 250,000 dan 285,714 μmol mL-1 menit-1; ki berturut-turut sebagai berikut: 0,081; 0,079 dan 0,071 menit-1; waktu paruh (t1/2) berturut-turut sebagai berikut: 8,556; 8,772 dan 9,760 menit; ΔGi berturut-turut sebagai berikut: 98,584; 98,688 dan 98,980 kJ mol-1. Modifikasi kimia enzim protease dari Bacillus subtilis ITBCCB148 menggunakan sitrakonat anhidrida dapat meningkatkan stabilitas termal sebesar 1,0-1,2 kali yang dapat dilihat dari penurunan nilai ki, peningkatan waktu paruh dan ΔGi.

Sintesis, Karakterisasi, dan Uji Aktivitas Antibakteri Senyawa Organotimah(IV) 4-Nitrobenzoat Sutopo Hadi; Nova Tri Irianti; Noviany Noviany
ALCHEMY Jurnal Penelitian Kimia Vol 18, No 1 (2022): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.18.1.47872.19-29

Dua buah senyawa organotimah(IV) yaitu berupa senyawa trifeniltimah(IV) 4-nitrobenzoat (2) dan difeniltimah(IV) di-4-nitrobenzoat (4) telah berhasil disintesis melalui reaksi antara senyawa trifeniltimah(IV) hidroksida (1) dan difeniltimah(IV) oksida (3) dengan ligan asam 4-nitrobenzoat (HNBA). Senyawa hasil sintesis dikarakterisasi dengan menggunakan spektrofotomer IR, spektrofotomer UV, spektrometer NMR dan microelemental analyzer untuk melihat kemurnian senyawa. Aktivitas biologis senyawa turunan organtotimah(IV) 4-nitrobenzoat telah diuji terhadap bakteri Gram positif Staphylococcus aureus dan Gram negatif Escherichia coli. Hasil uji dengan metode difusi agar menunjukkan senyawa 2 pada konsentrasi 200 ppm (3,87 × 10-4 M) memberikan penghambatan yang lebih efektif dibandingkan senyawa 4, senyawa awal 1 dan 3 serta ligan HNBA.Synthesis, Characterization, and Antibacterial Activity Test of Organotin(IV) 4-nitrobenzoate. Two organotin(IV) compounds, namely triphenyltin(IV) 4-nitrobenzoate (2) and diphenyltin(IV) di-4-nitrobenzoate (4) compounds have been successfully synthesized through a reaction between triphenyltin(IV) hydroxide (1) and diphenyltin(IV) oxide (3) with 4-nitrobenzoic acid (HNBA) The synthesized compounds were characterized using IR, UV, NMR spectrometer, and a microelemental analyzer to check the compound purity. The biological activity of the organotin(IV) 4-nitrobenzoate derivative was tested against Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli. The test results with the agar diffusion method showed that compound 2 at a concentration of 200 ppm (3.87 x 10-4 M) provide more effective inhibition than compound 4, the starting materials 1 and 3, and the ligand HNBA.

IN VITRO ACTIVITY AND COMPARATIVE STUDIES OF SOME ORGANOTIN(IV) BENZOATE DERIVATIVES AGAINST LEUKEMIA CANCER CELL, L-1210 Sutopo Hadi; Mita Rilyanti; Suharso Suharso
Indonesian Journal of Chemistry Vol 12, No 2 (2012)
Publisher : Universitas Gadjah Mada

A series of dibutyl-, diphenyl- and triphenyltin(IV) benzoate derivatives has been prepared. The products were obtained by reacting the dibutyltin(IV) dichloride, diphenyltin(IV) dichloride and triphenyltin(IV) chloride respectively via the dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with benzoate acid and its derivative. The targeted compounds have been tested with anticancer activity against leukemia cancer cell, L-1210. The compounds synthesized were well characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies as well as based on the microanalytical data. The results showed that triphenyltin(IV) benzoate and its derivative prepared exhibit higher anticancer activity than those of dibutyltin(IV) and diphenyltin(IV) analogous.

THE SYNTHESIS AND NMR STUDY ON THE STABILITY OF DIMETHYLMETHOXOPLATINUM(IV) COMPLEXES Sutopo Hadi
Indonesian Journal of Chemistry Vol 5, No 2 (2005)
Publisher : Universitas Gadjah Mada

he synthesis of two stable platinum(IV) complexes containing methoxo ligand, [Pt(CH3)2(OCH3)(OH)py2] (1) and fac-[Pt(CH3)2(OCH3)(H2O)3] (2), has been successfully performed. Complex 1 was prepared by oxidative addition reaction of cis-[Pt(CH3)2py2] with dry methanol, and a subsequent reaction of 1 with 70 % HClO4 in water produced the platinum complex 2. The stability of complex 2 in acidic aqueous solution was investigated and monitored with 1H and 195Pt NMR. The platinum complex 2 was found to be quite stable toward hydrolysis and no -hydride elimination was observed.

STUDY OF REACTION OF TRANS-[Pt(15NH3)2(H2O)2]2+ WITH N-ACETYL-L-CYSTEINE Sutopo Hadi; Trevor G Appleton
Indonesian Journal of Chemistry Vol 5, No 1 (2005)
Publisher : Universitas Gadjah Mada

A study of the reaction between trans-[Pt(15NH3)2(H2O)2](NO3)2 and N-acetyl-L-cysteine (H3accys) was undertaken to confirm the identity of the products formed. In alkaline solution, the platinum products observed were mononuclear species, while in acidic solution, the oligomeric products were obtained. The mass spectrometry of the reaction in alkaline solution showed a sulfur-bridged dinuclear platinum(II) species, trans-[{Pt(H2accys-S)2(15NH3)2}2((-H2accys-S)]+ giving m/z 948 and the lost of two ammines was observed.

Penyuluhan Keselamatan Penggunaan Plastik Kemasan pada Makanan Bagi Ibu-Ibu PKK dan Masyarakat Di Desa Bumi Raharjo, Kecamatan Bumi Ratu Nuban, Lampung Tengah Sutopo Hadi; Yandri Yandri; Tati Suhartati
SINAR SANG SURYA Vol 6, No 1 (2022): Februari 2022
Publisher : UM Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/sss.v6i1.1903

ABSTRAK Plastik adalah suatu produk kimia yang telah dikenal dan digunakan secara luas oleh seluruh lapisan masyarakat, baik yang bermukim di pedesaan apalagi yang tinggal di kota-kota besar. Saat ini setiap hari ketergantungan terhadap plastik semakin tinggi, namun bahayanya kurang disadari oleh masyarakat. Sesungguhnya penggunaan bahan plastik dalam konsumsi makanan tidak perlu ditakutkan, asalkan kita tahu cara menggunakannya dengan benar. Bagi masyarakat awam, cara mudah untuk menghindari bahaya plastik, yaitu dengan membedakan antara plastik untuk kemasan makanan dan untuk keperluan lainnya. Karena karakteristik peruntukannya, maka bahan baku dan proses pembuatannya pun beda, sehingga masyarakat harus faham dan memerlukan pengetahuan khsusus tentang plastik. Hasil penyampaian materi tentang plastik berdampak juga positif kepada Ibu-Ibu anggota PKK di desa Bumi Raharjo dengan pemahaman yang meningkat sangat drastis tentang penggunaan plastik untuk bahan makanan. Kata kunci : Pelatihan Pengenalan Plastik, Penggunaan Plastik, Pengelolaan Plastik ABSTRACT Plastic is a chemical product that is widely known and used by all levels of society, both those who live in rural areas and those who live in big cities. Currently, every day the dependence on plastic is getting higher, but the dangers are not realized by the public. In fact, the use of plastic materials in food consumption is nothing to be afraid of, as long as we know how to use them properly. For ordinary people, an easy way to avoid the dangers of plastic is to differentiate between plastic for food packaging and for other purposes. Due to the characteristics of the designation, the raw materials and manufacturing processes are different, so people must understand and require special knowledge about plastics. The results of the delivery of material about plastics also had a positive impact on PKK members in the village of Bumi Raharjo with a drastically increased understanding of the use of plastic for food.Keywords: Plastic Recognition Training, Plastic Use, Plastic Management

Co-Authors Afriyani, Hapin Ahmadi, Peni Ambarwati, Yuli Ambarwati, Yuli Andi Setiawan Andi Setiawan Arai, Masayoshi Aspita Laila Bambang Irawan Bambang Irawan C. N. Ekowati Dwi Asmi Ezra Rheinsky Tiarsa Hardoko Insan Qudus Hardoko Insan Qudus Hendri Ropingi Heri Satria Humairoh Ratu Ayu Indah Pratiwi Irvana, Raihan Irza Sukmana John Hendri John Hendri John Hendri Juliasih, Ni Luh Gede Ratna Junaidi Junaidi Karo , Pulung Karo Khalimatus Sa’diah Lailatul Farihah Lina Marlina Lutfiah, Rosyidatul Malik, Daffa Abdul Marjunus, Roniyus Mita Rilyanti Muhammad Rizki NANIK SUWARSO Ni Luh Gede Ratna Juliasih NOPIANI NOPIANI Nova Tri Irianti Noviany Noviany Nurul Nadila Pulung Karo-Karo Qudus, Hardoko Insan Ridho Nahrowi Setiawan, Fendi Suharso Suharso Sumardi Sumardi Supriyanto Supriyanto Suripto Dwi Yuwono Suripto Dwi Yuwono Suripto Dwi Yuwono Suripto Dwi Yuwono, Suripto Dwi Surtono, Arif Syaiful Bahri SYAIFUL BAHRI Tati Suhartati Tati Suhartati Tati Suhartati Tati Suhartati Tati Suhartati Tati Suhartati Trevor G Appleton Valennisa Qunifah Wasinton Simanjuntak Wasinton Simanjuntak WAWAN ABDULLAH SETIAWAN, WAWAN ABDULLAH YANDRI AS Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri

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