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Journal : Medula

Efek Larvasida Ekstrak Biji Buah Pepaya (Carica papaya L.) terhadap Larva Instar III Aedes aegypti L. Arimaswati Arimaswati; La Ode Muhammad Sawaluddin; Hittah Wahi Sudrajat
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 2 (2017)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.131 KB) | DOI: 10.46496/medula.v4i2.2808

Abstract

ABSTRACTThe larvacide Effects of Pawpaw’s Seed Extract (Carica papaya L) Againts Third Instar Larvae of Aedes aegypti L. (Biolarvacide Alternative Study). The aim of this research was to determine the Larvacide Effects of Pawpaw’s Seed Extract (C.papaya L) towards Third Instar Larvae of A. aegypti L. The research was conducted at the laboratory of Biology Education Department and laboratory of Chemistry Education Department, FKIP Halu Oleo University. Independent Variable (X) in the research is Pawpaw’s Seed Extract (C.papaya L) with concentration level are control or was not gived extract (X0), 0.125% (X1), 0.250% (X2), 0.375% (X3), 0.500% (X4), and 0.625% (X5) and Dependent variable (Y) is the mortality of Third Instar Larvae of Aedes aegypti L. The method in the research was used experimental method with Completely Randomized Design (CRD), 3 times repetitions, each group containing 20 larvae, so the total of sample were 360 larvae. The data analyze tecnic was used descriptive analyze to knowing the larvacide effect of Seed Extract (Carica papaya L) against the mortality of Third Instar Larvae of Aedes aegypti L., varians analyze and BJND test with a significant value 95% (α = 0.05) and probit analyze to calculate LC50value or lethal concentration 50%. The result of the descriptive analyzed shows in the control group there are not mortality of larvae. The highest concentration Pawpaw’s Seed Extract (Carica papaya L) was gived mortality of larvae is 0.625% (X5) or 100% (20 larvae) and low concentration is 0.125% (X1) or 45% (9 larvae). The result of sidik ragam analyze showing that the value of Fhitung> Ftabel,  there was a significant influence of the Pawpaw’s Seed Extract (Carica papaya L) for the mortality of Third Instar Larvae of Aedes aegypti L.The result of probit analyzed is LC50 value was gived 50% mortality of larvae is 0.154%.Keywords :Pawpaw’s Seed Extract (Carica papaya L), Larvacide, Third Instar Larvae of Aedes aegypti L.
Hubungan Usia Lanjut dengan Perubahan Interval QTc Pada Pasien COVID-19 Yang Diterapi dengan Hydroxychloroquine Di RSUD Kota Kendari Jamaluddin Jamaluddin; Arimaswati Arimaswati; Andy Rafdi Al Bagiz
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 9, No 1 (2021)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v9i1.22766

Abstract

ABSTRAK Latar Belakang: Hydroxychloroquine adalah obat yang diduga dapat bermanfaat untuk terapi COVID-19. Obat ini diberikan pada berbagai jenis usia sesuai protokol penatalaksanaan COVID-19. Namun, obat ini dapat menghambat kanal kalium dan berpotensi memperpanjang interval QTc. Selain penggunaan hydroxychloroquine, usia juga merupakan salah satu faktor yang  dapat meningkatkan QTc karena proses penuaan yang dapat mengubah miokardium dengan peningkatan fibrosis miokard. Tujuan penelitian ini adalah untuk mengetahui hubungan usia lanjut dengan perubahan interval QTc pada pasien  COVID-19  yang  diterapi  dengan  hydroxychloroquine  di  RSUD  Kota  Kendari.  Metode: Penelitian ini adalah penelitian analitik observasional dengan pendekatan Cross Sectional. Data dalam penelitian bersifat  retrospektif,  dengan  melakukan  observasi terhadap  data  sekunder  berupa rekam medik di RSUD Kota Kendari pada bulan April sampai dengan bulan September tahun 2020. Sampel pada penelitian ini menggunakan Total Sampling. Data diolah menggunakan analisis uji t tidak berpasangan. Hasil: Hasil penelitian ini menunjukkan bahwa dari 106 subjek penelitian yang dibagimenjadi 2 kelompok usia yaitu >45 tahun sebanyak 32 orang (30,2%) dan   ≤45 tahun sebanyak 74 orang (69,8%)  sama-sama  mendapat  terapi hydroxychloroquine, didapatkan bahwa  usia  ≤45 tahunmemiliki median perubahan interval QTc sebesar 12,0 ms dan meningkat hampir dua kali lipat padausia >45 tahun sebesar 22,0 ms dengan menggunakan uji t tidak berpasangan diperoleh signifikansi p <0,001. Simpulan: Terdapat hubungan usia lanjut dengan perubahan interval QTc pada pasien COVID-19 yang diterapi dengan hydroxychloroquine di RSUD Kota Kendari.Kata Kunci: Usia COVID-19, Hydroxychloroquine, Interval QTc
Aktivitas Antibakteri Ekstrak Daun Turi (Sesbania grandiflora (L.)Press) terhadap Pertumbuhan Bakteri Salmonella thypi dan Streptococcus mutans (Antibacterial Activity of Turi Leaf Extract (Sesbania grandiflora (L.) Press) against Salmonella thypi and Streptococcus mutans) Arimaswati Arimaswati; Wa Ode Amrina Wulan Safitri; Hartati Hartati
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 7, No 1 (2019)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.691 KB) | DOI: 10.46496/medula.v7i1.11487

Abstract

Background: Infectious diseases are still one of the important public health issues in developing countries. Most infections are caused by bacteria, fungi, viruses and parasites. The relatively high use of antibiotics gives many problems especially resistance. So the use of traditional medicinal plants is needed as an alternative treatment. One of the traditional medicine that can be used for treatment is turi leaf (Sesbania grandiflora (L.) Pers). The potential of turi leaves is as antibacterial because its have contains alkaloids, flavonoids, saponins and tannins. The purpose of this research is to knowing about antibacterial activity of turi leaf extract (S. grandiflora (L.) Pers) on Salmonella thypi and Streptococcus mutans bacteria growth. Methods: This research uses post test only control design, independent variable is turi leaf extract and dependent variable is bacterial growth inhibition zone. Lean ethanol extract of turi leaf was obtained by maceration method after waiting for 3 x 24 hours. Testing of antibacterial activity using wells diffusion method. Results: showed that the fraction of ethyl acetate and n-hexane of turi leaves of had antibacterial activity on S. thypi and S. mutans growth with the gratest concentration value capable of inhibiting bacterial growth of 100%. The fraction of ethyl acetate and n-hexane of turi leaves inhibited S. thypi bacteria growth of 11 mm and 4 mm, while for S. mutans were 4.67 mm and 4mm. Minimum Stress Levels of ethyl acetate and n-hexane fractions on groeth of S. thypi and S. mutans bacteria were at concentrations of 10%. Conclusion: From this research it can be concluded that the fraction of ethyl acetate and turi leaf n-hexane fraction (S. grandiflora (L.) Pers) has antibacterial activity against S. thypi and S. mutans growth. with Minimum Stress Levels being at a concentration of 10%. The antibacterial activity is more sensitive to S. thypi than S. mutans. Keywords: Minimum Inhibitory, Turi Leaf (Sesbania grandiflora (L.) Pers), Salmonella typhi, Streptococcus mutans Latar Belakang: Penyakit infeksi masih merupakan salah satu masalah kesehatan masyarakat yang penting, khususnya di negara berkembang. Sebagian besar infeksi disebabkan oleh bakteri, fungi, virus dan parasit. Penggunaan antibiotik yang relatif tinggi menimbulkan berbagai permasalahan global terutama resistensi. Sehingga penggunaan tanaman obat tradisional diperlukan sebagai pengobatan alternatif. Salah satunya adalah S. grandiflora (L.) Pers. Potensi daun turi sebagai antibakteri karena mengandung alkaloid, flavonoid, saponin dan tanin. Tujuan: Tujuan dari penelitian ini adalah mengetahui aktivitas antibakteri ekstrak S. grandiflora (L.) Pers terhadap pertumbuhan bakteri S. thypi dan S. mutans. Metode: Penelitian ini menggunakan desain post test only control, variabel bebas adalah ekstrak daun turi dan variabel terikat adalah zona hambat pertumbuhan bakteri. Ekstrak etanol daun turi diperoleh dengan metode maserasi selama 3 x 24 jam. Pengujian aktivitas antibakteri menggunakan metode difusi sumuran. Hasil: Hasil penelitian menunjukkan fraksi etil asetat dan fraksi n-heksan S. grandiflora (L.) Pers memiliki aktivitas antibakteri terhadap pertumbuhan bakteri S. thypi dan S. mutans dengan nilai konsentrasi terbesar yang mampu menghambat pertumbuhan bakteri yaitu 100%. Fraksi etil asetat dan n-heksan daun turi menghambat pertumbuhan bakteri S. thypi sebesar 11 mm dan 4 mm, sedangkan untuk S. mutans berturut-turut sebesar 4,67 mm dan 4 mm. Kadar Hambat Minimum dari fraksi etil asetat dan n-heksan terhadap pertumbuhan bakteri S. thypi dan S. mutans berada pada konsentrasi 10%. Simpulan: Dari penelitian ini dapat disimpulkan bahwa fraksi etil asetat dan fraksi n-heksan S. grandiflora (L.) Pers memiliki aktivitas antibakteri terhadap pertumbuhan S. thypi dan S. mutans dengan Kadar hambat Minimum berada pada konsentrasi 10%.Aktivitas antibakteri lebih peka pada S. thypi dibandingkan S. mutans.Kata kunci:  daun turi (Sesbania grandiflora (L.) Pers), Salmonella thypi, Streptococcus mutans, kadar hambat minimum
Uji Aktivitas Antibakteri Ekstrak Kasar Bawang Putih (Allium sativum ) terhadap Bakteri Shigella dysenteriae yang Resisten terhadap Ampisilin Arimaswati Arimaswati; Yessy Toding Mendaun; Yenti Purnamasari
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 2 (2019)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.378 KB) | DOI: 10.46496/medula.v6i2.6723

Abstract

ABSTRACT Background : Gastrointestinal infections, especially caused by Shigella dysenteriae bacteria is still a health issue in Indonesia. The number of ampicillin resistance to S. dysenteriae has been widely reported. Garlic (Allium sativum) is a traditional medicine that efficacy as an antibacterial. Garlic contains an organosulfur compound  Allicin. Research Purpose: This study aimed to determine the antibacterial activity of garlic rule extract on the growth of S. dysenteriae bacteria that are resistant to ampicillin. Research Methods: This study used the experimental with post test only control group design. The antibacterial activity test was determined based on the diameter of clear zone formed. Test  were performed  on garlic filtrate, ciprofloxacin as a positive control and aquades as a negative control. Each treatment was performed three times. Research Result: This research showed that rule extract of garlic (A. sativum)  had a clear zone against S. dysenteriae that was resistant to ampicillin. Conclusion: The conclusion of this research was that rule extract of garlic (A. sativum) had an antibacterial activity against S. dysenteriae which resistant to ampicillin.  Keywords : Antibacterial activity, Garlic (A. sativum), S. dysenteriae
Co-Authors Adellya Febriyani Hadini Adius Kusnan Adry Leonardy Tendean Agusalim Ali Agussalim Ali Ali, Nurharpen Alifariki, La Ode Andi Ad’Yusuf Kithfirul Azis Andi Ad’Yusuf Kithfirul Azis Andi Noor Kholidah Andi Nurcholida Andy Rafdi Al Bagiz Anisha Ramadhani Aritrina, Pranita Asmarani Asmarani, Asmarani Astrid Yunita Kambu Bangu Bangu Dewi Nughrawati Putri Dionisius Excelsis Deo Sombolinggi Eso, Amiruddin Faning Fridayani Ferry Sandra Fitriani Fitriani Hamliati, Hamliati Hartati Hartati Heriviyatno Julika Siagian Hittah Wahi Sudrajat I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa, I Putu Indah Sayyidatul Annisa Indriyani Nasruddin, Nina Irawaty Irawaty Jamaluddin Jamaluddin Jamaluddin jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Juminten Saimin Juminten Saimin Juminten Saimin, Juminten Keysa Indira Salsabila Kholidah, Andi Noor Kolewora, Yusuf Musafir La Ode Kardin La Ode Muhammad Sawaluddin La Rangki La Rangki, La Rangki Laode Kardin Lasaima, Hasyiatul Rahmi Lianawati Lianawati Mubarak Mubarak Muhajir Muhajir Muhammad Fathur Rahman Muhammad Fathur Rahman Muhammad Rustam HN Mulyawati, Sufiah Asri Nasruddin, Nina Indriyani Nasrul Nasrul Nasrul Nasrul Naswin Naswin Nina Indriyani Nasruddin Nina Indriyani Nasruddin Nina Indriyani Nasruddin Nina Indriyani Nasruddin Nina Indryani Nasruddin Nur Indah Purnamasari Nur Rahmi Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah, Parawansah Pranita Aritrina Rahman, Muhammad Fathur Raja Al fath Widya Iswara rangki, la Sadly Salman Saida Saida, Saida Satrio Wicaksono Siagian, Heriviyatno Julika Steven Ridwan Steven Ridwan, Steven Sukrianto Halik Sukurni, Sukurni Susanty, Sri Syarifin, Andi Noor Kholidha Tety Yuniarty Sudiro Tien Tien Tien Tien Tien Tukatman Tukatman Wa Ode Amrina Wulan Safitri Wawan Hermawan Yenti Purnamasari Yenti Purnamasari Yessy Toding Mendaun Yohanis, Mono Valentino Yustika Al Haddad