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All Journal Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Jurnal Ilmu Keperawatan Jurnal Ners Narra J Makara Journal of Science jpki The International Journal of Tropical Veterinary and Biomedical Research Heca Journal of Applied Sciences Malacca Pharmaceutics Trends in Infection and Global Health Strada Jurnal Ilmiah Kesehatan (SJIK)
Kartini Hasballah
Department Of Pharmacology, School Of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Metabolite Signature of Fresh and Long-term Stored Coffee Pulp and Husk Lestari, Wahyu; Hasballah, Kartini; Listiawan, Muhammad Yulianto; Sofia, Sofia
Makara Journal of Science Vol. 26, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Every product from the food and agriculture industry produces waste that can cause environmental pollution when carelessly discarded. Coffee husk and pulp are the main wastes generated by coffee processing. The secondary metabolites in these wastes can still be utilized, but their level can be affected by long storage. This research aims to determine the differences in the compounds obtained from old and fresh Gayo Arabica coffee pulp and husk. Coffee husk and pulp samples from Gayo Arabica coffee are extracted for GC-MS analysis to determine similarities between fresh and long-term stored Gayo Arabica coffee husk and pulp. Results show differences in level and type among the secondary metabolites. Among various compounds, caffeine is found in all the samples. The compounds obtained from Gayo Arabica coffee husk and pulp, such as caffeine, (Z,Z)-9,12-octadecadienoic acid, and palmitic acid, can be used in health and agriculture.
Edukasi Shalat Tahajjud sebagai Aktivitas Ibadah Untuk Mencegah Hipertensi pada Kelompok Usia Muda Yusni, Yusni; Idayati, ratna; Zakiaturrahmi, Zakiaturrahmi; Hasballah, Kartini; Saminan, Saminan; Nugraha, Gartika Setiya; Asqalani, Muhammad Hafiz; Rangkuti, Raihan Daffa Anugrah
Jurnal Pengabdian Kedokteran Indonesia Vol 4 No 2 (2023): September 2023
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jpki.v4i2.265

Abstract

Shalat adalah aktifitas fisik yang memiliki gerakan yang sangat kompleks sehingga jika dilakukan secara benar dan teratur maka akan bermanfaat untuk meningkatkan kesehatan. Hasil penelitian yang kami lakukan menunjukkan bahwa tidak banyak orang muslim yang tahu bahwa shalat bermanfaat untuk kesehatan, dengan demikian kami berupaya untuk memberikan edukasi kepada masyarakat tentang manfaat tahajjud dalam mengontrol tekanan darah. Aceh sebagai salah satu daerah yang menerapkan syariat Islam sudah sepatutnya menggalakkan masyarakatnya gemar untuk shalat tahajjud secara teratur sehingga akan membantu upaya menurunkan risiko hipertensi pada usia muda. Metode kegiatan pengabdian yang dilakukan adalah memberikan kuesioner untuk mengetahui pengetahuan masyarakat tentang tahajjud, melakukan pemeriksaan tekanan darah, dan memberikan edukasi tentang tahajjud sebagai aktifitas fisik untuk preventif hipertensi. Kegiatan ini dilakukan terhadap 30 orang pria (n=14) dan wanita (n=16), usia 18-21 tahun, dan beragama Islam. Hasil kegiatan pengabdian ini: sebanyak 33,33% dari partisipan memiliki tekanan darah diatas normal, 63,33% partisipan melakukan tahajjud, namun yang tahajjud teratur hanya sekitar 16,67%, dan partisipan yang mengetahui bahwa tahajjud bermanfaat untuk kesehatan adalah berjumlah 16,67%. Kesimpulannya adalah tahajjud yang dilakukan secara teratur akan dapat mengontrol tekanan darah sehingga akan mengurangi resiko terjadinya hipertensi pada usia muda. Disarankan agar masyarakat terutama kaum muda untuk menggalakkan salat tahajjud untuk meningkatkan kesehatan khususnya unutk mengontrol tekanan darah sehingga dapat menurunkan resiko hipertensi.
A Comparative Study of Total Tannin Contents and Antimicrobial Activities in Methanol Extracts of Rhizophoraceae Species Indriaty, Indriaty; Ginting, Binawati; Hasballah, Kartini; Djufri, Djufri
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.89

Abstract

Rhizophoraceae is a large true mangrove family that produces mangrove tannins. Tannins have the potential to be used as antimutagenic, anticancer, antimicrobial, and antioxidant agents in the pharmaceutical and medical fields. The aim of the research was to determine the total tannin content, antimicrobial activity, and the correlation between the two in methanol extracts of four plant parts (roots, bark, leaves, and fruit/hypocotyl) from five Rhizophoraceae species, namely Bruguiera cylindrica, Bruguiera gymnorrhiza, Ceriops decandra, Rhizophora apiculata, and Rhizophora mucronata originating from the Langsa mangrove forest, Aceh, Indonesia. Folin Ciocalteu colorimetric method and tannic acid as a standard were used for the total tannin content (TTC) test. The disc diffusion method was used to conduct antimicrobial tests against Escherichia coli, Staphylococcus aureus, and Candida albicans bacteria at a 50% extract concentration. TTC content in Rhizophoraceae ranged from 8.17 ± 1.36 mg TAE/g to 813.35 ± 18.72 mg TAE/g (p < 0.05). The highest levels were found in C. decandra roots (813.35 ±18.72 mg TAE/g), C. decandra bark (704.36 ± 12.11 mg TAE/g), and R. apiculata bark (651.23 ± 2.36 mg TAE/g). The extract has moderate to strong antibacterial activity against gram-positive bacteria S. aureus, with an inhibition zone range of 6.64 ± 0.80 mm -15.02 ± 0.32 mm. The highest antibacterial activity was observed in the inhibition zones for S. aureus bacteria, with C. decandra fruit extract (15.02 ± 0.32 mm), R. apiculata bark (14.78 ± 0.90 mm), and C. decandra leaves (14.44 ± 1.18 mm) exhibiting the highest levels. TTC and antibacterial activity of S. aureus in Rhizophoraceae extracts showed a moderate correlation (Pearson correlation coefficient r = 0.566, p < 0.05). According to the results, it was concluded that Rhizophoraceae has the potential to produce optimal tannins that can be used as antibacterial agents against S. aureus.
Molecular docking of two cytotoxic compounds from Calotropis gigantea leaves against therapeutic molecular target of pancreatic cancer Purnama, Agnia; Mardina, Vivi; Puspita, Kana; Qanita, Intan; Rizki, Diva R.; Hasballah, Kartini; Iqbal, Mudassar; Sarong, Murniana
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.37

Abstract

The utilization of natural compounds as therapeutic agents to treat pancreatic cancer has recently focused on natural drug research. Calotropis gigantea has long been believed to be a medicinal plant that helps in treating various diseases. The bioactive compounds 9-metoxipinoresinol and isoliquiritigenin isolated from C. gigantea leaves are proven to act as therapeutic agents by inhibiting the cancer cell growth of Panc-1 cells. This study aimed to screen the potential molecular inhibition mechanisms of 9-metoxipinoresinol and isoliquiritigenin against pancreatic cancer development in-silico. We analyzed the activity of the aforementioned two compounds as inhibitors of several proteins that play a role in the growth of pancreatic cancer cells, such as GCNT3, GOT1, c-Met, PPARγ, BUB1, and NF-κβ, through molecular docking investigation. Our data suggested that 9-metoxipinoresinol and isoliquiritigenin were able to have well interaction with the target proteins, in which the predicted affinity energy ranged between -6.8 and 8.7 kcal/mol. The docking scores of 9-metoxipinoresinol and isoliquiritigenin were higher than the standard drug used (gemcitabine). Based on the binding affinity energy, GCNT3 and BUB1 are potentially to be used as target molecules for cancer therapy using 9-metoxipinoresinol and isoliquiritigenin, respectively.
A Perspective Study of Pogostemon cablin Benth as an Aphrodisiac Khairan, Khairan; Amanda, Rosi; Hasbi, Salsa Yubila; Diah, Muhammad; Hasballah, Kartini
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.61

Abstract

Pogostemon cablin Benth also known as a patchouli plant, is a member of Lamiaceae family, and the source of patchouli essential oil. This plant is an important herb which possesses many therapeutic properties. In traditional medicinal practices, patchouli oil is used to relieve depression, stress, calm nerves, control appetite and to improve sexual interest. Up to the present moment, almost 200 volatile and non-volatile compounds have been isolated and identified from Pogostemon cablin including flavonoid, phytosterols, glycosides, terpenes, sesquiterpenes, organic acids, and others. Modern studies revealed that the patchouli plant have been used for various applications such as an antioxidant, anti-inflammatory, analgesic, antidepressant, antithrombotic, antiplatelet, fibrinolytic, antiemetic, antimutagenic, and aphrodisiac. In aromatherapy, this plant is believed to be able to improve blood circulation and sexual interest. The flavonoid compounds, such as acacetin and apigenin are believed to play an important role as an aphrodisiac. The mechanisms of action of this plant as an aphrodisiac is believed by increasing androgens and estrogen levels in dehydroepiandrosterone (DHEA), which further increases arousal sexual desire. However, some uses need to be verified and may require standardizing and authenticating the bioactivity of purified compounds through scientific methods. This perspective study discusses the aphrodisiac potential of Pogostemon cablin Benth, including their chemical constituents, health benefit, mechanism action, and the role of main bioactive compound as an aphrodisiac.
The Role of Gut Microbiota-derived Tryptophan Metabolites in Mycobacterium tuberculosis Infection: A Mini-Review Maulina, Novi; Hayati, Zinatul; Hasballah, Kartini; Zulkarnain, Zulkarnain; Zulkifli, Baidillah
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 2 (2022): Vol. 7 (2) November 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v7i2.30165

Abstract

The gut microbiota has a major contribution in human physiology and influences disease pathogenesis, including in tuberculosis (TB) lung infection. Gut-lung axis has demonstrated the interplay of these two organs, mediated by metabolites produced by the gut microbes or derived from host molecules transformation. Tryptophan (Trp) is one of the essential aromatic amino acids catabolized as kynurenine, serotonin (5-hydroxytryptamine), and indole derivatives, including indole propionic acid (IPA), via 3 pathways. The latter was microbiota-derived Trp catabolism, which has known to have an immunomodulatory role, as ligands for Aryl hydrocarbon Receptor (AhR). Intriguingly,Mycobacterium tuberculosisrequired Trp as a nitrogen source, especially in CD4+ T cells-generated stress, to survive in the phagosome of macrophage and to cause disease. Recently, IPA is identified as a new anti-mycobacterial compound, which is specific and has broad spectrum of anti-mycobacterial activity. The structural similarity of this gut microbiota-derived metabolite and Trp allows IPA to inhibit the TrpE anthranilate synthase in Trp biosynthesis pathway in Mtb. In this review, wesummarize findings from recent work by focusing on the role of Trp metabolites in host cells in TB infection.A better understanding of this chemical signal could potentially serve as a novel strategy for managing this chronic inflammatory disease.
Delayed growth rate based on bone age in children with idiopathic nephrotic syndrome at a general hospital in Banda Aceh, Indonesia Haris, Syafruddin; Dimiati, Herlina; Hasballah, Kartini; Pardede, Sudung O.
Trends in Infection and Global Health Vol 4, No 2 (2024): December 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i2.42807

Abstract

Paediatric nephrotic syndrome is the most common kidney disease in children, with corticosteroids as the primary treatment. While effective, corticosteroid therapy may decrease bone mineral density. Concurrent vitamin D and calcium supplementation can mitigate bone loss but does not entirely prevent it and may introduce side effects. This study assessed growth delay based on bone age in children with idiopathic nephrotic syndrome receiving long-term steroid therapy at Dr. Zainoel Abidin Public Hospital in Banda Aceh, Indonesia. This observational analytic study used a retrospective cohort design, with data collected from the hospitals Paediatric Polyclinic over one month. Paediatric patients diagnosed with INS who met inclusion criteria were included, and data were extracted from electronic medical records. Statistical analysis was conducted using the Mann-Whitney test. Among the 50 children included, 32 (64%) were male and 18 (36%) were female. The median corticosteroid therapy duration was 24 months (range: 284 months). No significant association was found between corticosteroid therapy duration and growth delay, as measured by BA (p=0.363). INS was more common in boys, particularly in the six to 10-year age group. Most participants had normal nutritional status and stature, with steroid-resistant nephrotic syndrome being the most prevalent type. The findings suggest no relationship between corticosteroid therapy duration and growth delay based on bone age, providing reassurance about the treatments impact on growth outcomes.
The Effectiveness of Safety Alarm Implementation among Nurses on Fatigue Alarms in Aceh General Hospital's High Care Unit Room Sri Diana Putri; Teuku Tahlil; Kartini Hasballah
STRADA : Jurnal Ilmiah Kesehatan Vol. 10 No. 1 (2021): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v10i1.698

Abstract

This study aims to know the effect of implementing the safety alarm protocol among nurses on fatigue alarms in Aceh General Hospital's High Care Unit (HCU) Room. This research is quantitative research with a quasi-experiment model. The sample in this study was all nurses in Aceh General Hospital's High Care Unit room, with a total of 37 respondents. The research instrument was adopted from the Japanese Occupational Hygiene Association and the American Association of Critical-Care Nurses (AACN) Practice Alert. Data analysis used the Wilcoxon Rank test with a 95% confidence level. This study found that fatigue alarm scores decreased significantly after implementing the safety alarm protocol for 21 days (p <0.001). The safety alarm protocol implementation effectively reduces the incidence of fatigue alarm among nurses in Aceh General Hospital's High Care Unit (HCU) room. It means that the safety alarm protocol implementation effectively proved reduces the incidence of fatigue alarms.
Analysis of Physician Leadership and Leadership Development in Government-Owned Healthcare Institutions: A Mixed-Method Study Khorida, Arifatul; Hasballah, Kartini; Meliala, Andreasta; Nurjannah, Nurjannah
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50689

Abstract

Background: Physician involvement in leadership roles within healthcare institutions has been declining worldwide, despite evidence linking physician leadership with improved healthcare outcomes. Objective: To examine physicians’ leadership roles, individual characteristics, and factors influencing their leadership effectiveness in government-owned healthcare institutions in Indonesia, and to propose a contextually appropriate leadership development model. Methods: A mixed-method design was used. Phase I was a qualitative study conducted through in-depth interviews and focus group discussions with 49 physicians from 31 institutions, analyzed using thematic framework analysis (NVivo 12, COREQ guidelines). Phase II was a quantitative survey involving 358 physicians from 25 institutions, analyzed using structural equation modeling with partial least squares (SEM-PLS). Results: Qualitative findings revealed structural, personal, and managerial barriers to leadership engagement, including time constraints, administrative burdens, inadequate incentives, and political influences. However, physicians were perceived as strategic leaders due to their technical expertise, tiered experiences, and credibility in clinical management. The quantitative model demonstrated strong reliability and validity. Individual differences (experience, efficacy) significantly influenced motivation to lead (β=0.577), leadership behavior (β=0.496), and leadership outcomes (β=0.176, p<0.001). Motivation (β=0.197) and behavior (β=0.604) also significantly predicted leadership outcomes. Conclusion: Despite low participation, physicians possess leadership characteristics that positively contribute to leadership effectiveness. Physician leadership development should be institutionally driven, integrating managerial competencies with technical expertise, while addressing structural and motivational barriers.
Co-Authors . Saminan Agnia Purnama Amanda, Rosi Andreasta Meliala Asqalani, Muhammad Hafiz Binawati Ginting Chesy Oety Otawa Dedi Irawan Dewi K. Rusly Dewi Karlina Rusly Diah, Muhammad Diva R. Rizki Djufri - Gartika Setiya Nugraha Hajjul Kamil Hasbi, Salsa Yubila Heriyandi Heriyandi Herlina Dimiati, Herlina Hilwah Nora Imran Imran Indriaty, Indriaty Inong Sri Rahayu Intan Qanita Iqbal, Mudassar Kana Puspita Kanadi Sumapradja Keumalasari Keumalasari Khairan Khairan Khorida, Arifatul M. Yulianto Listiawan Mardina, Vivi Maulina, Novi Mudassar Iqbal Mudatsir Mudatsir Murniana Sarong Nurjanisah Nurjanisah Nurjannah Nurjannah Purnama, Agnia Puspita, Kana Qanita, Intan Rajuddin Rajuddin Rangkuti, Raihan Daffa Anugrah Ratna Idayati, Ratna Reno Keumalazia Kamarlis Rizki, Diva R. Sarong, Murniana Sofia Sofia, Sofia Sri Diana Putri Sudung O. Pardede, Sudung O. Syafruddin Haris, Syafruddin Tahlil, Teuku Teuku Tahlil Teuku Tahlil Vivi Mardina Wahyu Lestari Yusni Yusni Zakiaturrahmi, Zakiaturrahmi Zinatul Hayati Zulkarnain Zulkarnain Zulkifli, Baidillah