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All Journal Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Science and Technology Indonesia Jurnal Ilmu Keperawatan Jurnal Ners Narra J Makara Journal of Science jpki The International Journal of Tropical Veterinary and Biomedical Research Narra X Heca Journal of Applied Sciences Malacca Pharmaceutics Trends in Infection and Global Health Strada Jurnal Ilmiah Kesehatan (SJIK)
Kartini Hasballah
Department Of Pharmacology, School Of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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DPPH and Hep2 Cell Inhibitions by Ethyl Acetate Extract and Its Fractions from Indonesian Cassia siamea L. Stem Barks: In Vitro and Computational Prediction Hasballah, Kartini; Murniana, Murniana; Marlina, Marlina; Bakhtiar , Bakhtiar; Rusly, Dewi Karlina; Ginting, Binawati; Maidiani, Tika; Rahmazani, Shinta; Rampengan, Derren DCH
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.235-251

Abstract

Cassia siamea has been reported by multiple ethnopharmacological studies to treat a broad spectrum of diseases, including cancer. The aim of this study was to evaluate the antioxidant and antiproliferation activities of C. siamea stem bark extract. Following the maceration, the sample was fractionated using column chromatography, yielding 1 ethyl acetate extract and 4 different fractions (Fractions A–D). Antioxidant activities of the extract and its four fractions were assessed based on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition. Phytocompounds contained in the extract and its fractions were identified using Gas Chromatography-Mass Spectrometry (GC/MS) analysis, followed by in silico molecular docking. The ethyl acetate extract of C. siamea L. stem bark had total phenolic, flavonoid, and tannin contents of 280 mg GAE/g dry extract, 23.97 mg QE/g dry extract, and 26.5 mg TAE/ g dry extract, respectively. Strong antioxidant activities were exhibited by Fraction A and the ethyl acetate extract (IC50= 13.72 and 14.10, respectively). LC50s of the ethyl acetate extract and Fraction A against the A. salina larvae were 49.61 ppm and 51.52 ppm, respectively. Optimal inhibitions of Hep2 cell proliferation were observed in both ethyl acetate extract and Fraction A with IC50s of 936.34 ppm and 580.76 ppm, respectively. Both the extract and Fraction A contained lupeol, among other compounds with anticancer potential. Complementary in silico docking analyses indicated that lupeol achieved optimal binding with laryngeal carcinoma–related targets (ΔG = –7.9 to 9.5 kcal/mol).
Co-Authors . Saminan Amanda, Rosi Amna, Usratul Andreasta Meliala Asqalani, Muhammad Hafiz Bakhtiar , Bakhtiar Binawati Ginting Chesy Oety Otawa Dedi Irawan Dewi K. Rusly Dewi Karlina Rusly Dewi Karlina Rusly Diah, Muhammad Diva R. Rizki Djufri - Fadlia, Yosi Gartika Setiya Nugraha Hajjul Kamil Hasbi, Salsa Yubila Heriyandi Heriyandi Herlina Dimiati, Herlina Hilwah Nora Husni, Muhammad NRR. Imran Imran Indriaty, Indriaty Inong Sri Rahayu Intan Qanita Iqbal, Mudassar Kana Puspita Kanadi Sumapradja Keumalasari Keumalasari Khairan Khairan Khorida, Arifatul M. Yulianto Listiawan Maidiani, Tika Mardina, Vivi Marlina Marlina Maulina, Novi Mudassar Iqbal Mudatsir Mudatsir Murniana , Murniana Murniana Murniana Murniana Sarong Nurjanisah Nurjanisah Nurjannah Nurjannah Purnama, Agnia Puspita, Kana Qanita, Intan Rahmazani, Shinta Rajuddin Rajuddin Rampengan, Derren DCH Rangkuti, Raihan Daffa Anugrah Ratna Idayati, Ratna Reno Keumalazia Kamarlis Rizki, Diva R. Rusly, Renzavaldy Sarong, Murniana Sofia Sofia, Sofia Sri Diana Putri Sudung O. Pardede, Sudung O. Syafruddin Haris, Syafruddin Tahlil, Teuku Teuku Tahlil Teuku Tahlil Vivi Mardina Wahyu Lestari Yusni Yusni Zakiaturrahmi, Zakiaturrahmi Zinatul Hayati Zulkarnain Zulkarnain Zulkifli, Baidillah