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All Journal Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Indonesian Journal of Pharmaceutical Science and Technology Science and Technology Indonesia Jurnal Ilmu Keperawatan Jurnal Ners Narra J Makara Journal of Science jpki The International Journal of Tropical Veterinary and Biomedical Research Heca Journal of Applied Sciences Malacca Pharmaceutics Trends in Infection and Global Health Strada Jurnal Ilmiah Kesehatan (SJIK)
Kartini Hasballah
Department Of Pharmacology, School Of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Potential of avocado seed ethanol extract (Persea americana Mill. var Miki) as an anti-aging Alya, Syadza; Hasballah, Kartini; Fitria, Fitria; Harnelly, Essy; Sary, Nirwana Lazuardi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69540

Abstract

Skin aging, characterized by decreased skin elasticity, is a global concern closely related to elastin degradation caused by oxidative stress and elastase activity. Natural ingredients rich in antioxidants are increasingly explored as potential anti-aging agents. Avocado (Persea americana) seeds contain various bioactive compounds that may protect elastin and slow the skin aging process. This study employed in silico and in vitro approaches to evaluate the antioxidant and anti-elastase activities of ethanol extract of avocado seeds from Bener Meriah, Aceh. Extraction was performed using maceration with 70% ethanol, followed by phytochemical screening. Antioxidant activity was assessed using the DPPH method. Anti-elastase activity was evaluated in silico through molecular docking against porcine pancreatic elastase (PPE) and in vitro using the SANA substrate and PPE enzyme. The avocado seed ethanol extract showed strong antioxidant activity with an IC₅₀ value of 47.31 ppm. It also demonstrated potent anti-elastase activity with an IC₅₀ value of 6.980 ppm. Molecular docking revealed that cholestan-3-ol, 2-methylene-, (3β,5α)- had a binding affinity of −8.0 kcal/mol, comparable to the control. Overall, the ethanol extract of avocado seeds exhibits very strong antioxidant and significant anti-elastase activities both in silico and in vitro, indicating its potential as a natural anti-aging agent.
Co-Authors . Saminan Alya, Syadza Amanda, Rosi Andreasta Meliala Arifatul Khorida Asqalani, Muhammad Hafiz Bakhtiar , Bakhtiar Binawati Ginting Chesy Oety Otawa Dedi Irawan Dewi K. Rusly Dewi Karlina Rusly Dewi Karlina Rusly Diah, Muhammad Diva R. Rizki Djufri - Essy Harnelly Fitria Fitria Gartika Setiya Nugraha Hajjul Kamil Hasbi, Salsa Yubila Heriyandi Heriyandi Herlina Dimiati, Herlina Hilwah Nora Imran Imran Indriaty, Indriaty Inong Sri Rahayu Intan Qanita Iqbal, Mudassar Kana Puspita Kanadi Sumapradja Keumalasari Keumalasari Khairan Khairan M. Yulianto Listiawan Maidiani, Tika Mardina, Vivi Marlina Marlina Maulina, Novi Mudassar Iqbal Mudatsir Mudatsir Murniana Murniana Murniana Sarong Nurjanisah Nurjanisah Nurjannah Nurjannah Purnama, Agnia Puspita, Kana Qanita, Intan Rahmazani, Shinta Rajuddin Rajuddin Rampengan, Derren DCH Rangkuti, Raihan Daffa Anugrah Ratna Idayati, Ratna Reno Keumalazia Kamarlis Rizki, Diva R. Sarong, Murniana Sary, Nirwana Lazuardi Sofia Sofia, Sofia Sri Diana Putri Sudung O. Pardede, Sudung O. Syafruddin Haris, Syafruddin Tahlil, Teuku Teuku Tahlil Teuku Tahlil Vivi Mardina Wahyu Lestari Yusni Yusni Zakiaturrahmi, Zakiaturrahmi Zinatul Hayati Zulkarnain Zulkarnain Zulkifli, Baidillah