Claim Missing Document
Check
Articles

Found 22 Documents
Search

Analysis of Physician Leadership and Leadership Development in Government-Owned Healthcare Institutions: A Mixed-Method Study Arifatul Khorida; Kartini Hasballah; Andreasta Meliala; Nurjannah Nurjannah
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50689

Abstract

Background: Physician involvement in leadership roles within healthcare institutions has been declining worldwide, despite evidence linking physician leadership with improved healthcare outcomes. Objective: To examine physicians’ leadership roles, individual characteristics, and factors influencing their leadership effectiveness in government-owned healthcare institutions in Indonesia, and to propose a contextually appropriate leadership development model. Methods: A mixed-method design was used. Phase I was a qualitative study conducted through in-depth interviews and focus group discussions with 49 physicians from 31 institutions, analyzed using thematic framework analysis (NVivo 12, COREQ guidelines). Phase II was a quantitative survey involving 358 physicians from 25 institutions, analyzed using structural equation modeling with partial least squares (SEM-PLS). Results: Qualitative findings revealed structural, personal, and managerial barriers to leadership engagement, including time constraints, administrative burdens, inadequate incentives, and political influences. However, physicians were perceived as strategic leaders due to their technical expertise, tiered experiences, and credibility in clinical management. The quantitative model demonstrated strong reliability and validity. Individual differences (experience, efficacy) significantly influenced motivation to lead (β=0.577), leadership behavior (β=0.496), and leadership outcomes (β=0.176, p<0.001). Motivation (β=0.197) and behavior (β=0.604) also significantly predicted leadership outcomes. Conclusion: Despite low participation, physicians possess leadership characteristics that positively contribute to leadership effectiveness. Physician leadership development should be institutionally driven, integrating managerial competencies with technical expertise, while addressing structural and motivational barriers.
Potential of avocado seed ethanol extract (Persea americana Mill. var Miki) as an anti-aging Alya, Syadza; Hasballah, Kartini; Fitria, Fitria; Harnelly, Essy; Sary, Nirwana Lazuardi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69540

Abstract

Skin aging, characterized by decreased skin elasticity, is a global concern closely related to elastin degradation caused by oxidative stress and elastase activity. Natural ingredients rich in antioxidants are increasingly explored as potential anti-aging agents. Avocado (Persea americana) seeds contain various bioactive compounds that may protect elastin and slow the skin aging process. This study employed in silico and in vitro approaches to evaluate the antioxidant and anti-elastase activities of ethanol extract of avocado seeds from Bener Meriah, Aceh. Extraction was performed using maceration with 70% ethanol, followed by phytochemical screening. Antioxidant activity was assessed using the DPPH method. Anti-elastase activity was evaluated in silico through molecular docking against porcine pancreatic elastase (PPE) and in vitro using the SANA substrate and PPE enzyme. The avocado seed ethanol extract showed strong antioxidant activity with an IC₅₀ value of 47.31 ppm. It also demonstrated potent anti-elastase activity with an IC₅₀ value of 6.980 ppm. Molecular docking revealed that cholestan-3-ol, 2-methylene-, (3β,5α)- had a binding affinity of −8.0 kcal/mol, comparable to the control. Overall, the ethanol extract of avocado seeds exhibits very strong antioxidant and significant anti-elastase activities both in silico and in vitro, indicating its potential as a natural anti-aging agent.