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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter The Journal of The Indonesian Medical Students´ Association Indonesian Journal of Pharmaceutical Science and Technology Dental Journal (Majalah Kedokteran Gigi) YARSI Medical Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J International Journal of Public Health Excellence (IJPHE) Jurnal Natural The Journal of Society Medicine (JSOCMED) The International Journal of Tropical Veterinary and Biomedical Research Narra X
Zinatul Hayati
Syiah Kuala University
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Energy Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Distribution and antimicrobial sensitivity pattern of multidrug-resistant Pseudomonas aeruginosa from the clinical specimen in Aceh, Indonesia Hayati, Zinatul; Ismail, Yulia S.; Suhartono, Suhartono; Zikra, Miftahul; Karmil, Teuku F.; Oktiviyari, Ade
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.87

Abstract

The development of P. aeruginosa resistance to antibiotics is increasing globally due to the inappropriate use of antibiotics. This retrospective descriptive study aimed to determine the distribution of multidrug resistant P. aeruginosa (MDRPA) and its antimicrobial sensitivity profiles. Data were taken from the bacterial identification and antibiotic sensitivity testing of clinical specimens in Aceh Provincial Referral Hospital from July 2017 to June 2019, where the VITEK® 2 Compact automatic device was used for the identification. In total, there were 307 P. aeruginosa isolates analyzed in this study. The results of this study revealed that 54.39% of P. aeruginosa isolates were multidrug resistant.  The MDRPA were mostly found in sputum and pus cultures (41.91% and 23.95%, respectively). Based on the wardroom as the source, most samples came from the internal medicine unit, intensive care unit, and surgical unit with prevalence of 27.54%, 25.74%, and 20.35%, respectively. High proportion of infected patients were male (52.09%) and aged 56–65 years (23.95%). P. aeruginosa showed the highest sensitivity rate to amikacin (77.1%), followed by meropenem (74.4%), ceftazidime (70.1%), levofloxacin (65.1%), tobramycin (64.9%), piperacillin-tazobactam (64.3%), and gentamicin (61.4%). In conclusion, our data suggest that the MDRPA infection is prevalent in Aceh Province and Amikacin is recommended as the highest standard of therapy for MDRPA.
Bacterial patterns and antibiotic susceptibility among pus culture in dr. Zainoel Abidin General Hospital, Banda Aceh KEUMALAHAYATI, MEUTIA; HAYATI, ZINATUL; MAELANI, IMELDA; RIDWAN, AZWAR; RAHMAWATI, CUT VIKA; MULIANA, DESI; PUTRI, FARAH DHITA ANISSA; MAHDANI, WILDA
Jurnal Natural Volume 25 Number 1, February 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v25i1.44523

Abstract

The collection of pus samples is crucial for identifying serious bacterial infections. Accurate identification of the pathogen and selection of the appropriate antibiotics are essential for effective treatment. This study used a descriptive retrospective method to investigate pus specimens bacterial patterns and antibiotic susceptibility at dr. Zainoel Abidin General Hospital in Banda Aceh in 2023. Out of 1,274 examined pus specimens, 782 yielded positive cultures, revealing 61 bacterial species, predominantly Escherichia coli (22%), Staphylococcus aureus (16%), and Pseudomonas aeruginosa (9%). Gram-negative bacteria constituted 70.20% of the isolates. High antibiotic susceptibility rates were observed for Vancomycin (98%) and Linezolid (98%) in Gram-positive bacteria, while Amikacin (86%) and Meropenem (74.74%) were effective against Gram-negative bacteria. Notable resistance was found in Methicillin-resistant S. aureus (81%) and E. coli resistant to third-generation Cephalosporins (55%). These findings underscore the importance of monitoring bacterial patterns and antibiotic resistance for improved infection management at dr. Zainoel Abidin General Hospital, Banda Aceh.
PETA DISTRIBUSI DAN RESISTENSI Acinetobacter baumannii DARI SPESIMEN KLINIK DI RSUD DR. ZAINOEL ABIDIN TAHUN 2018 Mahdani, Wilda; Hayati, Zinatul; Yusriadi, Teuku
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.6 : No.1 (Mei, 2020)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v6i1.2666

Abstract

Kemampuan hidup Acinetobacter baumannii pada berbagai keadaan dikombinasikan dengan resistensi berkaitan erat dengan Healthcare Associated Infections (HAIs). Kemunculan strain resisten telah banyak dilaporkan. Penelitian ini bersifat observasional deskriptif. Pemeriksaan spesimen klinik dilakukan di Laboratorium Mikrobiologi Klinik RSUD dr. Zainoel Abidin Banda Aceh. Isolat Acinetobacter baumannii dikumpulkan,  dilakukan uji kepekaan serta dinilai tingkat resistensinya. Angka insidensi Acinetobacter baumannii adalah 4,6% yang dominan terisolasi dari spesimen sputum. Strain resisten sangat umum dijumpai pada ruang rawat intensif, ruangan non intensif memiliki lebih banyak strain susceptible. Strain MDR menunjukkan kepekaan terhadap amikacin, trimethoprim-sulfamethoxazole, tobramycin, ampicillin-sulbactam, dan meropenem. Acinetobacter baumannii strain XDR hanya menunjukkan kepekaan yang masih baik terhadap amikacin. Data epidemiologi resistensi antibiotik adalah komponen utama Program Pengendalian Resistensi Antibiotik di rumah sakit.
The Implementation of Female Circumcision by Midwives in Aceh Warahmah, Mawaddah; Nurjannah, Nurjannah; Hayati, Zinatul; Usman, Said; Saputra, Irwan
International Journal of Public Health Excellence (IJPHE) Vol. 5 No. 1 (2025): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v5i1.1411

Abstract

The practice of Female Genital Mutilation (FGM), also known as female circumcision, is still maintained, especially in Aceh, despite being banned by the WHO and the government. This practice is not taught in the school, including the midwifery school, as midwives are among the healthcare providers who generally offer this service. The dynamics of policy changes and deeply rooted differences in religious and cultural views create confusion for midwives in the field, particularly given the still high demand and community encouragement. The purpose of this research was to analyse the factors influencing the implementation of female circumcision by midwives. This was a cross-sectional study with the population of midwives who were working in the Aceh Province region in 2024. The sample of this study consisted of midwives who provide female circumcision services in Aceh, with a sample size of 86 people. Statistical analysis used the Chi-Square test with the SPSS v.25 . The majority of midwives performed circumcision about 1-2 times a month, and midwives perceived circumcision as a social necessity. Midwives aged ≥ 43 years, with work experience ≥ 13 years, working for ≥ 20 years, possessing good knowledge, and having a positive attitude tended to perform risky circumcisions. The results of the statistical test indicated that there was no significant relationship between age, years of service, duration of providing female circumcision services, knowledge, attitude, and social needs regarding the implementation of female circumcision. The research results indicated that midwives in Aceh continue to practice female circumcision, with the majority performing it in a risky manner. Although midwives have positive knowledge and attitudes, social necessity factors are the main drivers in its implementation
In Vitro Antibacterial Activity of Curcumin and Protocatechuic Acid Against Extended-Spectrum β-Lactamase–Producing Klebsiella pneumoniae Isolated from Chronic Cough Sputum Hayati, Zinatul; Iwan Tona , Azwar; Prima , Agus
Journal of Society Medicine Vol. 5 No. 1 (2026): January
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v5i1.258

Abstract

Introduction: Curcumin and protocatechuic acid are naturally occurring phenolic compounds that have been investigated for their potential antimicrobial properties. Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae is a major clinical concern because of the limited therapeutic options. This study aimed to isolate and identify K. pneumoniae ESBL from the sputum of patients with chronic cough and evaluate the antibacterial effects of curcumin and protocatechuic acid. Methods: A laboratory-based experimental study was conducted using sputum specimens from 100 patients with chronic cough. Bacterial isolation and identification were performed using standard microbiological procedures, followed by the confirmation of ESBL production. The antibacterial activities of curcumin and protocatechuic acid at 25 %, 50 %, and 75% concentrations were assessed using the disc diffusion method. Statistical analyses were performed using one-way analysis of variance (ANOVA) followed by post hoc testing. Results: Nine bacterial species were identified in the sputum samples. Klebsiella pneumoniae accounted for 27.5% of isolates, of which 7.5% were confirmed as ESBL-producing strains. Curcumin, at all tested concentrations, produced inhibition zones of approximately 6 mm, with no statistically significant differences between the concentrations tested. In contrast, protocatechuic acid demonstrated concentration-dependent antibacterial activity, producing mean inhibition zones of 20.6, 16.0, and 10.8 mm at 25%, 50%, and 75% concentrations, respectively, with statistically significant differences. The antibacterial effect of 75% protocatechuic acid was comparable to that of 10 µg meropenem. Conclusion: Curcumin showed no significant antibacterial activity against ESBL-producing K. pneumoniae, while protocatechuic acid exhibited significant and concentration-dependent inhibitory effects. These findings suggest that protocatechuic acid is a potential natural antibacterial agent against ESBL-producing K. pneumoniae.
Effects of Platelet Rich Plasma and Hydroxyapatite Implants Derived from Cuttlefish Bone (Sepia Sp) on Bone Generation and Osteogenic Activity Sofia, Sofia; Firdaus, Azhar; Erwin, Erwin; Hayati, Zinatul
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.70155

Abstract

Bone defects require biocompatible biomaterials that support osteoconduction and tissue regeneration. Hydroxyapatite (HA) derived from cuttlebone (Sepia sp.) offers high calcium content and a porous structure with potential as a bone implant, while Platelet Rich Plasma (PRP) contains growth factors that enhance regeneration. This study aimed to evaluate the effects of PRP and cuttlebone HA on bone defect healing in rats using histopathological features. Nine male Wistar rats were divided into three groups: K1 (negative control), K2 (HA + PRP), and K3 (HA). Alveolar bone defects (5 mm in diameter) were surgically created, and treatments were applied accordingly. Samples were evaluated on day 30 using hematoxylin eosin staining and histomorphometric analysis. Parameters assessed included osteoblast, osteocyte, and osteoclast counts and neovascularization in the implant bone. One-way ANOVA revealed significant differences in osteoblast (p-value =0.000), osteoclast (p-value =0.033), and osteocyte (p-value =0.001) counts across groups. Kruskal-Wallis test showed significant difference in neovascularization (p-value =0.047). Histopathological examination demonstrated no necrosis and increased bone marrow proliferation in the K2 group. This study indicates that cuttlebone-derived hydroxyapatite holds potential as a regenerative implant, particularly when combined with PRP
Co-Authors . Junaidi Abdillah Imron Nasution Ade Oktiviyari, Ade Azwar Azwar Basri A. Gani Basri Gani Boy M Bachtiar Cut Soraya Darniati . Diah, Muhammad Endang Winiati B Erwin Erwin Firdaus, Azhar Harapan Harapan I. Wayan T. Wibawan Iqbal Muhammad Ismail, Yulia S. Iwan Tona , Azwar Karmil, Teuku F. Kartini Hasballah KEUMALAHAYATI, MEUTIA Kurnia Fitri Jamil Maelani, Imelda Mahdani, Wilda Maulina, Novi Mawaddah Warahmah Mudatsir Mudatsir MULIANA, DESI Noratul Hafdhah Nurjannah Nurjannah Prima , Agus Puspita, Ira PUTRI, FARAH DHITA ANISSA RAHMAWATI, CUT VIKA Ramadhana, Ika F. Ridwan, Azwar Santi Chismirina Saputra, Irwan Sofia Sofia, Sofia Usman, Said Yossadania, Asyriva Yusriadi, Teuku Zikra, Miftahul Zulkarnain Zulkarnain Zulkifli, Baidillah