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All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Penelitian Sains (JPS) Microbiology Indonesia SEMIRATA 2015 CHEMPUBLISH JOURNAL Jurnal Penelitian Sains (JPS) IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Science and Technology Indonesia Jurnal Penelitian Sains Martabe : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam Molekul: Jurnal Ilmiah Kimia JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Jurnal Abdi Insani Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal Pengabdian Masyarakat Indonesia SRIWIJAYA JOURNAL OF ENVIRONMENT BIOVALENTIA: Biological Research Journal Joong-Ki : Jurnal Pengabdian Masyarakat Jurnal Pepadu Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia Joong-Ki Joong-Ki Analit: Analytical And Environmental Chemistry
Heni Yohandini
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, University Of Sriwijaya, Inderalaya, Ogan Ilir, South Sumatra, 30662 Indonesia
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Journal : CHEMPUBLISH JOURNAL

 1 
Analgesic Effect of Ethanol Extract of Dillenia ochreata (Miq.) Teijsm. & Binn. Ex Martelli in Wistar Rats Yohandini, Heni; Ghaniya, Fahdelaa; Muharni, Muharni; Fitrya, Fitrya
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.43080

Abstract

Dillenia ochreata is a traditional medicine used to treat wounds and scabies. In wound healing, one of the treatments is to reduce pain (analgesic). Some compounds of triterpenoid groups have been known to be active as analgesic compounds. The leaf of D. ochrea was reported to contain secondary metabolites triterpenoid centulic acid and 3β-glucopyranosyl-lup-20(29)-en-28 oat. This study aimed to evaluate the analgesic activity and standardization of the ethanol extract of D. ochreata leaf and determine the mechanism of action. Analgesic activity was determined by a hot plate method and formalin test, and the mechanism of action was through muscarinic, dopamine, and opiate receptors, standardization of extract using the method issued by the Indonesian Ministry of Health.  The ethanol extract of D. ochreata leaf at a 400 mg/kg bw dose has higher analgesic activity (24.85%) than the positive control (18.32%).  Statistical analysis showed a significant difference in analgesic activity percentage between the positive group and those with a 400 mg/kg bw group dose. The 400 mg/kg bw dose also showed a significant difference (p<0.05) between neurogenic pain (46.92%) and inflammation (61.19%) in the formalin test caused by opioid receptors. The evaluation of the analgesic mechanism showed the ethanol extract of D. ochreata leaf works through opioid receptors. The extract meets the requirements of the standard parameters.  The leaf extract of D. ochreata can be developed as an anti-analgesic from natural medicine.
Co-Authors . AKHMALOKA Abd. Rasyid Syamsuri Ady Mara, Ady Afreni Hamidah Alfarado, Daniel Alfian Hasbi Almunady T. Panagan Almunady T. Panagan Ani Sarah Arini, Feggy Augesti Erisna Ayu Lestari Ayu Safitri Bella Safitri Bijak Riyandi Ahadito Budiono Budiono Carissa, Restri Diah Cenora, Cindy Cindy Cenora Desnelli Desnelli Dirli Fahmi Rizal Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elisa Nurnawati Eliza Eliza Eliza Eliza Eliza Eliza Elvi Elvi Esthy Rahman Asih Evi Kaderani Barutu Fatma Feggy Arini Ferlinahayati Ferlinahayati FIDA MADAYANTI Fitrya . Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Ghaniya, Fahdelaa Hadir Kaban, Hadir Hary Widjajanti Hary Widjajanti Hermansyah Hermansyah Hermansyah Hermansyah Herwin Purnomo IHSAN IVANTRI Isrowiyatun Daiyah Jasmi Jasmi Jojor Uli Gultom Jorena Jorena, Jorena Julinar Julinar Julinar Julinar Julinar Julinar Julinar Juraida Roito Hrp Jurnal Pepadu Juswardi Juswardi Lily Restusari Maghfirahmah Amsyah Putri Marieska Verawaty Maryadi Maryadi Maryadi Maryadi Melinda Susanti S Melly Wardanis Melsa Nilmalasari Miksusanti Miksusanti Mila Wulandari Mila Wulandari Mita Puspitasari Mudinillah, Adam MUHAMMAD SAID Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni, . Munawar Munawar Nirwan Syarif Nirwan Syarif, Nirwan Nita Aminasih Nova Yuliasari oktaviani, muthia PINGKAN ADITIAWATI Poedji Loekitowati Hariani Poedji Loekitowati Hariani Pramoe Wibowo Putra Setia Aji Candra Rahmi Junaida Rifdah Nabila Riska Adillah Rivai, M Yunus Rivai, M Yunus Rizkiani, Delisa Rr. Kusuma Nurin Husna Safitri, Bella Salni Salni Seni Metasari Seni Metasari Stephani Stephani Suheyanto Suheryanto Susilawati Susilawati Susilawati, Susilawati Syafrina Lamin, Syafrina Yeni Aryani Yulia Fitri Yundari, Yundari