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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmiah Universitas Batanghari Jambi JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia JURNAL MEDIA KESEHATAN Jurnal Farmagazine Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Pharmaceutical and Sciences.

Henny Lucida

Fakultas Farmasi, Universitas Andalas

Author-ID : 279714

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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In Silico Analysis of Physical-Chemical Properties, Target Potential, and Toxicology of Pure Compounds from Natural Products Purnawan Pontana Putra; Annisa Fauzana; Henny Lucida
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 3 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i3.26403

Several studies have shown that pure compounds from west sumatera medicinal plants have beneficial therapeutic effects so that they are potential candidates for active pharmaceutical ingredients (API). Andalas Sitawa Fitolab has been able to produce 10 pure isolates. The development of a new drug candidate requires an in silico study to predict physicochemical properties, potential target, and toxic properties. The purpose of this study was to initially screen the structure of candidates to predict the potential the compound as an API by using big data and machine learning. The chemical structure were analyzed using software and servers. The Software used was Marvin Sketch, QSAR Toolbox, Swiss Potential Target and ChemBioDraw. Results showed that log P of compounds revealed in a range of -0.54 to 4.64, Polar Surface Area (PSA) in range of 20.23 to 315.21. Asiaticoside did not meet Lipinski's rules. Compounds with high potential hazard were catechin, curcumin, andrographolide, asiaticoside deoxyelephantopin, ethylmethoxycinnamate, alpha-mangostin and piperine. The compounds such as curcumin, alpha mangostin, plumbagin, and piperine were predicted to have spesific target proteins. This study concluded that asiaticoside compounds have a high potential hazard, if it was developed as an API.Keywords: analysis of physical-chemical properties, in silico, pure isolate, toxicology

Homology modeling and mutation prediction of ACE2 from COVID-19 Purnawan Pontana Putra; Annisa Fauzana; Khairunnisa Assyifa Salva; Maya Sofiana; Intan Permata Sari; Henny Lucida
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

SARS-CoV-2 has become a pandemic in the world. The virus binds to the Angiotensin-Converting Enzyme 2 (ACE2) receptor, which is found in epithelial cells such as in the lungs, to generate the pathology of COVID-19. It is essential to analyze the characteristics of ACE2 in understanding the development of the disease and study potential new drugs. The analysis was carried out using computer simulations to speed up protein analysis that utilized Artificial Intelligence technology, databases, and big data. Homology modeling is a method to exhibit homologous of protein families, hence the model and arrangement of protein sequences modeled are established. This research aims to determine the possibility of mutations in ACE2 by performing the mutation prediction. The result shows reliable homologous modeling with the score of GA341, MPQS, Z-DOPE, and TSVMod NO35 were 1; 1.28252; -0.47; and 0.793, respectively. Moreover, Gene Ontology (GO) analysis describes that ACE2 has a molecular transport function in cells while there are no mutations found occurred in ACE2 analyzed using SIFT and PROVEAN.

Studi Penilaian Klinis Penggunaan Antibiotik pada Pasien Penyakit Ginjal Kronis Mita Restinia; Henny Lucida; Wasif Gillani S
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

A 6-week longitudinal prospective study was conducted to assess the effectiveness and the safety antibiotic used in chronic kidney disease (CKD) patients in internal medicine ward. We compared white blood count and glomerular fi ltration rate before and after antibiotic used. The CKD patients who admitted in the internal medicine ward and age ≥18 years old were included this study. Patients with incomplete laboratory data and renal replacement therapy were excluded in this study. The 25 patients who enrolled in this study were recruited. The majority gender of CKD was male (64%), the mean of age was 61.52±14.17 years old with length of stay (LOS) was 6.92±4.05 days. The highest number of patients was in CKD stage 3 (n=10, 40%) and was followed by CKD stage 2 (n=6, 24%). Most of them were diagnosed community acquired pneumonia. Tablet azithromycin (n=16, 64%) then Cefotaxime intra venous injection (IV) (n= 6, 24%), and Ceftazidime IV (n=5, 20%), Cloxacillin IV (n=4, 16%) were the most antibiotics prescribed. Generally patients had been prescribed appropriate dose of antibiotic and 88% of them showed improved white blood count. In contrast, the glomerular fi ltration rate of 44% CKD patients was getting worse. In conclusion, this study clearly indicate the CKD patients require close monitoring to maintenance of renal function even the antibiotic had been prescribed appropriately.

Karakterisasi dan Studi Aktivitas Antioksidan dari Ekstrak Etanol Secang (Caesalpinia sappan L.) Febriyenti Febriyenti; Netty Suharti; Henny Lucida; Elidahanum Husni; Olivia Sedona
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Secang (Caesalpinia sappan L.) secara tradisional digunakan untuk mengobati berbagai penyakit. Secang mengandung senyawa fenolik seperti asam gallat, brazilin dan brazilein. Tujuan penelitian ini adalah untuk mengkarakterisasi simplisia dan ekstrak etanol secang, mengevaluasi kandungan fenolik total dan menentukan aktivitas antioksidan ekstrak etanol secang. Karakterisasi simplisia secang diperoleh susut pengeringan sebesar 10,349 %, kadar sari larut air sebesar 3,293 %, kadar sari larut etanol sebesar 6,026 %, kadar abu total sebesar 0,6509 % dan kadar abu tidak larut asam simplisia adalah sebesar 0,480 %. Karakterisasi ekstrak etanol secang diperoleh kadar abu total sebesar 1,26 %, kadar abu tidak larut asam ekstrak sebesar 0,059 %, kadar air ekstrak didapatkan hasil 8,63 %. Kadar fenolik total ekstrak etanol secang adalah 71,144 g/100g. Semakin tinggi kadar fenolik total, maka semakin tinggi pula aktivitas antioksidannya. Aktivitas antioksidan ekstrak etanol secang ditentukan dengan metode FRAP (Ferric Reducing Antioxidant Power) dan hasilnya adalah 13,99 mmol Fe(II)/100g.

Validasi Metoda Analisis Penetapan Kadar Ketoprofen pada Tablet Salut Enterik secara Kromatografi Cair Kinerja Tinggi dan Spektrofotometri UV Salman Umar; Saafrida Saafrida; Henny Lucida
Jurnal Sains Farmasi & Klinis Vol 8, No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Ketoprofen yang beredar di Indonesia sebagian besar dalam bentuk sediaan tablet salut enterik, tetapi metoda analisis untuk penetapan kadar dan uji disolusinya belum tersedia dalam farmakope. Tujuan dari penelitian ini adalah mengembangkan metode kromatografi cair kinerja tinggi (KCKT) dan spektrofotometri ultraviolet visibel (UV) untuk melakukan analisis tablet salut enterik ketoprofen. Penetapan kadar dan keseragaman kandungan ketoprofen tablet salut enterik ditentukan secara KCKT isokratik fase terbalik yang telah divalidasi menggunakan kolom reverse phase (RP-18 ) (250 x 4,6 mm) diameter partikel 5 µm, fase gerak metanol-dapar fosfat 13 mM pH 6,5 perbandingan 60:40 v/v, laju alir 1,0 mL/menit dan detektor UV 258 nm. Spesifisitas, linieritas, akurasi, dan presisi memenuhi persyaratan International Conference on Harmonization (ICH). Metode KCKT memberikan lineritas yang sangat baik (r > 0,999) pada rentang konsentrasi 15 – 35 µg/mL, presisi dinyatakan dalam persen deviasi standar relative (% RSD <0,87) dan perolehan kembali yang baik (R> 99,97%). Metode KCKT lebih sensitif dibandingkan metode spektrofotometri UV, dengan nilai LOD masing-masing adalah 0,18 dan 0,67 µg/mL serta LOQ 1,20 dan 2,49 µg/mL. Hasil validasi dan uji penetapan kadar ketoprofen pada tablet salut enterik dengan metode KCKT tidak berbeda nyata dibandingkan dengan metode spektrofotometri UV (P>0,05)

Perbandingan Efektivitas Pendidikan Kesehatan terhadap Pengetahuan dan Kemampuan Ibu Merawat Balita ISPA di Puskesmas Padang Pasir dan Pauh Dwi Novrianda; Henny Lucida; Irfandy Soumariris
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Health education with booklet media is an effort to increase knowledge and ability in caring Acute respiratory infection (ARI). This study aimed to identify comparison effectivity in health education towards knowledge and ability in caring between Padang Pasir and Pauh Health Center. Method used pre experimental with pretest posttest design. Subject was mothers with children having ARI amount 15 samples. Data was collected by questionnaires. Data analysis used wilcoxon to identify difference pre and posttest of mother’s knowledge and ability in caring, mann whitney-U to know difference between both of them. Study showed there was difference of knowledge and ability in caring between pre and posttest (p=0,002). There was difference in effectivity of health education between Padang Pasir and Pauh on ability in caring (p=0,004).It suggested health education with more interesting media like booklet must be given especially for mothers so ARI’s rate can be reduced in children.

Pengembangan dan Validasi Metoda Disolusi Tablet Salut Enterik Ketoprofen Saafrida - saafrida; Salman Umar; Henny Lucida
Jurnal Sains Farmasi & Klinis Vol 9, No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.285-290.2022

Tablet salut enterik Ketoprofen adalah obat yang beredar luas di Indonesia. Digunakan untuk mengatasi nyeri arthiritis tulang, rematik dan demam. Namun, sejauh ini uji disolusinya secara spesifik belum tersedia dalam farmakope manapun. Uji disolusi termasuk parameter yang harus diperhatikan untuk mengetahui kualitas produk obat sediaan padat. Tujuan dari penelitian ini adalah mengembangkan dan memvalidasi metode pegujian disolusi dari tablet salut enterik ketoprofen. Profil disolusi diamati terhadap 3 produk tablet salut enterik ketoprofen yang beredar di kota Padang. Uji disolusi dilakukan dua tahap menggunakan 750 mL larutan HCl 0,1 N ( tahap asam) dan 1000 mL larutan dapar fosfat pH 6,8 dan 7,4 (tahap basa), alat tipe 1 (keranjang) dan tipe 2 (dayung) kecepatan 50 dan 75 rpm. Hasil uji disolusi selanjutnya ditentukan secara spektrofotometri UV. Metoda uji disolusi hyperdiscriminating diperoleh pada uji disolusi menggunakan alat tipe 1, kecepatan rotasi 75 rpm dan media disolusi 1000 mL dapar fosfat pH 6,8 dengan nilai Q45 ≥ 75%. Spesifiitas, linieritas (r = 0,9988), presisi (RSD = 1,12%) dan akurasi (recoveri = 95,7 - 97,6%) memenuhi syarat keberterimaan sesuai pedoman ICH dan USP. Uji disolusi yang dikembangkan dapat digunakan untuk tujuan pengawasan mutu tablet salut enterik ketoprofen .

STUDI INTERAKSI SENYAWA BAKU PEMBANDING DARI ANDALAS SITAWA FITOLAB TERHADAP KLEBSIELLA PNEUMONIAE DENGAN IN SILICO Purnawan Pontana Putra; Annisa Fauzana; Nola Florida; Gio Vanny Yusuf; Henny Lucida
Jurnal Farmagazine Vol 10, No 1 (2023): Jurnal Farmagazine
Publisher : STF Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47653/farm.v10i1.641

Bakteri, virus dan mycoplasma dapat menyebabkan pneumonia. Klebsiella pneumoniae adalah penyebab umum infeksi resisten antimikroba pada pasien rawat inap. Miroba ini secara alami resisten terhadap penisilin. Pnemoniae dapat disebabkan oleh bakteri, virus dan mycoplasma. Bakteri Klebsiella pneumoniae mampu menginfeksi dan memperparah pasien yang terkena penyakit COVID-19. Bakteri ini telah resisten terhadap antibiotik. Dilakukan metode molecular docking untuk memprediksi interaksi antara klebsiella pneumoniae dan senyawa bahan alam yang terdapat pada database andalas sitawa yaitu Alpha Mangostin, Andrographolide, Asiaticoside, Catechin. Curcumin, Deoxyelephantopin, Ethyl methoxycinnamate, Hydroxychavicol, Piperine dan Plumbagin. Perangkat lunak yang digunakan dalam simulasi yaitu Autodock Vina. Optimasi geometri dilakukan dengan MMFF94 untuk senyawa bahan alam. Dari hasil diperoleh senyawa yang memiliki energi bebas gibbs yang terbaik adalah Asiaticoside dengan energi -10.22 (kcal/mol). Asiaticoside memiliki interaksi pada asam amino yaitu Ikatan Hidrogen pada asam amino Asn79, Arg151 selanjutnya Ikatan Van der walls pada Ile152, Met156, dan Ser156. Ikatan Pi-Alkyl pada asam amino Tyr125, His195 dan ikatan Alkyl pada asam amino Arg155. Simulasi dinamika molekul senyawa Asitiacoside dengan protein fluktuasi terbesar pada residu asam amino 245-248 yaitu Leusine, Tyrosine, Phenylalanine, dan Glutamine dengan rentang fluktuasi 3,2169-3,2525 nm

Perbandingan Mutu dan Profil Disolusi Tablet Griseofulvin Merek Dagang Generik Azhoma Gumala; Henny Lucida; Salman Salman
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29982

Abstract: Griseofulvin is an active pharmaceutical ingredient in Biopharmaceutic Classification Systems Class II and the price of the dosage form from commercial brands four times higher than the generic. A comparative study on physical properties and dissolution profiles between generic and commercial brands of griseofulvin tablets has been conducted to assess whether there is difference between their qualities. The pharmaceutical properties were assessed based on the Indonesian and the United State Pharmacopeias. Results showed that the tablets fulfilled the requirements for size uniformity, weight uniformity (0.5995± 0.0075) gram - (0.6989±0.0080) gram, friability 0.08-1.10 %, hardness (10±0.7746) - (19.6±0.9165) kg/cm2, disintegration time 07.12 - 17.17 minutes with drug content of 94.20 - 99.67%. The commercial brand griseofulvin tablets A1& A2 and generic B1 met the official specification for physical characteristics. Results of dissolution test for commercial brand A1 & A2 and generic B1 showed that griseofulvin had T60min (Q ≤ 70%) and the dissolution test profiles did not follow neither first order, Higuchi, Korsmeyer Peppas, nor Langenbucher kinetic models (r < 0,95). The dissolution test for griseofulvin tablet A1 met the USP specification, T90min (Q ≥ 75%) with the release mechanism follow Langenbucher kinetic model. Abstrak: Griseofulvin merupakan zat aktif golongan Sistem Klasifikasi Biofarmasetik kelas II dengan perbedaan harga antara tablet merek dagang lebih mahal hingga empat kalinya dibandingkan tablet generik. Uji disolusi terbanding dilakukan untuk melihat adakah perbedaan mutu yang signifikan antar tablet tersebut. Metode evaluasi mutu dilakukan sesuai dengan ketentuan Farmakope Indonesia dan USP. Hasil evaluasi mutu fisik tablet meliputi keseragaman ukuran, keseragaman bobot yaitu (0,5995± 0,0075) – (0,6989±0,0080) gram, kerapuhan 0,08 - 1,10%, kekerasan (10±0,7746) - (19,6±0,9165) kg/cm2, & waktu hancur 07.12 - 17.17 menit dan penetapan kadar 94,20 - 99,67%, memenuhi ketentuan Farmakope Indonesia. Profil disolusi tidak mengikuti model kinetika orde satu, Higuchi, Korsmeyer Peppas, ataupun Langenbucher (r < 0,95). Hasil uji disolusi tablet A1 yang dilakukan berdasarkan USP memenuhi persyaratan T90 min (Q ≥ 75%) dan memiliki profil disolusi mengikuti persamaan Langenbucher (r>0,95). Keywords: Profil disolusi, tablet griseofulvin, mutu tablet, model matematika

Nanotope™ sebagai Sistem penghantaran Cosmeceutical untuk Meningkatkan Intensitas Efek pada Kulit Ulma Sintia; Regina Andayani; Henny Lucida
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Nanotope™ as a monolayer nanoencapsulated vesicular delivery system, consisting of a membrane formed by phospholipids (lecithin) and cosurfactants. Nanotope™ is an Ultra-small Unilamellar Carrier (USUC) having an average globule size of 0-40 nm. The diameter of the globule size which is smaller than the size of the skin pores allows the active ingredients to penetrate the stratum corneum to reach the target. Natural active compounds such as catechin, alpha mangostin, quercetin, and ascorbic acid have great potential as active ingredients to be formulated in cosmetic preparations. However, these compounds have limited penetration into the skin. Therefore, the Nanotope™ delivery system is the best solution for encapsulating these active ingredients without reducing their effectiveness. Cosmetic serums, creams and emulgel are preparations that are most likely to be formulated with the Nanotope™ delivery system. This review article presents Nanotope™ preparation techniques along with their evaluations, as well as active compounds from natural ingredients that have the potential for cosmetic applications with the Nanotope™ delivery system.

Co-Authors AA Sudharmawan, AA Anita Lukman Auzal Halim Azhoma Gumala Azhoma Gumala Ben, Elfi Sahlan Chris Deviarny Dachriyanus Dwi Novrianda Elfi Delita Elyunaida, Elyunaida Erizal Zaini Fahmy, Rahmi Fauzana, Annisa Fitri, Ema Gio Vanny Yusuf Gumala, Azhoma Helmi Arifin Hj. Lajisc, Nordin Hj. Lajisc, Nordin Hosiana, Vinny Husni, Patihul Intan Permata Sari Irfandy Soumariris Jannah, Yasmin Raudhatul Jonisa, Rahma Aprilya Kamal Rullah Khairunnisa Assyifa Salva Marlina Marlina Maya Sofiana Mita Restinia Muslim Suardi Netty Suharti Nola Florida Okti Rahayu Asih Olivia Sedona Patihul Husni Pradifta, Reysa Rahmat, Rosita Dewi Rahmat, Rosita Dewi Regina Handayani Handayani, Regina Handayani Riah Trisnawati Rizal Fahmi Rustini Rustini Saafrida - saafrida Saafrida Saafrida Saafrida, Saafrida saafrida, Saafrida - Safni Safni Salman - Salman Salman Salman Salman Salman Umar Salsabila, Amilia Saputra, Harry Saputra, Harry Sari, Aulia Desvita Saufitri, Dian Saufitri, Dian Sintia, Ulma Vinny Hosiana Vinny Hosiana Vivi Muharmi Wasif Gillani S Wira Noviana, Wira Noviana Wira Noviana, Wira Noviana Yoneta Srangenge Yunazar Manjang Yuningzia, Vannesha Zahara Gayo Zifriyanthi Minanda Putri

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