Article Per Year (5 Year)
p-Index From 2021 - 2026
2.147
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmiah Universitas Batanghari Jambi JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia JURNAL MEDIA KESEHATAN Jurnal Farmagazine Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Pharmaceutical and Sciences.
Henny Lucida
Fakultas Farmasi, Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 36 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 36 Documents
Search

 1   2   3   4 
Identifikasi dan Edukasi Adverse Drug Reactions dan Drug Related Problems pada Masyarakat Lanjut Usia di Posyandu Lansia Lubuk Begalung Padang Azhoma Gumala; Yoneta Srangenge; Henny Lucida
Warta Pengabdian Andalas Vol 30 No 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.2.346-353.2023

Abstract

Geriatric tend to suffer from more than one disease and consume more than one drug yearly. This study aimed to identify and educate geriatrics in the elderly community in Lubuk Begalung Padang, West Sumatra, about adverse drug reactions and drug-related problems. This society activity was carried out by direct interviews using a questionnaire and counselling individual patients. The results of this activity were presented descriptively. A total of 30 female (93.1%) and male (2.60%) subjects were involved in this study. Data showed that 86.70% of the subjects did not carry out regular medical check-ups, 63.4% of the subjects used three or more types of drugs, 77% of the subjects did not know the names of the drugs given, and 56.70% did not know nor did not receive information of the usage of the drug. In conclusion, the people in Lubuk Begalung sub-district Padang still lack knowledge regarding drugs and the risk of polypharmacy, so drug education and counselling for the community needs to be improved. In this activity, the effect of providing education on changes in the knowledge or behaviour of the respondents was not measured. However, the respondents expressed their satisfaction with this activity and hoped that the activities would continue in the future
Perbandingan Mutu dan Profil Disolusi Tablet Griseofulvin Merek Dagang Generik Azhoma Gumala; Henny Lucida; Salman Salman
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29982

Abstract

Abstract: Griseofulvin is an active pharmaceutical ingredient in Biopharmaceutic Classification Systems Class II and the price of the dosage form from commercial brands four times higher than the generic.  A comparative study on physical properties and dissolution profiles between generic and commercial brands of griseofulvin tablets has been conducted to assess whether there is difference between their qualities. The pharmaceutical properties were assessed based on the Indonesian and the United State Pharmacopeias. Results showed that the tablets fulfilled the requirements for size uniformity, weight uniformity (0.5995± 0.0075) gram - (0.6989±0.0080) gram, friability 0.08-1.10 %, hardness (10±0.7746) - (19.6±0.9165) kg/cm2, disintegration time 07.12 - 17.17 minutes with drug content of 94.20 - 99.67%. The commercial brand griseofulvin tablets A1& A2 and generic B1 met the official specification for physical characteristics. Results of dissolution test for commercial brand A1 & A2 and generic B1 showed that griseofulvin had T60min (Q ≤ 70%) and the dissolution test profiles did not follow neither first order, Higuchi, Korsmeyer Peppas, nor Langenbucher kinetic models (r < 0,95). The dissolution test for griseofulvin tablet A1 met the USP specification, T90min (Q ≥ 75%) with the release mechanism follow Langenbucher kinetic model. Abstrak: Griseofulvin merupakan zat aktif golongan Sistem Klasifikasi Biofarmasetik kelas II dengan perbedaan harga antara tablet merek dagang lebih mahal hingga empat kalinya dibandingkan tablet generik. Uji disolusi terbanding dilakukan untuk melihat adakah perbedaan mutu yang signifikan antar tablet tersebut. Metode evaluasi mutu dilakukan sesuai dengan ketentuan Farmakope Indonesia dan USP. Hasil evaluasi mutu fisik tablet meliputi keseragaman ukuran, keseragaman bobot yaitu (0,5995± 0,0075) – (0,6989±0,0080) gram, kerapuhan 0,08 - 1,10%, kekerasan (10±0,7746) - (19,6±0,9165) kg/cm2, & waktu hancur  07.12 - 17.17 menit dan penetapan kadar  94,20 - 99,67%, memenuhi ketentuan Farmakope Indonesia. Profil disolusi tidak mengikuti model kinetika orde satu, Higuchi, Korsmeyer Peppas, ataupun Langenbucher (r < 0,95). Hasil uji disolusi tablet A1 yang dilakukan berdasarkan  USP memenuhi persyaratan T90 min  (Q ≥ 75%) dan memiliki profil disolusi mengikuti  persamaan Langenbucher (r>0,95). Keywords: Profil disolusi, tablet griseofulvin, mutu tablet, model matematika
Validasi Metoda Analisis Penetapan Kadar Ketoprofen pada Tablet Salut Enterik secara Kromatografi Cair Kinerja Tinggi dan Spektrofotometri UV Umar, Salman; Saafrida, Saafrida; Lucida, Henny
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.2.200-207.2021

Abstract

Ketoprofen yang beredar di Indonesia sebagian besar dalam bentuk sediaan tablet salut enterik, tetapi metoda analisis untuk penetapan kadar dan uji disolusinya belum tersedia dalam farmakope.  Tujuan dari penelitian ini adalah  mengembangkan metode kromatografi cair kinerja tinggi (KCKT) dan spektrofotometri ultraviolet visibel (UV) untuk  melakukan analisis tablet salut enterik ketoprofen. Penetapan kadar  dan keseragaman kandungan ketoprofen tablet salut enterik ditentukan secara KCKT isokratik fase terbalik yang telah divalidasi menggunakan kolom reverse phase (RP-18 ) (250 x 4,6 mm) diameter partikel 5 µm, fase gerak metanol-dapar fosfat 13 mM pH 6,5 perbandingan 60:40 v/v, laju alir 1,0 mL/menit dan detektor UV 258 nm. Spesifisitas, linieritas, akurasi, dan presisi  memenuhi persyaratan International Conference on Harmonization (ICH). Metode KCKT memberikan lineritas yang sangat baik (r > 0,999) pada rentang konsentrasi 15 – 35 µg/mL, presisi dinyatakan dalam persen deviasi standar relative (% RSD <0,87) dan perolehan kembali yang baik (R> 99,97%). Metode KCKT lebih sensitif dibandingkan metode spektrofotometri UV, dengan nilai LOD masing-masing adalah 0,18 dan 0,67 µg/mL serta LOQ 1,20 dan 2,49 µg/mL.  Hasil validasi dan uji penetapan kadar ketoprofen pada tablet salut enterik dengan metode KCKT tidak berbeda nyata dibandingkan dengan metode spektrofotometri UV (P>0,05)
Pengembangan dan Validasi Metoda Disolusi Tablet Salut Enterik Ketoprofen saafrida, Saafrida -; Umar, Salman; Lucida, Henny
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.285-290.2022

Abstract

Tablet salut enterik Ketoprofen adalah obat yang beredar luas di  Indonesia. Digunakan  untuk mengatasi nyeri arthiritis tulang, rematik dan demam. Namun, sejauh ini uji disolusinya secara spesifik belum tersedia dalam farmakope manapun.  Uji disolusi termasuk parameter yang harus diperhatikan untuk mengetahui kualitas produk obat sediaan padat. Tujuan dari penelitian ini adalah  mengembangkan dan memvalidasi metode pegujian disolusi dari tablet salut enterik ketoprofen. Profil disolusi diamati terhadap 3 produk tablet salut enterik ketoprofen yang beredar di kota Padang. Uji disolusi dilakukan dua tahap menggunakan 750 mL larutan HCl 0,1 N ( tahap asam) dan 1000 mL larutan dapar fosfat pH 6,8 dan 7,4 (tahap basa), alat tipe 1 (keranjang) dan tipe 2 (dayung) kecepatan 50 dan 75 rpm. Hasil uji disolusi selanjutnya ditentukan secara spektrofotometri UV. Metoda uji disolusi  hyperdiscriminating  diperoleh pada uji disolusi menggunakan alat tipe 1,  kecepatan rotasi 75 rpm dan  media disolusi 1000 mL dapar fosfat pH 6,8 dengan nilai Q45 ≥ 75%. Spesifiitas, linieritas  (r = 0,9988), presisi (RSD = 1,12%) dan akurasi (recoveri = 95,7 - 97,6%)  memenuhi syarat keberterimaan sesuai pedoman ICH dan USP. Uji disolusi yang dikembangkan dapat digunakan untuk tujuan pengawasan mutu tablet salut enterik ketoprofen .  
Perbandingan Mutu dan Profil Disolusi Tablet Griseofulvin Merek Dagang Generik Gumala, Azhoma; Lucida, Henny; Salman, Salman
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 4 No. 2 (2022)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29982

Abstract

Abstract: Griseofulvin is an active pharmaceutical ingredient in Biopharmaceutic Classification Systems Class II and the price of the dosage form from commercial brands four times higher than the generic.  A comparative study on physical properties and dissolution profiles between generic and commercial brands of griseofulvin tablets has been conducted to assess whether there is difference between their qualities. The pharmaceutical properties were assessed based on the Indonesian and the United State Pharmacopeias. Results showed that the tablets fulfilled the requirements for size uniformity, weight uniformity (0.5995± 0.0075) gram - (0.6989±0.0080) gram, friability 0.08-1.10 %, hardness (10±0.7746) - (19.6±0.9165) kg/cm2, disintegration time 07.12 - 17.17 minutes with drug content of 94.20 - 99.67%. The commercial brand griseofulvin tablets A1& A2 and generic B1 met the official specification for physical characteristics. Results of dissolution test for commercial brand A1 & A2 and generic B1 showed that griseofulvin had T60min (Q ≤ 70%) and the dissolution test profiles did not follow neither first order, Higuchi, Korsmeyer Peppas, nor Langenbucher kinetic models (r < 0,95). The dissolution test for griseofulvin tablet A1 met the USP specification, T90min (Q ≥ 75%) with the release mechanism follow Langenbucher kinetic model. Abstrak: Griseofulvin merupakan zat aktif golongan Sistem Klasifikasi Biofarmasetik kelas II dengan perbedaan harga antara tablet merek dagang lebih mahal hingga empat kalinya dibandingkan tablet generik. Uji disolusi terbanding dilakukan untuk melihat adakah perbedaan mutu yang signifikan antar tablet tersebut. Metode evaluasi mutu dilakukan sesuai dengan ketentuan Farmakope Indonesia dan USP. Hasil evaluasi mutu fisik tablet meliputi keseragaman ukuran, keseragaman bobot yaitu (0,5995± 0,0075) – (0,6989±0,0080) gram, kerapuhan 0,08 - 1,10%, kekerasan (10±0,7746) - (19,6±0,9165) kg/cm2, & waktu hancur  07.12 - 17.17 menit dan penetapan kadar  94,20 - 99,67%, memenuhi ketentuan Farmakope Indonesia. Profil disolusi tidak mengikuti model kinetika orde satu, Higuchi, Korsmeyer Peppas, ataupun Langenbucher (r < 0,95). Hasil uji disolusi tablet A1 yang dilakukan berdasarkan  USP memenuhi persyaratan T90 min  (Q ≥ 75%) dan memiliki profil disolusi mengikuti  persamaan Langenbucher (r>0,95). Keywords: Profil disolusi, tablet griseofulvin, mutu tablet, model matematika
Formulation of Nanoemulsion Gel Cayenne Pepper (Capsicum frutescens) Extract as an Anti-inflammatory in Gout Arthritis Pain Salsabila, Amilia; Jonisa, Rahma Aprilya; Jannah, Yasmin Raudhatul; Yuningzia, Vannesha; Sari, Aulia Desvita; Lucida, Henny
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.92-101.2025

Abstract

Cayenne pepper fruit extract has anti-inflammatory effects and could be a natural remedy of arthritis gout pain. The research aims to find the optimal formula for cayenne pepper extract nanoemulsion gel to improve its permeation capability and assess its effect on inflammation in mice induced by 1.5% carrageenan. Extraction using the maceration method followed by standardizing the extract. The optimal nanoemulsion formula is determined by constructing a pseudo-ternary diagram of the nanoemulsion base. The optimal formula obtained was 80% aquadest, 2% VCO, 18% SMIX (surfactant and cosurfactant). The cayenne pepper extract nanoemulsion is integrated with a gel base followed by evaluation. The extract nanoemulsion has been proven to form globules with a size of 54.4 nm, zeta potential of -23.6 mV, and polydispersity index of 0.403. Exudate volume and TNF-α levels were measured using the air pouch method to assess for anti-inflammatory activity. In comparison to other treatment groups, rats treated with chili pepper extract nanoemulsion gel had the lowest average exudate volume, with a statistically significant difference (DNMRT; P <0.05), according to the results of an ANOVA test combined with Duncan's post-hoc test. Meanwhile, the test for TNF-α levels did not show any significant differences
Co-Authors AA Sudharmawan, AA Anita Lukman Auzal Halim Azhoma Gumala Azhoma Gumala Ben, Elfi Sahlan Chris Deviarny Dachriyanus Dwi Novrianda Elfi Delita Elyunaida, Elyunaida Erizal Zaini Fahmy, Rahmi Fauzana, Annisa Fitri, Ema Gio Vanny Yusuf Gumala, Azhoma Helmi Arifin Hj. Lajisc, Nordin Hj. Lajisc, Nordin Hosiana, Vinny Husni, Patihul Intan Permata Sari Irfandy Soumariris Jannah, Yasmin Raudhatul Jonisa, Rahma Aprilya Kamal Rullah Khairunnisa Assyifa Salva Marlina Marlina Maya Sofiana Mita Restinia Muslim Suardi Netty Suharti Nola Florida Okti Rahayu Asih Olivia Sedona Patihul Husni Pradifta, Reysa Rahmat, Rosita Dewi Rahmat, Rosita Dewi Regina Handayani Handayani, Regina Handayani Riah Trisnawati Rizal Fahmi Rustini Rustini Saafrida - saafrida Saafrida Saafrida Saafrida, Saafrida saafrida, Saafrida - Safni Safni Salman - Salman Salman Salman Salman Salman Umar Salsabila, Amilia Saputra, Harry Saputra, Harry Sari, Aulia Desvita Saufitri, Dian Saufitri, Dian Sintia, Ulma Vinny Hosiana Vinny Hosiana Vivi Muharmi Wasif Gillani S Wira Noviana, Wira Noviana Wira Noviana, Wira Noviana Yoneta Srangenge Yunazar Manjang Yuningzia, Vannesha Zahara Gayo Zifriyanthi Minanda Putri