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All Journal Jurnal Terapan Abdimas Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Ilmu Kedokteran dan Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Ners Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Calvaria Medical Journal Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran
Pratika Yuhyi Hernanda
Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
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Association of Pain Location and Lidocaine Dosage with Clinical Response to Targeted Intramuscular Lidocaine Injection in Diabetic Neuropathic Pain Wiradinata, Harsono; Roethmia Yaniari; I Made Subhawa Harsa; Atik Sri Wulandari; Pratika Yuhyi Hernanda
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.5056

Abstract

Background: Diabetic neuropathic pain (DNP) is often refractory to oral analgesics. It is a complication of diabetes mellitus that causes sensory disturbances. Oral pharmacological therapies, including antidepressants, anticonvulsants, and opioids, often have limited efficacy and may cause systemic adverse effects. Objective: This prospective observational cohort study evaluated whether anatomical pain location and lidocaine dose predict the short-term analgesic response to targeted intramuscular lidocaine injection at the patient’s site of maximal pain in patients with diabetic neuropathic pain. Methods: Thirty-one adults with DNP treated at Bhayangkara Hospital were enrolled. They received 1% plain lidocaine at doses of 3, 4, or 5 mg/kg, administered intramuscularly at the site of maximal pain. Pain intensity was assessed at baseline and at 30 minutes, 1, 2, 4, and 6 hours after injection using the Visual Analog Scale (VAS) and the Neuropathic Pain Symptom Inventory (NPSI). Result: The results showed a dose-dependent decrease in mean VAS scores, and this dose-response trend was statistically significant (ANOVA, p = 0.018). The composite NPSI score decreased by an average of 34.2%. Furthermore, patients with dorsal foot pain and those experiencing electric shock/paresthesia sensory phenotypes showed the greatest reductions in pain scores. Conclusion: These findings indicate that targeted IM lidocaine produced rapid short-term analgesia within 30 minutes, lasting approximately 4 to 6 hours. Anatomical targeting and dose selection may influence analgesic outcomes and may support individualized, symptom-directed strategies for managing diabetic neuropathic pain.  
Co-Authors Ajeng Tribawati Ama, Fuad Anna Lewi Santoso Anna Lewi Santoso Anton Sumarpo Aqila Luthfan Ghiralda Arimbi, Muzaijadah Retno Aritania, Putu Oky Aryanti, Novina Atik Sri Wulandari Ayling Sanjaya Budhi Setiawan Erny Erny, Erny Febtarini Rahmawati HARMAN AGUSAPUTRA hernando, wiowen izaaz Husodo, Muhammad Imam Lebdo I Gede Wisnu Nugraha I Made Subhawa Harsa Inawati Inawati Inawati Inawati Intan Nurani Indrajanu Ira Idawati Irene Lingkan Parengkuan Lilis Widayati Listya Santoso, Ardanna Lusiani Tjandra Lutfia Oktaviana Patau Maria Widijanti Sugeng Masfufatun Masfufatun Muzaijadah Retno Arimbi Ni Putu Manik Suryaningsih Noer Kumala Indahsari, Noer Kumala Pramita Laksitarahmi Isrianto Pramugyono, Pramugyono RAHARJO, BUDIONO Ramona Frisca Ariansyah Rini Purbowati Roethmia Yaniari Roethmia Yaniari Shalsabillah, Nadia Fitri Sri Lestari Utami Sugeng, Maria W Sugeng, Maria Wijayanti Suhartati Suhartati Syahfitri Nur Afifah Utami, Sri Lestari Widayati, Lilis Wiradinata, Harsono Wirayudha, Sri Annung Wulandari, Ida Septika