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All Journal Jurnal Kesehatan Andalas MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Medika Malahayati As-Sidanah : Jurnal Pengabdian Masyarakat Indonesian Journal of Cancer Hang Tuah Medical Journal Jurnal Pengabdian Masyarakat Bangsa Surabaya Biomedical Journal Jurnal Kedokteran Meditek Surabaya Biomedical Journal
Wienta Diarsvitri
Faculty Of Medicine, Hang Tuah University, Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Identification of Bioactive Compounds from Pedada Fruit Extract (Sonneratia Caseolaris) to Prevent Stunting Damayanti, Azarine Ahnafia; Diarsvitri, Wienta; Nefertiti, Eva Pravitasari; Rahayu, Indri Ngesti
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7491

Abstract

Stunting is a problem that still cannot be resolved throughout the world, especially in Indonesia. Children who are malnourished show high levels of blood oxidative stress biomarkers as well as inhibition in growth. To understand prevention of stunting, research was conducted using pedada fruit (Sonneratia caseolaris) which is a mangrove plant taken at the Wonorejo Magrove Ecotourism, Rungkut District, Surabaya City, East Java. The results of the research were used to reveal that there are bioactive compounds in pedada fruit extract to prevent stunting. This research used One Shot Experimental Study. The variables studied used primary data from screening of phenolic and flavonoid antioxidant metabolite compounds at the FK UHT Pharmacy Laboratory and screening for Cu, Fe, Zn mineral content at the UPT East Java Nutrition Laboratory. Result: Based on the results of qualitative phytochemical screening, pedada fruit contained phytochemical compounds, namely phenolics and flavonoids. Mineral screening of pedada fruit was carried out using the Atomic Absorption Spectrophotometry (AAS) method. Pedada fruit extract contained zinc (Zn) of 1.057 mg, while copper (Cu) and iron (Fe) of 0 mg.
ANGINA STABIL Diarsvitri, Wienta
Surabaya Biomedical Journal Vol 2 No 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.39

Abstract

Tujuan Penelitian: Penyakit jantung dan pembuluh darah masih merupakan salah satu penyebab utama kematian dan kecacatan di seluruh dunia, serta membutuhkan biaya kesehatan yang tinggi. Penelitian ini bertujuan untuk membahas faktor resiko, patogenesis dan tata laksana angina stabil. Metode : Penelitian literature review ini menggunakan 14 artikel dengan kriteria inklusi artikel yang dipublikasikan di jurnal nasional terakreditasi dan jurnal internasional antara tahun 2017-2021, berbahasa Indonesia atau Inggris, dan dapat diakses full text. Artikel didapatkan dari mesin pencari PubMed, Google Scholar dan Cochrane dengan beberapa kata kunci. Hasil : Angina stabil terjadi saat endotelium dari arteri terpapar dengan berbagai faktor risiko seperti dislipidemi, hormon vasokonstriktor, hasil glikosidasi terkait hiperglikemi, sitokin pro inflamasi dari jaringan adiposa atau produk bakteri tertentu, yang menyebabkan peningkatan ekspresi molekul adesi pada bagian dalam dinding arteri. Pada angina stabil remodeling arteri yang sering dijumpai adalah lesi aterosklerosis dengan negative remodelling (tipe stenosis). Sekitar sepertiga pasien dengan angina stabil yang telah mendapatkan terapi farmakologis dan revaskularisasi melaporkan keluhan angina kronis Kesimpulan : Keberhasilan terapi angina stabil tidak hanya ditentukan oleh terapi farmakologi, namun juga modifikasi gaya hidup dan faktor resiko.
Atrial Septal Defect Hakim, An Nahl Aulia; Adnaya, Anak Agung Ngurah Maheza; Prasetyo, Ananda Bangun; Pikir, Rizqi Rokhmadhoni; Diarsvitri, Wienta; Suhadi, Ananda Rizki; Dita, Anastasia
Surabaya Biomedical Journal Vol 4 No 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.147

Abstract

Background: Atrial Septal Defect (ASD) is one of the most common congenital heart diseases, occurring in about 25% of children and accounting for 6-10% of all congenital heart conditions. ASD is more frequently observed in females with a ratio of 2:1 and often does not show symptoms in infants, unless there is an increase in right ventricular volume. Case Report: A 7-year-old girl was referred with complaints of shortness of breath and cyanosis at the fingertips, accompanied by palpitations. Initial diagnosis was established through physical examination and echocardiography, which revealed a secundum ASD measuring 1.9 cm. The ASD closure surgery was performed but had to be halted due to intraoperative bradycardia. The patient then underwent subsequent therapy with Lisinopril and Spironolactone and was in good condition at the last follow-up. Discussion: Management of ASD, whether through surgical or catheter-based intervention, is recommended to prevent further complications such as paradoxical embolism and pulmonary hypertension. This case underscores the importance of timely diagnosis and treatment to prevent long-term health impacts in patients with ASD.
Pengaruh Kebiasaan Cuci Tangan Selama Masa Pandemi Covid-19 Terhadap Kejadian Dermatitis Tangan Pada Mahasiswa Fakultas Kedokteran Universitas Hang Tuah Willy, Johannes; Ardiana, Dian; Noer Shoffi, Muhammad; Diarsvitri, Wienta
Jurnal Medika Malahayati Vol 8, No 3 (2024): Volume 8 Nomor 3
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v8i3.14958

Abstract

Pandemi Covid-19 menyebabkan munculnya beberapa kebiasaan baru, diantaranya kebiasaan cuci tangan. Peningkatan frekuensi cuci tangan menyebabkan peningkatan kejadian dermatitis tangan. Tujuan penelitian untuk mengetahui pengaruh frekuensi cuci tangan dan jenis antiseptik terhadap kejadian dermatitis tangan pada mahasiswa. Jenis penelitian adalah analitik observasional. Data didapatkan melalui kuesioner online. Responden dalam penelitian ini adalah mahasiswa semester 7 Fakultas Kedokteran Universitas Hang Tuah tahun 2022, yang bersedia dan tidak memiliki riwayat penyakit asma, hay fever, serta dermatitis atopik pada masa kanak-kanak. Data diolah dengan uji statistik Chi-Square. Hasil penelitian menunjukkan 51,5% responden memiliki frekuensi cuci tangan lebih dari lima kali sehari dan 86,4% responden melakukan cuci tangan dengan air dan sabun. Uji Chi-Square menunjukkan nilai p = 0,964 dan  p = 0,727 yang berarti tidak terdapat pengaruh frekuensi cuci tangan maupun jenis antiseptik terhadap kejadian dermatitis tangan pada mahasiswa.
Pengabdian Masyarakat Lintas Stakeholder Di Kawasan RW 10 Kelurahan Tambakrejo Kecamatan Simokerto Kota Surabaya Djuari, Lilik; Prajitno, Subur; Diarsvitri, Wienta; Nurida, Annisa; Wartiningsih, Minarni; Silitonga, Hanna Tabita Hasianna; Saleh, Maya Syahria; Sincihu, Yudhiakuari; Dewi, Dewa Ayu Liona
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 1 (2025): Maret
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i1.2133

Abstract

Pengabdian masyarakat lintas stakeholder di kawasan RW 10 kelurahan Tambakrejo melibatkan beberapa stakeholder yang mempunyai tujuan yang sama yaitu memberikan pelayanan kesehatan pada masyarakat yang tinggal di sekitar rel kereta api secara gratis. Stakeholder yang terlibat yaitu PDK3MI, Puskesmas Tambakrejo, Gereja Bethel Indonesia, Kelurahan Tambakrejo beserta jajarannya termasuk kader kesehatan. Masing-masing stakeholder mempunyai peran yang berbeda dan saling menguntungkan. Jumlah masyarakat yang dilayani sebanyak 151 orang (75,5% dari target). Masyarakat yang datang sebagian besar wanita dan lansia dengan penyakit terbanyak adalah infeksi saluran pernafasan atas Pengadaan obat sebesar Rp. 2. 489.895,- dan yang digunakan sebesar 67,49%. Perlu pengadaan obat yang lebih maksimal dalam pengabdian masyarakat tersebut.
Delayed Speech Dengan dan Tanpa Gangguan Pendengaran pada Anak Usia 6 Bulan sampai 3 Tahun di Jala Puspa RSPAL Dr. Ramelan Surabaya Periode 2017-2020 Halim, Anthony Stephen; Limantara, Edward; Diarsvitri, Wienta
Jurnal Kesehatan Andalas Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1710

Abstract

Late or untreated delayed speech can be a risk for social, emotional, behavioral and cognitive problems in adulthood. Delayed speech is associated with hearing loss, mental retardation, autism spectrum disorder (OSD), bilingualism, and lack of psychosocial stimuli. Objectives: To determine the prevalence of delayed speech with and without hearing loss in children aged six months until three years. Methods: This study used 872 medical records of delayed speech children aged six months until three years with and without hearing loss in 2017 until 2020 period at Jala Puspa RSPAL Dr. Ramelan, Surabaya. The presence or absence of hearing loss was examined using Brainstem Evoked Response Audiometry (BERA), and the degree of hearing loss was examined using Auditory Steady-State Response (ASSR) test. Results: From a total of 872 medical records data studied, 558 (64.0%) were males and 314 (36.0%) were females. The majority (44.8%) of delayed speech children were from the two-year age group. There were 565 (64.8%) delayed speech children with hearing loss and 307 (35.2%) without hearing loss. Of those with hearing loss, 48.0% showed a profound degree. There was an increase in delayed speech children without hearing loss compared to those with hearing loss, from 1:2.04 in 2017 to 1:1.12 in 2020. Conclusion: There was an increase in delayed speech children without hearing loss compared to those with hearing loss.Keywords:  ASSR, BERA, delayed speech, hearing loss
Atrial Septal Defect Hakim, An Nahl Aulia; Adnaya, Anak Agung Ngurah Maheza; Prasetyo, Ananda Bangun; Pikir, Rizqi Rokhmadhoni; Diarsvitri, Wienta; Suhadi, Ananda Rizki; Dita, Anastasia
Surabaya Biomedical Journal Vol. 4 No. 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.147

Abstract

Background: Atrial Septal Defect (ASD) is one of the most common congenital heart diseases, occurring in about 25% of children and accounting for 6-10% of all congenital heart conditions. ASD is more frequently observed in females with a ratio of 2:1 and often does not show symptoms in infants, unless there is an increase in right ventricular volume. Case Report: A 7-year-old girl was referred with complaints of shortness of breath and cyanosis at the fingertips, accompanied by palpitations. Initial diagnosis was established through physical examination and echocardiography, which revealed a secundum ASD measuring 1.9 cm. The ASD closure surgery was performed but had to be halted due to intraoperative bradycardia. The patient then underwent subsequent therapy with Lisinopril and Spironolactone and was in good condition at the last follow-up. Discussion: Management of ASD, whether through surgical or catheter-based intervention, is recommended to prevent further complications such as paradoxical embolism and pulmonary hypertension. This case underscores the importance of timely diagnosis and treatment to prevent long-term health impacts in patients with ASD.
The Characteristics of Sociodemography, Histopathologic Features, Stage, and Management of Ovarian Cancer in Dr. Ramelan Navy Hospital Surabaya Rahmalia, Karina; Sudiarta, Ketut Edy; Setianingsih, Herin; Diarsvitri, Wienta
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1050

Abstract

Background: Ovarian cancer is considered a silent killer disease, mainly due to the late diagnosis. It is often diagnosed at an advanced stage, thus increasing the mortality rate. Ovarian cancer can happen to any age, with different characteristics according to the age group, the most often being the epithelial type.Methods: This research is a descriptive study with a quantitative method. This study aims to determine the characteristics and histopathological features of ovarian cancer in Dr. Ramelan Navy Hospital from January 2019 to December 2021. There were 155 samples out of 635 patients, with the information acquired through medical records.Results: The highest incidence of ovarian cancer occurs in the 40-60-year-old group at 52.9%. Among all participants, 85.8% of patients were not employed. Of most histopathological features in epithelial ovarian cancer, 34.8% were the serous carcinoma subtype. The majority of these cases were diagnosed at stage IIIC at 21.3%, and the most prevalent treatment for ovarian cancer was surgery and chemotherapy at 49.7%.Conclusions: The most common type of ovarian cancer is epithelial ovarian cancer, a subtype of serous carcinoma, with histopathological features of round nucleated anaptic cells, prominent nucleoli, forming acini, papillae, and thin connective tissue stroma. 
Adiponectin and Endothelin-1 are Correlated with the Development of Normal-tension Glaucoma in Metabolic Syndrome Patients Prayitnaningsih, Seskoati; Oktarina, Virna Dwi; Nusanti, Syntia; Diarsvitri, Wienta; Rif'ati, Lutfah; Siswanto, Bambang Budi; Santoso, Anwar
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3196

Abstract

BACKGROUND: Glaucoma can lead to irreversible blindness, but normotension glaucoma (NTG) often shows no early symptoms. However, to date, there is limited knowledge regarding the potential parameters for early detection. Therefore, in this study, various metabolic parameters and biomarkers which may contribute to NTG in metabolic syndrome (MetS) patients were evaluated.METHODS: A retrospective cross-sectional study was conducted in the National Cardiac Center Harapan Kita Hospital. Mets were confirmed following the IDF criteria. NTG was determined based on normal intraocular pressure (IOP) with a mean defect (MD) of the visual field, thinning of the retinal nerve fiber layer (RNFL), and enlargement of cup disc ratio (CDR) by ocular coherence tomography (OCT). Metabolic parameters results of waist circumference (WC), body weight, body height, body mass index (BMI), blood pressures, HbA1c, fasting blood glucose (FBG), lipid profiles; and biomarkers including thiobarbituric acid reactive substance (TBARS) and ferric reducing antioxidant power (FRAP), leptin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and endothelin-1 (ET-1) were analyzed. Statistical analysis was performed using comparative and correlative tests.RESULTS: From 29 subjects, 19 subjects (65.5%) were included in the NTG group and 10 subjects (34.5%) were included in the non-NTG group. In the NTG group, we found significant correlation between MD with systolic blood pressure (p=0.035); CDR with ET-1 (p=0.049); and CDR with adiponectin (p=0.010). The non-NTG group had a significant correlation between MD with BMI (p=0.043); CDR with LDL (p=0.042); and CDR with TG (p=0.031).CONCLUSION: There are correlation between adiponectin and ET-1 with NTG in MetS patients. Therefore, they might be considered as potential early detectors for NTG in MetS patients.KEYWORDS: normal tension glaucoma, metabolic syndrome, biomarker, endothelin-1, adiponectin
Karakteristik Anak Penderita PJB dengan Pirau Kiri ke Kanan Disertai Pembesaran Ventrikel Kiri di RSPAL dr.Ramelan Fitria Maharani Subroto, Inggrid; Rokhmadoni Pikir, Rizqi; Risma; Diarsvitri, Wienta
Jurnal Kedokteran Meditek Vol 31 No 5 (2025): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i5.3535

Abstract

Introduction: Congenital Heart Disease (CHD) is one of the most common congenital disabilities, with an incidence of 8-10 per 1000 live births in full-term infants and ten times higher in preterm infants. In Indonesia, the incidence of CHD is estimated at around 8 per 1000 live births.  Understanding the anatomy and pathophysiology of the defect that occurs contributes to the accuracy of management planning.  Purpose: This study aims to identify the characteristics of pediatric patients with CHD featuring left-to-right shunt accompanied by left ventricular enlargement at RSPAL dr. Ramelan Surabaya from 2020 to 2023. Methods:  The descriptive study uses secondary data (medical records) of pediatric CHD patients with left-to-right shunt and left ventricular enlargement, specifically focusing on ventricular septal defect (VSD) and patent ductus arteriosus (PDA) at the pediatric clinic of RSPAL dr. Ramelan.  Results: Based on medical records from 45 samples, the majority of CHD patients were aged 1-12 months (23 children). CHD with VSD was more common in males (18 children), while PDA was more common in females (11 children). Most CHD patients showed no initial complaints (39 children) and did not have other types of congenital heart diseases, with 23 children having VSD and 10 having PDA. Additionally, most patients did not have comorbidities (39 children). Echocardiographic results indicated that most patients had an ejection fraction (EF) greater than 75% (27 children) and a fractional shortening (FS) greater than 45% (23 children). The main management involved echocardiographic evaluation and medication.  Conclusion: The predominant age group for CHD cases at the pediatric clinic of RSPAL dr. Ramelan was 1-12 months, with echocardiographic results showing normal left ventricular function, with EF >75% and FS >45%.  
Co-Authors Adnaya, Anak Agung Ngurah Maheza Amiril Mukminin Annisa Nurida Anthony Stephen Halim Anwar Santoso Ardiana, Dian Bambang Budi Siswanto Biutifasari, Verna Damayanti, Azarine Ahnafia Dewi, Dewa Ayu Liona Dita, Anastasia Edward Limantara Ellen Ferlita Tirtana ERIC HARTONO Fitria Maharani Subroto, Inggrid Hakim, An Nahl Aulia Halim, Anthony Stephen Hanna Tabita Hasianna Silitonga Herman Herman Indri Ngesti Rahayu Joko Subur Kezia Seraphine LEONI Lilik Djuari Limantara, Edward Maya Syahria Saleh Minarni Wartiningsih Mita Herdiyantini Muhammad Noer Shoffi Nefertiti, Eva Pravitasari NI KOMANG SRI DWI UTAMI Nirmalasari Idha Wijaya Noer Shoffi, Muhammad Oktarina, Virna Dwi Orlando Pikatan Pikir, Rizqi Rokhmadhoni Prajitno, Subur Pramita Anindya Prasetyo, Ananda Bangun Rahmalia, Karina Redemptus Yudadi Rif'ati, Lutfah Risma Rokhmadoni Pikir, Rizqi Seskoati Prayitnaningsih Setianingsih, Herin Sincihu, Yudhiakuari Sudiarta, Ketut Edy Suhadi, Ananda Rizki Syntia Nusanti Willy, Johannes