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All Journal PROSIDING SEMINAR NASIONAL MEDISAINS Medula Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan Majalah Farmasetika Mattawang: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Nusantara (JPN) Journal of Innovative and Creativity MARAS : Jurnal Penelitian Multidisplin Jurnal Pengabdian Kepada Masyarakat Meambo EDUJ : English Education Journal J-Shelves of Indragiri (JSI) Jurnal Paradigma: Pemberdayaan & Pengabdian Kepada Masyarakat Journal of Community Engagement in Health Jurnal Pengabdian Kepada Masyarakat KABANTI MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Pariwisata
Eso, Amiruddin
Department Of Biomedical Sciences, Faculty Of Medicine, Universitas Halu Oleo, Kendari, Southeast Sulawesi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : medisains

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Comparative antibacterial activity of Ziziphus spina-christi and Piper betle extracts against Escherichia coli across different concentrations Amiruddin Eso; Sulastrianah; Sufiah Asri Mulyawati; Aanisah Rahman; Arif Eka Surya; Aliyyah Zhafirah Bafadal; Annisa Dwi Aulia Putri
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30324

Abstract

Background: Antimicrobial resistance among Gram-negative bacteria, including Escherichia coli, has increased the need to explore alternative antibacterial agents. Although medicinal plants have demonstrated antibacterial potential, comparative evidence on the activity of Ziziphus spina-christi and Piper betle extracts against E. coli across different concentrations remains limited. Objective: This study aimed to compare the antibacterial activity of ethanolic extracts of Z. spina-christi and P. betle against E. coli and to evaluate the effects of extract type, concentration, and their interaction. Method: A laboratory experimental study using a 2×3 factorial completely randomized design with additional positive and negative control groups was conducted. Ethanolic extracts of Z. spina-christi and P. betle were evaluated at concentrations of 1500, 2000, and 2500 ppm using the disk diffusion method. Inhibition-zone diameters were analyzed using two-way analysis of variance followed by Tukey’s honestly significant difference test.  Results: The mean inhibition-zone diameter of Z. spina-christi increased from 8.83±0.76 mm at 1500 ppm to 30.33±2.08 mm at 2500 ppm, whereas that of P. betle increased from 16.33±0.38 mm to 23.08±3.51 mm. Concentration significantly affected antibacterial activity (F(2,12)=105.02; p<0.001), whereas extract type showed no significant main effect (F(1,12)=1.89; p=0.194). A significant interaction between extract type and concentration was observed (F(2,12)=29.34; p<0.001). Conclusion: The antibacterial activity of Z. spina-christi and P. betle extracts against E. coli varied according to concentration, with a significant interaction between extract type and concentration. The greatest inhibition among the extract treatments was observed with Z. spina-christi at 2500 ppm.
Co-Authors Aanisah Rahman Abdul Hafit Ade Kurniarif Widjojo Adius Kusnan Adius Kusnan Agus Saifuddin Ahmad Syaiful Aisyah Az-Zahrah Mansur Alifariki, La Ode Aliyyah Zhafirah Bafadal Andi Noor Kholidah Annisa Dwi Aulia Putri Ansor Putra Ansor Putra Arif Eka Surya Arimaswti Arimaswati Arman Arman Asmarani Asmarani Asmarani Asmarani Asmarani, Asmarani Asriati Asriati Astri Yustina Kambu Deni Sastra Mandarin Diva Ayudia Djusiana Eka Cessaria Dwi Pascawitasari Eka Rahmawati Ela Martisa Herfina Dahlan I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa, I Putu Indra Dika Pratama Indria Hafizah Indriyati Indriyati Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jana, Nur Juminten Saimin Kholidah, Andi Noor La Ode Alifariki La Ode Muh. Albar La Ode Muhammad Sety Laode Kardin Luphyta Nimandana Melvin Manuel Philips Miranty Aditya Hadini Muh. Syarief Muhammad Fathur Rahman Muhammad Fathur Rahman Muhammad Junaid Azis Muhammad Rustam HN Muhammad Zulfikarrahim Mulyawati, Sufiah Asri Nasruddin Nasruddin Nina Indriyani Nasruddin Nur Jana Nuralifah Nuralifah, Nuralifah Nurul Afifah Yusran Nuzul Aulia Fajarwati B Oza Jumatan Aso Parawansah Parawansah, Parawansah Parawansah, P Pranita Aritrina Pranita Aritrina Syafri Puteri Febriyanthi Rachman Rahman, Muhammad Fathur Rahmawati Rahmawati Raja Alfath Widya Iswara Raja Alfath Widya Iswara Rezky Tandi Saida Saida Sapto Raharjo Sarniati Nuru Satrio Wicaksono Sri Susanty Sufiah Asri Mulyawati Sufiah Asri Mulyawati Sulastrianah Sulastrianah, Sulastrianah Syarifin, Andi Noor Kholidha Tien Tien Veren Karolina Bidang Vira Adiningsi Wa Ode Chesaria F.A Wa Ode Salma Wikal Sulistia Dwi Putra Yelsi Beatrice Patandianan Yenti Purnamasari Yusmiati Yusmiati Yusni Nurul Hidayah