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All Journal Medical Journal of Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Ilmu Kefarmasian Indonesia Majalah Patologi Indonesia Journal of Stem Cell Research and Tissue Engineering Journal Orthopaedi and Traumatology Surabaya (JOINTS) Nommensen Journal of Medicine Makara Journal of Health Research Cerdika: Jurnal Ilmiah Indonesia Journal of Global Pharma Technology
Jeanne Adiwinata Pawitan
Department Of Histology, Faculty Of Medicine, Universitas Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary

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Sel Punca Kanker Kolorektal Hilbertina, Noza; Adiwinata Pawitan, Jeanne
Cerdika: Jurnal Ilmiah Indonesia Vol. 1 No. 4 (2021): Cerdika : Jurnal ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v1i4.70

Abstract

Latar belakang: Kemoterapi dan radioterapi pasien kanker kolorektal sering gagal, atau kambuh kembali, yang disebabkan adanya kelompokan sel dengan sifat sel punca yang disebut sel punca kanker kolorektal. Tujuan penelitian ini adalah mengetahui asal sel punca kolorektal dan sifatnya. Metode penelitian: Untuk menulis studi pustaka ini kami melakukan pencarian di Pubmed/ Medline dan Google Scholar dan memilih artikel yang berkaitan dengan sel punca kanker kolorektal, dalam hal asalnya, cara isolasi dan identifikasinya dan dampak sel punca kanker kolorektal pada prognosis kanker kolorektal. Data dianalisis, dikelompokkan dalam subjudul, dibuat tabel dan ditampilkan secara naratif. Hasil dan pembahasan: Isolasi dan identifikasi sel punca kanker kolorektal dapat dilakukan melalui berbagai sifatnya seperti kemampuan membentuk spheres, dye exclusion dan keberadaan marka permukaan sel. Selain itu, identifikasi dapat dilakukan dengan melihat jalur pensinyalan, aktifitas enzim, marka faktor transkripsi dan uji invivo sebagai baku emas. Kesimpulan: Sel punca kanker kolorektal diduga berasal dari sel punca kolon yang mengalami mutasi dan berhubungan dengan kemampuan invasi, metastasis dan juga survival penderita kanker tersebut.
Effect of umbilical cord-mesenchymal stem cells on skin tensile strength in pressure ulcers: a rat model study Aulia, Indri; Dilogo, Ismail Hadisoebroto; Prasetyono, Theddeus Octavianus Hari; Pawitan, Jeanne Adiwinata; Kekalih, Aria; Siregar, Nurjati Chairani; Whulanza, Yudan; Hasibuan, Lisa
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.268222

Abstract

BACKGROUND Stem cell therapy has emerged as a promising alternative for the management of chronic wounds, including pressure ulcers. Tensile strength, which reflects the biomechanical integrity of the skin, serves as an objective measure of wound healing. This study aimed to evaluate the effect of locally administered umbilical cord-mesenchymal stem cells (UC-MSCs) on the tensile strength of healing 3rd-degree pressure ulcers in a Sprague Dawley rat model. METHODS 21 adult male Sprague Dawley rats were divided into 3 groups: normal rats without ulcers, untreated pressure ulcer as control, and pressure ulcers treated with UC-MSCs. The treatment group received locally injected 4 × 10⁶ UC-MSCs at the ulcer site. On day-21, the tensile strength parameters (rupture point, elongation at break, and elastic modulus) of the dorsal skin were assessed using the Universal Testing System. RESULTS When expressed relative to normal skin tensile strength, the UC-MSC group exhibited higher tensile parameters that were higher than the controls by 2.08% for rupture point, 3.29% for elongation at break, and 8.42% for elastic modulus. Although these differences between the UC-MSCs and control groups across all tensile strength parameters were not statistically significant, a clear trend toward improved tensile strength parameters were observed in the UC-MSCs group. CONCLUSIONS Local UC-MSCs administration showed a consistent trend toward improved tensile strength in healing 3rd-degree pressure ulcers, albeit without statistically significant differences compared to controls. These findings support the further exploration of UC-MSCs as a potential treatment for promoting biomechanical restoration in healing pressure ulcers.
Novel Rabbit Model for Femoral Head Osteonecrosis Characterized by Osteoclast Activity and Number of Empty Lacunae Sihombing, Masri; Dewi, Fitriya Nur Anisa; Siregar, Nurjati Chairani; Utomo, Dwikora Novembri; Pawitan, Jeanne Adiwinata; Dilogo, Ismail Hadisoebroto; Kekalih, Aria
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 15 No. 1 (2026): April 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v15i1.2026.35-47

Abstract

Background: Osteonecrosis, or avascular necrosis (AVN) of the femoral head, is a progressive and irreversible bone pathological condition with an increasing amount of morbidity each year in Indonesia. Testing therapeutic strategies requires an ethical and reliable protocol for inducing femoral head AVN in animal models. This study evaluates a rabbit protocol's feasibility to support a larger investigation into secretome-based treatments.Methods: In this in vivo study, New Zealand white rabbits were divided into three test groups and one control group (n = 3 per group). Methylprednisolone was injected three times at 24-hour intervals, with lipopolysaccharide administered to the third test group on day four. Following a four-week observation period, effects were evaluated using histology, immunohistochemistry, lipid profiles, and radiology.Results: The results showed that both a dose of 20 mg/kgBW methylprednisolone plus 10 μg/kgBW lipopolysaccharide and 20 mg/kgBW methylprednisolone alone resulted in statistically significant femoral head AVN induction, characterized by an increase number of osteoclasts on caspase-3 staining and empty lacunae on hematoxylin–eosin staining. Conversely, the test group with a lower concentration did not show significant differences.Conclusion: These findings support the recommendation of a credible and promising animal model of femoral head osteonecrosis as a basis for the study of osteocytes, osteoblasts, and osteoclast regeneration, along with secretome therapy, which acts as a potential non-surgical treatment option. The absence of radiological confirmation limits a more established analysis, and further studies on this matter are needed.
Co-Authors Ahmad Aulia Antarianto, Radiana Aria Kekalih Barasila, Atikah Chalida Budiman Bela CAROLINE TAN SARDJONO Christine Verawaty Sibuea Cosphiadi Irawan Des Suryani Dewi Sukmawati Dewi, Fitriya Nur Annisa Dian Ratih Laksmitawati Dwikora Novembri Utomo Ecie Budiyanti Fasha, Iqbal Indri Aulia Ismail Hadisoebroto Dilogo Jonlean, Reganedgary K Kartini Kousar, Iqra Liem, Isabella Kurnia Lisa Hasibuan Mahmood, Amer Melinda Remelia Melisa Leviana Melva Louisa Mohamad Sadikin Morioka, Hiroshi Murdani Abdullah Nishikawa, Satoshi Noza Hilbertina Noza Hilbertina, Noza Nurjati Chairani Siregar Nuzli Fahdia Mazfufah Oktarina, Caroline Purwoko, Reza Yuridian Radiana Dhewayani Antarianto Rahyussalim Rahyussalim, Rahyussalim Retno Wilujeng Susilowati Ria Anggraeni Ria Margiana Sihombing, Masri Silvia Tri Widyaningtyas Starifulkani Arif Tandarto, Kevin Theddeus O. H. Prasetyono Twidy Tarcisia Uesugi, Seiichi Wahyunia Likhayati Septiana Yogi Ismail Gani Yudan Whulanza