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All Journal Jurnal Natur Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Ilmiah Ilmu Kesehatan: Wawasan Kesehatan LEKSIKA Chemistry Indonesian Journal of Chemical Research JFL : Jurnal Farmasi Lampung Social, Humanities, and Educational Studies (SHEs): Conference Series Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Kesehatan Jurnal Ilmiah Publika International Research on Big-data and Computer Technology (IRobot) Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding International Journal of Education and Social Science (IJESS) Jurnal Abdi Masyarakat Multidisiplin Jurnal Ilmiah Fokus Ekonomi, Manajemen, Bisnis & Akuntansi (EMBA) Jurnal Pusat Akses Kajian Pangan dan Gizi Nanggroe: Journal Of Scholarly Service JOURNAL OF Mother and Child Health Concerns Nanggroe: Journal of Scholarly Service Jurnal Portofolio: Jurnal Manajemen dan Bisnis Pengabdian Kepada Masyarakat Indonesia SEAN (ABDIMAS SEAN)
Desi Kurniawati
Universitas Sebelas Maret
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Pemodelan Farmakofor untuk Identifikasi Inhibitor Heat Shock Proteins-90 (HSP-90): Pharmacophore Modeling to Identify Heat Shock Proteins-9 (HSP-90) Inhibitors Arba, Muhammad; Arfan; Trisnawati, Ayu; Kurniawati, Desi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15036

Abstract

Heat shock proteins-90 (HSP-90) is a protein that plays an important role in the life cycle of normal and cancer cells for their self protection from thermal stress, oxidative damage, and cell hypoxia. Inhibition of HSP90 is one way to suppress the growth of cancer cells. In this study, pharmacophore modeling and molecular docking were conducted to identify hit compounds as inhibitors of HSP-90. The pharmacophore feature consists of three hydrogen bond acceptors, one hydrogen bond donor and one hydrophobic feature with Area Under Curve of Receiver Operating Characteristics (AUCROC) is 0.5 and the Goodness of Hit (GH) value is 0.752. Screening in the ZINC database generated 1,500 hit compounds, were subjected to molecular docking to determine their binding energy and interactions with HSP-90. The range of binding energy (E) of all hit compounds is -5.68 to -12.24 kcal/mol and there are four best hit compounds namely lig_543, lig_527, lig_1337 and lig_337, when compared to native ligands (PU2, E=-8.25 kkal/mol) based on the binding energy and orientation, which indicate their potential as new HSP-90 inhibitors.
Hubungan Karakteristik Ibu, Riwayat BBLR, Riwayat ASI Eksklusif dan Praktik Responsive Feeding dengan Kejadian Wasting pada Balita Usia 6 – 24 Bulan di Desa Pancalang Kurniawati, Desi; Badzlina, Fildzah; Faridi, Ahmad
Jurnal Pustaka Padi (Pusat Akses Kajian Pangan dan Gizi) Vol 4 No 2 (2025): Jurnal Pustaka PADI (Pusat Kajian Pangan dan Gizi)
Publisher : Pustaka Galeri Mandiri

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Abstract

Periode 1000 hari pertama kehidupan merupakan periode emas dalam tumbuh kembang anak. Optimalisasi kualitas gizi dalam periode ini merupakan kunci kualitas generasi penerus bangsa. Wasting merupakan salah satu permasalahan gizi pada anak akibat tidak optimalnya kualitas gizi pada periode ini. Tujuan penelitian ini untuk mengetahui hubungan karakteristik ibu (usia ibu dan pengetahuan ibu), riwayat BBLR, riwayat ASI eksklusif, dan praktik responsive feeding dengan kejadian wasting pada balita usia 6 - 24 bulan di Desa Pancalang. Desain penelitian yang digunakan adalah cross-sectional. Populasi dalam penelitian ini yaitu balita usia 6 – 24 bulan di Desa Pancalang dengan sampel penelitian sebanyak 78 balita yang diambil menggunakan teknik total sampling. Hasil univariat menunjukkan balita usia 6 - 24 bulan memiliki status gizi (BB/PB) dengan kategori wasting sebesar 15,4%, usia ibu saat hamil berisiko (9%), pengetahuan ibu kurang (42,3%), riwayat BBLR (7,7%), riwayat tidak ASI eksklusif (39,7%), dan praktik responsive feeding kurang (26,9%). Berdasarkan hasil uji statistik Chi-square dan Fisher’s Exact menunjukkan bahwa tidak ada hubungan usia ibu saat hamil (p=1,000) dan riwayat ASI eksklusif (p=1,000) dengan kejadian wasting pada balita usia 6 - 24 bulan. Ada hubungan pengetahuan ibu (p=0,013), riwayat BBLR (p=0,044) dan praktik responsive feeding (p=0,050) dengan kejadian wasting pada balita usia 6 - 24 bulan.
ANALISIS PENGARUH MOTIVASI KONSUMEN, PERSEPSI KUALITAS DAN SIKAP KONSUMEN TERHADAP KEPUTUSAN PEMBELIAN PRODUK EIGER DI KOTA SEMARANG Kurniawati, Desi; Wahyuningsih, Susanti
Jurnal Ilmiah Fokus Ekonomi, Manajemen, Bisnis & Akuntansi (EMBA) Vol 1, No 3: Desember 2022
Publisher : STIE PENA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34152/emba.v1i3.639

Abstract

This study aims to determine whether Consumer Motivation, Perceived Quality, and Consumer Attitudes influence the Eiger Product Purchase Decision in Semarang City. The population in this study are Eiger Product Users in Semarang City. Sampling was carried out using purposive sampling method and the number of samples was 96 respondents. The type of data used is primary data. This study uses a questionnaire in collecting data. The test techniques used are validity test, reliability test, classic assumption test including normality test, multicollinearity test, and heteroscedasticity test. Hypothesis testing in this study used multiple linear regression analysis and hypothesis testing with the help of SPSS version 23. The results of this study indicate that Consumer Motivation has a significant positive effect on Purchasing Decisions. This is evidenced by a significance level of 0.00 <0.05 while tcount is 4.918 > 1.66159, it can be concluded that H1 is accepted. Perceived quality does not affect purchasing decisions. This is evidenced by the significance level of 0.520 > 0.05 while the tcount is 0.645 <1.66159, it can be concluded that H2 is rejected. Consumer Attitude has a significant positive effect on Purchasing Decisions. This is evidenced by a significance level of 0.00 <0.05 while tcount is 5.071 > 1.66159, it can be concluded that H3 is accepted. Consumer Motivation, Perceived Quality, and Consumer Attitudes simultaneously have a significant effect on Purchasing Decisions. This can be seen from the Fcount value which is 74.719 which is smaller than the Ftable value which is 2.70, while with a significance value of 0.000 which is smaller than the significance value below 0.05.Keywords: Consumer Motivation, Perceived Quality, Consumer Attitudes, and Purchase Decisions.
Pengaruh Pengetahuan Perpajakan dan Ketegasan Penerapan Sanksi Terhadap Peningkatan Kepatuhan Pajak Individu: Studi Kasus Pada KPP Pratama Serpong 2020-2024 Syahriel, Muhammad; Kurniawati, Desi
Jurnal Portofolio : Jurnal Manajemen dan Bisnis Vol. 4 No. 3 (2025): Manajemen Pemerintahan Dalam Alokasi Dana dan Pemasukkan Daerah
Publisher : Prisani Cendekia

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Abstract

Tax is the main source of state revenue used to finance national development. The level of compliance among individual taxpayers (WPOP) in Indonesia remains an issue that requires special attention. This study aims to analyze the influence of tax knowledge and the strict enforcement of sanctions on improving individual tax compliance. This research is quantitative in nature, employing an associative method. The population consists of individual taxpayers registered at KPP Pratama Serpong, with a sample of 100 respondents determined using Slovin’s formula. Primary data were collected through questionnaires with a Likert scale. Data analysis was conducted using the Structural Equation Modeling-Partial Least Squares (SEM-PLS) method with SmartPLS 4 software. The results show that: (1) tax knowledge has a positive and significant effect on individual tax compliance; (2) strict enforcement of sanctions has a positive and significant effect on individual tax compliance; (3) simultaneously, tax knowledge and strict enforcement of sanctions explain 47.3% of the variation in tax compliance (R² = 0.473). In conclusion, the higher the level of tax understanding and the stricter the enforcement of sanctions, the greater the increase in individual taxpayer compliance. This study is expected to contribute to the Directorate General of Taxes in improving education and law enforcement strategies, as well as serving as a reference for future research.
Co-Authors Adia Silvani, Mauline Arba, Muhammad Arfan Arifin Arifin Asri Rahmawati Ayu Liskinasih Badzlina, Fildzah Budi Sutomo, Budi Budi, Saksono Christiawati, Devi Dewi, Fitria Dwi Rahma Doni, Deani Edi Nasra Erliana, Erliana Faridi, Ahmad Fatimah, Wahyu Dwi Febriyanto, Muhammad Ikhsan Halimah, Imar Heni Pujiastuti Holyness Nurdin Singadimedja Ikhanto, M Nur Indah Pertiwi, Indah Kadir, Laode A. Khairiyah, Ghina Khuluq, Khusnul Lukmanul Hakim Musta, Rustam Noprida, Dayana Nur Meisinca, Dzulhijjah Nurjana, Siti Nurliana, Laily - Oktavia Dewita, Febby Oktria, Wandi Prima Endang Susilowati Rahmawati Rahim Riga, Riga Rostika, Silma Rusfandi Rusfandi Sapto Raharjo Saputra, Anggun Sumarlin Sumarlin Sunanto, Ghea Astrid Susanti Wahyuningsih, Susanti Syahriel, Muhammad Trisnawati, Ayu Umam, Danang Choirul Widiastuti, Tri Cahyani Yogaswari, Yosinia Yulyanah, Yulyanah YUSNITA YUSNITA