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Rudi Kartika, Rudi
Jurusan Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health

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BEBERAPA JENIS METABOLIT SEKUNDER YANG BERPOTENSI SEBAGAI ANTI KANKER : A MINI REVIEW Rizkirullah, Muhammad Adhitya; Kartika, Rudi; Aswat, Raihan; Mahrus, Muhammad Haissul; Rahman, Fatur; Kurniawan, Andi; Azka, Andi Aulia Urrahman; Sanian, Sanian
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Cancer is one of the leading causes of death worldwide, including in Indonesia. This review explores the potential of various plants as sources of anticancer compounds through secondary metabolite analysis. Plants such as Rosa damascena, Wild Onion (Scorodocarpus borneensis Becc), and Acalypha Indica have been studied for anticancer activity using in vitro methods. The results showed that extracts from Rosa damascena had varying IC50 values ​​against various types of cancer cells, including 16.28 μg/mL in liver cancer cells (HepG-2) and 18.09 μg/mL in breast cancer cells (MCF-7). In addition, Wild Onion showed very strong anticancer activity with an IC50 value of 1.1061 μg/mL in L1210 leukemia cells. Secondary metabolites such as flavonoids, alkaloids, and tannins were identified as key components contributing to the anticancer effects. These findings highlight the importance of further research to develop more effective and safe plant-based cancer therapies. Keyword: Anticancer, Cancer, Secondary Metabolites, Plants
Uji Aktivitas Antibakteri Hasil Fermentasi Bakteri Endofit Umbi Talas (Colocasia esculenta L.) terhadap Bakteri: MINI REVIEW Azka, Andi Aulia Urrahman; Kartika, Rudi; Jofri, Dirga Hosea Seventeen; Rizkirullah, Muhammad Adhitya; Kurniawan, Andi; Aswat, Muhammad Raihan
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Antibacterial agents are substances used to eliminate microorganisms, especially those harmful to humans. These antibacterial compounds can be directly extracted from plants, where the extracts contain secondary metabolite compounds with antibacterial activity. The antibacterial testing is conducted on gram-positive bacteria, such as Propionibacterium, Staphylococcus, and others. The research method employed is a literature review of 10 national and international articles published within the last 10 years. The cited articles focus on studies of plants with potential as antibacterial agents against several gram-positive bacteria, including the extraction solvents used, the metabolite compounds present in the extracts, and their effectiveness based on the inhibition zone diameter and/or minimum inhibitory concentration using the disc diffusion method. Keywords : Antibacterial, Diffusion Discs, Gram Positive, Secondary Metabolites
Identification of Cadalene-β-Carboxylic Acid from Barks of Bawang Hutan (Scorodocarpus borneensis Becc.) Kartika, Rudi; Bustanussalam, Bustanussalam; Farida, Farida; Simanjuntak, Partomuan
Annales Bogorienses Vol. 16 No. 2 (2012): Annales Bogorienses
Publisher : BRIN

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One sesquiterpene compound has isolated and identified from ethylacetate extract of bawang hutan (Scorodocarpus borneensis Becc.) barks. The barks were macerated with methanol, and then partitioned with mixture of ethylacetate-water (1:1). Fractionation of the ethylacetate phase by column chromatography gave pure compound. Based on data interpretation from of ultra-violet (UV) spectra, Fourier Transform Infra Red (FT-IR), NMR 1D (1H and 13C-NMR); NMR 2D (HMQC, COSY, HMBC) and comparison with literature, the pure isolated compound was determined as a sesquiterpene compound, cadalene-β-carboxylic acid which exhibit LC50 of 42.32 ppm.
PENYERAPAN LOGAM BERAT SECARA BIOKIMIAWI OLEH BAKTERI GRAM POSITIF DAN GRAM NEGATIF: A MINI RIVIEW Dilo Jhosea Luciano Eduardo; Rudi Kartika; Ripaldy Apriansya; Shaparuddin Nur Arifullah; Muhammad Adhitya Rizkirullah
PROSIDING SEMINAR KIMIA Vol 4 No 1 (2025): Prosiding SNK 2025
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Scenedesmus sp. is a freshwater green alga that functions as an ionic biosorbent and can also be a bioindicator for water contaminated with hexavalent chromium Cr(VI) ion. This study aimed to observe the growth of Scenedesmus sp. exposed to Cr(VI) ion at various concentrations and analyze the remaining Cr(VI) ion that did not undergo biosorption by microalgae. This research was conducted on Scenedesmus sp. microalgae growth media using five bioreactors, each with a different Cr(VI) ion exposure concentration. The remaining ion in the growth media was analyzed for its concentration with an ultraviolet-visible spectrophotometer at time variations with an interval of two days. Maximum biosorption with exposure to Cr(VI) occurred at a concentration of 1.0 ppm on day 12 of 99.93%. At concentrations of 5.0 ppm and 7.0 ppm, microalgae growth was very poor, indicating the medium was toxic. Keywords: Biosorption, Hexavalent Chromium, Scenedesmus sp, Toxicity
PENYERAPAN LOGAM Pb2+ SECARA BIOLOGIS OLEH BAKTERI Escherichia coli Muhammad Sigit Ariski; Rudi Kartika; Rahmat Gunawan
PROSIDING SEMINAR KIMIA Vol 4 No 1 (2025): Prosiding SNK 2025
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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The biological absorption of Pb2+ metal by Escherichia coli bacteria has been conducted. This study aims to determine the ability of Escherichia coli bacteria to absorb Pb2+ metal based on variations in Pb2+ exposure concentrations (0, 3, 6, 9, 12, 15 ppm) over different exposure times (days) and to identify the optimal concentration and time required for Escherichia coli in the biological absorption of Pb2+ metal. The maximum wavelength of the standard Pb2+ solution is 520 nm. Based on the test results, Escherichia coli was able to absorb Pb2+ at varying exposure concentrations (3, 6, 9, 12, 15 ppm) with biosorption percentages of 49.118%, 23.985%, 14.500%, 10.150%, and 7.808%, respectively. The optimal concentration and time required for Escherichia coli to absorb Pb2+ occurred on the 3rd day with a Pb2+ exposure concentration of 3 ppm. Keywords: Biosorption, Pb2+ metal, Escherichia coli
BIOSORPSI LOGAM OLEH BAKTERI Muhammad Harry Rahmadan; Rudi Kartika; Rahmat Gunawan
PROSIDING SEMINAR KIMIA Vol 4 No 1 (2025): Prosiding SNK 2025
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

The growth of industry in Indonesia, especially in the textile sector, has led to an increase in the production of liquid waste containing heavy metals such as chromium (Cr), lead (Pb), and copper (Cu). These metals can pose significant health risks if they enter the body of living things. To overcome this, one alternative method of reducing liquid waste is to utilize biosorption by bacteria. This study aims to determine the ability of metal absorption by several bacteria, namely Streptococcus mutans, Flavobacterium sp, Pseudomonas sp, and Bacillus subtilis. The results showed that Streptococcus mutans was able to absorb Cr (VI) with a maximum efficiency of 90.80% at a concentration of 5 ppm on the 5th day. While Flavobacterium sp was able to absorb Pb at a maximum of 96% at a concentration of 2 ppm on the 18th day. Pseudomonassp showed maximum uptake of 96.192% for Cr(VI) at 5 ppm on day 14, 36.874% for Pb at 4 ppm on day 16, and 84.447% for Cu(II) at 3 ppm on day 16. Bacillussubtilis showed maximum uptake of 97.42% for Pb at 10 ppm. These findings indicate that bacteria have significant potential for heavy metal biosorption in wastewater treatment. Keywords: Absorption,Metal,Bacteria
REVIEW ARTIKEL: AKTIVITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER PADA BEBERAPA EKSTRAK TANAMAN TERHADAP BAKTERI Escherichia coli Ripaldy Apriansya; Rudi Kartika; Shaparuddin Nur Arifullah; Dilo Jhosea Luciano Eduardo; Muhammad Raihan Aswat; Muhammad Adhitya Rizkirullah
PROSIDING SEMINAR KIMIA Vol 4 No 1 (2025): Prosiding SNK 2025
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Indonesia's current biodiversity makes it something valuable for the community. Especially the use of plants that are used as medicinal materials. This is supported by the content of secondary metabolite compounds found in plants such as flavonoids, phenolics, steroids, saponins, tannins and others. These compounds have antibacterial activity that can be used to inhibit the growth of microbes that harm humans. By conducting a literature study of 10 national and international articles in the last 10 years of publication to review the ability of several plants that have potential as antibacterials. Tests were carried out on Escherichia coli bacteria which included the extract solvent used, the content of metabolite compounds in the extract and its activity based on the inhibition zone diameter value and/or minimum inhibitory concentration (MIC). Keywords: Antibacterial, inhibition zone diameter, Escherichia coli, minimum inhibitory concentration, secondary metabolites
FERMENTASI BIJI BUAH NANGKA (Artocarpus heterophyllus Lam.) MENGHASILKAN ETANOL OLEH Saccharomyces cerevisiae DENGAN ANALISA KROMATOGRAFI GAS (GC) Fitriani, Ana; Kartika, Rudi; Akkas, Erwin
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/df0qqc47

Abstract

Research of bioethanol production from jackfruit seeds through fermentation using saccharomyces cerevisiae with the addition of tofu waste as nutrition source of microorganism. the aims of this research to determine the concentration of bioethanol that has been produced with the variation of concentration of tofu waste nutrients and variation of fermentation time. the hydrolysis process through enzymatic uses alfa-amylase on liquefaction process and glucoamylase on saccharification process. the fermentation process used Saccharomyces cerevisiae and tofu waste as a source of nutrition. variation of fermentation time 6, 8 and 10 days and variation of tofu waste nutrients concentration 0,75%; 1,5% and 2,25% (w/v). Ethanol content was obtained by gas chromatography analysis, the result showed the highest concentration of bioethanol obtained at the addition of tofu waste nutrients was 1,5% (w/v) and fermentation time for 10 days with bioethanol concentration obtained at 65,72%.
UJI Brine Shrimp Lethality Test (BSLT) UMBI BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb) DAN UJI TOKSISITAS AKUT FRAKSI AKTIF Lestari, Dwi; Kartika, Rudi; Marliana, Eva
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.43

Abstract

Eleutherine bulbosa (Mill.) Urb come from the Iridaceae family, this species contains secondary metabolites in the form of flavonoids and quinones. This research method includes Brine Shrimp Lethality Test (BSLT) toxicity using Artemia salina Leach larvae to determine the LC50 value. This study used experimental methods pharmacologically using a completely randomized design in the same direction pattern in the selection of test animals, 25 animals used were white mice divided into 5 groups with 5 mice per group, with 4 hours observed to find out toxic symptoms and continued observation every 24 hours to see death. Testing of BSLT results showed that ethanol extract had LC50 toxicity = 66.68 ppm (very toxic category), n-hexane fraction had LC50 toxicity = 47.64 ppm (very toxic category), chloroform fraction had LC50 toxicity = 295.1 ppm ( toxic category), and the water fraction has a toxicity of LC50 = 194.54 ppm (very toxic category). The chloroform fraction is an active fraction. Acute toxicity test LD50 value according to the calculation method of Miller Tainter Probit (187,499 mg/KgBB), the method of calculation of Thompson Weil (182,810 mg/KgBB), how to calculate Indonesian Pharmacopoeia (187,068 mg/KgBB). Based on the three calculations, the LD50 value is in the medium category (50-500 mg/kgBB).
MINI REVIEW: MENGKAJI POTENSI BAKTERI UNTUK PRODUKSI BIOETHANOL BERKELANJUTAN Muhammad Raihan Aswat; Rudi Kartika
PROSIDING SEMINAR KIMIA Vol 4 No 2 (2025): Prosiding SNKT 2025
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

The need for renewable energy such as bioethanol is increasingly urgent to overcome dependence on fossil fuels and food security issues. The use of bacteria to ferment non-food lignocellulosic biomass is a strategic alternative due to its ability to process a variety of substrates, including pentose that cannot be metabolized by yeast. This article presents a systematic literature review of international journals (2015-2025) to evaluate the effectiveness of various bacteria in bioethanol production. The study methodology focused on comparing the types of microorganisms, raw materials, process methodologies, bioethanol yields produced. The results of the study highlight the great potential of specific bacteria. Zymomonas mobilis showed the highest efficiency, achieving 100% yield through a cell-free system due to its superior Entner-Doudoroff metabolic pathway. Other bacteria such as Escherichia coli (90%) and Bacillus subtilis (76.8%) demonstrated excellent raw material flexibility. Additionally, engineered Clostridium thermocellum (70%) stood out for its ability to perform Consolidated Bioprocessing at high temperatures. However, challenges were encountered with Enterobacter sp., which only produced 23.6% ethanol due to its natural metabolism, which tends toward mixed acid fermentation. It was concluded that the use of bacteria is highly effective for bioethanol production but its effectiveness is highly dependent on strain selection and process engineering. Keywords: Bioethanol, Bacteria, Zymomonas mobilis, Entner-Doudroff,
Co-Authors Abimanyu, Priem Reyhan Adha, Laila Sufina Aditya, Roy Admaja, Junior Try Adnyana, Ketut Cahyadi Ahmad Suryadi, Ahmad Akkas, Erwin Alimuddin - Alimuddin Alimuddin Aman S Panggabean Aman S Panggabean, Aman S Aman S. Panggabean Aman Sentosa Panggabean Andi Kurniawan Annuary Laksono Arifwan - Ary Rizki Darmawi Ary Rizki Darmawi, Ary Rizki Aswad, Muhammad Raihan Aswat, Muhammad Raihan Aswat, Raihan Azka, Andi Aulia Urrahman Bayu Iskandar Bohari Yusuf Bohari Yusuf Bonifasius, Bonifasius Bustanussalam Bustanussalam Bustanussalam Bustanussalam, Bustanussalam Chairul Saleh Corebima, Damianus Develistur Delina Khairunnisa Dilo Jhosea Luciano Eduardo Dimas P, Riansyah Djihan Ryn Pratiwi, Djihan Ryn Dwi Fitria Sari Dwi Lestari Dwi Susanto Edi Novian Jaya Edman Tandirerung Eka Damayanti Setyningrum Eka Setia Rini Eka Siswanto Syamsul Eno Julia Shafarini Erwin - Erwin Erwin Eva Marliana, Eva Fahmi, Miraz’hul Fahmi, Miraz’ul Farida Farida Fathur Rahman Fathur Rahman fatur Rahman, fatur Fauzi Rachman Fauzi Rachman Firmansyah - Fitriana, Mila Fitriani, Ana Gelung, Antonius Hamsiana - Hendra Priatna Hendric Surya Putra I Wayan Arief Pradana Putra Iskandar, Bayu Jaya, Edi Novian Jofri, Dirga Hosea Seventeen Jofri, Dirga Hosea Seventin Julianto, Faisal Reja Kalmud Nia Tekha Laksono, Annuary Lila Karina Nuryanti Lilik Sulastri Lumban Gaol Veronica Destiana Mahrus, Muhammad Haissul Maria Amelia Kristianingrum Marliani, Nelly Marlina, Eva Mila Fitriana Mira Wahyuni Mira Wahyuni, Mira Miraz’hul Fahmi Muhammad Adhitya Rizkirullah Muhammad Haissul Mahrus Muhammad Harry Rahmadan Muhammad Raihan Aswat Muhammad Sigit Ariski Nasution, Safridah Hannum Noor Hindryawati Noor Hindryawati, Noor Nur Asmawati Nur, Istianti Irfa'a Octavianus, Riyan Octavianus, Riyan Partomouan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Prastiwi, Mela Pratama, Riansyah Dimas Rahmat Gunawan Rahmat Gunawan Rahmat Gunawan Rezky Estrada Ricard, Romoldus Jonius Rico Ramadhan, Rico Rida Awliyani Rina Ermawati Ripaldy Apriansya Riyan Octavianus Rizkirullah, M. Adhitya Rizkirullah, Muhammad Adhitya Rizkirullah, Muhammad Aditya Rizkullah, Muhammad Adhitya rizky maulida amalia hanif Ruga, Ritbey Rutdianti Rutdianti Rutdianti, Rutdianti Sahriani, Andi Saibun Sitorus Saleh, Chairul Sanian, Sanian Sari Setianingsih Setianingsih, Sari Setyningrum, Eka Damayanti Shafarini, Eno Julia Shaparuddin Nur Arifullah Simanjuntak, Partomuan Slamet Ningsih Hadi Raharjo Solman, Solman Suaibatul Aslamiah Subur P Pasaribu Sudrajat Sudrajat Sukanadi, I Putu Sukma Wiratama Sulistiani, Oktaviana Dewi Sulistiyawati, Rizki Ramadhani Syelvia Lousiana Kalauw Syelvia Lousiana Ningsih Kalauw Syelvialousiana Ningsih Kalauw Tandirerung, Edman Tanjung, Faisal Taufik Hamdani Trisnawati, Eka Elly Ulfa, Yulyanti Sartika Utami, Nanda Putri Wahyu Budi Utama Wahyu Budi Utama Wahyu Teguh Santoso Wahyu Teguh Santoso Wajdie, Farid Winni Astuti Winni Astuti, Winni Wulan Verani Yeni Agustina Yeni Agustina, Yeni Yerwanto Ilang Yerwanto Ilang, Yerwanto