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All Journal The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Efendi Lukas
Faculty of Medicine University of Hasanuddinj Dr. Wahidin Sudiro Husodo Hospital Makassar
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment Randabunga, Ervan J; Lukas, Efendi; Tumedia, Josephine L; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.561 KB) | DOI: 10.32771/inajog.v6i4.848

Abstract

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin   Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer. Metode: Pemeriksaan kadar prostaglandin (PGF2α) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35). Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol. Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer. Kata kunci : Dismenore primer, piridoksin, prostaglandin
Hubungan 8 OHdG (8-Hydroxy-2- Deoxyguanosin) Urin Neonatus dan Preeklamsia Tannur, Sebastianus; Lukas, Efendi; Mailoa, Johnsen; Alasiry, Ema; Irianta, Trika; Chalid, Maisuri T.
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.582

Abstract

Pendahuluan: Preeklamsia merupakan penyakit dengan berbagai teori (disease of theory) yang menggambarkan ketidakpastian patofisiologi dan penyebabnya. preeklamsia bukan hanya menyebabkan komplikasi terhadap maternal namun juga menimbulkan komplikasi terhadap janin, baik jangka pendek maupun jangka panjang. Peningkatan jumlah radikal bebas merupakan tanda terjadinya stres oksidatif pada kehamilan dengan preeklamsia. 8-OHdG adalah produk utama yang dibentuk dari radikal hidroksil pada residu guanine DNA.Metode: Penelitian ini merupakan penelitian analitik yang dikembangkan dengan desain penelitian cross-sectional. Sampel penelitian adalah neonatus yang lahir dari wanita hamil dengan dan tanpa didiagnosa preeklamsia. Pengambilan sampel dilakukan secara purposive sampling. dilakukan di Rumah Sakit Wahidin Sudirohusodo,dan rumah sakit jejaring pendidikan. Pengujian/running sampel dilakukan di unit Laboratorium Penelitian RSPTN Universitas Hasanuddin dengan metode Elisa. Data dianalisis dengan uji Chi squae, uji Mann whitney dan uji Kruskal wallis Hasil: Hasil penelitian yang telah dilakukan terdapat sebanyak 82 orang yang terbagi menjadi 41 orang sampel yang merupakan kelompok dengan preklamsia dan 41 orang sampel kelompok kontrol (normal). Berdasarkan hasil penelitian yang telah dilakukan mengenai kadar 8-OHdG urin neonatus (8-hydroxy-2- deoxyguanosin) pada kehamilan dengan Preeklamsia diperoleh nilai rerata kadar 8-OHdG urin neonatus pada kehamilan normal sebesar 3.79±1.99, sedangkan kehamilan dengan preeklamsia sebesar 14.25±16.81. uji statistik chi-square menunjukkan nilai p sebesar 0.00 dimana nilai p<0.05 yang artinya terdapat perbedaan kadar 8-OHdG urin neonatus terhadap kejadian preeklamsia dan ibu hamil normal pada penelitian ini. Kesimpulan: Terdapat perbedaan yang signifikan bermakna kadar 8-OHdG urin neonatus yaitu lebih tinggi kadar pada ibu hamil penderita preeklamsia daripada ibu hamil normal.Relationship Between 8 OHdG (8-Hydroxy-2- Deoxyguai›osine) in Neonate Urine and PreeclampsiaAbstractIntroduction: Preeclampsia is a disease with various theories (disease of theory) that describes the uncertainty of its pathophysiology and causes. Preeclampsia not only causes complications for the mother but also causes complications for the fetus, both short and long term. An increase in the number of free radicals is a sign of oxidative stress in preeclampsia. 8-OHdG is the main product formed from hydoxyl radicals in DNA guanine residues. Method: The research was an analytical study developed with a cross-sectional research design. The research sample was neonates born to pregnant women with and without a diagnosis of preeclampsia. The sample was determined by using purposive sampling technique carried out at Wahidin Sudirohusodo Hospital and educational network hospitals. Sample testing was carried out at Hasanuddin University RSPTN Research Laboratory unit using Elisa method. Data were analyzed using Chi square test, Mann Whitney test, and Kruskal Wallis test. Results: The research was carried out to 82 people who were divided into 41 samples in the group with preeclampsia and 41 samples in the control group (normal). Based on the results of research that has been carried out regarding the level of 8-OHdG in neonate urine (8-hydroxy-2-deoxyguanosine) in pregnancies with preeclampsia, the mean value of 8-OHdG level in neonate urine in normal pregnancies is 3.79 z 1.99, while the one in pregnancies with preeclampsia it is 14.25 z 16.81. The chi-square statistical test shows a p value 0.00 which p value <0.05, which means that there is a difference in the level of 8-OHdG in neonate urine in the occurrence of preeclampsia and normal pregnant women. Conclusion: There is a significant difference between the level of 8-OHdG in neonate urine, where the level is higher in pregnant women with preeclampsia than in normal pregnant women.Key words: 8-OHdG, neonate urine, preeclampsia
Hubungan Antara Neutrophil Gelatinase Associated Lipocaline (NGAL) dan Kejadian Preeklamsia: Penelitian Potong-Lintang Koesuma, Edward Chandra; Lukas, Efendi; Tahir, Mardiah; Sunarno, Isharyah; Jusuf, Elizabet C; Abidin, Nuraini
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.567

Abstract

Tujuan: Untuk mengetahui hubungan antara kadar Neutrophil Gelatinase Associated Lipocaline (NGAL) pada kehamilan normal, Preeklamsia Berat (PEB) tanpa Komplikasi, dan PEB dengan Komplikasi.Metode:Desain penelitian cross sectional dilakukan pada ibu hamil dengan usia kehamilan lebih dari 20 minggu di RSUP Dr. Wahidin Sudirohusodo dan rumah sakit jejaring pendidikan lainnya sejak bulan Januari hingga Juni tahun 2022. Data dikumpulkan menggunakan sampel darah dan diperiksa lebih lanjut dengan metode ELISA. Uji Chi-Square digunakan untuk menganalisis hubungan antara kadar NGAL dan derajat keparahan PEB.Hasil: Pada penelitian ini mencakup 156 sampel, yang terdiri atas wanita hamil normal (n=53), wanita hamil dengan PEB tanpa komplikasi (n=50), dan wanita hamil dengan PEB dan komplikasi (n=53). Penelitian ini menemukan bahwa semakin  berat derajat preeklamsia, maka  semakin rendah kadar NGAL-nya yaitu kadar NGAL diamati pada 58% wanita PEB dengan komplikasi dan 32,1% wanita PEB tanpa komplikasi dan 9,8% pada kehamilan normal (p <0,05). Hasil penelitian ini  tidak sesuai dengan teori yang menemukan peningkatan kadar NGAL pada pasien PEB. Penurunan kadar NGAL ini mungkin dapat disebabkan oleh prevalensi obesitas yang banyak pada kelompok PEB dengan dan tanpa komplikasi. Obesitas merupakan  kondisi inflamasi sistemik dan NGAL dapat bertindak sebagai regulator negatif terhadap aktivitas inflamasi yang dimediasi oleh disfungsi adiposit. Pada kelompok PEB juga didapatkan pemberian MgSO4, yang  memiliki peran untuk menghambat kadar IL-6 sehingga dapat menurunkan kadar NGALKesimpulan: Penurunan kadar NGAL berpotensi untuk menjadi biomarker dalam menilai derajat keparahan preeklamsia.Correlation Between Neutrophil Gelatinase Associated Lipocaline (NGAL) and Preeclampsia: A Cross-sectional StudyAbstract    Objective: to observe the correlation between level of Neutrophil Gelatinase Associated Lipocaline (NGAL) on normal pregnancy, severe preeclampsia (SPE) without complication, & SPE with complication. Method: Cross-sectional Study Design method is performed on pregnant women with gestational age of more than 20 weeks at Dr. Wahidin Sudirohusodo hospital & the other educational networking hospitals from January to June 2022. Data were collected using blood samples & further examined with ELISA method. Chi-Square test   is used to analyze the correlation between NGAL level & degree of severity of the severe preeclampsia.Results: this study includes 156 samples consisting of normal pregnant women (n=53), pregnant women with SPE without complication (n= 50), & pregnant women with SPE with complication (n= 53), we found out that the more severe the degree of preeclampsia, the lower the level of NGAL where the level of NGAL is observed on 58% of pregnant women with complication & 32.1% pregnant women without complication, & 9.8% on women with normal pregnancy (p<0.05). This study result is irrelevant with the theory which  found the rising level of NGAL on patients with SPE, this decreasing level of NGAL might be caused by obesity prevalence mostly found on pregnant with & without complication since obesity is a systemic  inflammatory condition & NGAL can act as negative regulator against inflammatory activity mediated by adipocyte disfunction. On SPE group there is also MgSO4 administration functioning as a hindrance for IL6 level thus may lessen the NGAL level.Conclusion: the decreasing level of NGAL  is potential to become a biomarker in evaluating the severity of preeclampsia.Key words: degree of severity, Neutrophil Gelatinase Associated Lipocaline, preeclampsia
Accuracy of Transperineal Ultrasoun Examination in Predicting Vaginal Delivery Rauf, Fauzia Tamara; Chalid, Maisuri Tadjuddin; Lukas, Efendi; Susiawaty; Farid, Monika Fitria; Hamid, Firdaus
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2184

Abstract

MCM6 rs4988235 Allele G, AGT rs699 Allele C, ACE rs4343 Allele A, FADS1 rs174547 Allele C, DCHR7 rs12785878 Allele G, and GC rs7041 Allele T: Candidate Genes for Preeclampsia Prevention Riu, Deviana Soraya; Sunarno, Isharyah; Lukas, Efendi
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3422

Abstract

BACKGROUND: Preeclampsia is the primary cause of maternal and neonatal morbidity and mortality; however, currently there is no definitive method exists to prevent preeclampsia. Recent findings indicate a possible genetic influence on preeclampsia. Therefore, this study was conducted to assess nutrigenomic patterns in preeclampsia as a potential mechanism for identifying appropriate preventive strategies through a nutrigenomic approach.METHODS: This descriptive study focused on 15 primiparous pregnant women diagnosed with preeclampsia. The nutrigenomic test was performed using DNA microarray method to examine variant genes associated with food response and nutrient metabolites. The genetic tendencies were categorized as "low," "average," and "high." The frequencies of alleles and probabilities were assessed for gene variants expressing "high" and "low" genotypic tendencies.RESULTS: The identified genetic variations were MCM6 rs4988235 allele G that indicated lactose intolerance (allele frequency 100%), AGT rs699 allele C and ACE rs4343 allele A that were associated with sodium metabolism (allele frequency 82% and 90%, respectively), as well as FADS1 rs174547 allele C that was pertained to omega metabolism (allele frequency 85%). Likewise, DCHR7 rs12785878 allele G and GC rs7041 allele T were relevant for vitamin D (allele frequencies 82% and 77%, respectively). However, MCM6 rs4988235 allele G, FADS1 rs174547 allele C, DCHR7 rs12785878 allele G, and GC rs7041 allele T had not been explicitly linked to preeclampsia.CONCLUSION: MCM6 rs4988235 allele G, AGT rs699 allele C, ACE rs4343 allele A, FADS1 rs174547 allele C, DCHR7 rs12785878 allele G, and GC rs7041 allele T are the dominant variant genes observed. The associations between preeclampsia and AGT rs699 allele C and ACE rs4343 allele A are consistent with other study.KEYWORDS: preeclampsia, nutrigenomics, nutrition metabolism
Co-Authors Abidin, Nuraini Chalid, Maisuri Tadjuddin Dahlan, Intje S Ema Alasiry, Ema Farid, Monika Fitria Fauzia Tamara Rauf Hamid, Firdaus Josephine L Tumedia Jusuf, Elizabet C Koesuma, Edward Chandra Mailoa, Johnsen Maisuri T Chalid, Maisuri T Maisuri T. Chalid, Maisuri T. Nasruddin, Zulfaekasari Randabunga, Ervan J Riu, Deviana Soraya Rusmardiani, Andhinna Sunarno, Isharyah Susiawaty Syahrul Rauf T Chalid, St. Maisuri T. Chalid, St. Maisuri Tahir, Mardiah Tahir, Mardiah Tannur, Sebastianus Trika Irianta Umar Malinta