Article Per Year (5 Year)
p-Index From 2021 - 2026
0.888
P-Index
This Author published in this journals
All Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Efendi Lukas
Faculty of Medicine University of Hasanuddinj Dr. Wahidin Sudiro Husodo Hospital Makassar
Health Professions Medicine & Pharmacology Public Health

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 15 Documents
Search

 1   2 
Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment Randabunga, Ervan J; Lukas, Efendi; Tumedia, Josephine L; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.561 KB) | DOI: 10.32771/inajog.v6i4.848

Abstract

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin   Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer. Metode: Pemeriksaan kadar prostaglandin (PGF2α) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35). Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol. Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer. Kata kunci : Dismenore primer, piridoksin, prostaglandin
Hubungan 8 OHdG (8-Hydroxy-2- Deoxyguanosin) Urin Neonatus dan Preeklamsia Tannur, Sebastianus; Lukas, Efendi; Mailoa, Johnsen; Alasiry, Ema; Irianta, Trika; Chalid, Maisuri T.
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.582

Abstract

Pendahuluan: Preeklamsia merupakan penyakit dengan berbagai teori (disease of theory) yang menggambarkan ketidakpastian patofisiologi dan penyebabnya. preeklamsia bukan hanya menyebabkan komplikasi terhadap maternal namun juga menimbulkan komplikasi terhadap janin, baik jangka pendek maupun jangka panjang. Peningkatan jumlah radikal bebas merupakan tanda terjadinya stres oksidatif pada kehamilan dengan preeklamsia. 8-OHdG adalah produk utama yang dibentuk dari radikal hidroksil pada residu guanine DNA.Metode: Penelitian ini merupakan penelitian analitik yang dikembangkan dengan desain penelitian cross-sectional. Sampel penelitian adalah neonatus yang lahir dari wanita hamil dengan dan tanpa didiagnosa preeklamsia. Pengambilan sampel dilakukan secara purposive sampling. dilakukan di Rumah Sakit Wahidin Sudirohusodo,dan rumah sakit jejaring pendidikan. Pengujian/running sampel dilakukan di unit Laboratorium Penelitian RSPTN Universitas Hasanuddin dengan metode Elisa. Data dianalisis dengan uji Chi squae, uji Mann whitney dan uji Kruskal wallis Hasil: Hasil penelitian yang telah dilakukan terdapat sebanyak 82 orang yang terbagi menjadi 41 orang sampel yang merupakan kelompok dengan preklamsia dan 41 orang sampel kelompok kontrol (normal). Berdasarkan hasil penelitian yang telah dilakukan mengenai kadar 8-OHdG urin neonatus (8-hydroxy-2- deoxyguanosin) pada kehamilan dengan Preeklamsia diperoleh nilai rerata kadar 8-OHdG urin neonatus pada kehamilan normal sebesar 3.79±1.99, sedangkan kehamilan dengan preeklamsia sebesar 14.25±16.81. uji statistik chi-square menunjukkan nilai p sebesar 0.00 dimana nilai p<0.05 yang artinya terdapat perbedaan kadar 8-OHdG urin neonatus terhadap kejadian preeklamsia dan ibu hamil normal pada penelitian ini. Kesimpulan: Terdapat perbedaan yang signifikan bermakna kadar 8-OHdG urin neonatus yaitu lebih tinggi kadar pada ibu hamil penderita preeklamsia daripada ibu hamil normal.Relationship Between 8 OHdG (8-Hydroxy-2- Deoxyguai›osine) in Neonate Urine and PreeclampsiaAbstractIntroduction: Preeclampsia is a disease with various theories (disease of theory) that describes the uncertainty of its pathophysiology and causes. Preeclampsia not only causes complications for the mother but also causes complications for the fetus, both short and long term. An increase in the number of free radicals is a sign of oxidative stress in preeclampsia. 8-OHdG is the main product formed from hydoxyl radicals in DNA guanine residues. Method: The research was an analytical study developed with a cross-sectional research design. The research sample was neonates born to pregnant women with and without a diagnosis of preeclampsia. The sample was determined by using purposive sampling technique carried out at Wahidin Sudirohusodo Hospital and educational network hospitals. Sample testing was carried out at Hasanuddin University RSPTN Research Laboratory unit using Elisa method. Data were analyzed using Chi square test, Mann Whitney test, and Kruskal Wallis test. Results: The research was carried out to 82 people who were divided into 41 samples in the group with preeclampsia and 41 samples in the control group (normal). Based on the results of research that has been carried out regarding the level of 8-OHdG in neonate urine (8-hydroxy-2-deoxyguanosine) in pregnancies with preeclampsia, the mean value of 8-OHdG level in neonate urine in normal pregnancies is 3.79 z 1.99, while the one in pregnancies with preeclampsia it is 14.25 z 16.81. The chi-square statistical test shows a p value 0.00 which p value <0.05, which means that there is a difference in the level of 8-OHdG in neonate urine in the occurrence of preeclampsia and normal pregnant women. Conclusion: There is a significant difference between the level of 8-OHdG in neonate urine, where the level is higher in pregnant women with preeclampsia than in normal pregnant women.Key words: 8-OHdG, neonate urine, preeclampsia
Hubungan Antara Neutrophil Gelatinase Associated Lipocaline (NGAL) dan Kejadian Preeklamsia: Penelitian Potong-Lintang Koesuma, Edward Chandra; Lukas, Efendi; Tahir, Mardiah; Sunarno, Isharyah; Jusuf, Elizabet C; Abidin, Nuraini
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.567

Abstract

Tujuan: Untuk mengetahui hubungan antara kadar Neutrophil Gelatinase Associated Lipocaline (NGAL) pada kehamilan normal, Preeklamsia Berat (PEB) tanpa Komplikasi, dan PEB dengan Komplikasi.Metode:Desain penelitian cross sectional dilakukan pada ibu hamil dengan usia kehamilan lebih dari 20 minggu di RSUP Dr. Wahidin Sudirohusodo dan rumah sakit jejaring pendidikan lainnya sejak bulan Januari hingga Juni tahun 2022. Data dikumpulkan menggunakan sampel darah dan diperiksa lebih lanjut dengan metode ELISA. Uji Chi-Square digunakan untuk menganalisis hubungan antara kadar NGAL dan derajat keparahan PEB.Hasil: Pada penelitian ini mencakup 156 sampel, yang terdiri atas wanita hamil normal (n=53), wanita hamil dengan PEB tanpa komplikasi (n=50), dan wanita hamil dengan PEB dan komplikasi (n=53). Penelitian ini menemukan bahwa semakin  berat derajat preeklamsia, maka  semakin rendah kadar NGAL-nya yaitu kadar NGAL diamati pada 58% wanita PEB dengan komplikasi dan 32,1% wanita PEB tanpa komplikasi dan 9,8% pada kehamilan normal (p <0,05). Hasil penelitian ini  tidak sesuai dengan teori yang menemukan peningkatan kadar NGAL pada pasien PEB. Penurunan kadar NGAL ini mungkin dapat disebabkan oleh prevalensi obesitas yang banyak pada kelompok PEB dengan dan tanpa komplikasi. Obesitas merupakan  kondisi inflamasi sistemik dan NGAL dapat bertindak sebagai regulator negatif terhadap aktivitas inflamasi yang dimediasi oleh disfungsi adiposit. Pada kelompok PEB juga didapatkan pemberian MgSO4, yang  memiliki peran untuk menghambat kadar IL-6 sehingga dapat menurunkan kadar NGALKesimpulan: Penurunan kadar NGAL berpotensi untuk menjadi biomarker dalam menilai derajat keparahan preeklamsia.Correlation Between Neutrophil Gelatinase Associated Lipocaline (NGAL) and Preeclampsia: A Cross-sectional StudyAbstract    Objective: to observe the correlation between level of Neutrophil Gelatinase Associated Lipocaline (NGAL) on normal pregnancy, severe preeclampsia (SPE) without complication, & SPE with complication. Method: Cross-sectional Study Design method is performed on pregnant women with gestational age of more than 20 weeks at Dr. Wahidin Sudirohusodo hospital & the other educational networking hospitals from January to June 2022. Data were collected using blood samples & further examined with ELISA method. Chi-Square test   is used to analyze the correlation between NGAL level & degree of severity of the severe preeclampsia.Results: this study includes 156 samples consisting of normal pregnant women (n=53), pregnant women with SPE without complication (n= 50), & pregnant women with SPE with complication (n= 53), we found out that the more severe the degree of preeclampsia, the lower the level of NGAL where the level of NGAL is observed on 58% of pregnant women with complication & 32.1% pregnant women without complication, & 9.8% on women with normal pregnancy (p<0.05). This study result is irrelevant with the theory which  found the rising level of NGAL on patients with SPE, this decreasing level of NGAL might be caused by obesity prevalence mostly found on pregnant with & without complication since obesity is a systemic  inflammatory condition & NGAL can act as negative regulator against inflammatory activity mediated by adipocyte disfunction. On SPE group there is also MgSO4 administration functioning as a hindrance for IL6 level thus may lessen the NGAL level.Conclusion: the decreasing level of NGAL  is potential to become a biomarker in evaluating the severity of preeclampsia.Key words: degree of severity, Neutrophil Gelatinase Associated Lipocaline, preeclampsia
Accuracy of Transperineal Ultrasoun Examination in Predicting Vaginal Delivery Rauf, Fauzia Tamara; Chalid, Maisuri Tadjuddin; Lukas, Efendi; Susiawaty; Farid, Monika Fitria; Hamid, Firdaus
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2184

Abstract

Precision Chromosomal Surgery before Birth: Allele-Specific CRISPR-Cas9 Editing for Trisomy 21 in Perinatal Medicine Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Prabowo, Wisnu; Yuliantara, Eric Edwin; Lukas, Efendi; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Wiradnyana, Anak Agung Gede Putra; Mulyana, Ryan Saktika; Kusuma, Anak Agung Ngurah Jaya; Pangkahila, Evert Solomon; Gumilar, Khanisyah Erza; Darmawan, Ernawati; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Pribadi, Adhi; Anwar, Anita Deborah; Suryawan, Aloysius; Putra, Ridwan Abdullah; Gondo, Harry Kurniawan; Nugraha, Laksmana Adi Krista; Andanaputra, Waskita Ekamaheswara Kasumba; Dharma, Wibisana Andika Krista; Djanas, Dovy; Stanojevic, Milan
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.965

Abstract

Objective: Trisomy 21 remains the most common live-born aneuploidy and a major contributor to perinatal morbidity. Although prenatal screening, particularly non-invasive prenatal testing (NIPT), has advanced substantially, clinical management offers no corrective options. Emerging allele-specific genome-editing approaches propose targeted removal or silencing of the extra chromosome 21. This review summarizes current evidence and evaluates the translational relevance of these technologies in perinatal medicine.Methods: A narrative review was conducted following PRISMA-aligned procedures. A structured search of PubMed, Scopus, and Web of Science (January 2000–July 2025) identified 1,242 records. After duplicate removal, title/abstract screening, and full-text assessment based on predefined inclusion criteria, 54 studies met eligibility requirements. Data were synthesized across four domains: mechanistic strategies, developmental applicability, translational feasibility, and ethical–regulatory considerations.Results: Allele-specific CRISPR-Cas9 studies demonstrated selective cleavage of the supernumerary chromosome 21 in cellular models, with partial restoration of near-euploid transcriptional patterns. Additional approaches—XIST-mediated silencing and centromere destabilization—provided alternative mechanisms with varying stability and specificity. Evidence remains limited to in vitro systems, with no validated embryo or fetal applications. Key challenges include mosaicism, delivery barriers, individualized SNP targeting, and ethical governance.Conclusions: Allele-specific chromosome editing represents a promising but still experimental direction for future perinatal therapeutics. Current findings justify continued multidisciplinary investigation while emphasizing cautious interpretation and rigorous ethical oversight prior to any clinical translation. Abstrak Tujuan: Trisomi 21 tetap menjadi aneuploidi yang paling sering ditemukan pada kelahiran hidup dan merupakan kontributor utama terhadap morbiditas perinatal. Meskipun skrining prenatal—khususnya non-invasive prenatal testing (NIPT)—telah mengalami kemajuan yang signifikan, penatalaksanaan klinis hingga kini belum menawarkan opsi korektif. Pendekatan pengeditan genom spesifik alel yang mulai berkembang mengusulkan penghilangan atau penghambatan terarah terhadap salinan ekstra kromosom 21. Tinjauan ini merangkum bukti terkini serta mengevaluasi relevansi translasional teknologi tersebut dalam kedokteran perinatal.Metode: Tinjauan naratif dilakukan dengan mengikuti prosedur yang selaras dengan PRISMA. Pencarian terstruktur terhadap PubMed, Scopus, dan Web of Science (Januari 2000–Juli 2025) mengidentifikasi 1.242 rekaman. Setelah penghapusan duplikasi, penyaringan judul/abstrak, dan penilaian teks lengkap berdasarkan kriteria inklusi yang telah ditentukan, sebanyak 54 studi memenuhi persyaratan kelayakan. Data disintesis ke dalam empat domain: strategi mekanistik, aplikabilitas perkembangan, kelayakan translasional, serta pertimbangan etika dan regulasi.Hasil: Studi CRISPR-Cas9 spesifik alel menunjukkan pemotongan selektif terhadap kromosom 21 supernumerari pada model seluler, dengan pemulihan parsial pola transkripsi menuju profil ekspresi gen yang menyerupai kondisi euploid. Pendekatan lain—seperti penghambatan berbasis XIST dan destabilisasi sentromer—menyediakan mekanisme alternatif dengan tingkat kestabilan dan spesifisitas yang bervariasi. Bukti saat ini terbatas pada sistem in vitro, tanpa aplikasi yang tervalidasi pada embrio maupun janin. Tantangan utama meliputi mosaikisme, hambatan pengantaran, kebutuhan penargetan SNP individual, serta tata kelola etis.Kesimpulan: Pengeditan kromosom spesifik alel merupakan arah yang menjanjikan, namun masih bersifat eksperimental bagi terapi perinatal di masa mendatang. Temuan saat ini mendukung keberlanjutan penelitian multidisipliner, sekaligus menekankan perlunya interpretasi yang hati-hati dan pengawasan etika yang ketat sebelum penerapannya dalam praktik klinis.Kata Kunci: Bedah genom janin; CRISPR-Cas9; Penyuntingan gen perinatal; Terapi kromosom; Trisomi 21
Co-Authors Abidin, Nuraini Adhi Pribadi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Aloysius Suryawan Andanaputra, Waskita Ekamaheswara Kasumba Andonotopo, Wiku Anita Deborah Anwar Bachnas, Muhammad Adrianes Chalid, Maisuri Tadjuddin Cut Meurah Yeni Dahlan, Intje S Darmawan, Ernawati Dharma, Wibisana Andika Krista Djanas, Dovy Ema Alasiry, Ema Eric Edwin Yuliantara Evert Solomon Pangkahila Farid, Monika Fitria Fauzia Tamara Rauf Hamid, Firdaus Harry Kurniawan Gondo I Nyoman Hariyasa Sanjaya Josephine L Tumedia Julian Dewantiningrum Jusuf, Elizabet C Khanisyah Erza Gumilar Koesuma, Edward Chandra Kusuma, Anak Agung Ngurah Jaya Mailoa, Johnsen Maisuri T Chalid, Maisuri T Maisuri T. Chalid, Maisuri T. Nasruddin, Zulfaekasari Nugraha, Laksmana Adi Krista Nuswil Bernolian Pramono, Mochammad Besari Adi Putra, Ridwan Abdullah Randabunga, Ervan J Rusmardiani, Andhinna Ryan Saktika Mulyana Stanojevic, Milan Sunarno, Isharyah Susiawaty Syahrul Rauf T Chalid, St. Maisuri T. Chalid, St. Maisuri Tahir, Mardiah Tahir, Mardiah Tannur, Sebastianus Trika Irianta Umar Malinta Wiradnyana, Anak Agung Gede Putra WISNU PRABOWO