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All Journal Medical Journal of Indonesia Universa Medicina Paediatrica Indonesiana Majalah Kedokteran Andalas Cermin Dunia Kedokteran eJournal Kedokteran Indonesia Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Jurnal Kedokteran Meditek Ophthalmologica Indonesiana Cermin Dunia Kedokteran
Wresti Indriatmi B. Makes
Division Of Venereology, Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Indonesia-dr. Cipto Mangunkusumo Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hubungan Konsumsi Coklat dengan Perburukan Akne Vulgaris pada Remaja dan Dewasa Muda dengan Akne Vulgaris: Laporan Kasus Berbasis Bukti Shelly; Rizki Irianti Rakasiwi Ningrum; Wresti Indriatmi
Cermin Dunia Kedokteran Vol 50 No 10 (2023): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i10.808

Abstract

Introduction: Acne vulgaris (AV) is a common dermatological problem. AV can occur in all age groups, especially in the adolescent. Chocolate is one of the most consumed foods by teenagers, its relationship with AV has not been established. Objective: To determine whether chocolate consumption is associated with worsening AV in adolescents and young adults with AV. Methods: Article searches used the PubMed, EMBASE, Proquest, and Scopus databases using the keywords adolescent and young adult, chocolate, acne. Search for relevant studies was also carried out from the reference list. Results: Three articles met the eligibility criteria. Critical reviews demonstrated that white chocolate is associated with an increase in total, non-inflammatory, and inflammatory acne lesions in adolescents and young adults with AV. There is still no agreement regarding the association of dark chocolate with worsening AV in adolescents and young adults with AV. Conclusion: White chocolate is associated with worsening AV in adolescents and young adults with AV, whereas the relationship of dark chocolate with worsening of AV in adolescents and young adults with AV is still inconclusive.
Perbandingan Efektivitas Terapi Asiklovir dibandingkan dengan Plasebo pada Pitiriasis Rosea: Sebuah Laporan Kasus Berbasis Bukti Arlha Aporia Debinta; Christa Desire Gracia; Wresti Indriatmi
Jurnal Kedokteran Meditek Vol 28 No 3 (2022): SEPTEMBER-DESEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i3.2396

Abstract

Pitiriasis rosea merupakan kelainan kulit eritroskuamosa swasirna yang diduga disebabkan oleh human herpesvirus 6 dan 7. Etiologi dan patomekanisme penyakit yang belum diketahui dengan pasti menimbulkan tantangan dalam tata laksana penyakit ini. Pengobatan yang dianjurkan beragam, mulai dari simtomatik, antivirus, antibiotik, hingga fototerapi, namun, belum terdapat pedoman tatalaksana yang baku. Tujuan dari tinjauan sistematis ini adalah untuk membandingkan asiklovir dibandingkan plasebo dalam regresi lesi pitiriasis rosea. Metode penelitian menggunakan penelusuran artikel di tiga database yaitu PubMed, Cochrane dan Scopus. Hasil penelusuran ditemukan 29 artikel, kemudian terpilih satu meta-analisis dari uji klinis yang sesuai berdasarkan validitas, kepentingan, dan aplikabilitas. Meta-analisis tersebut menunjukkan bahwa asiklovir unggul terhadap plasebo dalam regresi lesi pitiriasis rosea di hari ke-7. Kesimpulan dari penelusuran ini menunjukkan bahwa asiklovir lebih efektif dalam mengobati lesi pitiriasis rosea dibandingkan dengan plasebo.
Comparison of Intraocular Pressure After Water Drinking Test in Primary Open Angle Glaucoma Patients Controlled with Latanoprost and Trabeculectomy Emma Rusmayani; Widya Artini; Wresti Indriatmi
Majalah Oftalmologi Indonesia Vol 47 No 1 (2021): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v47i1.100157

Abstract

Purpose: To compare intraocular pressure (IOP) after water drinking test in primary open angle glaucoma patients controlled with latanoprost 0.005% and trabeculectomy.Methods: Observational study with cross-sectional design of 28 eyes with primary open angle glaucoma (POAG) patients. Subjects were divided into two groups, 14 patients controlled with trabeculectomy and 14 patients with latanoprost monotherapy. All subjects were under clinical therapy and had an intraocular pressure (IOP) equal or lower than 18 mm Hg, monitored during the follow up period. All subjects were submitted to the water drinking test. The results of the water drinking test, which were peak and fluctuation of IOP, were then compared between groups. Results: There were no significant difference between IOP peak between two groups (p=0.88). IOP fluctuation also showed no significant difference between groups (p=0.84). In both groups, baseline IOP strongly correlated with peak IOP in water drinking test with correlation coefficient r=0.96 (p<0.001) and r=0.71 (p=0.04), while baseline IOP in trabeculectomy group was strongly correlated with IOP fluctuation with correlation coefficient r=0.86 (p<0.001). Conclusions: Peak and fluctuation of IOP after water drinking test in primary open angle patients controlled with latanoprost and trabeculectomy showed no significant difference.
DIAGNOSIS DAN TATA LAKSANA KEKAMBUHAN KUSTA Caroline Oktarina; Melani Marissa; Wresti Indriatmi; Sri Linuwih Menaldi
Media Dermato-Venereologica Indonesiana Vol 49 No 2 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i2.340

Abstract

Leprosy relapse is defined as the reappearance of leprosy’s signs and symptoms following completion of adequate Multidrug Therapy (MDT) regimen. Indonesia is the third biggest contributor for leprosy relapse with 284 cases in 2018. Several factors contribute to the occurrence of relapse, which include presence of persisters, history of inadequate therapy, drug resistance, history of irregular treatment, history of dapsone monotherapy, high initial bacteriological index, high number of skin and nerve lesions, negative lepromin test, history of antireaction therapy, human immunodeficiency virus (HIV) infection, and pregnancy. Diagnosis of relapse can be established based on clinical, bacteriological, and therapeutic criteria, also histopathological and serological criteria, if possible. With those criteria, it should be easier to differentiate relapse from reaction, resistance, reactivation, and reinfection. The principal management for leprosy relapse is re-administration of MDT according to the type of relapse; however, therapy should be modified if there are any evidences of drug resistance. Things which are important to be taken into account during relapse treatment are leprosy type, past medication history, and the possibility of drug resistance. With proper knowledge and diagnostic algorithm, it is expected that the treatment can be administered immediately in order to prevent disability and transmission of infection.
Cotton swabs for the measurement of NF-ĸB, IFN-γ, and FOXP3+Treg from lesions of anogenital wart patients Hutabarat, Hernayati; Bramono, Kusmarinah; Indriatmi, Wresti; Wibowo, Heri; Budianti, Windy Keumala; Suyatna, Fransiscus Dhyanagiri; Prihartono, Joedo; Mawardi, Prasetya
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247496

Abstract

BACKGROUND Local tissue immunity plays a significant role in anogenital warts’ (AGW) pathomechanism and persistence. Assessing biomarkers from lesions instead of serum is recommended to evaluate therapeutic response. Since biopsy is invasive, it is necessary to find less invasive and more comfortable methods. This study aimed to assess the reliability of cotton swabs and tape stripping for evaluating AGW’s lesions biomarkers. METHODS We compared cotton swab versus tape stripping method to quantify nuclear factor-κappaB (NF-ĸB), interferon-gamma (IFN-γ), and FOXP3+regulatory T cell (FOXP3+Treg) from 3 patients with AGW in the preliminary study. The method was selected based on contamination possibility, side effects, and a simpler approach. The main study examined 48 patients with AGW for reliability and reproducibility using the best sampling method from preliminary result and Spearman’s Rho analysis, while considering the HIV status and CD4+ counts. RESULTS Both cotton swabs and tape stripping obtained adequate protein content for biomarkers examination. However, the tape stripping method was causing serum contamination and painful for patients due to the stripping. The total lesion volume in cotton swab method was positively correlated with all patients’ NF-ĸB (p = 0.001). IFN-γ had a negative correlation in all reactive HIV patients (p = 0.012). FOXP3+Treg and CD4+ counts were negatively correlated with total volume in reactive HIV patients (p = 0.046 and 0.017, respectively). CONCLUSIONS The cotton swab method was reliable in examining NF-ĸB, IFN-γ, and FOXP3+Treg due to its convenience and lack of serum contamination from AGW lesions, potentially improving patient comfort and practical benefits.
Developing an online reproductive health module on sexually transmitted infections for Indonesian adolescents: a qualitative mixed methods study Nilasari, Hanny; Indriatmi, Wresti; Gunardi, Hartono; Kayika, I Putu Gede; Kekalih, Aria; Siregar, Kemal Nazaruddin; Kurniawan, Kristian; Lesmana, Elvira; Haswinzky, Rose Amalia
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247635

Abstract

BACKGROUND A notable rise in sexually transmitted infection (STI) cases among youth correlates with a lack of reproductive health awareness, affecting nearly 80% of Indonesian adolescents. Additionally, sociocultural taboo acts as a challenge to reproductive health implementation in Indonesia. Therefore, this study aimed to develop an online reproductive health module focused on STIs for Indonesian adolescents. METHODS This research was a mixed methods approach, integrating quantitative study using univariate analysis (survey and questionnaire) and qualitative study using the Delphi method (open discussion and focus group discussion). The study was conducted between March 2 and July 28, 2022. We began by conceptualizing a literature-based module, an online survey, and virtual discussions involving students, teachers, and parents. Then, we consulted with clinical psychologists and dermatovenereologists. Additionally, students completed an assessment to establish a baseline of their knowledge, attitudes, and behaviors (KAB) regarding reproductive health and STIs. RESULTS Of 327 high school students across Jakarta, analysis of the 129 completed KAB surveys showed that only 56.6% and 65.1% attained acceptable scores (>65) for knowledge and behavior, respectively, with 24.8% being at risk for STIs. Key recommendations included incorporating multimedia elements, ensuring clarity and simplicity in language, adopting non-judgmental tone, providing comprehensive explanations of STIs and their long-term impact, and supporting learning with face-to-face sessions and ongoing access to concise, cost-effective educational resources. CONCLUSIONS Adolescents need a comprehensive, interactive, instructive, accessible, non-discriminatory reproductive module that strengthens the self-concept that upholds Indonesian values and norms.
Hubungan Konsumsi Coklat dengan Perburukan Akne Vulgaris pada Remaja dan Dewasa Muda dengan Akne Vulgaris: Laporan Kasus Berbasis Bukti Shelly; Rizki Irianti Rakasiwi Ningrum; Wresti Indriatmi
Cermin Dunia Kedokteran Vol 50 No 10 (2023): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i10.808

Abstract

Introduction: Acne vulgaris (AV) is a common dermatological problem. AV can occur in all age groups, especially in the adolescent. Chocolate is one of the most consumed foods by teenagers, its relationship with AV has not been established. Objective: To determine whether chocolate consumption is associated with worsening AV in adolescents and young adults with AV. Methods: Article searches used the PubMed, EMBASE, Proquest, and Scopus databases using the keywords adolescent and young adult, chocolate, acne. Search for relevant studies was also carried out from the reference list. Results: Three articles met the eligibility criteria. Critical reviews demonstrated that white chocolate is associated with an increase in total, non-inflammatory, and inflammatory acne lesions in adolescents and young adults with AV. There is still no agreement regarding the association of dark chocolate with worsening AV in adolescents and young adults with AV. Conclusion: White chocolate is associated with worsening AV in adolescents and young adults with AV, whereas the relationship of dark chocolate with worsening of AV in adolescents and young adults with AV is still inconclusive.
INOSINE PRANOBEX SEBAGAI TERAPI TAMBAHAN PADA KUTIL GENITAL: SEBUAH LAPORAN KASUS Adisasmito, Ayutika Saraswati; Nur Azizah, Anggita; Halim, Melissa; Irawan, Yudo; Marissa, Melani; Nilasari, Hanny; Indriatmi, Wresti
Media Dermato-Venereologica Indonesiana Vol 52 No 3 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i3.446

Abstract

Pendahuluan: Beberapa modalitas terapi telah tersedia untuk mengobati kondiloma akuminata. Pendekatan tata laksana multimodalitas diperlukan pada kasus yang sulit sembuh. Inosine pranobex (IP) telah dilaporkan sebagai terapi tambahan untuk kutil anogenital. Kemampuan IP memanipulasi imunitas seluler dan humoral dapat bersifat antivirus. Pada laporan kasus ini, kami melaporkan keberhasilan terapi IP pada pasien imunokompeten yang sebelumnya mengeluhkan progresivitas kutil walaupun dalam terapi konvensional. Kasus: Seorang laki-laki berusia 26 tahun datang dengan keluhan kutil pada sisi kanan orifisium uretra eksternal (OUE) sejak 2 bulan yang lalu. Setelah empat sesi terapi asam trikloroasetat (TCA) 90%, pasien mengeluhkan kutil bertambah pada sisi kiri OUE. Terapi IP 3 gram per hari ditambahkan ke dalam regimen terapi pasien. Setelah pasien mengonsumsi IP secara rutin selama 2 minggu dan menyelesaikan 6 sesi tambahan tutul TCA 90%, kutil menghilang secara klinis. Pasien menyangkal timbulnya efek samping setelah konsumsi rutin IP. Diskusi: Respons terapi yang terbatas terhadap TCA 90% pada pasien ini menunjukkan kemungkinan manfaat terapi lainnya. Penambahan IP, sebagai imunomodulator yang meningkatkan imunitas seluler dan humoral, memberikan perbaikan klinis dengan efek samping minimal hingga tidak ada. Hasil ini mendukung penerapan kombinasi TCA 90% dan IP sebagai alternatif terapi pada kutil anogenital yang memberi respons minimal terhadap monoterapi. Kesimpulan: Penambahan IP pada terapi konvensional memberikan perbaikan klinis pada pasien kutil anogenital yang tidak membaik dengan terapi TCA 90% saja.
Discrepancy of PCR and serologic test on genital herpes: a case report Jhauharina Rizki Fadhilla; Wresti Indriatmi; Hanny Nilasari; Yudo Irawan
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/s440xr58

Abstract

Background: Laboratory investigation for genital herpes (GH) includes serologic tests and polymerase chain reaction (PCR) with different sensitivity and specificity; occasionally, the results are not conclusive. Clinical symptoms are often atypical. We report a case of GH in HIV-infected patients with a non-reactive serologic test but positive PCR. Case Description: A 29-years old HIV-positive man presented with multiple painful shallow ulcers with pus on his penis in the last five days. PCR examination showed a positive result, whereas anti-HSV 1 IgM, anti-HSV 2 IgM, anti-HSV 2 IgG, VDRL, and TPHA were negative. The anti-HSV- 1 IgG result was reactive with a CD4 value of 122 cells/μL. The patient was given Acyclovir 3x400 mg for ten days and Co-amoxiclav 3x625 mg for seven days. Significant improvement was obtained, and the pain subsided. Conclusion: Clinical features of GH in infected HIV patients are often atypical and resemble other genital ulcers, thus requiring additional investigations. The serologic test may sometimes present a false negative, whereas PCR is much more sensitive and specific, nearing 100%. In patients with HIV infection, GH diagnosis at an early stage can shorten the course of the disease and prevent complications.
INFEKSI MENULAR SEKSUAL PADA PEREMPUAN YANG BERHUBUNGAN SEKS DENGAN PEREMPUAN Halim, Melissa; Krisanti, Roro Inge Ade; Indriatmi, Wresti; Nilasari, Hanny; Irawan, Yudo
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.426

Abstract

ABSTRAK Sebagian perempuan menunjukkan orientasi atau ketertarikan seksual, identitas gender, dan perilaku seksual yang berbeda. Infeksi menular seksual (IMS) pada perempuan yang berhubungan seks dengan perempuan (PSP), perempuan yang berhubungan seks dengan perempuan dan laki-laki (PSPL) baik riwayat lampau atau saat ini, maupun transgender laki-laki, jarang mendapat perhatian. Terdapat beragam faktor risiko penularan IMS pada kelompok PSP, PSPL, dan transgender laki-laki. IMS yang dialami dapat disebabkan oleh virus, bakteri, atau pun protozoa. Strategi pencegahan IMS termasuk pemeriksaan penapisan perlu disesuaikan dengan anatomi dan aktivitas seks setiap orang. Prinsip tata laksana IMS pada kelompok minoritas seksual tersebut sama dengan tata laksana IMS secara umum. Keterbatasan studi mengenai IMS pada kelompok ini menyebabkan belum tersedia data epidemiologi yang representatif. Pemahaman mengenai IMS pada PSP, PSPL, dan transgender laki-laki dapat meningkatkan kualitas pelayanan kesehatan pada kelompok minoritas ini.
Co-Authors Adisasmito, Ayutika Saraswati Ahmad Yudianto Aldri Frinaldi Andi Yasmon Anggraini, Ika Anissa, Lidwina Aria Kekalih Arlha Aporia Debinta Badriul Hegar Benny Nelson Budi Iman Santoso Caroline Oktarina Christa Desire Gracia Christine Lieana Djaja Surya Atmadja Efendi, Ida Effendi, Ida Emma Rusmayani Endi Novianto Erwinanto Evita Halim Effendi Evita Halim Effendi Evita Karianni Bermanshah Fathan, Hafiza Fauziah, Siti Nurani Fourina, Peppy Githa Rahmayunita Gultom, Desy A. Hafiza Fathan Halim, Melissa Hanny Nilasari Harrina E. Rahardjo Hartono Gunardi Haswinzky, Rose Amalia Heri Wibowo Herkutanto Hutabarat, Hernayati Hutasuhut, Magna I Putu G Kayika Ika Anggraini Indina Sastrini Inge Ade Krisanti Irawan, Yudo Irene Dorthy Santoso Jacoeb, Tjut N.A. Jhauharina Rizki Fadhilla Joedo Prihartono Kemal N. Siregar Krisanti, Inge Ade Kuraga, Rahmaniar Desianti Kurniawan, Kristian Kusmarinah Bramono Larisa Paramitha Leonardo Lesmana, Elvira Lidwina Anissa Lili Legiawati Manalu, Patricsia Marissa, Melani Martinus Tarina Martinus, Martinus Mawardi, Prasetya Melani Marissa Melani Marissa Nadjib Advani Nelson, Benny Ningrum, Rizki Irianti Rakasiwi Nur Azizah, Anggita Nurhadi Ibrahim Patricsia Manalu Peppy Fourina Pusponegoro, Erdina H.D. Rahadi Rihamadja Rahadi Rihatmadja Rahadi Rihatmadja Rahmaniar Desianti Kuraga Rinadewi Astriningrum Rinawati Rohsiswatmo Rizki Irianti Rakasiwi Ningrum Roro Inge Ade Krisanti Saleha Sungkar Santoso, Dewi Irawati Soeria Santoso, Irene Dorthy Sastrini, Indina Satya Wydya Yenny Setyorini, Mirawati Shannaz Nadia Yusharyahya Shelly Shelly Sirait, Sondang Panjaitan Siti Nurani Fauziah Siti Setiati Sondang Pandjaitan Sirait Sri L. Menaldi Sugiharto, Ade Firmansyah Surahman Hakim Suyatna, Fransiscus Dhyanagiri Tetty Yuniarti Tiara Aninditha Valdi Ven Japranata Wahyu Widodo Widjajalaksmi Kusumaningsih, Widjajalaksmi Widya Artini Windy Keumala Budianti Yeva Rosana Yudo Irawan Yudo Irawan Yvan Vandenplas Zainal Hakim