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All Journal Medical Journal of Indonesia Universa Medicina Journal of General Procedural Dermatology and Venereology Indonesia Majalah Kedokteran Andalas Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia Jurnal Kedokteran Meditek Ophthalmologica Indonesiana
Wresti Indriatmi B. Makes
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The role of dermoscopy in non-pigmented skin disorders Fathan, Hafiza; Indriatmi, Wresti; Rihatmadja, Rahadi; Krisanti, Inge Ade
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

The use of dermoscopy in non-pigmented skin disorders includes dermoscopy as a diagnostic tool for non- pigmented skin tumors, inflammatory diseases (inflammoscopy) and/or infectious disease (entomodermoscopy), lesions on nail fold and as a tool to monitor skin reaction as a response to treatment and/or side effect. The diagnosis becomes easier, faster and less expensive with dermoscopy without the need for invasive procedures. Knowledge on vascular pattern and its architectural arrangement; which is coupled with additional dermoscopic features, can aid clinicians to the diagnosis. Dermatoscopy can also predict, monitor and evaluate therapeutical response and/or side effect of skin disorders. Nonetheless, dermoscopy has its limitations. Many of various non-pigmented disorders have more specific clinical features than dermoscopic ones, for clinicians to rely on to establish a diagnosis.
Photodermatoses in Children Fauziah, Siti Nurani; Indriatmi, Wresti; Legiawati, Lili
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

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Abstract

Photodermatoses cover the skin’s abnormal reactions to sunlight, usually to its ultraviolet (UV) component or visible light. Etiologically, photodermatoses can be classified into 4 categories: (1) immunologically mediated photodermatoses (idiopathic photodermatoses); (2) drug- or chemical-induced photosensitivity; (3) hereditary photodermatoses; and (4) photoaggravated dermatoses. The incidence of photodermatoses in the pediatric population is much lower than in adults, Polymorphous light eruption (PMLE) is the most common form of photodermatoses in children, followed by erythropoietic protoporphyria. Early diagnosis and investigations should be performed to avoid long-term complications. Photoprotection is the mainstay of photodermatoses management, including use of physical protection and sunscreen.
Vaginal microbiota in menopause Martinus, Martinus; Wibawa, Larisa Paramitha; Effendi, Evita Halim; Yusharyahya, Shannaz Nadia; Nilasari, Hanny; Indriatmi, Wresti
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 1, No. 3
Publisher : UI Scholars Hub

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The human vagina together with its resident, microbiota, comprise a dynamic ecosystem. Normal microbiota is dominated by Lactobacillus species, and pathogen microbiota such as Gardnerella species and Bacteroides species can occur due to decrease in Lactobacillus domination. Lactobacillus plays an essential role in keeping normal vaginal microbiota in balance. Vaginal microbiota adapts to pH change and hormonal value. Changes in the vaginal microbiota over a woman’s lifespan will influence the colonization of pathogenic microbes. They include changes in child, puberty, reproductive state, menopause, and postmenopause. Estrogen levels change will affect the colonization of pathogenic microbium, leading to genitourinary syndrome of menopause. Vulvovaginal atrophy is often found in postmenopausal women, and dominated by L. iners, Anaerococcus sp, Peptoniphilus sp, Prevotella sp, and Streptococcus sp. The normal vaginal microbiota’s imbalance in menopause will cause diseases such as bacterial vaginosis, and recurrent vulvovaginal candidiasis due to hormonal therapies. Changes in the vaginal microbiota due to bacterial vaginosis are characterized by decrease in H2O2-producing Lactobacillus. They are also caused by the increase in numbers and concentration of Gardnerella vaginalis, Mycoplasma hominis, and other anaerob species such as Peptostreptococci, Prevotella spp, and Mobiluncus spp.
Efficacy of inosine pranobex as an adjuvant oral therapy in anogenital warts: an evidence-based case report Nelson, Benny; Sastrini, Indina; Anissa, Lidwina; Manalu, Patricsia; Fourina, Peppy; Kuraga, Rahmaniar Desianti; Indriatmi, Wresti
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Human papillomavirus (HPV) causes the most prevalent sexually transmitted infection and is an important etiological factor in genital cancer. HPV infection manifests in broad spectrum, from genital warts to cervical intraepithelial neoplasia and cancers. Genital warts remain a frequent problem in primary care. Current modalities provide unsatisfactory result in curing genital warts completely. To date, there are many convincing studies encouraging oral inosine pranobex as an adjuvant therapy to improve post-conventional therapy cure-rate. Aim: To assess the efficacy of inosine pranobex as an adjuvant oral therapy in anogenital warts. Methods: Literature search was performed using Pubmed, Ebsco and Science Direct database. Inclusion criteria were human subjects, randomized controlled trial on patients with genital warts, and inosine pranobex as adjuvant therapy. The studies were appraised and findings were formulated to find the best evidence for collating recommendations in treating genital warts patients. Results: There were three articles related to the clinical questions. All articles were found to be valid after selection based on exclusion and inclusion criteria. Discussion: All articles recommended the addition of oral inosine pranobex as an adjuvant therapy in treating patient with genital warts. Based on the critical appraisal performed previously, addition of oral inosine pranobex may minimize conventional therapy failure. Conclusion: Based on the best evidence available, we would recommend the addition of oral inosine pranobex as adjuvant for treating genital warts, except in special conditions, such as for patients with financial problem as this therapy was not covered by national health insurance.
Ulcus vulvae acutum - A rare case Santoso, Irene Dorthy; Anggraini, Ika; Indriatmi, Wresti; Irawan, Yudo; Nilasari, Hanny; Marissa, Melani; Sirait, Sondang P.; Rihatmadja, Rahadi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Background: Ulcus vulvae acutum, also known as Lipschütz ulcer, is a rare condition characterized by multiple, painful, and acute genital ulceration in young women without venereal infections, associated with systemic symptoms like malaise, fever, and inguinal lymphadenopathy. Case Illustration: A 24-year-old woman developed multiple and painful vulvar ulcers that recurred for almost a year. The patient was primarily diagnosed and treated as genital herpes in several hospitals with only slight improvement and no complete healing. The patient came to our hospital for examinations to rule out sexually-transmitted infection (STI) (genital herpes, syphilis, HIV, and chancroid) and possibility of Behçet’s. The patient was treated with a combination of 2.5% lidocaine and 2.5% prilocaine creams for 1 week, 2% fusidic acid ointment for 1 week, with no significant progression. Later, the therapy was changed to 0.05% clobetasol propionate ointment for 10 days. Complete healing occurred in about 10 weeks with no scarring. Discussion: Diagnosis of ulcus vulvae acutum in this patient was made by excluding other differential diagnoses. Conclusion: Ulcus vulvae acutum is a difficult diagnosis, and clinician should be aware of this entity especially when encountering young woman without previous sexual experience problem with ulcer.
Perbandingan Efektivitas Terapi Asiklovir dibandingkan dengan Plasebo pada Pitiriasis Rosea: Sebuah Laporan Kasus Berbasis Bukti Arlha Aporia Debinta; Christa Desire Gracia; Wresti Indriatmi
Jurnal Kedokteran Meditek Vol 28 No 3 (2022): SEPTEMBER-DESEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i3.2396

Abstract

Pitiriasis rosea merupakan kelainan kulit eritroskuamosa swasirna yang diduga disebabkan oleh human herpesvirus 6 dan 7. Etiologi dan patomekanisme penyakit yang belum diketahui dengan pasti menimbulkan tantangan dalam tata laksana penyakit ini. Pengobatan yang dianjurkan beragam, mulai dari simtomatik, antivirus, antibiotik, hingga fototerapi, namun, belum terdapat pedoman tatalaksana yang baku. Tujuan dari tinjauan sistematis ini adalah untuk membandingkan asiklovir dibandingkan plasebo dalam regresi lesi pitiriasis rosea. Metode penelitian menggunakan penelusuran artikel di tiga database yaitu PubMed, Cochrane dan Scopus. Hasil penelusuran ditemukan 29 artikel, kemudian terpilih satu meta-analisis dari uji klinis yang sesuai berdasarkan validitas, kepentingan, dan aplikabilitas. Meta-analisis tersebut menunjukkan bahwa asiklovir unggul terhadap plasebo dalam regresi lesi pitiriasis rosea di hari ke-7. Kesimpulan dari penelusuran ini menunjukkan bahwa asiklovir lebih efektif dalam mengobati lesi pitiriasis rosea dibandingkan dengan plasebo.
Comparison of Intraocular Pressure After Water Drinking Test in Primary Open Angle Glaucoma Patients Controlled with Latanoprost and Trabeculectomy Emma Rusmayani; Widya Artini; Wresti Indriatmi
Majalah Oftalmologi Indonesia Vol 47 No 1 (2021): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v47i1.100157

Abstract

Purpose: To compare intraocular pressure (IOP) after water drinking test in primary open angle glaucoma patients controlled with latanoprost 0.005% and trabeculectomy.Methods: Observational study with cross-sectional design of 28 eyes with primary open angle glaucoma (POAG) patients. Subjects were divided into two groups, 14 patients controlled with trabeculectomy and 14 patients with latanoprost monotherapy. All subjects were under clinical therapy and had an intraocular pressure (IOP) equal or lower than 18 mm Hg, monitored during the follow up period. All subjects were submitted to the water drinking test. The results of the water drinking test, which were peak and fluctuation of IOP, were then compared between groups. Results: There were no significant difference between IOP peak between two groups (p=0.88). IOP fluctuation also showed no significant difference between groups (p=0.84). In both groups, baseline IOP strongly correlated with peak IOP in water drinking test with correlation coefficient r=0.96 (p<0.001) and r=0.71 (p=0.04), while baseline IOP in trabeculectomy group was strongly correlated with IOP fluctuation with correlation coefficient r=0.86 (p<0.001). Conclusions: Peak and fluctuation of IOP after water drinking test in primary open angle patients controlled with latanoprost and trabeculectomy showed no significant difference.
DIAGNOSIS DAN TATA LAKSANA KEKAMBUHAN KUSTA Caroline Oktarina; Melani Marissa; Wresti Indriatmi; Sri Linuwih Menaldi
Media Dermato-Venereologica Indonesiana Vol 49 No 2 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i2.340

Abstract

Leprosy relapse is defined as the reappearance of leprosy’s signs and symptoms following completion of adequate Multidrug Therapy (MDT) regimen. Indonesia is the third biggest contributor for leprosy relapse with 284 cases in 2018. Several factors contribute to the occurrence of relapse, which include presence of persisters, history of inadequate therapy, drug resistance, history of irregular treatment, history of dapsone monotherapy, high initial bacteriological index, high number of skin and nerve lesions, negative lepromin test, history of antireaction therapy, human immunodeficiency virus (HIV) infection, and pregnancy. Diagnosis of relapse can be established based on clinical, bacteriological, and therapeutic criteria, also histopathological and serological criteria, if possible. With those criteria, it should be easier to differentiate relapse from reaction, resistance, reactivation, and reinfection. The principal management for leprosy relapse is re-administration of MDT according to the type of relapse; however, therapy should be modified if there are any evidences of drug resistance. Things which are important to be taken into account during relapse treatment are leprosy type, past medication history, and the possibility of drug resistance. With proper knowledge and diagnostic algorithm, it is expected that the treatment can be administered immediately in order to prevent disability and transmission of infection.
Cotton swabs for the measurement of NF-ĸB, IFN-γ, and FOXP3+Treg from lesions of anogenital wart patients Hutabarat, Hernayati; Bramono, Kusmarinah; Indriatmi, Wresti; Wibowo, Heri; Budianti, Windy Keumala; Suyatna, Fransiscus Dhyanagiri; Prihartono, Joedo; Mawardi, Prasetya
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247496

Abstract

BACKGROUND Local tissue immunity plays a significant role in anogenital warts’ (AGW) pathomechanism and persistence. Assessing biomarkers from lesions instead of serum is recommended to evaluate therapeutic response. Since biopsy is invasive, it is necessary to find less invasive and more comfortable methods. This study aimed to assess the reliability of cotton swabs and tape stripping for evaluating AGW’s lesions biomarkers. METHODS We compared cotton swab versus tape stripping method to quantify nuclear factor-κappaB (NF-ĸB), interferon-gamma (IFN-γ), and FOXP3+regulatory T cell (FOXP3+Treg) from 3 patients with AGW in the preliminary study. The method was selected based on contamination possibility, side effects, and a simpler approach. The main study examined 48 patients with AGW for reliability and reproducibility using the best sampling method from preliminary result and Spearman’s Rho analysis, while considering the HIV status and CD4+ counts. RESULTS Both cotton swabs and tape stripping obtained adequate protein content for biomarkers examination. However, the tape stripping method was causing serum contamination and painful for patients due to the stripping. The total lesion volume in cotton swab method was positively correlated with all patients’ NF-ĸB (p = 0.001). IFN-γ had a negative correlation in all reactive HIV patients (p = 0.012). FOXP3+Treg and CD4+ counts were negatively correlated with total volume in reactive HIV patients (p = 0.046 and 0.017, respectively). CONCLUSIONS The cotton swab method was reliable in examining NF-ĸB, IFN-γ, and FOXP3+Treg due to its convenience and lack of serum contamination from AGW lesions, potentially improving patient comfort and practical benefits.
Developing an online reproductive health module on sexually transmitted infections for Indonesian adolescents: a qualitative mixed methods study Nilasari, Hanny; Indriatmi, Wresti; Gunardi, Hartono; Kayika, I Putu Gede; Kekalih, Aria; Siregar, Kemal Nazaruddin; Kurniawan, Kristian; Lesmana, Elvira; Haswinzky, Rose Amalia
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247635

Abstract

BACKGROUND A notable rise in sexually transmitted infection (STI) cases among youth correlates with a lack of reproductive health awareness, affecting nearly 80% of Indonesian adolescents. Additionally, sociocultural taboo acts as a challenge to reproductive health implementation in Indonesia. Therefore, this study aimed to develop an online reproductive health module focused on STIs for Indonesian adolescents. METHODS This research was a mixed methods approach, integrating quantitative study using univariate analysis (survey and questionnaire) and qualitative study using the Delphi method (open discussion and focus group discussion). The study was conducted between March 2 and July 28, 2022. We began by conceptualizing a literature-based module, an online survey, and virtual discussions involving students, teachers, and parents. Then, we consulted with clinical psychologists and dermatovenereologists. Additionally, students completed an assessment to establish a baseline of their knowledge, attitudes, and behaviors (KAB) regarding reproductive health and STIs. RESULTS Of 327 high school students across Jakarta, analysis of the 129 completed KAB surveys showed that only 56.6% and 65.1% attained acceptable scores (>65) for knowledge and behavior, respectively, with 24.8% being at risk for STIs. Key recommendations included incorporating multimedia elements, ensuring clarity and simplicity in language, adopting non-judgmental tone, providing comprehensive explanations of STIs and their long-term impact, and supporting learning with face-to-face sessions and ongoing access to concise, cost-effective educational resources. CONCLUSIONS Adolescents need a comprehensive, interactive, instructive, accessible, non-discriminatory reproductive module that strengthens the self-concept that upholds Indonesian values and norms.
Co-Authors Adisasmito, Ayutika Saraswati Aldri Frinaldi Andi Yasmon Anggraini, Ika Anissa, Lidwina Aria Kekalih Arlha Aporia Debinta Benny Nelson Caroline Oktarina Christa Desire Gracia Efendi, Ida Effendi, Ida Emma Rusmayani Endi Novianto Evita Halim Effendi Evita Halim Effendi Fathan, Hafiza Fauziah, Siti Nurani Fourina, Peppy Githa Rahmayunita Gultom, Desy A. Hafiza Fathan Halim, Melissa Hanny Nilasari Hartono Gunardi Haswinzky, Rose Amalia Heri Wibowo Hutabarat, Hernayati Ika Anggraini Indina Sastrini Inge Ade Krisanti Irawan, Yudo Irene Dorthy Santoso Jacoeb, Tjut N.A. Joedo Prihartono Kayika, I Putu Gede Kemal N. Siregar Krisanti, Inge Ade Kuraga, Rahmaniar Desianti Kurniawan, Kristian Kusmarinah Bramono Larisa Paramitha Lesmana, Elvira Lidwina Anissa Lili Legiawati Manalu, Patricsia Marissa, Melani Martinus Tarina Martinus, Martinus Mawardi, Prasetya Melani Marissa Melani Marissa Nelson, Benny Nur Azizah, Anggita Patricsia Manalu Peppy Fourina Pusponegoro, Erdina H.D. Rahadi Rihamadja Rahadi Rihatmadja Rahadi Rihatmadja Rahmaniar Desianti Kuraga Santoso, Irene Dorthy Sastrini, Indina Satya Wydya Yenny Shannaz Nadia Yusharyahya Sirait, Sondang P. Siti Nurani Fauziah Sondang Pandjaitan Sirait Sri L. Menaldi Suyatna, Fransiscus Dhyanagiri Widya Artini Windy Keumala Budianti Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yeva Rosana Yudo Irawan Zainal Hakim