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Radical Scavenging Activity and Quercetin Content of Muntingia calabura L. Leaves Extracted by Various Ethanol Concentration Ratih Dyah Pertiwi; Suwaldi; Ronny Martien; Erna Prawita Setyowati
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.581

Muntingia calabura is broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colorimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated that Muntingia calabura leaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M. calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent.

Radical Scavenging Activity and Quercetin Content of Muntingia calabura L. Leaves Extracted by Various Ethanol Concentration Ratih Dyah Pertiwi; Suwaldi; Ronny Martien; Erna Prawita Setyowati
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.581

Muntingia calabura is broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colorimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated that Muntingia calabura leaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M. calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent.

β-Carotene gingival mucoadhesive patch on Cx-43 and 8-Oxo-dg expression to prevent micronucleus formation due to panoramic radiography exposure Shantiningsih, Rurie Ratna; Suwaldi, Suwaldi; Astuti, Indwiani; Mudjosemedi, Munakhir
Padjadjaran Journal of Dentistry Vol 31, No 1 (2019): March 2019
Publisher : Universitas Padjadjaran

Introduction: β-carotene as a lipid-soluble antioxidant substance, expected to prevents the oxidative reaction and to improve the junctional communication detected by Cx-43. Micronucleus is known as one of the early markers of DNA damage which might be related to carcinogenesis mechanism that increased by panoramic radiography radiation exposure. The objective of this research was to analyse the effect of the β-carotene gingival mucoadhesive patch on Cx-43 expression and 8-oxo-dG to prevent micronucleus formation at the gingival mucosa of New Zealand rabbit due to panoramic radiography radiation exposure. Methods: β-carotene gingival mucoadhesive patch was applied to gingival mucosa of the experimental rabbits. In Group I, the rabbits without patch was a control group. Group II has applied the patch before radiography exposures, Group III during the radiography exposures, and Group IV after radiography exposures. Micronucleus samples were taken from the rabbit’s swabbed gingival mucosa, then stained using modified Feulgen-Rossenbeck. The 8-oxo-dG and Cx-43 expressions were detected using immunohistochemistry technique. The results were then analysed using two-way ANOVA. Results: The increasing number of micronucleus in Group I had a different mean (p < 0.05) with Group III and IV. The expression of 8-oxo-dG and Cx-43 had significant differences (p < 0.05) between Group I and III. This results indicated that β-carotene gingival mucoadhesive patch prevents the increasing number of micronucleus especially when it applied before and during panoramic radiography radiation exposure by the increasing Cx-43 and decreasing 8-oxo-dG expression. Conclusion: The β-carotene gingival mucoadhesive patch can be utilised to prevent the panoramic radiography radiation exposure’s effect. Keywords: β-carotene, gingival-mucoadhesive patch, micronucleus, radiation exposure

Analisis Label Halal pada Nama Dagang Obat Tablet Melalui Pengamatan pada Kemasan Sekunder terkait Jaminan Produk Halal di RSI Sultan Agung Semarang Aditya Dwi Meilani; Martodihardjo, Suwaldi; Ayu Ariessanti, Ida
Indonesian Journal of Medical and Pharmaceutical Science Vol. 1 No. 2 (2022)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v1i2.82

Background: Drug is a substance or mixture of materials used to prevent disease, treat, assist in diagnosis, render infertile or make muscles weak during surgery. The halal medicinal products in the manufacturing process, especially in the manufacturing of tablet drugs, must be free from ingredients containing pork and alcohol. In addition, tablet drugs can be said to be halal if in the production process it is proven that they are free from the critical point of halal medicinal ingredients. The purpose of this study was to find out how many trade names of tablet drugs were distributed by the Sultan Agung Islamic Hospital which included halal labels on the secondary packaging and the critical point of the halal tablet drugs. Methods: This study used an observational descriptive design. Data was collected by observing the secondary packaging of the Tablet Drug Trade Names found in the Hospital Pharmacy Logistics as many as 125 items of tablet drug trade names. The data is processed using tables and calculated the percentage of halal labels that have been listed as well as seeing the critical point of halal for drugs that have not been labeled halal. Results: The results of this study indicate that the inclusion of halal labels distributed by the Sultan Agung Islamic Hospital as many as 21 tablet drug items (16.8%) of the 125 tablet drug items have been labeled with a halal label and the rest have not included a halal label.Conclusion: Some of tablet drugs that are distributed by the Sultan Agung Islamic Hospital are not halal labelled, but still classified as halal drugs based on their composition and have been registered with BPOM.

Tingkat Pengetahuan Pasien Rawat Jalan di RSUD dr. Gondo Suwarno Ungaran terhadap Kehalalan Obat Martodihardjo, Suwaldi; Indriyati, Ajeng Mukti
Indonesian Journal of Medical and Pharmaceutical Science Vol. 3 No. 1 (2024)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v3i1.184

Background: Indonesia is a country where the majority of the population is Muslim. Ensuring the halalness of products, especially medicinal products in circulation, is a big concern for the government. For muslims consuming something halal is an obligation and command from Allah SWT, so that the halalness of a medicinal product becomes a necessity for consumers, especially muslim consumers. The purpose of this study is determine the level of knowledge of outpatients at RSUD dr. Gondo Suwarno Ungaran on halal medicine. Methods: This study using a cross sectional approach using a questionnaire that was announced to respondents. Results: The characteristics of respondents are divided into three they are, education, age and occupation. The majority of respondents are high school students (60%), age 18 years – 32 years (53.3%), with, private employee (36.7%). The level of patient knowledge of halal medicine (87.14%). Conclusion: Based on the research that has been conducted, it was found that the level of knowledge of outpatients at RSUD dr. Gondo Suwarno Ungaran on halal medicine 87.14% is included in the good category.

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