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All Journal e-Journal Pustaka Kesehatan Dentika Dental Journal Indonesian Journal of Cancer Chemoprevention STOMATOGNATIC- Jurnal Kedokteran Gigi Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) E-Dimas: Jurnal Pengabdian kepada Masyarakat Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Medica Hospitalia Jurnal Karinov Journal of Community Development Odonto dental journal Dental Agromedis
Banun Kusumawardani
Department Of Biomedical Sciences, Faculty Of Dentistry, Universitas Jember, Jember
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences

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Correlation between general health, nutrition, and oral health status of elderly in a typical retired community-house Kusumawardani, Banun; Dharmayanti, Agustin Wulan Suci; Robin, Dwi Merry Christmarini; Rahayu, Yani Corvianindya; Fitriyana, Nurul Isnaini
Padjadjaran Journal of Dentistry Vol 33, No 2 (2021): July 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no2.18950

Abstract

Introduction: Indonesia is in an aging population era marked by an increase in elderly population above 7%. An enhancement of elderly population presents health problems due to organ function deterioration and requires extraordinary attention. General health, nutrition, and oral health status are the most problems claimed by elderly, particularly retired. Objective of this study was to analyze the correlation between the general health, nutrition, and oral health status of elderly. Methods: Analytical descriptive research with cross sectional method was carried out on 36 respondents in Paguyuban Purnabakti, Patrang, Jember, East Java Province. The sampling was done by purposive sampling. Information about social-demography and general health status of respondents were obtained from the questionnaire. The social-demography investigation comprised sex, age, education level and status of residence. While general health observation, it comprised smoking status, general check-up, presence of systemic diseases, blood pressure and blood biochemical parameters.[CS1]  Nutritional status was examined by body mass index (BMI). Oral examination for identifying oral health status included the number of the teeth remaining in the oral cavity, use of dentures, oral hygiene index (OHI-s), and periodontal tissue health (CPITN). Results: The result exhibited that most of the respondents presented good general health status. However, there was no significant correlation between routine general health observation and age (p=0.906). Moreover, there was no significant relationship between blood biochemical profile (blood glucose, total cholesterol, and blood pressure level) with nutrition status (p=..., p=..., and p=... respectively), and oral health status (p=...), except with oral hygiene (p=...). Conclusion: This study is limited to Paguyuban Purnabakti, Patrang, Jember, East Java Province. Although this study could not be generated in all communities, this study concluded no relationship between general health (smoking, systemic disorders, and routine general health observation), nutritional status, and oral health in the elderly. [CS1]Disesuaikan dengan table 2
Edukasi dan Pemeriksaan Kesehatan Gigi Anak Usia Dini di Dusun Gayasan Kecamatan Jenggawah Kabupaten Jember Amara Kanya Maharan; Tsabitah Salsabil Aqilah; Syafiya Zata Yumni; Liesna Lusyana Nur; Banun Kusumawardani
Dental Agromedis Vol. 1 No. 1 (2023): Mei
Publisher : Fakultas Kedokteran Gigi, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/da.v1i1.348

Abstract

Early childhood is a vulnerable group for dental and oral health. Children at an early age are in the process of growth and development, and need attention and assistance from their parents in maintaining healthy teeth. The PKM-PM UNEJ aims to 1) increase knowledge about maintaining dental health for parents and early childhood; and 2) conduct dental health check-ups for early childhood. Implementation of activities is carried out by providing modules, practices, and questionnaires to measure target knowledge. The main potential of early childhood dental education and examination in Gayasan Hamlet, Jenggawah Village, Jember Regency is that early childhood can understand proper and correct tooth brushing techniques and methods accompanied by their parents. Partners are very enthusiastic and support PKM-PM activities. Next, partners really hope to be able to realize family dental health by preventing caries from an early age to support children's growth and development.Keywords: early childhood, developmental disorders, dental health
Analisa Pengetahuan PHBS pada Kader Posyandu Desa Tamanan Bondowoso dalam Upaya Penurunan Stunting Pada Balita Muhammad Nurul Amin; Tecky Indriana; I Dewa Ayu Ratna Dewanti; Nurud Diniyah; Budi Yuwono; Agus Sumono; Roedy Budirahardjo; Banun Kusumawardani
Dental Agromedis Vol. 2 No. 2 (2024): November
Publisher : Fakultas Kedokteran Gigi, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/da.v2i2.1722

Abstract

Stunting in toddlers is related to growth and development disorders. One important factor in preventing stunting is the implementation of Clean and Healthy Living Behaviour (CHLB). CHLB plays a role in improving the nutritional and health status of children, as well as preventing various diseases that can contribute to stunting. The role of cadres is very important because cadres are responsible for implementing the posyandu program, are the main movers in promotive, preventive activities and are motivators for community members. The aim of this service is to analyse knowledge about PHBS among posyandu cadres in Tamanan Village, Tamanan District, Bondowoso Regency. The service method is an outreach activity aimed at providing knowledge about CHLB with the hope that people will change their behaviour to protect their health and the environment independently. Formative evaluation procedures in the form of pretest and posttest. Data were analyzed using descriptive analysis techniques. Continue with the normality test and paired sample t-test. The results obtained were that this community service activity was carried out on all posyandu cadres. Evaluation showed that there was a difference in the average test scores before and after the counselling. Providing counselling is able to provide changes in the knowledge of posyandu cadres which is marked by an increase in posttest scores which are higher compared to posttest scores. The conclusion is that the knowledge of Tamanan Bondowoso Village Posyandu cadres regarding CHLB in efforts to reduce stunting in toddlers can be increased through the counselling provided.Keywords: CHLB, counseling, posyandu cadres, stunting.
Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells Kusumawardani, Banun; Febi, Qonita Nafilah; Rosidah, Malihatul; Azis, Deri Abdul; Puspitasari, Endah; Nugraha, Ari Satia
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp97-10

Abstract

Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells (African normal cell kidney line) in different concentrations. This study aimed to examine the cytotoxic potential of the flavonoid of Kasturi tobacco leaves against MCF-7 human breast cancer cells. Flavonoid obtained from methanolic extracts of Kasturi tobacco leaves, which have been purified from nicotine. The flavonoid of Kasturi tobacco leaves with concentrations of 20 to 640 μg/mL were exposed to MCF-7 and Vero cells for 24 h. Cell viability was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Flavonoid of Kasturi tobacco leaves with concentrations of 160 μg/mL decreased the MCF-7 cell viability more than 50%, with an inhibitory concentration 50 (IC50) value of 148.41 μg/mL. Meanwhile, it inhibited 50% of Vero cell viability at 255.35 μg/mL. The flavonoid of Kasturi tobacco leaves has cytotoxic activity on MCF-7 cells, and might be a potential alternative agent for human breast cancer therapy.Keywords: flavonoid, tobacco leaves, human breast cancer cells, anticancer activity
The effect of supernatants of Lactobacillus casei against Porphyromonas gingivalis Zainina, Iris Amelinda; Kusumawardani, Banun; Sari, Desi Sandra
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.101506

Abstract

Periodontitis is an inflammatory disease of the periodontal tissues primarily caused by Porphyromonas gingivalis (P. gingivalis). In recent years, probiotics have been proposed as a potential bacteriotherapeutic approach for periodontitis. Probiotic bacteria such as Lactobacillus casei (L. casei) are known to produce antibacterial compounds, which can be found in their culture supernatants. The ability of L. casei to grow and synthesize these substances depends on environmental factors, including pH. Based on preliminary findings, a pH of 6.5 was used in this study. This study aimed to evaluate the antibacterial activity of L. casei supernatant against P. gingivalis in vitro. The research employed an experimental post-test-only group design. Two control groups were included: a negative control (aquadest) and a positive control (0.2% chlorhexidine). The treatment groups received L. casei supernatant at volumes of 20 µl, 50 µl, and 80 µl, with incubation periods of 6, 12, and 24 hours. The results demonstrated that the L. casei supernatant exhibited the highest antibacterial activity against P. gingivalis at a volume of 80 µl after 12 hours of incubation. The Shapiro–Wilk test indicated that the data were normally distributed, while Levene’s test revealed a lack of homogeneity. Post hoc analysis showed significant differences among all treatment groups at the 12-hour incubation point. In conclusion, the supernatant of L. casei exhibits in vitro antibacterial activity against P. gingivalis.
THE CYTOTOXIC AND PROLIFERATIVE ACTIVITY OF COCOA POD HUSK EXTRACT (THEOBROMA CACAO L.) ON PERIODONTAL LIGAMENT FIBROBLASTS Rahayu, Yani Corvianindya; Triwahyuni, Iin Eliana; Kusumawardani, Banun; Sari, Dewi Yunita
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.479 KB) | DOI: 10.30659/odj.9.1.46-52

Abstract

Background: Theobroma cacao was considered agricultural wastes. Cocoa pod husk contain various bioactive compounds as natural antioxidants,antibacterial and anti-inflammatory. A good biomaterial must be non-toxic and have no detrimental effect on the biological environment. The aim of research was to determine the cytotoxicity and proliferative activity of cocoa pod husk extract on primary cells of periodontal ligament fibroblasts. Method: This experimental laboratory used primary cell culture of periodontal ligament fibroblasts. The cytotoxicity and proliferative activity were analyzed by MTT assay [2-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]. Extraction of cacao pods were obtained using the ultrasonic homogenizer method with ethanol 70%. The cytotoxicity test was observed for 24 hours and the doubling time proliferative test was observed for 24, 48, and 72 hours. Result: Cocoa pod husk extract showed there were no cytotoxic effects with viability of primary cells of periodontal ligament fibroblasts at the concentration of 1.56 pg/ml, 3.125 pg/ml, 6.25 pg/ml, 12.5 pg/ml, 25 pg/ml, 50 pg/ml, and 100 pg/ml. The proliferation test showed increasing of fibroblasts at 24 and 48 hours. Kruskal Wallis analysis obtained a significance value (p<0.05) Conclusion: Cytotoxicity and proliferation assays of Cocoa pod husk extract increased cell viability and cell proliferation of periodontal ligament fibroblast.
THE CYTOTOXIC AND PROLIFERATIVE ACTIVITY OF COCOA POD HUSK EXTRACT (THEOBROMA CACAO L.) ON PERIODONTAL LIGAMENT FIBROBLASTS Rahayu, Yani Corvianindya; Triwahyuni, Iin Eliana; Kusumawardani, Banun; Sari, Dewi Yunita
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.1.46-52

Abstract

Background: Theobroma cacao was considered agricultural wastes. Cocoa pod husk contain various bioactive compounds as natural antioxidants,antibacterial and anti-inflammatory. A good biomaterial must be non-toxic and have no detrimental effect on the biological environment. The aim of research was to determine the cytotoxicity and proliferative activity of cocoa pod husk extract on primary cells of periodontal ligament fibroblasts. Method: This experimental laboratory used primary cell culture of periodontal ligament fibroblasts. The cytotoxicity and proliferative activity were analyzed by MTT assay [2-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]. Extraction of cacao pods were obtained using the ultrasonic homogenizer method with ethanol 70%. The cytotoxicity test was observed for 24 hours and the doubling time proliferative test was observed for 24, 48, and 72 hours. Result: Cocoa pod husk extract showed there were no cytotoxic effects with viability of primary cells of periodontal ligament fibroblasts at the concentration of 1.56 pg/ml, 3.125 pg/ml, 6.25 pg/ml, 12.5 pg/ml, 25 pg/ml, 50 pg/ml, and 100 pg/ml. The proliferation test showed increasing of fibroblasts at 24 and 48 hours. Kruskal Wallis analysis obtained a significance value (p<0.05) Conclusion: Cytotoxicity and proliferation assays of Cocoa pod husk extract increased cell viability and cell proliferation of periodontal ligament fibroblast.
Penguatan Budaya Sadar Bencana Bagi Generasi Muda Desa Terdampak Erupsi Gunung Semeru di Desa Sumberwuluh, Kecamatan Candipuro, Kabupaten Lumajang Ali Badrudin; Banun Kusumawardani; Tecky Indriana; Agustina Dewi Setyari; Indra Nurtjahjaningtyas; Arif Mohammad Siddiq; Nindha Ayu Berlianti; Nilasari Dewi
Journal of Community Development Vol. 5 No. 3 (2025): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v5i3.676

Abstract

Mount Semeru as one of the highest mountains on the Java island has significant volcanic activity to date. The eruption of this volcano had a considerable impact on the surrounding area, including Sumberwuluh Village, Candipuro District, Lumajang Regency. The impact felt by the community is not only physical damage but also trauma. Therefore, a disaster awareness culture needs to be built and strengthened early in order to reduce the impact caused when a disaster occurs. The Institute for Research and Community Service (LP2M) of the University of Jember in collaboration with the Regional Disaster Management Agency (BPBD) of Lumajang Regency carried out service activities for elementary school students and teachers in Sumberwuluh Village with the aim of strengthening the culture of disaster awareness. This activity has been attended by students and teachers from SDN Sumberwuluh 1, SDN Sumberwuluh 2, SDN Sumberwuluh 3, SDN Sumberwuluh 4, SDN Sumberwuluh 5 and MI Miftahul Ulum. This is carried out through two stages, socialization about the importance of disaster preparedness and direct practice of disaster preparedness consisting of water boat evacuation, webbing and trauma healing. This program has succeeded in increasing disaster preparedness awareness through disaster education from an early age. In addition, this activity also succeeded in improving knowledge and practical skills in disaster preparedness by 88% and building a better mentality and readiness in dealing with emergency situations.
Confirmation of the potential mechanism of pentagamavunon-0 against temporomandibular arthritis using bioinformatic approaches Dwi Merry Christmarini Robin; Retno Ardhani; Dhania Novitasari; Banun Kusumawardani; Faaza Aulia Rahman; Edy Meiyanto; Nunuk Purwanti
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p367-375

Abstract

Background: Non-steroidal anti-inflammatory drugs (NSAID) are widely used in temporomandibular joint osteoarthritis management. However, the side effects of NSAIDs on multiple organs need to be anticipated. Curcumin is known for its anti-inflammatory and analgesic potential, comparable to that of NSAIDs. In a previous study, structurally modified curcumin increased the pharmacological effect and simultaneously reduced the toxicity and side effects of curcumin. Pentagamavunon-0 (PGV-0) is one of the active components synthesized by the structure modification of curcumin. Purpose: In this study, we identify the potential target of PGV-0 on the pathogenesis of temporomandibular arthritis characterized by inflammation. Methods: We used a bioinformatics approach to compare the PGV-0 target with curcumin and diclofenac sodium as controls. We identified overlapping gene targets of bioactive compounds (PGV-0, curcumin, or diclofenac sodium) retrieved from the SwissTargetPrediction and GeneCards platforms, specifically for temporomandibular arthritis. An interaction model among targets was developed using the STRING database and Gene Ontology Panther to expound on the bioactive compound’s function on the key signaling pathway. Finally, we formulated a molecular docking prediction between the bioactive compound and the target protein marker derived from the previous analysis using Molecular Operating Environment tools. Results: This study found that curcumin and PGV-0 targeted different molecular pathways in temporomandibular arthritis compared to diclofenac sodium. Curcumin and PGV-0 shared a similar pathway to curcumin by modulating metalloproteinases (MMPs), especially MMP-9 and MMP-13. Moreover, diclofenac sodium influenced cyclooxygenase metabolism. Conclusion: In this study, PGV-0 targeted metalloproteinase in temporomandibular arthritis pathogenesis. This finding underlines the PGV-0 advantage in preventing metalloproteinase-related tissue damage in temporomandibular arthritis.
Co-Authors Agustin Wulan Suci Dharmayanti Ali Badrudin Amara Kanya Maharan Amara Kanya Maharani Ari Satia Nugraha Arif Mohammad Siddiq Arini Haqli Putri Wasyim Azham Purwandhono Azis, Deri Abdul Budi Yuwono Budi Yuwono Chiquita Prahasanti Dea Ajeng Pravita Suendi Dea Ajeng Pravita Suendi Depi Praharani Desi Sandra Sari Dewi Setyari, Agustina Dewi Yunita Sari Dhania Novitasari Djaswadi Dasuki Djaswadi Dasuki Dwi Merry Christmarini Robin Dwi Warna Aju Fatmawati Edy Meiyanto Endah Puspitasari Erfin Ramadana Pratama Erna Dwi Saputri Faaza Aulia Rahman Febi, Qonita Nafilah Fitriyana, Nurul Isnaini Herniyati I Dewa Ayu Ratna Dewanti I Komang Evan Wijaksana Iin Eliana Triwahyuni Indah Rahma Islami Indra Nurtjahjaningtyas Intan Julita Purnamasari Irma Josefina Savitri Izzata Barid Kurnia Dwi Wulan Liesna Lusyana Nur Liesna Lusyana Nur Marsetyawan HNE. Soesatyo Marsetyawan Soesatyo Marsetyawan Soesatyo Morin Inas Altariq Muhammad Nurul Amin Niken Luthfiyya Arini Nilasari Dewi Nindha Ayu Berlianti Noer Ulfah Nunuk Purwanti Nurud Diniyah Onge Victoria Hendro Padmini Hari Parawita Dewanti Retno Ardhani Riria Hendarto Putri Roedy Budirahardjo Rosidah, Malihatul Rudi Joelijanto Rusliyana Nuarita Rusliyana Nuarita, Rusliyana Shahabe Saquib Abullais Suhartini Suhartini Suhartini Suhartini Suhartini Suhartini Sumono, Agus Syafiya Zata Yumni Tecky Indriana Tiara Almas Ghasani TRI HANDOYO Tsabitah Salsabil Aqilah Vainan Faroh Vananda Duanta Kantasa Wachju Subchan Widya Asmara Widya Asmara Windy Sukma Kemalasari Yani Corvianindya Rahayu Yuliana Mahdiyah Daat Arina Yunita Prasetyo Ningrum Zahara Meilawaty Zahreni Hamzah Zainina, Iris Amelinda