Article Per Year (5 Year)
p-Index From 2020 - 2025
6.575
P-Index
This Author published in this journals
All Journal Jurnal Sain Peternakan Indonesia Jurnal Ternak Tropika Animal Production : Indonesian Journal of Animal Production JURNAL ILMIAH PETERNAKAN TERPADU Jurnal Peternakan Nusantara Jurnal Ternak Jurnal Pengabdian Kepada Masyarakat MEMBANGUN NEGERI Jurnal Pengabdian Al-Ikhlas Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) REKASATWA : Jurnal Ilmiah Peternakan Bioscientist : Jurnal Ilmiah Biologi Buletin Peternakan Tropis (Bulletin of Tropical Animal Science) journal of Basic Medical Veterinary Jurnal sains dan teknologi industri peternakan Jurnal Ilmu Pengetahuan dan Tekhnologi Peternakan Jurnal Kedokteran Hewan Jurnal Intelek Dan Cendikiawan Nusantara KOPEMAS Dinamika Rekasatwa: Jurnal Ilmiah (e-Journal)
Mudawamah Mudawamah
Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Veterinary Other

Published : 51 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : journal of Basic Medical Veterinary

 1 
Amelioration of Cigarette Smoke-Induced Hepatic Injury by Green Tea (Camellia sinensis) Extract: Evidence from SGOT and SGPT Biomarkers in a Murine Model Indrajaya, Putra; Mudawamah, Mudawamah; Kalsum, Umi; Trisakti, Adinda Rizky; Rahmatullah, Aldin Akbar
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72636

Abstract

This study investigated the hepatoprotective effects of green tea extract (GTE) against cigarette smoke-induced liver damage in mice. Twenty-five male mice (Mus musculus) were divided into five groups: negative control (C-), positive control exposed to cigarette smoke (C+), and three experimental groups exposed to cigarette smoke and treated with different doses of GTE: 20 mg/kg BW (T1), 40 mg/kg BW (T2), and 60 mg/kg BW (T3). Following 36 days of treatment, serum SGOT and SGPT levels were measured as biomarkers of hepatocellular injury. Results showed significant elevation of both enzymes in the C+ group (SGOT: 50.46 ± 2.49 U/L; SGPT: 19.48 ± 1.47 U/L) compared to the C- group (SGOT: 35.10 ± 2.49 U/L; SGPT: 10.22 ± 1.68 U/L), indicating cigarette smoke-induced hepatotoxicity. GTE administration demonstrated dose-dependent hepatoprotection, with the highest dose (T3) showing the most substantial effect (SGOT: 38.26 ± 1.25 U/L; SGPT: 11.01 ± 1.05 U/L). Statistical analysis revealed significant differences between groups (p<0.05). The hepatoprotective mechanisms of GTE likely involve its potent antioxidant properties, enhancement of endogenous antioxidant systems, anti-inflammatory effects, modulation of xenobiotic metabolism, and mitochondrial protection. These findings suggest that green tea extract may serve as a promising natural hepatoprotective agent against cigarette smoke-induced liver injury, with potential applications in preventive healthcare strategies.
Co-Authors A, Aulanniam A. A. Mirella AA Sudharmawan, AA Ach. Akmal Basyar Achmad Iklilul L.L. As’ad Achmad Setiyono Afidhatul Masruroh Agus Budiarto Aisyah Dian Sulistyaningarum Alhikami, Waliyyul Ahdi Anan Matur Anggita, Arnes Armada armada Aulanni'am, Aulanni'am Badriyah B Badriyah B, Badriyah Badrus Sholeh Cicik Sulistyo Winarni D. Sunarto Darmawan, Drajad Azis Dedi Suryanto Deni Sartika Diani, Khonita Rahma Eka Putri, Yosephine Angelina Yulia Faiqul Mubarok Fatimah Azzahra Fitriyah Fitriyah Gatot Ciptadi Gusfarisa Rafika Putri Hadiansyah Hadiansyah Hairoh, Nikhmatul Hendy Mahendra Hendy Mahendra Herman Christantyo I Gusti Putu Diva Awatara I.D. Retnaningtyas I.D. Retnaningtyas, I.D. Indrajaya, Putra Inggit Kentjonowaty Juliadi Azhar Kurniawan Khoirur Roziqin Khonita R. Diani M. Auzaini M. Faisal Armanda M. Ricky Adi Santoso M. Rizqi Hamdilah M. Z. Anwar M. Z. Fadli M. Zainul Fadli M.F. Wadjdi M.F. Wadjdi, M.F. Mahendra, Hendy Meyya L. Zain Muh. Ainun Syamsuddin Haris Musdalifah, Faigah Nabila Latifa Hae Nahdiyatul Ummah Nur Rohman, Mohamad Agung Nurul Humaidah Oktavia Rahayu Puspita Oktavia Rahayu Puspitarini Rahman, A. K. Rahmatullah, Aldin Akbar Retnaningtyas, irawati Dinasari rohimah Rohimah S. Ali S. Susilowati S. Susilowati Sari, Ayu Mufidah Kartika Setiawan setiawan Sholihah, Anis Sri Susilowati Sugiono, Sugiono Sukiman, Anding Sumartono Sumartono Sumartono Sumartono Sumartono Sunaryo Sunaryo Supiyah Puteri Ramdhani Susilowati S Taufiqur Rahman Trijaya Trijaya Trisakti, Adinda Rizky Umi Kalsum Usman Ali Wibowo, Heru Budi widayat, moch widayat Widianto, Tri Yudi Hartoyo Yuwantoro yuwantoro Zulchaidi Zulchaidi